Coupling of mutated Met variants to DNA repair via Abl and Rad51.

abstract：:Brain invasion by glioblastoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating the invasive properties of glioblastoma has been identified. Here we report evidence favoring such a role for the noncanonical WNT family member Wnt5a. We found the most invasive gliomas to be ...

journal_title：Cancer research

authors： Binda E,Visioli A,Giani F,Trivieri N,Palumbo O,Restelli S,Dezi F,Mazza T,Fusilli C,Legnani F,Carella M,Di Meco F,Duggal R,Vescovi AL

更新日期：2017-02-15 00:00:00

abstract：:ALDH1(+)CD44(+) cells are putative tumor-initiating cells (TIC) in head and neck squamous cell carcinomas (HNC). miR-145 regulates tumorigenicity in various cancers but the breadth of its mechanistic contributions and potential therapeutic applications are not completely known. Here, we report that ALDH1(+)CD44(+)-HNC...

journal_title：Cancer research

authors： Yu CC,Tsai LL,Wang ML,Yu CH,Lo WL,Chang YC,Chiou GY,Chou MY,Chiou SH

更新日期：2013-06-01 00:00:00

abstract：:Four hr after either a single injection or continuous infusion of methotrexate (MTX) plus purified [3',5',9(n)-3H]MTX in cynomolgus or rhesus monkeys, 80 to 98% of the 3H radioactivity present in the plasma was found not to represent intact MTX. The percentage of 3H-containing MTX products in the urine after 4 hr was ...

journal_title：Cancer research

authors： Kimelberg HK,Biddlecome SM,Bourke RS

更新日期：1977-01-01 00:00:00

abstract：:Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

journal_title：Cancer research

authors： White DL,Brown AL,D'Andrea RJ,Rice AM

更新日期：2012-09-01 00:00:00

abstract：:The efficacy of novel cancer therapeutics has been hampered by the ability to deliver these agents to the tumor at effective concentrations. Liposomes have been used as a method to overcome some delivery issues and, in combination with hyperthermia, have been shown to increase drug delivery to tumors. Particle size ha...

journal_title：Cancer research

authors： Kong G,Braun RD,Dewhirst MW

更新日期：2000-08-15 00:00:00

abstract：:Ovarian cancer is currently the most lethal gynecological malignancy in the United States. Although effective therapies exist, the acquisition of multidrug resistance within persisting tumor cells renders curative therapies elusive for the majority of women with ovarian cancer. In an attempt to better define the evolu...

journal_title：Cancer research

authors： Lamendola DE,Duan Z,Yusuf RZ,Seiden MV

更新日期：2003-05-01 00:00:00

abstract：:Approximately 10% of gastric adenocarcinomas worldwide are associated with human EBV. These carcinomas generally do not express the latent membrane protein 1 (LMP1), the major known EBV oncogene. Recently, another EBV gene [ie., BARF1 (BamHI A rightward open reading frame)] was shown to have transforming and immortali...

journal_title：Cancer research

authors： zur Hausen A,Brink AA,Craanen ME,Middeldorp JM,Meijer CJ,van den Brule AJ

更新日期：2000-05-15 00:00:00

abstract：:Regulation of c-myc expression is known to be sensitive to a variety of mitogenic stimuli in various cell types. Since estrogen is a well documented mitogen of estrogen-responsive human breast cancer (HBC) cells, we studied the influence of estradiol and its antagonist tamoxifen on the expression of c-myc in HBC cell ...

journal_title：Cancer research

authors： Dubik D,Dembinski TC,Shiu RP

更新日期：1987-12-15 00:00:00

abstract：:We have shown that a mutant derivative of Chinese hamster ovary CHO-K1 cells, ADR-5, which shows hypersensitivity to topoisomerase II (topo II)-inhibitory drugs, is cross-sensitive to the site-selective cyclic AMP analogue 8-chloro-cyclic AMP. We tested the hypothesis that overexpression of the type I alpha regulatory...

journal_title：Cancer research

authors： North PS,Davies SL,Ciardiello F,Damiano V,Bianco C,Pepe S,Bianco AR,Harris AL,Hickson ID,Tortora G

更新日期：1994-08-01 00:00:00

abstract：:Electron micrographs of CCL237 and FET cells (two slowly growing, differentiated human colon carcinoma lines) revealed enlarged mitochondria with few cristae. Polarographic measurement of respiratory activity in mitochondria isolated from these cell lines was compared to that of CV-1 cells (a normal monkey kidney epit...

