Abstract：
:An assay has been developed and measurements of aryl hydrocarbon [benzo(a)pyrene] hydroxylase have been made in peripheral blood monocytes from a human population. Treatment with benz(a)anthracene in cell culture increased aryl hydrocarbon hydroxylase activity from 6.5 to 37-fold in monocytes from each of 25 apparently healthy donors. A weak correlation (r = 0.38) was observed between the induction ratios obtained with monocytes and lymphocytes from the same donors. Reproducibilities of the monocyte and lymphocyte assays were comparable. In monocytes, the measurement of basal and induced aryl hydrocarbon hydroxylases activity does not require pretreatment with mitogens as is the case with lymphocytes. Monocytes also exhibit a much wider range of induction ratios than do lymphocytes.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Bast RC Jr,Okuda T,Plotkin E,Tarone R,Rapp HJ,Gelboin HVsubject
Has Abstractpub_date
1976-06-01 00:00:00pages
1967-74issue
6eissn
0008-5472issn
1538-7445journal_volume
36pub_type
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