Protective effect of dehydroepiandrosterone against aflatoxin B1-and 7,12-dimethylbenz(a)anthracene-induced cytotoxicity and transformation in cultured cells.

abstract：:We report the chromosomal characteristics of a recurrent pineal non-seminomatous germ cell tumor in a 16-year-old male patient. This non-seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (6...

journal_title：Cancer research

authors： de Bruin TW,Slater RM,Defferrari R,Geurts van Kessel A,Suijkerbuijk RF,Jansen G,de Jong B,Oosterhuis JW

更新日期：1994-03-15 00:00:00

abstract：:Emerging knowledge on how the dysregulated function of signaling networks contributes to the malignant growth of squamous cell carcinoma of the head and neck (HNSCC) can now be exploited to identify novel mechanism-based anticancer treatments. In this regard, we have observed that persistent activation of the serine/t...

journal_title：Cancer research

authors： Amornphimoltham P,Patel V,Sodhi A,Nikitakis NG,Sauk JJ,Sausville EA,Molinolo AA,Gutkind JS

更新日期：2005-11-01 00:00:00

abstract：:High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by a single dose ...

journal_title：Cancer research

authors： Faiderbe S,Chagnaud JL,Geffard M

更新日期：1992-05-15 00:00:00

abstract：:Expression of non-self antigens by tumors can induce activation of T cells in vivo, although this activation can lead to either immunity or tolerance. CD8+ T-cell activation can be direct (if the tumor expresses MHC class I molecules) or indirect (after the capture and cross-presentation of tumor antigens by dendritic...

journal_title：Cancer research

authors： Zeelenberg IS,Ostrowski M,Krumeich S,Bobrie A,Jancic C,Boissonnas A,Delcayre A,Le Pecq JB,Combadière B,Amigorena S,Théry C

更新日期：2008-02-15 00:00:00

abstract：:We investigated the prognostic value of p53 mutation type for 145 soft tissue sarcoma patients. In a PCR-SSCP-sequencing analysis, 15 mutations were identified: 10 non-frameshift (non-fs) and 5 frameshift (fs) mutations. Patients possessing non-fs mutations had a significantly poorer prognosis than patients without p5...

journal_title：Cancer research

authors： Taubert H,Meye A,Würl P

更新日期：1996-09-15 00:00:00

abstract：:p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharo...

journal_title：Cancer research

authors： Shimada A,Kato S,Enjo K,Osada M,Ikawa Y,Kohno K,Obinata M,Kanamaru R,Ikawa S,Ishioka C

更新日期：1999-06-15 00:00:00

abstract：:The major heat shock protein Hsp72 is constitutively expressed in many tumor cell lines and biopsies, and its expression correlates with poor prognosis in several types of cancer. Hsp72 was suggested to play an important role in neoplastic transformation and tumor development. We addressed the role of Hsp72 in cancer ...

journal_title：Cancer research

authors： Yaglom JA,Gabai VL,Sherman MY

更新日期：2007-03-01 00:00:00

abstract：:The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the ...

journal_title：Cancer research

authors： Powis G,Seewald MJ,Gratas C,Melder D,Riebow J,Modest EJ

更新日期：1992-05-15 00:00:00

abstract：:Tumorigenesis is associated with enhanced cellular glucose uptake and increased metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we evaluated whether p53 regulates expression of the GLUT1 and GLUT4 glucose transporter genes. Transient cotransfection of osteosarcoma-derived SaOS-2 c...

journal_title：Cancer research

authors： Schwartzenberg-Bar-Yoseph F,Armoni M,Karnieli E

更新日期：2004-04-01 00:00:00

abstract：:Because both Rhodamine 123 (R123) and hyperthermia have been shown to be cytotoxic, we examined their effect, independently and in combination, on five different human malignant cell lines in vitro and on cultured melanoma cells grown intradermally in nude mice. The cell lines examined include two human melanomas, UCL...

