The role of host lymphoid populations in the response of mouse EMT6 tumor to photodynamic therapy.

abstract：:The influence of methotrexate (MTX), dibutyryl cyclic AMP, and actinomycin D on production of human chorionic gonadotropin (HCG) in normal first trimester human placental organ cultures was compared. Actinomycin D (10(-8) to 10(-6) M) elevated HCG production by as much as 3.5-fold in normal placenta, and a 2-fold incr...

journal_title：Cancer research

authors： Huot RI,Nardone RM,Stromberg K

更新日期：1987-01-15 00:00:00

abstract：:Athymic mice infected with pinworms or carrying human tumor xenografts frequently develop a lymphoproliferative disorder which eventually leads to lymphoma. By immunofluorescent analysis of involved tissues, the lymphomas appear to be mixtures of null cells, B-cells, and T-cells. When each lymphoma is established in t...

journal_title：Cancer research

authors： Baird SM,Beattie GM,Lannom RA,Lipsick JS,Jensen FC,Kaplan NO

更新日期：1982-01-01 00:00:00

abstract：:Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and consequently to allow for high levels of long-term, donor-type engraftment after bone marrow transplantation (BMT). Such a property...

journal_title：Cancer research

authors： Westerhof GR,Ploemacher RE,Boudewijn A,Blokland I,Dillingh JH,McGown AT,Hadfield JA,Dawson MJ,Down JD

更新日期：2000-10-01 00:00:00

abstract：:The antitumor effects of two immunotoxins were evaluated in vitro and in vivo against the human ovarian carcinoma cell line, OVCAR-3. The immunotoxins used were composed of recombinant ricin A chain (rRTA) covalently attached to a monoclonal antibody directed toward the human transferrin receptor (45412/rRTA, also cal...

journal_title：Cancer research

authors： Pearson JW,Hedrick E,Fogler WE,Bull RL,Ferris DK,Riggs CW,Wiltrout RH,Sivam G,Morgan AC,Groves E

更新日期：1990-10-01 00:00:00

abstract：:The A-240T and I/D polymorphisms in the angiotensin I-converting enzyme (ACE) gene are markers of circulating ACE levels and have been associated with numerous cardiovascular disease outcomes. More recently, the low-activity A and I alleles at these polymorphic sites have been inversely related with breast cancer risk...

journal_title：Cancer research

authors： Haiman CA,Henderson SO,Bretsky P,Kolonel LN,Henderson BE

更新日期：2003-10-15 00:00:00

abstract：:The treatment of K562 human myeloblastic leukemia cells and YAC-1 murine lymphoma cells with cadeguomycin at concentrations over 0.6 microM significantly enhanced the cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C). The degree of potentiation depended upon the antibiotic concentration. The treatment with 75 ...

journal_title：Cancer research

authors： Suzuki H,Kim SH,Tanara M,Okazaki K,Okabe T,Wu RT,Tanaka N

更新日期：1987-02-01 00:00:00

abstract：:Induction of an apoptotic cell death was studied in a mouse T-cell hybridoma. Apoptosis was induced in these cells following exposure to dexamethasone, X-radiation, 43 degrees C heat shock, A254 light, and hydrogen peroxide. In 5-Gy-exposed cells, a radiation-induced G2 phase cell cycle progression block was maximum b...

journal_title：Cancer research

authors： Warters RL

更新日期：1992-02-15 00:00:00

abstract：:Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to dete...

journal_title：Cancer research

authors： Feber A,Worth DC,Chakravarthy A,de Winter P,Shah K,Arya M,Saqib M,Nigam R,Malone PR,Tan WS,Rodney S,Freeman A,Jameson C,Wilson GA,Powles T,Beck S,Fenton T,Sharp TV,Muneer A,Kelly JD

更新日期：2016-08-15 00:00:00

abstract：:In order to examine the effects of the overexpression of c-erbB-2 (HER-2, neu) on human bronchial epithelial cells, a human c-erbB-2 expression vector was introduced into the simian virus 40 large T-antigen-immortalized human bronchial epithelial cell line BEAS-2B. Isolation of multiple clonal cell lines after selecti...

journal_title：Cancer research

authors： Noguchi M,Murakami M,Bennett W,Lupu R,Hui F Jr,Harris CC,Gerwin BI

更新日期：1993-05-01 00:00:00

abstract：:Gemcitabine is currently the best treatment available for pancreatic cancer, but the disease develops resistance to the drug over time. Agents that can either enhance the effects of gemcitabine or overcome chemoresistance to the drug are needed for the treatment of pancreatic cancer. Curcumin, a component of turmeric ...

