Lack of reciprocity in drug and light dose dependence of photodynamic therapy of pancreatic adenocarcinoma in vitro.

abstract：:Primary rat tracheal epithelial cells can be transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. The earliest recognizable morphological transformant is the enhanced growth variant (EGV), characterized by enhanced proliferative capacity. Transformed EGV colonies can progress to give rise to immortal cell lin...

journal_title：Cancer research

authors： Endo S,Nettesheim P,Oshimura M,Walker C

更新日期：1990-02-01 00:00:00

abstract：:Gastrointestinal adenocarcinomas (GIAC) of the tubular gastrointestinal (GI) tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer...

journal_title：Cancer research

authors： Pan J,Silva TC,Gull N,Yang Q,Plummer JT,Chen S,Daigo K,Hamakubo T,Gery S,Ding LW,Jiang YY,Hu S,Xu LY,Li EM,Ding Y,Klempner SJ,Gayther SA,Berman BP,Koeffler HP,Lin DC

更新日期：2020-07-01 00:00:00

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:Prostate cancer develops through a stochastic mechanism whereby precancerous lesions on occasion progress to multifocal adenocarcinoma. Analysis of human benign and cancer prostate tissues revealed heterogeneous loss of TGF-β signaling in the cancer-associated stromal fibroblastic cell compartment. To test the hypothe...

journal_title：Cancer research

authors： Kiskowski MA,Jackson RS 2nd,Banerjee J,Li X,Kang M,Iturregui JM,Franco OE,Hayward SW,Bhowmick NA

更新日期：2011-05-15 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:A body of evidence has shown the existence of a nuclear phosphoinositide cycle in different cell types. The cycle is endowed with kinases as well as phosphatases and phospholipase C (PLC). Among the PLC isozymes, the beta family is characterized by a long COOH-terminal tail that contains a cluster of lysine residues r...

journal_title：Cancer research

authors： Matteucci A,Faenza I,Gilmour RS,Manzoli L,Billi AM,Peruzzi D,Bavelloni A,Rhee SG,Cocco L

更新日期：1998-11-15 00:00:00

abstract：:Most solid malignancies display interstitial hypertension and a poor uptake of anticancer drugs. Platelet-derived growth factor (PDGF) and the cognate tyrosine kinase receptors are expressed in many tumors. Signaling through PDGFbeta receptors was shown recently to increase interstitial fluid pressure (IFP) in dermis ...

journal_title：Cancer research

authors： Pietras K,Ostman A,Sjöquist M,Buchdunger E,Reed RK,Heldin CH,Rubin K

更新日期：2001-04-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance. Here, we demonstrate that PDA tumor cell-derived proinflammatory cytokine IL1β is essential for the esta...

journal_title：Cancer research

authors： Das S,Shapiro B,Vucic EA,Vogt S,Bar-Sagi D

更新日期：2020-03-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study ...

journal_title：Cancer research

authors： Xia G,Kumar SR,Masood R,Zhu S,Reddy R,Krasnoperov V,Quinn DI,Henshall SM,Sutherland RL,Pinski JK,Daneshmand S,Buscarini M,Stein JP,Zhong C,Broek D,Roy-Burman P,Gill PS

更新日期：2005-06-01 00:00:00

abstract：:Caspase-8 is a proapoptotic protease that suppresses neuroblastoma metastasis by inducing programmed cell death. Paradoxically, caspase-8 can also promote cell migration among nonapoptotic cells; here, we show that caspase-8 can promote metastasis when apoptosis is compromised. Migration is enhanced by caspase-8 recru...

journal_title：Cancer research

authors： Barbero S,Mielgo A,Torres V,Teitz T,Shields DJ,Mikolon D,Bogyo M,Barilà D,Lahti JM,Schlaepfer D,Stupack DG

更新日期：2009-05-01 00:00:00

abstract：:Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis for this cooperation is uncertain. In this study, we used the gp130(F/F) (Il6st) knock-in mouse model to examine the pathogenic contribution of hyperactivation...