journal_title：Cancer research

authors： Modica-Napolitano JS,Steele GD Jr,Chen LB

更新日期：1989-06-15 00:00:00

abstract：:Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-...

journal_title：Cancer research

authors： Huang Z,Fasco MJ,Spivack S,Kaminsky LS

更新日期：1997-07-01 00:00:00

abstract：:Tumor-derived cell lines are used as in vitro cancer models, but their ability to accurately reflect the phenotype and genotype of the parental histology remains questionable, given the prevalence of documented cell line-specific cytogenetic changes. We have addressed the issue of whether copy number alterations seen ...

journal_title：Cancer research

authors： Greshock J,Nathanson K,Martin AM,Zhang L,Coukos G,Weber BL,Zaks TZ

更新日期：2007-04-15 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00

abstract：:8-Chloroadenosine 3',5'-monophosphate has been reported to inhibit growth of various mammalian cell lines at micromolar concentrations. We have used Chinese hamster ovary cell lines with mutated cyclic AMP-dependent protein kinase or altered cyclic nucleotide metabolism to show that a metabolite, 8-chloroadenosine, is...

journal_title：Cancer research

authors： Van Lookeren Campagne MM,Villalba Díaz F,Jastorff B,Kessin RH

更新日期：1991-03-15 00:00:00

abstract：:Rhabdomyosarcomas are the most frequent malignant soft tissue tumors of childhood; however, because current multimodality treatments fail to improve the poor survival rate of children with metastatic rhabdomyosarcoma, new treatments are required. We previously identified the gamma-subunit of the fetal acetylcholine re...

journal_title：Cancer research

authors： Gattenlöhner S,Marx A,Markfort B,Pscherer S,Landmeier S,Juergens H,Müller-Hermelink HK,Matthews I,Beeson D,Vincent A,Rossig C

更新日期：2006-01-01 00:00:00

abstract：:The lysyl oxidase gene family members function as extracellular matrix modulating enzymes. We have found that another member of this family, lysyl oxidase related protein-1 (LOR-1), is highly expressed in metastatic breast cancer-derived cell lines but not in the nonmetastatic estrogen-dependent MCF-7 cells. Furthermo...

journal_title：Cancer research

authors： Akiri G,Sabo E,Dafni H,Vadasz Z,Kartvelishvily Y,Gan N,Kessler O,Cohen T,Resnick M,Neeman M,Neufeld G

更新日期：2003-04-01 00:00:00

abstract：:Endogenous formation of N-nitrosoproline (NPRO) was demonstrated by monitoring its excretion in the urine of a male volunteer who had ingested vegetable juice, as a source of nitrate, and proline. The resulting NPRO was analyzed after derivatization by combined gas-liquid chromatography thermal energy analysis. The am...

journal_title：Cancer research

authors： Ohshima H,Bartsch H

更新日期：1981-09-01 00:00:00

abstract：:The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions. Here, we describe for the first time the expression and function of Foxp3 in pancreatic ductal adenocarcinoma cells and tumors. Foxp3 e...

journal_title：Cancer research

authors： Hinz S,Pagerols-Raluy L,Oberg HH,Ammerpohl O,Grüssel S,Sipos B,Grützmann R,Pilarsky C,Ungefroren H,Saeger HD,Klöppel G,Kabelitz D,Kalthoff H

更新日期：2007-09-01 00:00:00

abstract：:The Notch family of proteins plays an integral role in determining cell fates, such as proliferation, differentiation, and apoptosis. We show that Notch-1 and its ligands, Delta-like-1 and Jagged-1, are overexpressed in many glioma cell lines and primary human gliomas. Immunohistochemistry of a primary human glioma ti...

journal_title：Cancer research

authors： Purow BW,Haque RM,Noel MW,Su Q,Burdick MJ,Lee J,Sundaresan T,Pastorino S,Park JK,Mikolaenko I,Maric D,Eberhart CG,Fine HA

更新日期：2005-03-15 00:00:00

abstract：:We tried to purify carcinoembryonic antigen (CEA)-related antigens in normal human feces and found that, besides nonspecific cross-reacting antigen (fecal NCA), there are three other molecular species of CEA-related antigens which have been inclusively called normal fecal antigen (NFA). These were designated normal fe...

journal_title：Cancer research

authors： Kuroki M,Koga Y,Matsuoka Y

更新日期：1981-02-01 00:00:00

abstract：:The phosphatidylinositol 3'-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated wi...

