Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses.

abstract：:Thioguanine and mercaptopurine are prodrugs requiring conversion into thiopurine nucleotides to exert cytotoxicity. Thiopurine S-methyltransferase (TPMT), an enzyme subject to genetic polymorphism, catabolizes thiopurines into inactive methylated bases, but also produces methylthioguanine nucleotides and methylmercapt...

journal_title：Cancer research

authors： Dervieux T,Blanco JG,Krynetski EY,Vanin EF,Roussel MF,Relling MV

更新日期：2001-08-01 00:00:00

abstract：:Many epithelial tumors show deletion of the short arm of chromosome 8 that is related to aggressive disease or adverse prognosis. In undissected samples of urothelial cell carcinoma of the bladder, at least two regions of loss of heterozygosity (LOH) were identified previously within a small region of 8p11-p12. LOH an...

journal_title：Cancer research

authors： Adams J,Williams SV,Aveyard JS,Knowles MA

更新日期：2005-01-01 00:00:00

abstract：:We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35)...

journal_title：Cancer research

authors： Niethammer AG,Xiang R,Ruehlmann JM,Lode HN,Dolman CS,Gillies SD,Reisfeld RA

更新日期：2001-08-15 00:00:00

abstract：:We review and compare statistical methods for the analysis of in vivo tumor growth experiments. The methods most commonly used are deficient in that they have either low power or misleading type I error rates. We propose a set of multivariate statistical modeling methods that correct these problems, illustrating their...

journal_title：Cancer research

authors： Heitjan DF,Manni A,Santen RJ

更新日期：1993-12-15 00:00:00

abstract：:The expression of genes involved in p53-mediated apoptosis was studied using cDNA microarray after treating isogenic cell lines with either ionizing radiation or doxorubicin. Most of the known p53 transcriptional activation target genes clustered in a functional category defined by early and p53-dependent induction, r...

journal_title：Cancer research

authors： Robles AI,Bemmels NA,Foraker AB,Harris CC

更新日期：2001-09-15 00:00:00

abstract：:We describe a method to postlabel, in vivo, biotinylated monoclonal antibodies pretargeted onto tumor deposits when most of the non-tumor-bound antibodies have already been cleared as avidin-bound complexes. The application of this principle to tumor detection by immunoscintigraphy was tested in 20 patients with histo...

journal_title：Cancer research

authors： Paganelli G,Magnani P,Zito F,Villa E,Sudati F,Lopalco L,Rossetti C,Malcovati M,Chiolerio F,Seccamani E

更新日期：1991-11-01 00:00:00

abstract：:TNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a 26-kDa membrane tethered form (mTNF-α) or a soluble 17-kDa cytokine (sTNF-α), the vast majority of pub...

journal_title：Cancer research

authors： Ardestani S,Li B,Deskins DL,Wu H,Massion PP,Young PP

更新日期：2013-07-01 00:00:00

abstract：:Human prostate cancer has a high predisposition to metastasize to bone, resulting in the formation of osteoblastic metastases. The mechanism through which prostate cancer cells promote osteoblastic lesions is undefined. Vascular endothelial growth factor (VEGF) has been implicated as a mediator of osteoblast activity....

journal_title：Cancer research

authors： Dai J,Kitagawa Y,Zhang J,Yao Z,Mizokami A,Cheng S,Nör J,McCauley LK,Taichman RS,Keller ET

更新日期：2004-02-01 00:00:00

abstract：:We applied 1H-decoupling and nuclear Overhauser enhancement to obtain well-resolved 31P magnetic resonance spectra accurately localized to 20 soft tissue sarcomas in vivo, using three-dimensional chemical shift imaging. Fifteen spectra had large phosphomonoester signals (21% of total phosphorus) that contained high am...

journal_title：Cancer research

authors： Li CW,Kuesel AC,Padavic-Shaller KA,Murphy-Boesch J,Eisenberg BL,Schmidt RG,von Roemeling RW,Patchefsky AS,Brown TR,Negendank WG

更新日期：1996-07-01 00:00:00

abstract：:Two characteristics of immune responses to weakly immunogenic plasma cell tumors were demonstrated in this study. (a) Elevated lymphoproliferative responses following in vivo inoculation of sublethal doses of plasma cell tumors were detected by a mixed lymphocyte-tumor interaction (MLTI) assay. Specificity of elevated...

journal_title：Cancer research

authors： Boyer PJ,Fahey JL

更新日期：1976-04-01 00:00:00

abstract：:The Ku70/80 autoantigens (Ku) are the DNA-binding components of a DNA-dependent protein kinase (PK) involved in DNA double strand breaks repairing a V(D)J recombination. Because apoptosis is associated with DNA fragmentation and, consequently, creation of double strand breaks, and a variety of DNA-damaging drugs kill ...

