Role for stromal heterogeneity in prostate tumorigenesis.

abstract：:Vitamin E succinate (VES), a derivative of the fat-soluble vitamin D-alpha-tocopherol (vitamin E), inhibited growth and induced apoptotic cell death of estrogen receptor-negative human breast cancer cells. VES-induced apoptosis in MDA-MB-231 and SKBR-3 cells occurred through a Fas pathway. Total protein levels of the ...

journal_title：Cancer research

authors： Turley JM,Fu T,Ruscetti FW,Mikovits JA,Bertolette DC 3rd,Birchenall-Roberts MC

更新日期：1997-03-01 00:00:00

abstract：:CC-1065, a novel antibiotic produced by Streptomyces zelensis, was active against several experimental tumors in vivo and a broad spectrum of human tumor cells in vitro. This report describes its biological and biochemical effects of L1210 leukemia cells. CC-1065 is one of the most cytotoxic agents known. The concentr...

journal_title：Cancer research

authors： Li LH,Swenson DH,Schpok SL,Kuentzel SL,Dayton BD,Krueger WC

更新日期：1982-03-01 00:00:00

abstract：:Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passag...

journal_title：Cancer research

authors： Wang X,Schoenhals JE,Li A,Valdecanas DR,Ye H,Zang F,Tang C,Tang M,Liu CG,Liu X,Krishnan S,Allison JP,Sharma P,Hwu P,Komaki R,Overwijk WW,Gomez DR,Chang JY,Hahn SM,Cortez MA,Welsh JW

更新日期：2017-02-15 00:00:00

abstract：:Whereas transcriptional silencing of genes due to epigenetic mechanisms is one of the most important alterations in acute lymphoblastic leukemia (ALL), some recent studies indicate that DNA methylation contributes to down-regulation of miRNAs during tumorigenesis. To explore the epigenetic alterations of miRNAs in ALL...

journal_title：Cancer research

authors： Agirre X,Vilas-Zornoza A,Jiménez-Velasco A,Martin-Subero JI,Cordeu L,Gárate L,San José-Eneriz E,Abizanda G,Rodríguez-Otero P,Fortes P,Rifón J,Bandrés E,Calasanz MJ,Martín V,Heiniger A,Torres A,Siebert R,Román-Gomez J,

更新日期：2009-05-15 00:00:00

abstract：:In order to study the possible role of intercellular communication in the process of in vitro cell transformation, the communicating capacity of BALB/c 3T3 cells transformed by 20-methylcholanthrene was investigated using a dye transfer method. Morphologically transformed foci, detectable 4 to 5 weeks after treatment ...

journal_title：Cancer research

authors： Enomoto T,Yamasaki H

更新日期：1984-11-01 00:00:00

abstract：:The C3H/10T1/2 CL8 cell line (10T1/2) is being widely used as a quantitative assay system for chemical and physical carcinogens. 10T1/2 cells, but not their transformed counterparts, exhibit a decreased final saturation density with decreasing serum concentration. Exposure of carcinogen-treated cultures to 5% serum 8 ...

journal_title：Cancer research

authors： Bertram JS

更新日期：1977-02-01 00:00:00

abstract：:Sixteen steroids with different endocrine activities were administered to female rats for 6 or 7 days, in a broad range of doses. Liver growth was recorded by measuring weight and DNA contents and monooxygenase activity by assaying the turnover of five different substrates. According to their effects on these paramete...

journal_title：Cancer research

authors： Schulte-Hermann R,Ochs H,Bursch W,Parzefall W

更新日期：1988-05-01 00:00:00

abstract：:Non-small cell lung cancer patients carrying oncogenic EGFR mutations initially respond to EGFR-targeted therapy, but later elicit minimal response due to dose-limiting toxicities and acquired resistance. EGF816 is a novel, irreversible mutant-selective EGFR inhibitor that specifically targets EGFR-activating mutation...

journal_title：Cancer research

authors： Jia Y,Juarez J,Li J,Manuia M,Niederst MJ,Tompkins C,Timple N,Vaillancourt MT,Pferdekamper AC,Lockerman EL,Li C,Anderson J,Costa C,Liao D,Murphy E,DiDonato M,Bursulaya B,Lelais G,Barretina J,McNeill M,Epple R,Mar

更新日期：2016-03-15 00:00:00

abstract：:Therapeutic strategies targeting DNA repair pathway defects have been widely explored, but often only benefit small numbers of patients. Here we characterized potential predictive biomarkers for treatment with AsiDNA, a novel first-in-class DNA repair inhibitor. We evaluated genetic instability and DNA repair defects ...

