Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells.

abstract：:Subcutaneous inoculation of Epstein-Barr virus (EBV) transformed peripheral blood B-lymphocytes (PBL) from an untreated chronic lymphocytic leukemia (CLL) patient produced progressively growing lethal tumors in 4 of 11 whole body irradiated (440 rads) nude mice. In one tumor bearing mouse there was splenomegaly and ge...

journal_title：Cancer research

authors： Lee CL,Uniyal S,Fernandez LA,Lee SH,Ghose T

更新日期：1986-05-01 00:00:00

abstract：:Cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF) are significantly associated with tumor growth and metastasis. Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). This cyclop...

journal_title：Cancer research

authors： Grau R,Iñiguez MA,Fresno M

更新日期：2004-08-01 00:00:00

abstract：:In cancer patients and in those at high risk, systemic exposure to agents for therapy or prevention is accompanied by undesirable side effects. We hypothesized that it is possible to prevent and treat breast cancer by introducing anticancer agents into the mammary ductal network. Here, we show the efficacy of intraduc...

journal_title：Cancer research

authors： Murata S,Kominsky SL,Vali M,Zhang Z,Garrett-Mayer E,Korz D,Huso D,Baker SD,Barber J,Jaffee E,Reilly RT,Sukumar S

更新日期：2006-01-15 00:00:00

abstract：:It is currently widely accepted that genetic instability is key to cancer development. Many types of cancers arise as a consequence of a gradual accumulation of nucleotide aberrations, each mutation conferring growth and/or survival advantage. Genetic instability could also proceed in sudden bursts leading to a more d...

journal_title：Cancer research

authors： Bavoux C,Leopoldino AM,Bergoglio V,O-Wang J,Ogi T,Bieth A,Judde JG,Pena SD,Poupon MF,Helleday T,Tagawa M,Machado C,Hoffmann JS,Cazaux C

更新日期：2005-01-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:A cultured renal carcinoma cell line, ACHN, continued to proliferate in the absence of exogenous growth factors supplied by fetal calf serum. ACHN cells had been previously used as the immunogen for the production of monoclonal antibody 5F4. Subsequent immunohistochemical studies showed that 5F4 strongly and selective...

journal_title：Cancer research

authors： Kochevar J

更新日期：1990-05-15 00:00:00

abstract：:Borderline ovarian tumors possess many of the same morphological features as their malignant counterparts, but they do not destructively invade the ovarian stroma, and the women in whom they develop generally have a favorable prognosis. Female residents of three urban counties of western Washington diagnosed with sero...

journal_title：Cancer research

authors： Harlow BL,Weiss NS,Roth GJ,Chu J,Daling JR

更新日期：1988-10-15 00:00:00

abstract：:Previous studies have shown that all-trans-retinoic acid fails to inhibit chemically induced transformation in 10T1/2 cells except at toxic levels, whereas retinol and many synthetic retinoids are potent inhibitors. In contrast, in many systems retinoic acid is a more effective modulator of differentiation and carcino...

journal_title：Cancer research

authors： Rundhaug J,Gubler ML,Sherman MI,Blaner WS,Bertram JS

更新日期：1987-11-01 00:00:00

abstract：:The ability of glucocorticoids (GCs) to induce death in lymphoid-origin cells is the basis for their frequent use in the therapy of various human hematological malignancies. However, the occurrence of primary or secondary GC resistance limits their clinical usefulness. Prior investigations into the mechanism of GC res...

journal_title：Cancer research

authors： Geley S,Hartmann BL,Hala M,Strasser-Wozak EM,Kapelari K,Kofler R

更新日期：1996-11-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is activated in the majority of melanomas, and its activity is essential for cell survival. In this report, we examined the effects of a novel raf inhibitor BAY 43-9006 on melanoma cell viability and intracellular signaling and found that it induces apoptosis through a caspase-i...

journal_title：Cancer research

authors： Panka DJ,Wang W,Atkins MB,Mier JW

更新日期：2006-02-01 00:00:00

abstract：:SMYD3 methyltransferase is nearly undetectable in normal human tissues but highly expressed in several cancers, including breast cancer, although its contributions to pathogenesis in this setting are unclear. Here we report that histone H2A.Z.1 is a substrate of SMYD3 that supports malignancy. SMYD3-mediated dimethyla...

