Abstract:
:The transcription factor B-Myb plays a critical role in regulating gene expression and is implicated in controlling carcinogenesis and cellular senescence. Transcription of the B-Myb gene is regulated by retinoblastoma proteins acting directly on the B-Myb promoter. Recently, we found that microRNAs also control the abundance of B-Myb mRNA during senescence, adding another level of complexity to B-Myb regulation. This review focuses on the importance of B-Myb in cancer and senescence, with an emphasis on the regulation of B-Myb expression and activity.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Martinez I,Dimaio Ddoi
10.1158/0008-5472.CAN-11-1044subject
Has Abstractpub_date
2011-08-15 00:00:00pages
5370-3issue
16eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-11-1044journal_volume
71pub_type
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