Abstract：
:We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Numata S,Claudio PP,Dean C,Giordano A,Croce CMsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
3741-7issue
15eissn
0008-5472issn
1538-7445journal_volume
59pub_type
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