journal_title：Cancer research

authors： Kunnumakkara AB,Guha S,Krishnan S,Diagaradjane P,Gelovani J,Aggarwal BB

更新日期：2007-04-15 00:00:00

abstract：:Use of steroid biosynthesis inhibitors to suppress estrogen production is a logical strategy in the treatment of women with hormone-dependent breast cancer. The clinical availability of aminoglutethimide as an inhibitor of cytochrome P-450-mediated steroid hydroxylations prompted study of the precise pharmacological a...

journal_title：Cancer research

authors： Santen RJ,Santner SJ,Tilsen-Mallett N,Rosen HR,Samojlik E,Veldhuis JD

更新日期：1982-08-01 00:00:00

abstract：:Excess production of the proinflammatory IL6 has both local and systemic tumor-promoting activity in many cancers, including ovarian cancer. However, treatment of advanced ovarian cancer patients with a neutralizing IL6 antibody yielded little efficacy in a previous phase II clinical trial. Here, we report results tha...

journal_title：Cancer research

authors： Milagre CS,Gopinathan G,Everitt G,Thompson RG,Kulbe H,Zhong H,Hollingsworth RE,Grose R,Bowtell DD,Hochhauser D,Balkwill FR

更新日期：2015-04-01 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:Recently, the cDNA encoding a novel candidate for prostate cancer-specific antigen, named prostate-specific membrane antigen (PSM), was cloned from the LNCaP prostate cancer cell line (R. S. Israeli, C. T. Powell, W. R. Fair, and W. D. W. Heston, Cancer Res., 53: 227-230,1993). More recently, they also identified an a...

journal_title：Cancer research

authors： Kawakami M,Nakayama J

更新日期：1997-06-15 00:00:00

abstract：:We have used culture conditions which simulate the microenvironment of breast tumors for the isolation and propagation of primary breast tumor cells in vitro. In this monolayer setup, the mixture of cells dissociated from primary breast tumors is subjected to self-created gradients of oxygen and nutrients as well as m...

journal_title：Cancer research

authors： Dairkee SH,Deng G,Stampfer MR,Waldman FM,Smith HS

更新日期：1995-06-15 00:00:00

abstract：:Three loci have been implicated in the etiology of familial breast cancer; the BRCA1 locus on 17q, the p53 gene on 17p, and the androgen receptor gene on the X chromosome. However, it has been estimated that in approximately 50% of all breast cancer families the predisposing genetic defect is not linked to any of thes...

journal_title：Cancer research

authors： Lindblom A,Skoog L,Rotstein S,Werelius B,Larsson C,Nordenskjöld M

更新日期：1993-09-15 00:00:00

abstract：:Vinblastine (VLB) is moderately active clinically against advanced breast cancer. Since VLB is extensively taken up by platelets and thus only partially available to tumor cells, to enhance the therapeutic index of VLB we have therefore administered this agent by continuous i.v. infusion to patients with advanced brea...

journal_title：Cancer research

authors： Lu K,Yap HY,Loo TL

更新日期：1983-03-01 00:00:00

abstract：:The possible alteration of transformation-related antigens in cells that revert to a normal phenotype but that continue to retain the viral genome, has been investigated in [3H]glucosamine-labeled extracts of rat cells exhibiting a reversible temperature-dependent restriction in the expression of transformation and in...

journal_title：Cancer research

authors： Rieber M,Bacalao J,Rieber M

更新日期：1977-04-01 00:00:00

abstract：:Phosphorylation of heat shock protein 27 (HSP27) has been suggested to play an important role in the regulation of F-actin dynamics in response to growth factors and stress. Because the microfilament network is one of the earliest targets of oxidative stress and because phosphorylation of HSP27 is strongly induced by ...

journal_title：Cancer research

authors： Huot J,Houle F,Spitz DR,Landry J

更新日期：1996-01-15 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by MHC class I (MHC-I) molecules. Herein, we demonstrate that genetic or pharmacological inhibition of ERAP1 on human tumor cell lines perturbs their ability to engage several classes of ...

journal_title：Cancer research

authors： Cifaldi L,Romania P,Falco M,Lorenzi S,Meazza R,Petrini S,Andreani M,Pende D,Locatelli F,Fruci D

更新日期：2015-03-01 00:00:00

abstract：:Angiogenesis is one of the crucial events for cancer development and growth. Two members of the vascular endothelial growth factor (VEGF) family, VEGF-A and placental growth factor (PlGF), which are able to heterodimerize if coexpressed in the same cell, are both required for pathologic angiogenesis. We have generated...

