Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

abstract：:Palytoxin (PTX), one of the most toxic nonprotein molecules known, is cytotoxic at picomolar concentrations against a wide variety of cell types. In contrast to most cytotoxins, PTX exerts its activity extracellularly. A method for targeting PTX to tumor cells is described in which a monoclonal antibody-enzyme conjuga...

journal_title：Cancer research

authors： Bignami GS,Senter PD,Grothaus PG,Fischer KJ,Humphreys T,Wallace PM

更新日期：1992-10-15 00:00:00

abstract：:An immunogenic tumor and a nonimmunogenic tumor were used in C57BL/Ka and CBA/Rij mice, respectively, in a study in which lymph node morphology was quantitatively measured. Lymph nodes were cut in semiseries, and a morphometrical analysis was done on the paracortical and cortical areas as major parts of the active lym...

journal_title：Cancer research

authors： van de Velde CJ,Meyer CJ,Cornellsse CJ,van der Velde EA,van Putten LM,Swaveling A

更新日期：1978-03-01 00:00:00

abstract：:An autocrine (noninterleukin 2) growth factor, which we term leukemia derived growth factor (LDGF), has previously been found in the culture supernatant of the human malignant T-lymphoid cell line MOLT-4f. We now show that two other human malignant T-lymphoid cell lines, CCRF-CEM and CCRF-HSB-2 also produce such a fac...

journal_title：Cancer research

authors： Uittenbogaart CH,Nishanian PG,Anisman DJ,Erikson TK,Fahey JL

更新日期：1986-03-01 00:00:00

abstract：:The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract ...

journal_title：Cancer research

authors： DiCicco LM,Truitt GA,Wheelock EF

更新日期：1986-01-01 00:00:00

abstract：:An animal lectin purified from loach (Misgurnus anguillicaudatus) eggs induced release of cytotoxin from fresh bone marrow cells from mice, although the other lectins tested, wheat germ agglutinin, concanavalin A, and phytohemagglutinin did not. The cytotoxin released from bone marrow cells was a heat-labile protein w...

journal_title：Cancer research

authors： Okutomi T,Nakajima Y,Sakakibara F,Kawauchi H,Yamazaki M

更新日期：1987-01-01 00:00:00

abstract：:Determination of neopterin [D-erythro-6-(1',2',3'-trihydroxypropyl)pterin] in body fluids is a powerful diagnostic tool in a variety of diseases in which activation of cellular immune mechanisms is involved, such as certain malignancies, allograft rejection, and autoimmune and infectious diseases. In vitro, neopterin ...

journal_title：Cancer research

authors： Werner-Felmayer G,Werner ER,Fuchs D,Hausen A,Reibnegger G,Wachter H

更新日期：1990-05-15 00:00:00

abstract：:Previously we described a human B-lymphoma xenotransplantation model in which the immunotherapeutic activity of monoclonal antibodies (mAbs), directed against human B-cell antigens, can be studied. An anti-CD19 mAb of IgG2a subclass was therapeutically active by itself in this model, and its efficacy was increased by ...

journal_title：Cancer research

authors： Vuist WM,van Buitenen F,Hekman A,Melief CJ

更新日期：1990-09-15 00:00:00

abstract：:Factors affecting the expression of carcinoembryonic antigen (CEA) at the surface of in vitro human colon carcinoma cells were determined using 125I-labeled antibodies. Binding of specific anti-CEA antibodies resulted in polar redistribution of CEA, followed by endocytosis of most of the CEA-anti-CEA complexes. These ...

journal_title：Cancer research

authors： Rosenthal KL,Tompkins WA,Rawls WE

更新日期：1980-12-01 00:00:00

abstract：:An androgen-dependent tumor (SCC8 tumor) was obtained by inoculating an androgen-responsive cell line derived from the androgen-responsive Shionogi carcinoma 115 (SC115) into mice and then treating the mice with testosterone propionate (TP) at a pharmacological dose (400 micrograms/day). The SCC8 tumor differed in his...

journal_title：Cancer research

authors： Terada N,Yamamoto R,Uchida N,Takada T,Taniguchi H,Takatsuka D,Sawada M,Tsuji M,Li W,Kitamura Y