journal_title：Cancer research

authors： Geng L,Tan J,Himmelfarb E,Schueneman A,Niermann K,Brousal J,Fu A,Cuneo K,Kesicki EA,Treiberg J,Hayflick JS,Hallahan DE

更新日期：2004-07-15 00:00:00

abstract：:The murine monoclonal antibodies TURP-27 and HNK-1 have been shown to detect antigens which are heavily expressed by benign prostatic hyperplasia and carcinoma of the prostate. Western blot analysis of prostate extracts showed that monoclonal antibodies TURP-27 and HNK-1 bound glycoproteins with molecular weights of 1...

journal_title：Cancer research

authors： Lipford GB,Wright GL Jr

更新日期：1991-05-01 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:Methyl-CpG binding domain (MBD) proteins have been shown to couple DNA methylation to transcriptional repression. This biological property suggests a role for MBD proteins in the silencing of tumor suppressor genes that are hypermethylated at their promoter CpG islands in cancer cells. Despite the demonstration of the...

journal_title：Cancer research

authors： Lopez-Serra L,Ballestar E,Fraga MF,Alaminos M,Setien F,Esteller M

更新日期：2006-09-01 00:00:00

abstract：:Sleep fragmentation (SF) is a highly prevalent condition and a hallmark of sleep apnea, a condition that has been associated with increased cancer incidence and mortality. In this study, we examined the hypothesis that sleep fragmentation promotes tumor growth and progression through proinflammatory TLR4 signaling. In...

journal_title：Cancer research

authors： Hakim F,Wang Y,Zhang SX,Zheng J,Yolcu ES,Carreras A,Khalyfa A,Shirwan H,Almendros I,Gozal D

更新日期：2014-03-01 00:00:00

abstract：:Vaccine strategies for treatment of human papillomavirus-induced cervical cancer are based on either the recombinant E7 fusion oncoprotein or E7 CTL peptides. The therapeutic potential of the E7-based vaccine depends on the use of different adjuvants. In this study, we describe for the first time the expression of the...

journal_title：Cancer research

authors： Franconi R,Di Bonito P,Dibello F,Accardi L,Muller A,Cirilli A,Simeone P,Donà MG,Venuti A,Giorgi C

更新日期：2002-07-01 00:00:00

abstract：:Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and relevant therapeutic target molecule is essential for the further development of therapeutic strategy. Herein, we identified that 3-phosphoinositide-dependent ...

journal_title：Cancer research

authors： Chinen Y,Kuroda J,Shimura Y,Nagoshi H,Kiyota M,Yamamoto-Sugitani M,Mizutani S,Sakamoto N,Ri M,Kawata E,Kobayashi T,Matsumoto Y,Horiike S,Iida S,Taniwaki M

更新日期：2014-12-15 00:00:00

abstract：:Aclacinomycin A (aclarubicin) is an anthracycline anticancer agent with demonstrated activity against both leukemias and solid tumors. Previous results suggested that a major activity of aclacinomycin A is the inhibition of topoisomerase II catalytic activity. We have applied a yeast system to test whether aclacinomyc...

journal_title：Cancer research

authors： Nitiss JL,Pourquier P,Pommier Y

更新日期：1997-10-15 00:00:00

abstract：:Breast cancer has been redefined into three clinically relevant subclasses: (i) estrogen/progesterone receptor positive (ER+/PR+), (ii) HER2/ERRB2 positive, and (iii) those lacking expression of all three markers (triple negative or basal-like). While targeted therapies for ER+/PR+ and HER2+ tumors have revolutionized...

journal_title：Cancer research

authors： McCleland ML,Adler AS,Shang Y,Hunsaker T,Truong T,Peterson D,Torres E,Li L,Haley B,Stephan JP,Belvin M,Hatzivassiliou G,Blackwood EM,Corson L,Evangelista M,Zha J,Firestein R

更新日期：2012-11-15 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA) is expressed in normal human prostate epithelium and is highly up-regulated in prostate cancer. We previously reported a series of novel small molecule inhibitors targeting PSMA. Two compounds, MIP-1072, (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic a...

journal_title：Cancer research

authors： Hillier SM,Maresca KP,Femia FJ,Marquis JC,Foss CA,Nguyen N,Zimmerman CN,Barrett JA,Eckelman WC,Pomper MG,Joyal JL,Babich JW

更新日期：2009-09-01 00:00:00