TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies.

abstract：:We report on the identification of autoantigens commonly recognized by sera from patients with breast cancer. We selected ten sera from patients with invasive ductal carcinoma (IDC) of the breast with high titer IgG autoantibodies for biopanning of a T7 phage breast cancer cDNA display library. A high throughput metho...

journal_title：Cancer research

authors： Fernández-Madrid F,Tang N,Alansari H,Granda JL,Tait L,Amirikia KC,Moroianu M,Wang X,Karvonen RL

更新日期：2004-08-01 00:00:00

abstract：:Mice transgenic for the human carcinoembryonic antigen (CEA) gene were prepared for use as a preclinical model for immunotherapy. A 32.6-kb fragment containing the complete human CEA gene and flanking sequences was isolated from a genomic cosmid clone and used to produce transgenic C57BL/6 mice. A homozygous line was ...

journal_title：Cancer research

authors： Clarke P,Mann J,Simpson JF,Rickard-Dickson K,Primus FJ

更新日期：1998-04-01 00:00:00

abstract：:In order to characterize the promoting activity of the peroxisome proliferator [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (WY-14,463), male F344 rats which received a single 150-mg/kg dose of diethylnitrosamine (DEN) were fed 0.1% WY-14,643 or 0.05% phenobarbital in the diet for 11, 22, or 54 wk. WY-14,6...

journal_title：Cancer research

authors： Cattley RC,Popp JA

更新日期：1989-06-15 00:00:00

abstract：:We examined several parameters of urine excretion during a two-year initiation-promotion experiment in male Fischer rats using four weeks of N-[4-(5-nitro-2-furyl)-2-thiazoly]formamide at 0.2% of the diet as the initiating agent and either 5% sodium saccharin or 2% L-tryptophan in the diet as promoting agents. Rats fe...

journal_title：Cancer research

authors： Demers DM,Fukushima S,Cohen SM

更新日期：1981-01-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T) is an autosomal recessive syndrome associated with a greatly increased incidence of malignant neoplasms in homozygous affected individuals. Heterozygotes for the gene for A-T are thought to comprise about 1% of the general population and, therefore, it is important to know whether this gene...

journal_title：Cancer research

authors： Swift M,Sholman L,Perry M,Chase C

更新日期：1976-01-01 00:00:00

abstract：:Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 indu...

journal_title：Cancer research

authors： Das S,Ongusaha PP,Yang YS,Park JM,Aaronson SA,Lee SW

更新日期：2006-08-15 00:00:00

abstract：:MLH1 is an integral part of the mismatch repair complex, and the loss of this protein is associated with the acquisition of a mutator phenotype, microsatellite instability, and a predisposition to cancer. Deficiencies in the mismatch repair complex, including the loss of MLH1, result in elevated resistance to specific...

journal_title：Cancer research

authors： Hardman RA,Afshari CA,Barrett JC

更新日期：2001-02-15 00:00:00

abstract：:Estrogen sulfotransferase (EST; SULT 1E1 or STE gene) sulfonates estrogens to inactive estrogen sulfates, whereas steroid sulfatase (STS) hydrolyzes estrone sulfate to estrone. Both EST and STS have been suggested to play important roles in regulating the in situ production of estrogens in human breast carcinoma tissu...

journal_title：Cancer research

authors： Suzuki T,Nakata T,Miki Y,Kaneko C,Moriya T,Ishida T,Akinaga S,Hirakawa H,Kimura M,Sasano H

更新日期：2003-06-01 00:00:00

abstract：:Serum hypergastrinemia promotes the growth of colorectal adenocarcinoma. Some colorectal adenomas express cholecystokinin B/gastrin receptor mRNA, and thus hypergastrinemia may increase progression through the adenoma-carcinoma sequence. This was investigated in the multiple intestinal neoplasia APC(Min-/+) mouse. Ser...

journal_title：Cancer research

authors： Watson SA,Smith AM

更新日期：2001-01-15 00:00:00

abstract：:Critical roles played by some protein kinases in neoplastic transformation and progression provide a rationale for developing selective, small-molecule kinase inhibitors as antineoplastic drugs. Protein kinase Cepsilon (PKCepsilon) is a rational target for cancer therapy, because it is oncogenic and prometastatic in t...

journal_title：Cancer research

authors： Chu F,Koomen JM,Kobayashi R,O'Brian CA

更新日期：2005-11-15 00:00:00

abstract：:Splenocytes from mice bearing a cachexia-inducing tumor (MAC16) have been fused with mouse myeloma cells to produce hybridomas, which have been cloned to produce antibody reactive to a material which copurified with a lipid-mobilizing factor isolated from the same tumor. The monoclonal antibody has been used to invest...