journal_title：Cancer research

authors： Goffney WH,Wong JH,Kern DH,Chase D,Krag DN,Storm FK

更新日期：1990-02-01 00:00:00

abstract：:Signaling through the insulin-like growth factor-I receptor (IGF-IR) is implicated in cellular proliferation, apoptosis, carcinogenesis, metastasis, and resistance to cytotoxic cancer therapies. Targeted disruption of IGF-IR signaling combined with cytotoxic therapy may therefore yield improved anticancer efficacy ove...

journal_title：Cancer research

authors： Allen GW,Saba C,Armstrong EA,Huang SM,Benavente S,Ludwig DL,Hicklin DJ,Harari PM

更新日期：2007-02-01 00:00:00

abstract：:The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared ...

journal_title：Cancer research

authors： Welch DR

更新日期：2016-04-01 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:A superinduction of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT) accompanies the phenotype-specific cytotoxic response to a class of antitumor polyamine analogues in several important human solid tumor models. A highly specific antiserum against the human SSAT protein has been develo...

journal_title：Cancer research

authors： Casero RA Jr,Gabrielson EW,Pegg AE

更新日期：1994-08-01 00:00:00

abstract：:Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with ...

journal_title：Cancer research

authors： Wang H,Song X,Logsdon C,Zhou G,Evans DB,Abbruzzese JL,Hamilton SR,Tan TH,Wang H

更新日期：2009-02-01 00:00:00

abstract：:Global blood flow (TBF), tumor vascular resistance, laser Doppler flow in superficial tumor areas, and mean arterial blood pressure were evaluated in rats bearing s.c. DS sarcomas. Measurements were performed before and after i.v. administration of rhTNF-alpha 2 or recombinant human lymphotoxin (rhLT) (1 mg/kg). Upon ...

journal_title：Cancer research

authors： Kluge M,Elger B,Engel T,Schaefer C,Seega J,Vaupel P

更新日期：1992-04-15 00:00:00

abstract：:The effects of temperature in the fever range (37-42 degrees) on the membrane potentials of normal and simian virus 40-transformed hamster lymphocytes were analyzed. The transmembrane distributions of radiolabeled triphenylmethylphosphonium and thiocyanate were measured, and they provide upper and lower limits for the...

journal_title：Cancer research

authors： Mikkelsen RB,Koch B

更新日期：1981-01-01 00:00:00

abstract：:We have performed isobologram analyses of the ability of tamoxifen (TAM) to alter the response to Adriamycin (ADR) and vinblastine (VBL) in human breast cancer cells. MCF-7 cells express functional receptors for estrogen and progesterone but do not express detectable levels of M(r) 170,000 glycoprotein (gp170). CL 10....

journal_title：Cancer research

authors： Leonessa F,Jacobson M,Boyle B,Lippman J,McGarvey M,Clarke R

更新日期：1994-01-15 00:00:00

abstract：:Long-term carcinogenicity studies were carried out in male Sprague-Dawley rats maintained on vitamin A-sufficient (SLO+) and vitamin A-deficient (SLO-) diets and treated with tobacco extract (TE). Three-week-old rats received by gavage a total dose of 860 mg of TE at a daily dose of 3 mg/rat over a period of 21 months...

journal_title：Cancer research

authors： Bhide SV,Ammigan N,Nair UJ,Lalitha VS

更新日期：1991-06-01 00:00:00

abstract：:Nerve growth factor-like substance(s) were identified in both conditioned media of a human prostatic tumor epithelial cell line (TSU-pr1) and a human prostatic stromal cell line (HPS) by Western blot analysis and bioassay of neurite outgrowth of PC12 cells. Nerve growth factor-beta (NGF) immunofluorescence was also lo...

journal_title：Cancer research

authors： Djakiew D,Delsite R,Pflug B,Wrathall J,Lynch JH,Onoda M

更新日期：1991-06-15 00:00:00

abstract：:Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the express...

