Tumor necrosis factor as an autocrine growth factor for neuroblastoma.

abstract：:The mechanism of latent membrane protein LMP1 of EBV in inducing cell transformation and tumorigenesis was investigated in Rat-1 fibroblasts. A plasmid encoding a site-specific mutant of LMP1 defective in binding to tumor necrosis factor receptor-associated death domain protein was constructed. This LMP1(TRADD) gene i...

journal_title：Cancer research

authors： He Z,Xin B,Yang X,Chan C,Cao L

更新日期：2000-04-01 00:00:00

abstract：:Similar histologic subtypes of cancers often exhibit different spectrum of genetic and epigenetic alterations. The heterogeneity observed due to lack of consistent and defined alterations affecting a unique set of gene(s) or gene products in cancers derived from a specific tissue, or an organ, pose a challenge in unra...

journal_title：Cancer research

authors： Thiagalingam S

更新日期：2006-08-01 00:00:00

abstract：:The complement cascade is a part of the innate immune system that acts primarily to remove pathogens and injured cells. However, complement activation is also peculiarly associated with tumor progression. Here we report mechanistic insights into this association in multiple immunocompetent orthotopic models of lung ca...

journal_title：Cancer research

authors： Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA

更新日期：2018-01-01 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:Two human pancreatic cell lines, MIA PaCa 2 and Capan 2, were treated by photodynamic therapy in vitro with Photophrin (0.01-25 micrograms/ml; 24 h) and then light (1-50 J/cm2; lambda = 630 nm). The following model was fit to 6 datasets with weighted nonlinear regression: [sequence: see text] The symbols are: E, cell ...

journal_title：Cancer research

authors： Moesta KT,Greco WR,Nurse-Finlay SO,Parsons JC,Mang TS

更新日期：1995-07-15 00:00:00

abstract：:Fischer X Copenhagen rats bearing Dunning R3327-AT tumors were treated with hematoporphyrin derivative and red light (630 nm from an argon-driven dye laser) alone or in combination with the hypoxic cell radiosensitizer, misonidazole (MISO). In vitro studies had suggested that hypoxia might significantly decrease the c...

journal_title：Cancer research

authors： Gonzalez S,Arnfield MR,Meeker BE,Tulip J,Lakey WH,Chapman JD,McPhee MS

更新日期：1986-06-01 00:00:00

abstract：:Oncogenic activation of the BRAF serine/threonine kinase has been associated with initiation and maintenance of melanoma tumors. As such, development of pharmacologic agents to target RAF proteins or their effector kinases is an area of intense investigation. Here we report the biological properties of GDC-0879, a hig...

journal_title：Cancer research

authors： Hoeflich KP,Herter S,Tien J,Wong L,Berry L,Chan J,O'Brien C,Modrusan Z,Seshagiri S,Lackner M,Stern H,Choo E,Murray L,Friedman LS,Belvin M

更新日期：2009-04-01 00:00:00

abstract：:Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render cells glucose dependent. Although manipulation of glucose metabolism may provide a means to specifically eliminate cancer cells, mechanistic links between cell met...

journal_title：Cancer research

authors： Coloff JL,Macintyre AN,Nichols AG,Liu T,Gallo CA,Plas DR,Rathmell JC

更新日期：2011-08-01 00:00:00

abstract：:A dose-response study in carcinogenesis was carried out with N-nitrosomorpholine in female F344 rats. The compound was administered in drinking water, which was supplied in controlled amounts of 20 ml per day per rat, 5 days a wk. At the two highest dose rates, 100 mg/liter and 40 mg/liter, treatment lasted 25 and 40 ...

journal_title：Cancer research

authors： Lijinsky W,Kovatch RM,Riggs CW,Walters PT

更新日期：1988-04-15 00:00:00

abstract：:Human and murine cancers can express multiple independent antigens as targets for cytolytic T-cells (CTLs). The immune response against one such tumor was studied at the cellular and molecular level by analyzing the T-cell receptor beta chains of CTLs responding in vivo to a murine UV light-induced cancer. A 5-13-fold...

journal_title：Cancer research

authors： Seung S,Urban JL,Schreiber H

更新日期：1993-02-15 00:00:00

abstract：:GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of epidermal growth factor receptor (EGFR, ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like conformation of EGFR that is ver...

journal_title：Cancer research

authors： Wood ER,Truesdale AT,McDonald OB,Yuan D,Hassell A,Dickerson SH,Ellis B,Pennisi C,Horne E,Lackey K,Alligood KJ,Rusnak DW,Gilmer TM,Shewchuk L