journal_title：Cancer research

authors： Jdey W,Thierry S,Popova T,Stern MH,Dutreix M

更新日期：2017-08-15 00:00:00

abstract：:Pregnancy at early, but not late age, has a strong and life-long protective effect against breast cancer. The expected overall increase in breast cancer incidence demands the development of a pharmaceutical mimicry of early-age pregnancy-mediated protection. Recently, converging results from rodent models and women on...

journal_title：Cancer research

authors： Meier-Abt F,Bentires-Alj M,Rochlitz C

更新日期：2015-03-01 00:00:00

abstract：:Amplification of the c-myc and HER2/neu genes was found in 20 and 23%, respectively, of primary breast cancer tissues derived from 282 patients (median follow-up, 74 months). c-myc amplification was observed more frequently in larger tumors (P = 0.01) and in lymph node-positive patients (P = 0.01) but was not associat...

journal_title：Cancer research

authors： Berns EM,Klijn JG,van Putten WL,van Staveren IL,Portengen H,Foekens JA

更新日期：1992-03-01 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a master transcription factor that is critical for the regulation of a variety of cellular functions. HIF-1alpha is rapidly degraded under normoxic conditions by ubiquitin-mediated proteasome pathway controlled by the tumor suppressor von Hippel Lindau (VHL). Several rec...

journal_title：Cancer research

authors： Zhang D,Li J,Costa M,Gao J,Huang C

更新日期：2010-01-15 00:00:00

abstract：:To examine genetic instability during carcinogenesis, we screened 171 carcinomas of the breast, liver, proximal colon, stomach, pancreas, uterine cervix, and ovary for replication error at four microsatellite marker loci on chromosome 2, 3, and 17. A significantly high incidence of genetic instability was observed in ...

journal_title：Cancer research

authors： Han HJ,Yanagisawa A,Kato Y,Park JG,Nakamura Y

更新日期：1993-11-01 00:00:00

abstract：:It is increasingly accepted that steroidal receptor co-regulators may also function in the cytoplasmic compartment. Proline-, glutamic acid-, and leucine-rich protein-1 (PELP1) is a novel coregulator that plays a role in both the genomic and extranuclear actions of estrogen receptors (ER) in hormonally responsive tiss...

journal_title：Cancer research

authors： Vadlamudi RK,Manavathi B,Balasenthil S,Nair SS,Yang Z,Sahin AA,Kumar R

更新日期：2005-09-01 00:00:00

abstract：:With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the efficacy of these vaccines in humans. However, the only tumor models available to study vaccines against human papillomavirus (HPV) 16 have been developed in C57BL/6...

journal_title：Cancer research

authors： Eiben GL,Velders MP,Schreiber H,Cassetti MC,Pullen JK,Smith LR,Kast WM

更新日期：2002-10-15 00:00:00

abstract：:The SK3 channel, a potassium channel, was recently shown to control cancer cell migration, a critical step in metastasis outgrowth. Here, we report that expression of the SK3 channel was markedly associated with bone metastasis. The SK3 channel was shown to control constitutive Ca(2+) entry and cancer cell migration t...

journal_title：Cancer research

authors： Chantôme A,Potier-Cartereau M,Clarysse L,Fromont G,Marionneau-Lambot S,Guéguinou M,Pagès JC,Collin C,Oullier T,Girault A,Arbion F,Haelters JP,Jaffrès PA,Pinault M,Besson P,Joulin V,Bougnoux P,Vandier C

更新日期：2013-08-01 00:00:00

abstract：:The EphA2 receptor tyrosine kinase is overexpressed in many different types of human cancers where it functions as a powerful oncoprotein. Dramatic changes in the subcellular localization and function of EphA2 have also been linked with cancer, and in particular, unstable cancer cell-cell contacts prevent EphA2 from s...

journal_title：Cancer research

authors： Coffman KT,Hu M,Carles-Kinch K,Tice D,Donacki N,Munyon K,Kifle G,Woods R,Langermann S,Kiener PA,Kinch MS

更新日期：2003-11-15 00:00:00

abstract：:Despite the frequent detection of circulating tumor antigen-specific T cells, either spontaneously or following active immunization or adoptive transfer, immune-mediated cancer regression occurs only in the minority of patients. One theoretical rate-limiting step is whether effector T cells successfully migrate into m...

journal_title：Cancer research

authors： Harlin H,Meng Y,Peterson AC,Zha Y,Tretiakova M,Slingluff C,McKee M,Gajewski TF

更新日期：2009-04-01 00:00:00

abstract：:The interaction of Adriamycin and pivaloyloxymethyl butyrate (AN-9) was investigated in IMR-32 neuroblastoma and MCF-7 breast adenocarcinoma cells. Adriamycin is a widely used anticancer drug, whereas AN-9 is an anticancer agent presently undergoing Phase II clinical trials. The anticancer activity of AN-9 has been at...