journal_title：Cancer research

authors： Tsai CH,Chen YJ,Yu CJ,Tzeng SR,Wu IC,Kuo WH,Lin MC,Chan NL,Wu KJ,Teng SC

更新日期：2016-10-15 00:00:00

abstract：:Cyclooxygenase-2 (Cox-2) expression can induce mammary tumorigenesis in transgenic mice, and selective Cox-2 inhibitors are both chemopreventive and chemotherapeutic in rat models of breast cancer. We analyzed the expression of Cox-2 protein by immunohistochemistry in tissue array specimens of 1576 invasive breast can...

journal_title：Cancer research

authors： Ristimäki A,Sivula A,Lundin J,Lundin M,Salminen T,Haglund C,Joensuu H,Isola J

更新日期：2002-02-01 00:00:00

abstract：:Molecular markers of pancreatic neoplasia could aid in the evaluation of visible pancreatic lesions and indicate neoplasia invisible to imaging. We evaluated methylation-specific PCR (MSP) assays that detect aberrantly methylated DNA for their use as markers of pancreatic neoplasia. Methylation analysis was done on pa...

journal_title：Cancer research

authors： Matsubayashi H,Canto M,Sato N,Klein A,Abe T,Yamashita K,Yeo CJ,Kalloo A,Hruban R,Goggins M

更新日期：2006-01-15 00:00:00

abstract：:RhoC is a member of the Ras-homologous family of genes which have been implicated in tumorigenesis and tumor progression. However, the exact role of RhoC is controversial and is yet to be clarified. We have examined the effect of RhoC on prostate tumor cells and found that RhoC had no effect on cell proliferation in v...

journal_title：Cancer research

authors： Iiizumi M,Bandyopadhyay S,Pai SK,Watabe M,Hirota S,Hosobe S,Tsukada T,Miura K,Saito K,Furuta E,Liu W,Xing F,Okuda H,Kobayashi A,Watabe K

更新日期：2008-09-15 00:00:00

abstract：:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparentl...

journal_title：Cancer research

authors： Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HV

更新日期：1976-06-01 00:00:00

abstract：:The cytotoxic activity of 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA), a novel acridine derivative with clinical antitumor activity, has been examined in multicellular spheroids grown from Chinese hamster V79-171b cells. m-AMSA is much less effective against cells within these tumor-like structures than it...

journal_title：Cancer research

authors： Wilson WR,Whitmore GF,Hill RP

更新日期：1981-07-01 00:00:00

abstract：:Busulfan, a bifunctional alkylating agent, is a mainstay of myeloablative preparative regimens before hematopoietic stem cell transplantation. The apparent oral clearance of busulfan expressed relative to body surface area is 2-3-fold higher in children 1-4 years old than it is in adults. The first step in busulfan el...

journal_title：Cancer research

authors： Gibbs JP,Murray G,Risler L,Chien JY,Dev R,Slattery JT

更新日期：1997-12-15 00:00:00

abstract：:The mechanisms underlying the progression of prostate cancer to a state of resistance to hormone ablation remain poorly understood. Here, we have investigated the relationship between androgen receptor (AR) and Her-2/neu in prostate cancer cells. Overexpression of Her-2/neu (c-ErbB2) activates the AR pathway and confe...

journal_title：Cancer research

authors： Berger R,Lin DI,Nieto M,Sicinska E,Garraway LA,Adams H,Signoretti S,Hahn WC,Loda M

更新日期：2006-06-01 00:00:00

abstract：:Recent studies have demonstrated that cytochrome c plays an important role in cell death. In the present study, we report that teniposide and various other chemotherapeutic agents induced a dose-dependent increase in the expression of the mitochondrial respiratory chain proteins cytochrome c, subunits I and IV of cyto...

journal_title：Cancer research

authors： Sánchez-Alcázar JA,Khodjakov A,Schneider E

更新日期：2001-02-01 00:00:00

abstract：:Normal human cells can be transformed to anchorage-independent growth by transfection with DNA from MOLT-4 lymphoblasts, derived from a patient with acute lymphocytic leukemia. Cells were treated with polyethylene glycol 6000, and DNA was administered as a calcium phosphate coprecipitate . The transforming activity of...