更新日期：2004-09-15 00:00:00

abstract：:Previous data on the effects of a single dose of hydroxyurea on C3H mouse duodenum and mammary tumors from a fast growing line (S102F) were used to predict times that may be optimal (i.e., minimize killing of the duodenal S-phase cells while enhancing the killing of tumor S-phase cells) for the administration of subse...

journal_title：Cancer research

authors： Dethlefsen LA,Sorensen SP,Riley RM

更新日期：1975-03-01 00:00:00

abstract：:Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rate...

journal_title：Cancer research

authors： Ogbourne SM,Suhrbier A,Jones B,Cozzi SJ,Boyle GM,Morris M,McAlpine D,Johns J,Scott TM,Sutherland KP,Gardner JM,Le TT,Lenarczyk A,Aylward JH,Parsons PG

更新日期：2004-04-15 00:00:00

abstract：:Cytochromes P-450IIB1 and P-450IIB2 were recently shown to be inducible in rat hepatocyte cultures maintained on a reconstituted extracellular tumor matrix (Matrigel) as indicated by increases in P-450IIB1 and -IIB2 mRNAs and immunoreactive proteins (J. Cell. Physiol., 134: 309-323, 1988). Here we show that treatment ...

journal_title：Cancer research

authors： Sinclair PR,Bement WJ,Haugen SA,Sinclair JF,Guzelian PS

更新日期：1990-09-01 00:00:00

abstract：:A correlation exists between the ability of tumor cells to aggregate platelets and their tendency to metastasize. Tumor cell-induced platelet aggregation (TCIPA) facilitates the embolization of the vasculature with tumor cells and the formation of metastatic foci. It is well documented that matrix metalloproteinases (...

journal_title：Cancer research

authors： Jurasz P,Sawicki G,Duszyk M,Sawicka J,Miranda C,Mayers I,Radomski MW

更新日期：2001-01-01 00:00:00

abstract：:Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain: (a) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies; (b) H19, an untranslated RNA that is a putative growth suppress...

journal_title：Cancer research

authors： Feinberg AP

更新日期：1999-04-01 00:00:00

abstract：:The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tumorigenesis. Using ...

journal_title：Cancer research

authors： Ohm JE,Mali P,Van Neste L,Berman DM,Liang L,Pandiyan K,Briggs KJ,Zhang W,Argani P,Simons B,Yu W,Matsui W,Van Criekinge W,Rassool FV,Zambidis E,Schuebel KE,Cope L,Yen J,Mohammad HP,Cheng L,Baylin SB

更新日期：2010-10-01 00:00:00

abstract：:The D98/AH-2 cell line (a subline of HeLa) expresses a form of alkaline phosphatase (ALP) which closely resembles the adult and fetal intestinal forms of ALP. To characterize this ectopic form of ALP, four monoclonal antibodies were raised against D98/AH-2 ALP, and their binding with ALPs from D98/AH-2 cells, placenta...

journal_title：Cancer research

authors： Wray LK,Harris H

更新日期：1983-02-01 00:00:00

abstract：:Thymus, spleen, and bone marrow of 1-month-old neonatally Moloney murine leukemia virus-inoculated mice have been transferred to 400-R-irradiated syngeneic recipients of the opposite sex. The donor or recipient origin of T-cell lymphomas arising in the host animal was identified by the sex chromosome marker. Spleen an...

journal_title：Cancer research

authors： Asjö B,Skoog L,Palminger I,Wiener F,Isaak D,Cerny J,Fenyö EM

更新日期：1985-03-01 00:00:00

abstract：:Detailed ultrastructure of a new type of retrovirus (Sm-MTV) released by cultured cells (Sm-MT) of a spontaneous mammary tumor from a house musk shrew Suncus murinus, Insectivora, is described. The virus particles were revealed as three forms: intracellular; budding; and extracellular. The intracellular type A particl...

journal_title：Cancer research

authors： Yamashiro JM,Tsutsui Y,Nagayoshi S,Saga S,Takahashi M,Aoyama A,Hayakawa S,Yokoi T,Oda S,Yokoyama A

更新日期：1986-06-01 00:00:00

abstract：:Prostate cancer biology varies from locally confined tumors with low risk for relapse to tumors with high risk for progression even after radical prostatectomy. Currently, there are no reliable biomarkers to predict tumor relapse and poor clinical outcome. In this study, we correlated expression patterns of the androg...

journal_title：Cancer research

authors： Kahl P,Gullotti L,Heukamp LC,Wolf S,Friedrichs N,Vorreuther R,Solleder G,Bastian PJ,Ellinger J,Metzger E,Schüle R,Buettner R

