Ku autoantigen affects the susceptibility to anticancer drugs.

abstract：:Molecular docking is a standard computational approach to predict binding modes of protein-ligand complexes by exploring alternative orientations and conformations of the ligand (i.e., by exploring ligand flexibility). Docking tools are largely used for virtual screening of small drug-like molecules, but their accurac...

journal_title：Cancer research

authors： Antunes DA,Moll M,Devaurs D,Jackson KR,Lizée G,Kavraki LE

更新日期：2017-11-01 00:00:00

abstract：:Murine melanoma B16-F1 cells of low metastatic potential were transfected with the human gene for the prepro form of urokinase in an SV40 expression vector (plasmid pSV2-uPA), and cells expressing high amounts of the human urokinase gene product were selected for by an enzyme-linked immunosorbent assay specific for hu...

journal_title：Cancer research

authors： Yu HR,Schultz RM

更新日期：1990-12-01 00:00:00

abstract：:Some of the possible mechanisms by which polyethylene glycol (PEG) augments the ability of MOPC-315 tumor bearer spleen cells to mediate in vitro antitumor cytotoxicity were evaluated. The level of antitumor cytotoxicity obtained in 5-day cultures of tumor bearer spleen cell suspensions correlated inversely with the p...

journal_title：Cancer research

authors： Mokyr MB,Przepiorka D,Dray S

更新日期：1982-07-01 00:00:00

abstract：:OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and ...

journal_title：Cancer research

authors： Curti BD,Kovacsovics-Bankowski M,Morris N,Walker E,Chisholm L,Floyd K,Walker J,Gonzalez I,Meeuwsen T,Fox BA,Moudgil T,Miller W,Haley D,Coffey T,Fisher B,Delanty-Miller L,Rymarchyk N,Kelly T,Crocenzi T,Bernstein E,

更新日期：2013-12-15 00:00:00

abstract：:A deletion in an Alu repetitive sequence in the fifth intron of the c-sis gene of meningioma patients was previously described (M. Smidt et al., J. Clin. Invest., 86:1151-1157, 1990). The authors analyzed the structure of this intron in DNA from peripheral blood leukocytes and tumor samples of 86 patients with sporadi...

journal_title：Cancer research

authors： Smidt M,Dumanski JP,Collins VP,Ratner L

更新日期：1991-08-15 00:00:00

abstract：:Monoclonal antibodies (mabs) have considerable potential for specific cancer treatment. However, due to the antigen heterogeneity and especially the low uptake in solid tumors, mabs have not been used successfully in most clinical trials to date. This study investigates the effects of a mab-cobra venom factor (CVF) co...

journal_title：Cancer research

authors： Juhl H,Sievers M,Baltzer K,Helmig F,Wolf H,Brenner W,Kalthoff H

更新日期：1995-12-01 00:00:00

abstract：:Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in ...

journal_title：Cancer research

authors： Leek RD,Talks KL,Pezzella F,Turley H,Campo L,Brown NS,Bicknell R,Taylor M,Gatter KC,Harris AL

更新日期：2002-03-01 00:00:00

abstract：:APCL, a central nervous system-specific sequence homologue of the adenomatous polyposis coli tumor suppressor, can regulate the cytoplasmic level of beta-catenin as the adenomatous polyposis coli tumor suppressor does, but its overall biological function remains unclear. Using a yeast two-hybrid system, we attempted t...

journal_title：Cancer research

authors： Nakagawa H,Koyama K,Murata Y,Morito M,Akiyama T,Nakamura Y

更新日期：2000-01-01 00:00:00

abstract：:Although the cyclooxygenase pathway of the arachidonic acid cascade has been suggested to play an important role in colon carcinogenesis, the molecular species of prostanoids and receptors involved have not been fully elucidated yet. We examined the development of aberrant crypt foci (ACFs), putative preneoplastic les...

journal_title：Cancer research

authors： Watanabe K,Kawamori T,Nakatsugi S,Ohta T,Ohuchida S,Yamamoto H,Maruyama T,Kondo K,Ushikubi F,Narumiya S,Sugimura T,Wakabayashi K

更新日期：1999-10-15 00:00:00

abstract：:Up-regulation of vascular endothelial growth factor (VEGF) expression is a major event leading to neovascularization in malignant gliomas. Hypoxia is believed to be the crucial environmental stimulus for this up-regulation. To critically assess this hypothesis, we asked whether the mechanisms defined previously for hy...

journal_title：Cancer research

authors： Damert A,Machein M,Breier G,Fujita MQ,Hanahan D,Risau W,Plate KH

更新日期：1997-09-01 00:00:00

abstract：:The study by Jaratlerdsiri and colleagues represents the first whole-genome sequencing study of prostate cancer from men in sub-Saharan Africa. Preliminary findings include a higher tumor mutation burden in these tumors compared with data from other available prostate cancer cohorts. Although larger studies are needed...

journal_title：Cancer research

authors： Huang FW

更新日期：2018-12-15 00:00:00

abstract：:Cancer is a leading cause of mortality throughout the world and new treatments are urgently needed. Recent studies suggest that bone marrow-derived mesenchymal stem cells (MSC) home to and incorporate within tumor tissue. We hypothesized that MSCs engineered to produce and deliver tumor necrosis factor-related apoptos...

journal_title：Cancer research

authors： Loebinger MR,Eddaoudi A,Davies D,Janes SM

更新日期：2009-05-15 00:00:00

abstract：:Mucinous colorectal cancers exhibit a characteristic set of molecular genetic alterations and may be derived from progenitor cells committed to the goblet cell lineage. Previously, we demonstrated that the MUC2 mucin gene promoter drives transgene reporter expression with high specificity in small intestinal goblet ce...