journal_title：Cancer research

authors： Brooks GD,McLeod L,Alhayyani S,Miller A,Russell PA,Ferlin W,Rose-John S,Ruwanpura S,Jenkins BJ

更新日期：2016-02-15 00:00:00

abstract：:Chemotherapeutic agents may damage gastrointestinal epithelium and thereby impair the mucosal barrier to bacteria and their products. In order to obtain an objective measurement of gastrointestinal permeability to large molecules, we measured urinary excretion of [14C]polyvinylpyrrolidone administered p.o. (mean molec...

journal_title：Cancer research

authors： Siber GR,Mayer RJ,Levin MJ

更新日期：1980-10-01 00:00:00

abstract：:Cell isolation via antibody-targeted magnetic beads is a powerful tool for research and clinical applications, most recently for isolating circulating tumor cells (CTC). Nonetheless fundamental features of the cell-bead interface are still unknown. Here we apply a clinically relevant antibody against the cancer target...

journal_title：Cancer research

authors： Jain J,Veggiani G,Howarth M

更新日期：2013-04-01 00:00:00

abstract：:Insulin-like growth factor I action has been implicated in the pathogenesis of many different malignancies, including breast cancer. Insulin-like growth factor I receptors (IGF-IRs) are overexpressed in virtually all breast cancer cell lines, in which they are believed to enhance growth and inhibit apoptosis. In this ...

journal_title：Cancer research

authors： Resnik JL,Reichart DB,Huey K,Webster NJ,Seely BL

更新日期：1998-03-15 00:00:00

abstract：:The present work compared the blood variations in some committed stem cells (CSC), and corresponding differentiated WBC during the first three courses of a 6-day sequential chemotherapy given to 16 breast cancer patients for 28 days each. The granulomonocytic and lymphocytic colony-forming unit levels in blood were si...

journal_title：Cancer research

authors： Rusé-Riol F,Legros M,Bernard D,Chassagne J,Clavel H,Ferriere JP,Chollet P,Plagne R

更新日期：1984-05-01 00:00:00

abstract：:Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poorly understood. Here we show that intratumoral copper levels influence PD-L1 exp...

journal_title：Cancer research

authors： Voli F,Valli E,Lerra L,Kimpton K,Saletta F,Giorgi FM,Mercatelli D,Rouaen JRC,Shen S,Murray JE,Ahmed-Cox A,Cirillo G,Mayoh C,Beavis PA,Haber M,Trapani JA,Kavallaris M,Vittorio O

更新日期：2020-10-01 00:00:00

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling, such that tamoxifen nonresponsiveness or resi...

journal_title：Cancer research

authors： Busch S,Sims AH,Stål O,Fernö M,Landberg G

更新日期：2015-04-01 00:00:00

abstract：:The effects of estrogens on the growth and enzyme activities for androgen synthesis in a mouse Leydig cell tumor line (T 124958-R) were studied. The s.c. implantation of a diethylstilbestrol pellet resulted in a marked enhancement of the tumor growth. 5 alpha-Reductase activity (nmol/g/h) in tumors rapidly grown in th...

journal_title：Cancer research

authors： Noguchi S,Nishizawa Y,Takatsuka D,Sato B,Matsumoto K

更新日期：1986-02-01 00:00:00

abstract：:The numbers of ultraviolet light (UV)-induced pyrimidine dimers in the DNA of neonatal BALB/c mouse skin were measured by assessing the sensitivity of the DNA to Micrococcus luteus UV endonuclease. Irradiation of neonatal BALB/c mice with FS40 sunlamps caused a dose-dependent induction of endonuclease-sensitive sites ...

journal_title：Cancer research

authors： Ananthaswamy HN,Fisher MS

更新日期：1981-05-01 00:00:00

abstract：:Extravasation of tumor cells is a pivotal step in metastasis formation. This step is initiated by an interaction of extravasating tumor cells with endothelial cells. Among the molecules mediating tumor-endothelium interactions are selectins and their fucosylated ligands. In a previous study, we demonstrated that the f...

