Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L).

abstract：:Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB tumor growth via sec...

journal_title：Cancer research

authors： Chlenski A,Liu S,Crawford SE,Volpert OV,DeVries GH,Evangelista A,Yang Q,Salwen HR,Farrer R,Bray J,Cohn SL

更新日期：2002-12-15 00:00:00

abstract：:Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV...

journal_title：Cancer research

authors： Lin Q,Clark AB,McCulloch SD,Yuan T,Bronson RT,Kunkel TA,Kucherlapati R

更新日期：2006-01-01 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:This study was conducted to further characterize the previously described phenomenon of growth inhibition of neoplastically transformed C3H/10T1/2 cells (T10T1/2) by nontransformed C3H/10T1/2 clone 8 mouse embryo fibroblast (10T1/2) cells in the presence of inhibitors of cyclic adenosine 3':5'-monophosphate (cAMP) pho...

journal_title：Cancer research

authors： Bertram JS,Faletto MB

更新日期：1985-05-01 00:00:00

abstract：:Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors and cyclooxygenase-1 (COX-1) is now being reconsidered as a target for chemoprevention. Our aims were to determine whether selective COX-1 inhibition could delay or prevent cancer development a...

journal_title：Cancer research

authors： Li H,Zhu F,Chen H,Cheng KW,Zykova T,Oi N,Lubet RA,Bode AM,Wang M,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in spora...

journal_title：Cancer research

authors： Cairns P,Okami K,Halachmi S,Halachmi N,Esteller M,Herman JG,Jen J,Isaacs WB,Bova GS,Sidransky D

更新日期：1997-11-15 00:00:00

abstract：:The effect of dietary fat concentration and saturation on high energy phosphate metabolites and phospholipid turnover in transplanted line 168 murine mammary tumors was studied using surface coil 31P-nuclear magnetic resonance spectroscopy. Female BALB/c mice were fed one of five diets each containing at least the min...

journal_title：Cancer research

authors： Buckman DK,Erickson KL,Ross BD

更新日期：1987-11-01 00:00:00

abstract：:Two mutations of the ATM gene were recently suggested to confer breast cancer risks similar to mutations of BRCA1 or BRCA2. Here, we set out to confirm these findings in 961 families with non-BRCA1/BRCA2 breast cancer from diverse geographical regions. We did not detect the ATM 7271T-->G mutation in any family. The AT...

journal_title：Cancer research

authors： Szabo CI,Schutte M,Broeks A,Houwing-Duistermaat JJ,Thorstenson YR,Durocher F,Oldenburg RA,Wasielewski M,Odefrey F,Thompson D,Floore AN,Kraan J,Klijn JG,van den Ouweland AM,Wagner TM,Devilee P,Simard J,van 't Veer LJ,G

更新日期：2004-02-01 00:00:00

abstract：:SPARC is an extracellular matrix protein that exerts pleiotropic effects on extracellular matrix organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer. Chronic myelogenous leukemia (CML) cells resistant to the BCR-ABL inhibitor imatinib (IM-R cells) were found to overexpress ...

journal_title：Cancer research

authors： Fenouille N,Puissant A,Dufies M,Robert G,Jacquel A,Ohanna M,Deckert M,Pasquet JM,Mahon FX,Cassuto JP,Raynaud S,Tartare-Deckert S,Auberger P

更新日期：2010-12-01 00:00:00

abstract：:Specific inhibitors of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK) have been developed that efficiently inhibit the oncogenic RAF-MEK-ERK pathway. We used a systems-based approach to identify breast cancer subtypes particularly susceptible to MEK inhibitors and to understa...

journal_title：Cancer research

authors： Mirzoeva OK,Das D,Heiser LM,Bhattacharya S,Siwak D,Gendelman R,Bayani N,Wang NJ,Neve RM,Guan Y,Hu Z,Knight Z,Feiler HS,Gascard P,Parvin B,Spellman PT,Shokat KM,Wyrobek AJ,Bissell MJ,McCormick F,Kuo WL,Mills GB,

