Abstract：
:We report the chromosomal characteristics of a recurrent pineal non-seminomatous germ cell tumor in a 16-year-old male patient. This non-seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.
journal_name
Cancer Resjournal_title
Cancer researchauthors
de Bruin TW,Slater RM,Defferrari R,Geurts van Kessel A,Suijkerbuijk RF,Jansen G,de Jong B,Oosterhuis JWsubject
Has Abstractpub_date
1994-03-15 00:00:00pages
1542-4issue
6eissn
0008-5472issn
1538-7445journal_volume
54pub_type
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