journal_title：Cancer research

authors： Zipin A,Israeli-Amit M,Meshel T,Sagi-Assif O,Yron I,Lifshitz V,Bacharach E,Smorodinsky NI,Many A,Czernilofsky PA,Morton DL,Witz IP

更新日期：2004-09-15 00:00:00

abstract：:We showed recently that Helicobacter infection induces expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the mouse stomach, and that transgenic mice expressing both cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (K19-C2mE mice) develop hyperplastic gastric tumors with inflammatory...

journal_title：Cancer research

authors： Oshima M,Oshima H,Matsunaga A,Taketo MM

更新日期：2005-10-15 00:00:00

abstract：:The pharmacological properties of garlic and its derivatives are long known, and their underling mechanisms are being extensively investigated. In this study we have addressed the effects of diallyl disulfide (DADS), an oil-soluble garlic molecule, on cell growth of neuroblastoma cell SH-SY5Y, focusing on the redox ev...

journal_title：Cancer research

authors： Filomeni G,Aquilano K,Rotilio G,Ciriolo MR

更新日期：2003-09-15 00:00:00

abstract：:Recently, we have shown that prostate epithelium-specific deficiency for p53 and Rb tumor suppressors leads to metastatic cancer, exhibiting features of both luminal and neuroendocrine differentiation. Using stage-by-stage evaluation of carcinogenesis in this model, we report that all malignant neoplasms arise from th...

journal_title：Cancer research

authors： Zhou Z,Flesken-Nikitin A,Nikitin AY

更新日期：2007-06-15 00:00:00

abstract：:Recent evidence from our laboratory and from others suggested that pretreatment with alpha-difluoromethylornithine (DFMO) sensitizes some human and rodent tumor cell lines to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Many human tumor cells are resistant to chloroethylnitrosourea-induced DNA interstrand cross-linkin...

journal_title：Cancer research

authors： Seidenfeld J,Barnes D,Block AL,Erickson LC

更新日期：1987-09-01 00:00:00

abstract：:Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of these agents. Upregulation of β1 integrin (ITGB1) occurs in some bevacizumab-resistant glioblastomas (BRG) whereby, mediating tumor-micro...

journal_title：Cancer research

authors： Carbonell WS,DeLay M,Jahangiri A,Park CC,Aghi MK

更新日期：2013-05-15 00:00:00

abstract：:A monoclonal antibody prepared against the Rauscher virus envelope glycoprotein with a molecular weight of 70,000 targeted to neoplastic cells and cured the Rauscher leukemia virus-induced erythroleukemia in BALB/c mice. This antibody, 103A, specifically reacted with the Rauscher and Friend erythroleukemia viruses and...

journal_title：Cancer research

authors： Scheinberg DA,Strand M

更新日期：1982-01-01 00:00:00

abstract：:Successive B16 melanoma tumor lines were selected for their ability to form pulmonary tumor nodules. This was accomplished by injecting tumor cells i.v. into syngeneic C57BL/6 mice and 2 to 3 weeks later collecting the secondary tumor growths and placing them into tissue culture. These tumor cells were then injected i...

journal_title：Cancer research

authors： Fidler IJ

更新日期：1975-01-01 00:00:00

abstract：:A series of mouse mammary tumor subpopulation lines were compared for growth properties and sensitivity to chemotherapeutic drugs when grown as boluses in a collagen gel matrix versus in monolayer culture. Although the cell lines exhibited characteristic rates of bolus expansion in collagen, this growth was not parall...

journal_title：Cancer research

authors： Miller BE,Miller FR,Heppner GH

更新日期：1985-09-01 00:00:00

abstract：:Adenocarcinoma of the rete testis is an exceptionally rare and malignant testicular neoplasm. Although treatment of pregnant women with diethylstilbestrol (DES) results in reproductive tract abnormalities in their male offspring, increased incidence of testicular tumors has not been verified. However, recently three c...

journal_title：Cancer research

authors： Newbold RR,Bullock BC,McLachlan JA

更新日期：1985-10-01 00:00:00