更新日期：2009-01-15 00:00:00

abstract：:In vitro cell-mediated cytotoxicity (CMC) assays have been carried out in human melanoma system with blood effector lymphocytes on [3H]proline-labeled target cells in a 48-hr microcytotoxicity technique. Three lymphocyte purification procedures (Ficoll:Hypaque gradient, plasma gel sedimentation followed by nylon colum...

journal_title：Cancer research

authors： Mukherji B,Vassos D,Flowers A,Binder SC,Nathanson L

更新日期：1975-12-01 00:00:00

abstract：:A complex of polyinosinic-polycytidylic acid [poly(I) x poly(C)] and cationic liposome (LIC) inhibited the growth of many tumor cell lines at low concentration in vitro, but poly(I) x poly(C) alone had no such antiproliferative effect. The IC50 values of LIC against the tumor cells ranged from 0.1 to 1000 ng/ml. LIC h...

journal_title：Cancer research

authors： Hirabayashi K,Yano J,Inoue T,Yamaguchi T,Tanigawara K,Smyth GE,Ishiyama K,Ohgi T,Kimura K,Irimura T

更新日期：1999-09-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma is a treatment refractory malignancy with a high mortality and an increasing incidence worldwide. Recent studies have observed that activation of Notch and AKT signaling within mature hepatocytes is able to induce the formation of tumors displaying biliary lineage markers, thereby raisi...

journal_title：Cancer research

authors： Guest RV,Boulter L,Kendall TJ,Minnis-Lyons SE,Walker R,Wigmore SJ,Sansom OJ,Forbes SJ

更新日期：2014-02-15 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed ...

journal_title：Cancer research

authors： MacFarlane M,Kohlhaas SL,Sutcliffe MJ,Dyer MJ,Cohen GM

更新日期：2005-12-15 00:00:00

abstract：:The human melanoma cell line NEL-M1 proliferates in Ham's F-12 medium in the absence of serum, hormones, and growth factors. Culturing NEL-M1 cells in defined medium supplemented with insulin (5 micrograms/ml) and transferrin (5 micrograms/ml) results in a 94% increase in [3H]thymidine incorporation after 24 h and a 6...

journal_title：Cancer research

authors： DiSorbo DM

更新日期：1986-08-01 00:00:00

abstract：:The effect(s) of treadmill exercise and type and amount of dietary fat on the process of mammary tumorigenesis was investigated. Female Sprague-Dawley rats were fed a purified 5% fat diet (AIN-76A) from 21 to 64 days of age. At 50 days of age each rat was intubated p.o. with 5 mg 7,12-dimethylbenz(a)anthracene (DMBA)....

journal_title：Cancer research

authors： Thompson HJ,Ronan AM,Ritacco KA,Tagliaferro AR

更新日期：1989-04-15 00:00:00

abstract：:Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

journal_title：Cancer research

authors： Ways DK,Dodd RC,Earp HS

更新日期：1987-07-01 00:00:00

abstract：:Multiple myeloma (MM) is a treatable, but incurable, malignancy of plasma cells (PC) in the bone marrow (BM). It represents the final stage in a continuum of PC dyscrasias and is consistently preceded by a premalignant phase termed monoclonal gammopathy of undetermined significance (MGUS). The existence of this well-d...

journal_title：Cancer research

authors： van Nieuwenhuijzen N,Spaan I,Raymakers R,Peperzak V

更新日期：2018-05-15 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:Dickkopf3 (DKK3) is a secretory protein that belongs to the DKK family, but exhibits structural divergence from other family members, and its corresponding receptors remain to be identified. Although DKK3 has been shown to have oncogenic functions in certain cancer types, the underlying mechanism by which DKK3 promote...

journal_title：Cancer research

authors： Kajiwara C,Fumoto K,Kimura H,Nojima S,Asano K,Odagiri K,Yamasaki M,Hikita H,Takehara T,Doki Y,Morii E,Kikuchi A