更新日期：1989-02-01 00:00:00

abstract：:Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown. Herein, we first ...

journal_title：Cancer research

authors： Zhang K,Chu K,Wu X,Gao H,Wang J,Yuan YC,Loera S,Ho K,Wang Y,Chow W,Un F,Chu P,Yen Y

更新日期：2013-02-15 00:00:00

abstract：:An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a nitrogen atmosphere, ...

journal_title：Cancer research

authors： Polonis VR,Anderson GR,Brzykcy J,Vladutiu AO,Manly KF

更新日期：1984-05-01 00:00:00

abstract：:A new DNA precipitation assay used together with the alkali unwinding assay may provide a rapid means of detecting DNA damage in addition to strand breaks based on the relative amount of damage measured by the two assays. X-rays, Adriamycin, 4-nitroquinoline-N-oxide, N-methyl-N'-nitrosoguanidine, bleomycin, RSU 1172, ...

journal_title：Cancer research

authors： Olive PL,Chan AP,Cu CS

更新日期：1988-11-15 00:00:00

abstract：:Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA....

journal_title：Cancer research

authors： Lee JH,Lee JH,Lee SH,Do SI,Cho SD,Forslund O,Inn KS,Lee JS,Deng FM,Melamed J,Jung JU,Jeong JH

更新日期：2016-11-15 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell renal cell carcinoma (ccRCC) representing approximately 75% of all RCCs. Increased expression of the hypoxia-induced factors-1α (HIF1α) and HIF2α has been suggested as a pivotal step in ccRCC carcinogenesis,...

journal_title：Cancer research

authors： Fu L,Wang G,Shevchuk MM,Nanus DM,Gudas LJ

更新日期：2013-05-01 00:00:00

abstract：:Although in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell-penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on...

journal_title：Cancer research

authors： Stangl S,Varga J,Freysoldt B,Trajkovic-Arsic M,Siveke JT,Greten FR,Ntziachristos V,Multhoff G

更新日期：2014-12-01 00:00:00

abstract：:Species evolve by mutations and epigenetic changes acting on individuals in a population; tumors evolve by similar mechanisms at a cellular level in a tissue. This article reviews growing evidence about tumor dormancy and suggests that (i) cellular malignancy is a natural byproduct of evolutionary mechanisms, such as ...

journal_title：Cancer research

authors： Manjili MH

更新日期：2017-05-15 00:00:00

abstract：:The effects of transforming growth factor-beta (TGF beta) on a human colon carcinoma cell line (MOSER) were investigated. TGF beta, at low concentrations (between 0.1 and 1.0 ng/ml), inhibited the proliferation of MOSER cells both in monolayer culture and soft agarose, in a dose-dependent manner. MOSER cells adapted t...

journal_title：Cancer research

authors： Hoosein NM,Brattain DE,McKnight MK,Levine AE,Brattain MG

更新日期：1987-06-01 00:00:00

abstract：:For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for in situ imaging during resection. However, for cancers with difficult imaging conditions, surg...

journal_title：Cancer research

authors： Gao RW,Teraphongphom NT,van den Berg NS,Martin BA,Oberhelman NJ,Divi V,Kaplan MJ,Hong SS,Lu G,Ertsey R,Tummers WSFJ,Gomez AJ,Holsinger FC,Kong CS,Colevas AD,Warram JM,Rosenthal EL

更新日期：2018-09-01 00:00:00

abstract：:Primary rat tracheal epithelial cells can be transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. The earliest recognizable morphological transformant is the enhanced growth variant (EGV), characterized by enhanced proliferative capacity. Transformed EGV colonies can progress to give rise to immortal cell lin...

journal_title：Cancer research

authors： Endo S,Nettesheim P,Oshimura M,Walker C

更新日期：1990-02-01 00:00:00

abstract：:The conversion of transforming growth factor beta (TGF-beta) from a tumor suppressor to a tumor promoter occurs frequently during mammary tumorigenesis, yet the molecular mechanisms underlying this phenomenon remain undefined. We show herein that TGF-beta repressed nuclear factor-kappaB (NF-kappaB) activity in normal ...