journal_title：Cancer research

authors： Cutts SM,Rephaeli A,Nudelman A,Hmelnitsky I,Phillips DR

更新日期：2001-11-15 00:00:00

abstract：:Disulfiram (DSF) and its metabolites, diethyldithiocarbamic acid (DDC) and diethylamine (DEA), were studied as pretreatments in combination with the alkylating agent nitrogen mustard (HN2) on the cytotoxicity of HN2 against both leukemia cells and normal hematopoietic stem cells. Both time intervals and dose relations...

journal_title：Cancer research

authors： Valeriote F,Grates HE

更新日期：1989-12-01 00:00:00

abstract：:Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor co...

journal_title：Cancer research

authors： Chin KT,Chun AC,Ching YP,Jeang KT,Jin DY

更新日期：2007-02-01 00:00:00

abstract：:Dehydroepiandrosterone, an adrenal steroid that has been reported to be produced in subnormal amounts and found in lower plasma concentrations in women with benign and malignant breast tumors, protects cultured rat liver epithelial-like cells against aflatoxin B1-induced cytotoxicity and protects hamster embryonic fib...

journal_title：Cancer research

authors： Schwartz AG,Perantoni A

更新日期：1975-09-01 00:00:00

abstract：:In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired. Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation. In these studie...

journal_title：Cancer research

authors： Moran PL,Seligman PA

更新日期：1989-08-01 00:00:00

abstract：:The BCR/ABL fusion protein is a constitutively active tyrosine kinase that is responsible for the pathogenesis of chronic myelogenous leukemia (CML). Clinically, CML is characterized by a chronic phase (CP) that eventually terminates into a blast crisis (BC). BC transformation is associated with accumulation of CD34+ ...

journal_title：Cancer research

authors： Bonati A,Carlo-Stella C,Lunghi P,Albertini R,Pinelli S,Migliaccio E,Sammarelli G,Savoldo B,Tabilio A,Dall'Aglio PP,Pelicci PG

更新日期：2000-02-01 00:00:00

abstract：:We investigated primary human lung cancers resected surgically or obtained at autopsy. Included were squamous cell carcinoma (SQC) (five cases), adenocarcinoma (ADC) (six cases), large cell carcinoma (LCC) (four cases), and small cell carcinoma (SCC) (two cases). The objective of the study was to search for the presen...

journal_title：Cancer research

authors： Shigematsu K,Kataoka Y,Kamio T,Kurihara M,Niwa M,Tsuchiyama H

更新日期：1990-04-15 00:00:00

abstract：:Estrogen receptor (ER) agonists and antagonists elicit distinct responses in non-small cell lung cancer (NSCLC) cells. To determine how such responses are generated, the expression of ERalpha, ERbeta, and ER coregulators in human lung fibroblasts and human NSCLC cell lines was evaluated by immunoblot. Ligand-dependent...

journal_title：Cancer research

authors： Hershberger PA,Vasquez AC,Kanterewicz B,Land S,Siegfried JM,Nichols M

更新日期：2005-02-15 00:00:00

abstract：:Hypoxic conditions exist within pancreatic adenocarcinoma, yet pancreatic cancer cells survive and replicate within this environment. To understand the mechanisms involved in pancreatic cancer adaptation to hypoxia, we analyzed expression of a regulator of hypoxia-induced cell death, Bcl-2/adenovirus E1B 19 kDa intera...

journal_title：Cancer research

authors： Okami J,Simeone DM,Logsdon CD

更新日期：2004-08-01 00:00:00

abstract：:Although immunotherapies of tumors have demonstrated promise for altering the progression of malignancies, immunotherapies have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating immune cells from performing their anticancer functions. Prominent among immunosuppressive cells a...

journal_title：Cancer research

authors： Cresswell GM,Wang B,Kischuk EM,Broman MM,Alfar RA,Vickman RE,Dimitrov DS,Kularatne SA,Sundaram CP,Singhal S,Eruslanov EB,Crist SA,Elzey BD,Ratliff TL,Low PS

更新日期：2020-11-17 00:00:00

abstract：:The effects of cholera toxin (CT) on transforming growth factor beta 1-stimulated protooncogene expression, [gamma-35S]GTP binding, GTPase activity and growth under anchorage-independent and -dependent conditions were studied in AKR-2B fibroblast cells. CT was shown to inhibit TGF beta 1-stimulated c-sis and c-myc mRN...

journal_title：Cancer research

authors： Howe PH,Bascom CC,Cunningham MR,Leof EB

更新日期：1989-11-01 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

journal_title：Cancer research

authors： Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

更新日期：2004-01-01 00:00:00