journal_title：Cancer research

authors： Yan P,Coindre JM,Benhattar J,Bosman FT,Guillou L

更新日期：1999-07-01 00:00:00

abstract：:HL-60 cells were treated with the differentiating agent N-methylformamide and early changes in gene expression and protein content were investigated. Analysis of protein synthesis had previously shown an early (< 12 h) fall in the synthesis of M(r) 70,000 heat shock proteins (F. M. Richards, A. Watson, and J. A. Hickm...

journal_title：Cancer research

authors： Beere HM,Morimoto RI,Hickman JA

更新日期：1993-07-01 00:00:00

abstract：:Resistance of tumors to irradiation or chemotherapeutic agents is thought to be one of the reasons why patients who present with early malignancies may not be cured. Much is now known about the molecular mechanisms that underlie drug resistance, but until recently little was known about genetic contributions to radiat...

journal_title：Cancer research

authors： McKenna WG,Weiss MC,Endlich B,Ling CC,Bakanauskas VJ,Kelsten ML,Muschel RJ

更新日期：1990-01-01 00:00:00

abstract：:Two principal virus-directed antigens have been identified on the surface of oncornavirus-infected chick embryo cells. One is identical with the major virus type-specific envelope antigen, which is a glycoprotein with a molecular weight of 85,000. The 2nd antigen (tumor-specific cell surface antigen) is specific for t...

journal_title：Cancer research

authors： Bauer H,Kurth R,Rohrschneider L,Gelderblom H

更新日期：1976-02-01 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1-oxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 1...

journal_title：Cancer research

authors： Shiotani H,Denda A,Yamamoto K,Kitayama W,Endoh T,Sasaki Y,Tsutsumi N,Sugimura M,Konishi Y

更新日期：2001-02-15 00:00:00

abstract：:Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor co...

journal_title：Cancer research

authors： Chin KT,Chun AC,Ching YP,Jeang KT,Jin DY

更新日期：2007-02-01 00:00:00

abstract：:Despite the prevalence of KRAS mutations in human cancers, there remain no targeted therapies for treatment. The serine-threonine kinase STK33 has been proposed to be required for the survival of mutant KRAS-dependent cell lines, suggesting that small molecule kinase inhibitors of STK33 may be useful to treat KRAS-dep...

journal_title：Cancer research

authors： Babij C,Zhang Y,Kurzeja RJ,Munzli A,Shehabeldin A,Fernando M,Quon K,Kassner PD,Ruefli-Brasse AA,Watson VJ,Fajardo F,Jackson A,Zondlo J,Sun Y,Ellison AR,Plewa CA,San MT,Robinson J,McCarter J,Schwandner R,Judd T,C

更新日期：2011-09-01 00:00:00

abstract：:By the use of a variety of cell culture and separation methods, four cell lines were isolated from a single autochthonous BALB/cfC3H mammary tumor. These lines differ markedly from each other in culture morphology, various in vitro growth properties, expression of murine mammary tumor virus antigen, and karyotype, yet...

journal_title：Cancer research

authors： Dexter DL,Kowalski HM,Blazar BA,Fligiel Z,Vogel R,Heppner GH

更新日期：1978-10-01 00:00:00

abstract：:The most deadly phase in cancer progression is attributed to the inappropriate acquisition of molecular machinery leading to metastatic transformation and spread of disease to distant organs. Although it is appreciated that metastasis involves epithelial-mesenchymal interplay, the underlying mechanism defining this pr...

journal_title：Cancer research

authors： Powell AE,Anderson EC,Davies PS,Silk AD,Pelz C,Impey S,Wong MH

更新日期：2011-02-15 00:00:00

abstract：:A subset of aggressive colorectal cancers exhibit BRAF mutation, MLH1 methylation, and a CpG island methylator phenotype (CIMP), but precursors are poorly established. In this study, we determined the status of these markers in colorectal polyps and evaluated associated risk factors. The study included 771 polyp cases...

journal_title：Cancer research

authors： Burnett-Hartman AN,Newcomb PA,Potter JD,Passarelli MN,Phipps AI,Wurscher MA,Grady WM,Zhu LC,Upton MP,Makar KW

更新日期：2013-05-01 00:00:00