journal_title：Cancer research

authors： Todorov PT,McDevitt TM,Cariuk P,Coles B,Deacon M,Tisdale MJ

更新日期：1996-03-15 00:00:00

abstract：:A quantitative assay for the biochemical transformation of thymidine kinaseless mouse cells (N cIA cI10 cells) to an enzyme-positive phenotype by herpes simplex virus has been used to examine the effect of the carcinogen nitrosomethylurea on cell transformation. Exposure of cells to the chemical carcinogen, followed b...

journal_title：Cancer research

authors： Howett MK,Pegg AE,Rapp F

更新日期：1979-03-01 00:00:00

abstract：:The detection of high-grade bladder tumors prior to invasion is crucial for a good prognosis. We recently found that the levels of hyaluronic acid (HA), a glycosaminoglycan, are elevated in the urine of bladder cancer patients, and small angiogenic HA fragments are present in the urine of high-grade bladder cancer pat...

journal_title：Cancer research

authors： Pham HT,Block NL,Lokeshwar VB

更新日期：1997-02-15 00:00:00

abstract：:Somatostatin receptors (SSTR) are highly expressed in well-differentiated neuroendocrine tumors (NET). Octreotide, an SSTR agonist, has been used to suppress the production of vasoactive hormones and relieve symptoms of hormone hypersecretion with functional NETs. In a clinical trial, an empiric dose of octreotide tre...

journal_title：Cancer research

authors： Heidari P,Wehrenberg-Klee E,Habibollahi P,Yokell D,Kulke M,Mahmood U

更新日期：2013-12-01 00:00:00

abstract：:Elevated oxidative stress is observed more frequently in cancer cells than in normal cells. It is therefore expected that additional exposure to a low level of reactive oxygen species (ROS) will push cancer cells toward death, whereas normal cells might maintain redox homeostasis through adaptive antioxidant responses...

journal_title：Cancer research

authors： Xu Y,Fang F,Miriyala S,Crooks PA,Oberley TD,Chaiswing L,Noel T,Holley AK,Zhao Y,Kiningham KK,Clair DK,Clair WH

更新日期：2013-07-15 00:00:00

abstract：:Constitutively photomorphogenic 1 (COP1), a RING finger ubiquitin ligase with substrates including c-Jun and p53, was recently found to be overexpressed in a number of breast and ovarian tumor samples. In addition to its E3 activity, COP1 was also shown to be able to inhibit activator protein 1 (AP-1) transcription. T...

journal_title：Cancer research

authors： Yi C,Li S,Chen X,Wiemer EA,Wang J,Wei N,Deng XW

更新日期：2005-07-01 00:00:00

abstract：:Despite their extensive clinical and pathologic heterogeneity, all malignant germ cell tumors (GCT) are thought to originate from primordial germ cells. However, no common biological abnormalities have been identified to date. We profiled 615 microRNAs (miRNA) in pediatric malignant GCTs, controls, and GCT cell lines ...

journal_title：Cancer research

authors： Palmer RD,Murray MJ,Saini HK,van Dongen S,Abreu-Goodger C,Muralidhar B,Pett MR,Thornton CM,Nicholson JC,Enright AJ,Coleman N,Children's Cancer and Leukaemia Group.

更新日期：2010-04-01 00:00:00

abstract：:High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and significant chemoresistance, resulting in a recurrent phenotype that makes them impossible to eradicate in the long term. Targeting protumoral signals in the glioma microenvironment could have significant impact against tumor cell...

journal_title：Cancer research

authors： Nandhu MS,Hu B,Cole SE,Erdreich-Epstein A,Rodriguez-Gil DJ,Viapiano MS

更新日期：2014-10-01 00:00:00

abstract：:Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival, and differentiation. Aberrant Notch activation has been linked to a variety of human neoplasms. Here, we show that Notch1 signaling drives the vertical growth phase (VGP) of primary melanoma toward a more aggress...

journal_title：Cancer research

authors： Liu ZJ,Xiao M,Balint K,Smalley KS,Brafford P,Qiu R,Pinnix CC,Li X,Herlyn M

更新日期：2006-04-15 00:00:00

abstract：:Infection by human papillomaviruses (HPV) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. The formation of these lesions is dependent upon increased expression of proangiogenic factors. Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-in...

journal_title：Cancer research

authors： Bodily JM,Mehta KP,Laimins LA

更新日期：2011-02-01 00:00:00

abstract：:Interleukin (IL) 6 was measured in the serum of 138 patients with metastatic renal carcinoma before the initiation of IL-2 treatment. IL-6 was detectable in 66 patients with renal cancer (48%) and in only 8 of 70 normal adults (11%). Serum C reactive protein (CRP) and IL-6 levels are correlated, suggesting that IL-6 i...