journal_title：Cancer research

authors： Neil JR,Schiemann WP

更新日期：2008-03-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the producti...

journal_title：Cancer research

authors： Guo H,Li R,Zucker S,Toole BP

更新日期：2000-02-15 00:00:00

abstract：:Changes in the structure of the surface of mastocytoma cells were induced by hyperthermia and were investigated by means of cell electrophoresis. A decrease in the cell electrophoretic mobility was detected as early as 15 min after treatment at 42 degrees and progressed more rapidly under hypoxic conditions than under...

journal_title：Cancer research

authors： Sato C,Nakayama T,Kojima K,Nishimoto Y,Nakamura W

更新日期：1981-10-01 00:00:00

abstract：:We have applied Raman spectroscopy to analyze the chemical composition of microcalcifications occurring in benign and malignant lesions in the human breast. Microcalcifications were initially separated into two categories based on their Raman spectrum: type I, calcium oxalate dihydrate, and type II, calcium hydroxyapa...

journal_title：Cancer research

authors： Haka AS,Shafer-Peltier KE,Fitzmaurice M,Crowe J,Dasari RR,Feld MS

更新日期：2002-09-15 00:00:00

abstract：:The pathogenetic relationship between high-grade prostatic intraepithelial neoplasia (PIN), prostatic carcinoma, and metastases is poorly understood. We used fluorescence in situ hybridization (FISH) with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate numeric chromosomal anomalies in PIN (6...

journal_title：Cancer research

authors： Qian J,Bostwick DG,Takahashi S,Borell TJ,Herath JF,Lieber MM,Jenkins RB

更新日期：1995-11-15 00:00:00

abstract：:Telomerase activity (TA) is detected in most human cancers but, with few exceptions, not in normal somatic cells. Little is known about TA in soft tissue tumors. We have examined a series of benign and malignant soft tissue tumors for TA using the telomerase repeat amplification protocol assay. Analysis of the express...

journal_title：Cancer research

authors： Yan P,Coindre JM,Benhattar J,Bosman FT,Guillou L

更新日期：1999-07-01 00:00:00

abstract：:Lung carcinoma cell lines were analyzed in culture and in nude mouse xenograft for both morphological appearance and expression of specific proteins that participate in cross-linked envelope formation during normal squamous cell terminal differentiation. Cross-linked envelope formation, induced by artificial influx of...

journal_title：Cancer research

authors： Levitt ML,Gazdar AF,Oie HK,Schuller H,Thacher SM

更新日期：1990-01-01 00:00:00

abstract：:Given the prevalence of Ras mutations in human cancer, it is critical to understand the effector pathways downstream of oncogenic Ras leading to transformation. To directly assess the requirement for Rac1 in K-ras-induced tumorigenesis, we employed a model of lung cancer in which an oncogenic allele of K-ras could be ...

journal_title：Cancer research

authors： Kissil JL,Walmsley MJ,Hanlon L,Haigis KM,Bender Kim CF,Sweet-Cordero A,Eckman MS,Tuveson DA,Capobianco AJ,Tybulewicz VL,Jacks T

更新日期：2007-09-01 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:Methotrexate (MTX) is one of the most commonly used agents in the treatment of solid malignancies; however, the toxicities of MTX to bone marrow and gastrointestinal tract complicate this therapy. We, therefore, propose a gene-dependent enzyme prodrug therapy to limit these toxicities by localizing the production of M...

journal_title：Cancer research

authors： Hamstra DA,Pagé M,Maybaum J,Rehemtulla A

更新日期：2000-02-01 00:00:00

abstract：:Screening of the entire let-7 family of microRNAs (miRNA) by in situ hybridization identified let-7g as the only member, the diminished expression of which was significantly associated with lymph node metastasis and poor survival in breast cancer patients. Abrogation of let-7g expression in otherwise nonmetastatic mam...

journal_title：Cancer research

authors： Qian P,Zuo Z,Wu Z,Meng X,Li G,Wu Z,Zhang W,Tan S,Pandey V,Yao Y,Wang P,Zhao L,Wang J,Wu Q,Song E,Lobie PE,Yin Z,Zhu T

更新日期：2011-10-15 00:00:00