Abstract：
:We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Harrison H,Farnie G,Brennan KR,Clarke RBdoi
10.1158/0008-5472.CAN-10-1559subject
Has Abstractpub_date
2010-11-15 00:00:00pages
8973-6issue
22eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-10-1559journal_volume
70pub_type
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