journal_title：Cancer research

authors： Kim SH,Kim D,Han JS,Jeong CS,Chung BS,Kang CD,Li GC

更新日期：1999-08-15 00:00:00

abstract：:We have recently reported that apoptosis of T cells induced by squamous cell carcinoma of the head and neck (SCCHN) is partly Fas dependent. This tumor-induced T-cell death is mediated by the activities of caspase-8 and caspase-3 and is partially inhibited by antibodies to either Fas or Fas ligand. We report here that...

journal_title：Cancer research

authors： Gastman BR,Yin XM,Johnson DE,Wieckowski E,Wang GQ,Watkins SC,Rabinowich H

更新日期：2000-12-15 00:00:00

abstract：:Tumor metastasis is one of the most important clinical aspects of neoplastic disease because patient mortality is frequently attributable to disseminated rather than primary tumors. However, it still is not possible to definitively distinguish those individuals at high risk for disseminated disease, who would benefit ...

journal_title：Cancer research

authors： Hunter KW,Broman KW,Voyer TL,Lukes L,Cozma D,Debies MT,Rouse J,Welch DR

更新日期：2001-12-15 00:00:00

abstract：:Abnormal activation of DNA repair pathways by deregulated signaling of receptor tyrosine kinase systems is a compelling likelihood with significant implications in both cancer biology and treatment. Here, we show that due to a potential substrate switch, mutated variants of the receptor for hepatocyte growth factor Me...

journal_title：Cancer research

authors： Ganapathipillai SS,Medová M,Aebersold DM,Manley PW,Berthou S,Streit B,Blank-Liss W,Greiner RH,Rothen-Rutishauser B,Zimmer Y

更新日期：2008-07-15 00:00:00

abstract：:We examined the genetic requirements for the Myc family of oncogenes in normal Sonic hedgehog (Shh)-mediated cerebellar granule neuronal precursor (GNP) expansion and in Shh pathway-induced medulloblastoma formation. In GNP-enriched cultures derived from N-myc(Fl/Fl) and c-myc(Fl/Fl) mice, disruption of N-myc, but not...

journal_title：Cancer research

authors： Hatton BA,Knoepfler PS,Kenney AM,Rowitch DH,de Alborán IM,Olson JM,Eisenman RN

更新日期：2006-09-01 00:00:00

abstract：:Complete and accurate DNA replication is fundamental to cellular proliferation and genome stability. Obstacles that delay, prevent, or terminate DNA replication cause the phenomena termed DNA replication stress. Cancer cells exhibit chronic replication stress due to the loss of proteins that protect or repair stressed...

journal_title：Cancer research

authors： Ubhi T,Brown GW

更新日期：2019-04-15 00:00:00

abstract：:Brca2 is an important tumor suppressor associated with susceptibility to breast cancer. Although increasing evidence indicates that the primary function of Brca2 is to facilitate the repair of DNA damage via the homologous recombination pathway, how Brca2 prevents breast cancer is largely unknown. To study the role of...

journal_title：Cancer research

authors： Cheung AM,Elia A,Tsao MS,Done S,Wagner KU,Hennighausen L,Hakem R,Mak TW

更新日期：2004-03-15 00:00:00

abstract：:In prostate cancer, traditional treatments such as androgen response manipulation often provide only temporary resolution of disease, with emergence of a more aggressive, androgen-independent tumor following initial therapy. To treat recurrent disease, cell surface proteins that are specifically overexpressed on malig...

journal_title：Cancer research

authors： Swift SL,Burns JE,Maitland NJ

更新日期：2010-01-01 00:00:00

abstract：:Mice were treated with several different potentially carcinogenic components of tobacco smoke. The chemicals used were: 4-aminobiphenyl and aniline-HCl, which are found in high concentrations in sidestream tobacco smoke; hydrazine sulfate, which is found in high concentrations in mainstream tobacco smoke; and 2-methyl...

journal_title：Cancer research

authors： Sonnenfeld G,Hudgens RW

更新日期：1983-10-01 00:00:00

abstract：:B7-H4 (VTCN1, B7x, B7s) is a ligand for inhibitory coreceptors on T cells implicated in antigenic tolerization. B7-H4 is expressed by tumor cells and tumor-associated macrophages (TAM), but its potential contributions to tumoral immune escape and therapeutic targeting have been less studied. To interrogate B7-H4 expre...

journal_title：Cancer research

authors： Dangaj D,Lanitis E,Zhao A,Joshi S,Cheng Y,Sandaltzopoulos R,Ra HJ,Danet-Desnoyers G,Powell DJ Jr,Scholler N