journal_title：Cancer research

authors： Tarallo V,Vesci L,Capasso O,Esposito MT,Riccioni T,Pastore L,Orlandi A,Pisano C,De Falco S

更新日期：2010-03-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients with AML and that ROS production promotes proliferation of AML cells...

journal_title：Cancer research

authors： Robinson AJ,Hopkins GL,Rastogi N,Hodges M,Doyle M,Davies S,Hole PS,Omidvar N,Darley RL,Tonks A

更新日期：2020-03-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is a rare disease with an overall poor but heterogeneous prognosis. This heterogeneity could reflect different mechanisms of tumor development. Gene expression profiling by transcriptome analysis led to ACC being divided into two groups of tumors with very different outcomes. Somatic ina...

journal_title：Cancer research

authors： Ragazzon B,Libé R,Gaujoux S,Assié G,Fratticci A,Launay P,Clauser E,Bertagna X,Tissier F,de Reyniès A,Bertherat J

更新日期：2010-11-01 00:00:00

abstract：:The transmembrane neural cell adhesion receptor L1 is a Wnt/β-catenin target gene expressed in many tumor types. In human colorectal cancer, L1 localizes preferentially to the invasive front of tumors and when overexpressed in colorectal cancer cells, it facilitates their metastasis to the liver. In this study, we inv...

journal_title：Cancer research

authors： Gavert N,Shvab A,Sheffer M,Ben-Shmuel A,Haase G,Bakos E,Domany E,Ben-Ze'ev A

更新日期：2013-09-15 00:00:00

abstract：:Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to control prostate cancer in most patients. Androgen-independent acquisit...

journal_title：Cancer research

authors： Cerasuolo M,Paris D,Iannotti FA,Melck D,Verde R,Mazzarella E,Motta A,Ligresti A

更新日期：2015-08-01 00:00:00

abstract：:Despite the fact that osteosarcoma is one of the most common primary bone malignancies with poor prognosis, the mechanism behind the pathogenesis of osteosarcoma is only partially known. Here we characterized differentially expressed genes by extensive analysis of several publicly available gene expression profile dat...

journal_title：Cancer research

authors： Chen Y,Wang T,Huang M,Liu Q,Hu C,Wang B,Han D,Chen C,Zhang J,Li Z,Liu C,Lei W,Chang Y,Wu M,Xiang D,Chen Y,Wang R,Huang W,Lei Z,Chu X

更新日期：2020-06-15 00:00:00

abstract：:Spontaneous tumors in urodele amphibians have been considered uncommon, and this resistance has sometimes been associated with the natural regenerative capacity of tissues in such species. This report describes spontaneous, nonpigmented, benign epitheliomas which were found in 44 of 1586 (2.8%) adult newts, Cynops pyr...

journal_title：Cancer research

authors： Pfeiffer CJ,Nagai T,Fujimura M,Tobe T

更新日期：1979-06-01 00:00:00

abstract：:Thirteen patients with metastatic breast carcinoma were given injections of 50-1593 micrograms of 131I-monoclonal antibody (MAb) B6.2 immunoglobulin G and F(ab')2 for pharmacokinetic evaluation and radioimmunoimaging. Blood clearance of the 131I-MAb-B6.2 was biphasic. The mean half-times (t 1/2 alpha, t 1/2 beta) for ...

journal_title：Cancer research

authors： Hayes DF,Zalutsky MR,Kaplan W,Noska M,Thor A,Colcher D,Kufe DW

更新日期：1986-06-01 00:00:00

abstract：:HER2-directed therapies, such as trastuzumab and lapatinib, are important treatments for breast cancer. However, some tumors do not respond or develop resistance to these agents. We isolated and characterized multiple lapatinib-resistant, HER2-positive, estrogen receptor (ER)-positive breast cancer clones derived from...

journal_title：Cancer research

authors： Liu L,Greger J,Shi H,Liu Y,Greshock J,Annan R,Halsey W,Sathe GM,Martin AM,Gilmer TM

更新日期：2009-09-01 00:00:00

abstract：:Immunization to multiple defined tumor antigens for specific immune therapy of human cancer has thus far proven difficult. Eighteen HLA A*0201(+) patients with metastatic melanoma received injections s.c. of CD34(+)progenitor-derived autologous dendritic cells (DCs), which included Langerhans cells. DCs were pulsed wi...

journal_title：Cancer research

authors： Banchereau J,Palucka AK,Dhodapkar M,Burkeholder S,Taquet N,Rolland A,Taquet S,Coquery S,Wittkowski KM,Bhardwaj N,Pineiro L,Steinman R,Fay J

更新日期：2001-09-01 00:00:00