更新日期：2006-12-01 00:00:00

abstract：:Glycogen synthase kinase 3beta (GSK3beta) is a multifunctional serine/threonine kinase. We showed that the expression of GSK3beta was drastically down-regulated in human cutaneous squamous cell carcinomas and basal cell carcinomas. Due to its negative regulation of many oncogenic proteins, we hypothesized that GSK3bet...

journal_title：Cancer research

authors： Ma C,Wang J,Gao Y,Gao TW,Chen G,Bower KA,Odetallah M,Ding M,Ke Z,Luo J

更新日期：2007-08-15 00:00:00

abstract：:Antigenic stimulation of athymic mice on the BALB/c background by infection with the pinworms Aspiculuris tetraptera and Syphacia obvelata or by xenografts of human tumors induced a proliferation of T- and B-lymphocytes in spleen and lymph nodes and occasional germinal center formation. The proliferating T-lymphocytes...

journal_title：Cancer research

authors： Beattie GM,Baird SM,Lipsick JS,Lannom RA,Kaplan NO

更新日期：1981-06-01 00:00:00

abstract：:We have searched for the presence of genetic alterations in serum DNA obtained from 44 colorectal cancer patients. Microsatellite analysis using highly polymorphic markers revealed loss of heterozygosity and/or microsatellite instability in 35 of 44 (80%) primary tumors. No alterations were detected in the paired seru...

journal_title：Cancer research

authors： Hibi K,Robinson CR,Booker S,Wu L,Hamilton SR,Sidransky D,Jen J

更新日期：1998-04-01 00:00:00

abstract：:Interleukin 2 (IL2) was injected peritumorally and intranodally in 36 patients with unresectable squamous cell carcinoma of the head and neck enrolled in an Eastern Cooperative Oncology Group-sponsored phase Ib trial (EST P-Z388). Groups of 6 patients received escalating doses(200, 2 x 10(3), 2 x 10(4), 2 x 10(5), 2 x...

journal_title：Cancer research

authors： Whiteside TL,Letessier E,Hirabayashi H,Vitolo D,Bryant J,Barnes L,Snyderman C,Johnson JT,Myers E,Herberman RB

更新日期：1993-12-01 00:00:00

abstract：:A human immunoglobulin that binds prostatic acid phosphatases (PAP) was isolated from the serum of normal individuals by affinity chromatography using a PAP-Sepharose solid adsorbent. The yield of isolated protein, termed PAP-binding globulin (PAPBG), ranged from 4.7 to 16.3 microgram/ml serum. As shown by immunoelect...

journal_title：Cancer research

authors： Papsidero LD,Wojcieszyn JW,Horoszewicz JS,Leong SS,Murphy GP,Chu TM

更新日期：1980-08-01 00:00:00

abstract：:Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells roll on E-selectin(+) BMEC through E-selectin ligand-binding interactions under shear flow, and prostate cancer cells ex...

journal_title：Cancer research

authors： Barthel SR,Hays DL,Yazawa EM,Opperman M,Walley KC,Nimrichter L,Burdick MM,Gillard BM,Moser MT,Pantel K,Foster BA,Pienta KJ,Dimitroff CJ

更新日期：2013-01-15 00:00:00

abstract：:Signal transducers and activators of transcription 3 (Stat3) is activated by cytokines and growth factors in lung cancers and regulates expression of genes implicated in cell growth, survival, and transformation. Previously, we found that mice with a deletion of the G protein-coupled receptor, family C, group 5, membe...

journal_title：Cancer research

authors： Chen Y,Deng J,Fujimoto J,Kadara H,Men T,Lotan D,Lotan R

更新日期：2010-11-01 00:00:00

abstract：:The mechanisms by which estrogens and antiestrogens modulate breast cancer growth have not been totally defined. We have examined the cell cycle kinetic effects of estrogens and antiestrogens in cultured human breast cancer cell lines. In a previous study, we showed that tamoxifen induces a transition delay in early t...

journal_title：Cancer research

authors： Osborne CK,Boldt DH,Estrada P

更新日期：1984-04-01 00:00:00

abstract：:In the present study, we assessed the susceptibility of freshly isolated neuroblastoma cells to killing mediated by normal human natural killer (NK) cells and analyzed the receptor-ligand interactions that regulate this event. We show that killing of freshly isolated neuroblasts, similar to neuroblastoma cell lines, i...

journal_title：Cancer research

authors： Castriconi R,Dondero A,Corrias MV,Lanino E,Pende D,Moretta L,Bottino C,Moretta A

更新日期：2004-12-15 00:00:00