更新日期：2013-08-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men in America. Currently, steroid receptor coactivators have been proposed to mediate the development and progression of prostate cancer, at times in a steroid-independent manner. Steroid receptor coactivator-3 (SRC-3, p/CIP, AIB1, ACTR, RAC3, and TRAM-1) is a member of th...

journal_title：Cancer research

authors： Zhou HJ,Yan J,Luo W,Ayala G,Lin SH,Erdem H,Ittmann M,Tsai SY,Tsai MJ

更新日期：2005-09-01 00:00:00

abstract：:Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic intervention in advanced human prostate cancer. TBX2, a T-box family transcription factor that negatively regulates cell-cycle inhibitor p21, plays critical role...

journal_title：Cancer research

authors： Nandana S,Tripathi M,Duan P,Chu CY,Mishra R,Liu C,Jin R,Yamashita H,Zayzafoon M,Bhowmick NA,Zhau HE,Matusik RJ,Chung LW

更新日期：2017-03-15 00:00:00

abstract：:alpha-Interferon (IFN alpha) potentiates the cytotoxicity of 5-fluorouracil (FUra) in vitro, and the combination has clinical efficacy in advanced colorectal cancer. We have reported previously an IFN alpha-mediated elevation in cellular FdUMP levels accompanied by the stimulation of thymidine phosphorylase (TP) activ...

journal_title：Cancer research

authors： Schwartz EL,Baptiste N,O'Connor CJ,Wadler S,Otter BA

更新日期：1994-03-15 00:00:00

abstract：:We investigated the effects of somatostatin analogues and a synthetic bombesin/gastrin-releasing peptide (GRP) antagonist on the growth of the human malignant glioma cell lines U-87MG and U-373MG transplanted to nude mice or cultured in vitro. Nude mice bearing s.c. implanted U-87MG or U-373MG tumors were treated for ...

journal_title：Cancer research

authors： Pinski J,Schally AV,Halmos G,Szepeshazi K,Groot K

更新日期：1994-11-15 00:00:00

abstract：:The endoplasmic reticulum (ER) has been posited as a potential anticancer target. The synthetic antitumor alkyl-lysophospholipid analogue edelfosine accumulates in the ER of solid tumor cells. This ER accumulation of the drug leads to the inhibition of phosphatidylcholine and protein synthesis, G(2)-M arrest, depletio...

journal_title：Cancer research

authors： Nieto-Miguel T,Fonteriz RI,Vay L,Gajate C,López-Hernández S,Mollinedo F

更新日期：2007-11-01 00:00:00

abstract：:Multiple endocrine neoplasia 2B (MEN 2B) is an inherited syndrome of early onset endocrine tumors and developmental anomalies. The disease is caused primarily by a methionine to threonine substitution of residue 918 in the kinase domain of the RET receptor (2B-RET); however, the molecular mechanisms that lead to the d...

journal_title：Cancer research

authors： Gujral TS,Singh VK,Jia Z,Mulligan LM

更新日期：2006-11-15 00:00:00

abstract：:We have recently identified a new gene, interleukin-17 receptor-like (IL-17RL), which is expressed in normal prostate and prostate cancer. This investigation is focused on the role of IL-17RL in prostate cancer. We found that IL-17RL was expressed at significantly higher levels in several androgen-independent prostate...

journal_title：Cancer research

authors： You Z,Shi XB,DuRaine G,Haudenschild D,Tepper CG,Lo SH,Gandour-Edwards R,de Vere White RW,Reddi AH

更新日期：2006-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is a highly aggressive, heterogeneous disease with poor prognosis and no effective targeted therapies. EGFR is highly expressed in basal-like TNBC and is considered as a potential therapeutic target. However, EGFR targeting exerts only marginal clinical benefits, possibly due to ac...

journal_title：Cancer research

authors： Verma N,Müller AK,Kothari C,Panayotopoulou E,Kedan A,Selitrennik M,Mills GB,Nguyen LK,Shin S,Karn T,Holtrich U,Lev S

更新日期：2017-01-01 00:00:00

abstract：:The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the ...

journal_title：Cancer research

authors： Miller EC,Kadlubar FF,Miller JA,Pitot HC,Drinkwater NR

更新日期：1979-09-01 00:00:00

abstract：:Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregu...

journal_title：Cancer research

authors： Thomas-Tikhonenko A,Viard-Leveugle I,Dews M,Wehrli P,Sevignani C,Yu D,Ricci S,el-Deiry W,Aronow B,Kaya G,Saurat JH,French LE

更新日期：2004-05-01 00:00:00