更新日期：2018-11-01 00:00:00

abstract：:Two human pancreatic cell lines, MIA PaCa 2 and Capan 2, were treated by photodynamic therapy in vitro with Photophrin (0.01-25 micrograms/ml; 24 h) and then light (1-50 J/cm2; lambda = 630 nm). The following model was fit to 6 datasets with weighted nonlinear regression: [sequence: see text] The symbols are: E, cell ...

journal_title：Cancer research

authors： Moesta KT,Greco WR,Nurse-Finlay SO,Parsons JC,Mang TS

更新日期：1995-07-15 00:00:00

abstract：:Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder caused by mutations at the NF2 gene locus. Merlin, the protein product of the NF2 gene, has been shown to negatively regulate Rac1 signaling by inhibiting its downstream effector kinases, the p21-activated kinases (Pak). Given the implication of ...

journal_title：Cancer research

authors： Yi C,Wilker EW,Yaffe MB,Stemmer-Rachamimov A,Kissil JL

更新日期：2008-10-01 00:00:00

abstract：:Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a f...

journal_title：Cancer research

authors： Olkhanud PB,Baatar D,Bodogai M,Hakim F,Gress R,Anderson RL,Deng J,Xu M,Briest S,Biragyn A

更新日期：2009-07-15 00:00:00

abstract：:Although chemoresistance remains a primary challenge in the treatment of pancreatic ductal adenocarcinoma (PDAC), exploiting oxidative stress might offer novel therapeutic clues. Here we explored the potential of targeting cystine/glutamate exchanger (SLC7A11/xCT), which contributes to the maintenance of intracellular...

journal_title：Cancer research

authors： Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M

更新日期：2019-08-01 00:00:00

abstract：:A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issu...

journal_title：Cancer research

authors： Nikolsky Y,Sviridov E,Yao J,Dosymbekov D,Ustyansky V,Kaznacheev V,Dezso Z,Mulvey L,Macconaill LE,Winckler W,Serebryiskaya T,Nikolskaya T,Polyak K

更新日期：2008-11-15 00:00:00

abstract：:In the present study we have evaluated the prognostic significance of ploidy levels and proliferative activity in 279 cases of large bowel carcinomas which were included in a surgical prospective randomized trial. Ploidy levels and proliferative activity were determined on nuclei isolated from paraffin-embedded tissue...

journal_title：Cancer research

authors： Schutte B,Reynders MM,Wiggers T,Arends JW,Volovics L,Bosman FT,Blijham GH

更新日期：1987-10-15 00:00:00

abstract：:The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the a...

journal_title：Cancer research

authors： Martinez I,Dimaio D

更新日期：2011-08-15 00:00:00

abstract：:Cancer cells commonly display aberrant surface glycans and related glycoconjugate scaffolds. Compared with their normal counterparts, cancer cell glycans are variably produced and often structurally distinct, serving as biomarkers of cancer progression or as functional entities to malignancy. The glycan signature of a...

journal_title：Cancer research

authors： Dimitroff CJ

更新日期：2015-08-15 00:00:00

abstract：:Cultures of human mammary epithelial cells (HMECs) contain a subpopulation of variant cells with the capacity to propagate beyond an in vitro proliferation barrier. These variant HMECs, which contain hypermethylated and silenced p16(INK4a) (p16) promoters, eventually accumulate multiple chromosomal changes, many of wh...

journal_title：Cancer research

authors： Holst CR,Nuovo GJ,Esteller M,Chew K,Baylin SB,Herman JG,Tlsty TD

更新日期：2003-04-01 00:00:00

abstract：:Both activating and inactivating mutations in protein tyrosine phosphatase Ptpn11 (encoding Shp2) are associated with tumorigenesis. However, the underlying mechanisms remain unclear. Here, we show that Shp2 plays an important role in mitosis, dysregulation of which results in chromosome instability and cancer predisp...

journal_title：Cancer research

authors： Liu X,Zheng H,Qu CK

更新日期：2012-10-15 00:00:00