journal_title：Cancer research

authors： Sutherland BM,Bennett PV

更新日期：1984-07-01 00:00:00

abstract：:Two populations of nuclear androgen receptors have been characterized in human prostatic tissue, and the levels and proportions of each were found to differ in normal prostates, benign hyperplastic prostates (BPH), and malignant prostates. A significant percentage (35 to 50%) of total nuclear androgen receptors was as...

journal_title：Cancer research

authors： Barrack ER,Bujnovszky P,Walsh PC

更新日期：1983-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:Laminin (LN)-5, a heterotrimer of alpha3, beta3, and gamma2 chains, has been suggested to be involved in tumor cell invasion. The present immunohistochemical study investigated the distribution of the LN gamma2 chain in 48 different human gastric adenocarcinomas. The immunohistochemical analysis showed two distinct pa...

journal_title：Cancer research

authors： Koshikawa N,Moriyama K,Takamura H,Mizushima H,Nagashima Y,Yanoma S,Miyazaki K

更新日期：1999-11-01 00:00:00

abstract：:The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confi...

journal_title：Cancer research

authors： Draffin JE,McFarlane S,Hill A,Johnston PG,Waugh DJ

更新日期：2004-08-15 00:00:00

abstract：:Chemotherapy response in patients with primary breast cancer is difficult to predict and the role of host genetic factors has not been thoroughly investigated. We hypothesized that polymorphisms in oxidative stress (OS)-related genes, including estrogen-quinone metabolizing enzymes NQO2 and GSTM1-5, may influence dise...

journal_title：Cancer research

authors： Yu KD,Huang AJ,Fan L,Li WF,Shao ZM

更新日期：2012-01-15 00:00:00

abstract：:This study was initiated with the objective of separating and characterizing two or more nuclear subfractions, which could then be compared with respect to their relative propensity for binding carcinogenic polycyclic aromatic hydrocarbons. Nuclei were isolated from cloned AKR-2B mouse embryo cells, which are suscepti...

journal_title：Cancer research

authors： Webster RA,Moses HL,Spelsberg TC

更新日期：1976-08-01 00:00:00

abstract：:An undifferentiated status and the epigenetic inactivation of tumor-suppressor genes are hallmarks of transformed cells. Promoter CpG island hypermethylation of differentiating genes, however, has rarely been reported. The Groucho homologue Transducin-like Enhancer of Split 1 (TLE1) is a multitasked transcriptional co...

journal_title：Cancer research

authors： Fraga MF,Berdasco M,Ballestar E,Ropero S,Lopez-Nieva P,Lopez-Serra L,Martín-Subero JI,Calasanz MJ,Lopez de Silanes I,Setien F,Casado S,Fernandez AF,Siebert R,Stifani S,Esteller M

更新日期：2008-06-01 00:00:00

abstract：:Palytoxin (PTX), one of the most toxic nonprotein molecules known, is cytotoxic at picomolar concentrations against a wide variety of cell types. In contrast to most cytotoxins, PTX exerts its activity extracellularly. A method for targeting PTX to tumor cells is described in which a monoclonal antibody-enzyme conjuga...

journal_title：Cancer research

authors： Bignami GS,Senter PD,Grothaus PG,Fischer KJ,Humphreys T,Wallace PM

更新日期：1992-10-15 00:00:00

abstract：:This study was undertaken to examine relationships of the phenotype of malignant cells to target cell properties and to events early in the transformation process. Eighteen transformed lines were obtained by Kirsten murine sarcoma virus infection of cells from adrenal glands of rats ages 4 to 30 weeks, at first or sec...

journal_title：Cancer research

authors： Auersperg N,Wan MW,Sanderson RA,Wong KS,Mauldin D

更新日期：1981-05-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study ...

journal_title：Cancer research

authors： Xia G,Kumar SR,Masood R,Zhu S,Reddy R,Krasnoperov V,Quinn DI,Henshall SM,Sutherland RL,Pinski JK,Daneshmand S,Buscarini M,Stein JP,Zhong C,Broek D,Roy-Burman P,Gill PS

更新日期：2005-06-01 00:00:00