journal_title：Cancer research

authors： Blay JY,Negrier S,Combaret V,Attali S,Goillot E,Merrouche Y,Mercatello A,Ravault A,Tourani JM,Moskovtchenko JF

更新日期：1992-06-15 00:00:00

abstract：:Vaccination with irradiated tumor cells genetically modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF tumor vaccine) induces a potent systemic antitumor immunity. To develop a protocol for cancer therapy to further augment the host immune response, we examined the effects of the GM-CSF tumor...

journal_title：Cancer research

authors： Wakimoto H,Abe J,Tsunoda R,Aoyagi M,Hirakawa K,Hamada H

更新日期：1996-04-15 00:00:00

abstract：:We have searched for the presence of genetic alterations in serum DNA obtained from 44 colorectal cancer patients. Microsatellite analysis using highly polymorphic markers revealed loss of heterozygosity and/or microsatellite instability in 35 of 44 (80%) primary tumors. No alterations were detected in the paired seru...

journal_title：Cancer research

authors： Hibi K,Robinson CR,Booker S,Wu L,Hamilton SR,Sidransky D,Jen J

更新日期：1998-04-01 00:00:00

abstract：:During the course of a mechanism-based screening program designed to identify new microtubule-disrupting agents from natural products, we identified a crude extract from Tacca chantrieri that initiated Taxol-like microtubule bundling. Bioassay-directed purification of the extract yielded the highly oxygenated steroids...

journal_title：Cancer research

authors： Tinley TL,Randall-Hlubek DA,Leal RM,Jackson EM,Cessac JW,Quada JC Jr,Hemscheidt TK,Mooberry SL

更新日期：2003-06-15 00:00:00

abstract：:Treatment of male rats with the anticancer drug cisplatin leads to feminization of the profile of cytochrome P-450 and other microsomal enzymes involved in steroid hormone and drug metabolism (G.A. LeBlanc, and D.J. Waxman, J. Biol. Chem., 263: 15732-15739, 1988). The present study uses the rat model to evaluate the d...

journal_title：Cancer research

authors： LeBlanc GA,Sundseth SS,Weber GF,Waxman DJ

更新日期：1992-02-01 00:00:00

abstract：:Chemical and biological studies are presented for a new series of platinum(II) antitumor agents that violate the classical structure-activity relationships established for platinum complexes. These new agents, which have demonstrated activity against murine and human tumor systems, are cis-[Pt(NH3)2(Am)Cl]+ cations, i...

journal_title：Cancer research

authors： Hollis LS,Sundquist WI,Burstyn JN,Heiger-Bernays WJ,Bellon SF,Ahmed KJ,Amundsen AR,Stern EW,Lippard SJ

更新日期：1991-04-01 00:00:00

abstract：:Prostate cancer stem-like cells (PCSLC) are believed to be responsible for prostate cancer onset and metastasis. Autocrine and microenvironmental signals dictate PCSLC behavior and patient outcome. In prostate cancer patients, IL30/IL27p28 has been linked with tumor progression, but the mechanisms underlying this link...

journal_title：Cancer research

authors： Sorrentino C,Ciummo SL,Cipollone G,Caputo S,Bellone M,Di Carlo E

更新日期：2018-05-15 00:00:00

abstract：:Successive B16 melanoma tumor lines were selected for their ability to form pulmonary tumor nodules. This was accomplished by injecting tumor cells i.v. into syngeneic C57BL/6 mice and 2 to 3 weeks later collecting the secondary tumor growths and placing them into tissue culture. These tumor cells were then injected i...

journal_title：Cancer research

authors： Fidler IJ

更新日期：1975-01-01 00:00:00

abstract：:Little is known about the genetic and molecular events leading to the early stages of human astrocytoma formation. To examine this issue, we analyzed the significance of sequential accumulation of two somatic point mutations (R267W and E258D) in the TP53 gene during the initiation of astrocytoma in a patient born with...

journal_title：Cancer research

authors： Fulci G,Ishii N,Maurici D,Gernert KM,Hainaut P,Kaur B,Van Meir EG

更新日期：2002-05-15 00:00:00

abstract：:Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an ...

journal_title：Cancer research

authors： Swinnen JV,Beckers A,Brusselmans K,Organe S,Segers J,Timmermans L,Vanderhoydonc F,Deboel L,Derua R,Waelkens E,De Schrijver E,Van de Sande T,Noël A,Foufelle F,Verhoeven G

更新日期：2005-03-15 00:00:00