journal_title：Cancer research

authors： Gum JR Jr,Hicks JW,Gillespie AM,Rius JL,Treseler PA,Kogan SC,Carlson EJ,Epstein CJ,Kim YS

更新日期：2001-04-15 00:00:00

abstract：:Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study...

journal_title：Cancer research

authors： Chen JL,Walton KL,Qian H,Colgan TD,Hagg A,Watt MJ,Harrison CA,Gregorevic P

更新日期：2016-09-15 00:00:00

abstract：:The cytotoxic activity against human tumor cells of toxic conjugates of Pseudomonas exotoxin with anti-transferrin receptor antibody or epidermal growth factor was potentiated up to 10 to 20-fold by the calcium antagonists verapamil, D-600, and diltiazem and by the lysosomotropic agent beta-glycylphenyl-naphthylamide....

journal_title：Cancer research

authors： Akiyama S,Seth P,Pirker R,FitzGerald D,Gottesman MM,Pastan I

更新日期：1985-03-01 00:00:00

abstract：:Two subclones of L1210 murine leukemia (L1210-46.1 and L1210-56.3) were isolated in the absence of selective agents. Subclone 56.3 appeared to be more sensitive than was subclone 46.1 to treatment with dexamethasone, 1-beta-D-arabinofuranosyl cytosine, vincristine, and X-irradiation. No differences between the parent ...

journal_title：Cancer research

authors： Brouwer M,Smets LA,Jongsma AP

更新日期：1983-06-01 00:00:00

abstract：:The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confi...

journal_title：Cancer research

authors： Draffin JE,McFarlane S,Hill A,Johnston PG,Waugh DJ

更新日期：2004-08-15 00:00:00

abstract：:Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving ...

journal_title：Cancer research

authors： Lin HP,Cheng ZL,He RY,Song L,Tian MX,Zhou LS,Groh BS,Liu WR,Ji MB,Ding C,Shi YH,Guan KL,Ye D,Xiong Y

更新日期：2016-12-01 00:00:00

abstract：:A model for cell detachment which may influence metastasis in vivo is described involving the transfer of hamster melanoma cells from aggregates of those tumor cells to hamster fibroblast aggregates. The aggregates were made by the spontaneous association of cultured cells. Tumor and fibroblast aggregates were then in...

journal_title：Cancer research

authors： Umbreit JN,Erbe RW

更新日期：1979-06-01 00:00:00

abstract：:Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor cosmetic effect, and current chemotherapy is limited by low cure rate...

journal_title：Cancer research

authors： Ogbourne SM,Suhrbier A,Jones B,Cozzi SJ,Boyle GM,Morris M,McAlpine D,Johns J,Scott TM,Sutherland KP,Gardner JM,Le TT,Lenarczyk A,Aylward JH,Parsons PG

更新日期：2004-04-15 00:00:00

abstract：:The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C gamma 2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C gamma 2 was proved to be derived from chromosome 11 by somatic ...

journal_title：Cancer research

authors： Akao Y,Seto M,Takahashi T,Kubonishi I,Miyoshi I,Nakazawa S,Tsujimoto Y,Croce CM,Ueda R

更新日期：1991-03-01 00:00:00

abstract：:MLH1 is an integral part of the mismatch repair complex, and the loss of this protein is associated with the acquisition of a mutator phenotype, microsatellite instability, and a predisposition to cancer. Deficiencies in the mismatch repair complex, including the loss of MLH1, result in elevated resistance to specific...

journal_title：Cancer research

authors： Hardman RA,Afshari CA,Barrett JC

更新日期：2001-02-15 00:00:00

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:SOX9 is a member of the SOX [Sry-related high-mobility group (HMG) box] family of HMG DNA-binding domain transcription factors and is required for the development and differentiation of multiple cell lineages. This report shows that basal epithelial cells express SOX9 in normal prostate, with no detectable expression ...

journal_title：Cancer research

authors： Wang H,McKnight NC,Zhang T,Lu ML,Balk SP,Yuan X

更新日期：2007-01-15 00:00:00

abstract：:The antitumor effect of combined use of cis-diamminedichloroplatinum(II) (CDDP) and verapamil, a calcium influx blocker, was examined in neuroblastoma transplanted to BALB/c athymic mice. The response of the tumor to CDDP was related to the dose administered. Regression of the tumor was observed when CDDP was administ...

journal_title：Cancer research

authors： Ikeda H,Nakano G,Nagashima K,Sakamoto K,Harasawa N,Kitamura T,Nakamura T,Nagamachi Y

更新日期：1987-01-01 00:00:00

abstract：:Cyclin A is an S- and G2-M-phase regulatory protein, and its abnormal expression has been implicated in cellular transformation. This work was undertaken to investigate the frequency of cyclin A overexpression and the correlated clinical outcome in human hepatocellular carcinoma (HCC). Herein, 12 of 31 (39%) patients ...

journal_title：Cancer research

authors： Chao Y,Shih YL,Chiu JH,Chau GY,Lui WY,Yang WK,Lee SD,Huang TS

更新日期：1998-03-01 00:00:00

abstract：:We analyzed the epidermal growth factor receptor gene using a complementary DNA probe of the epidermal growth factor receptor gene in 21 uncultured primary breast carcinomas and found that the gene was amplified in three of these tumors. We further demonstrated by immunohistochemistry using a monoclonal antibody to th...

journal_title：Cancer research

authors： Ro J,North SM,Gallick GE,Hortobagyi GN,Gutterman JU,Blick M

更新日期：1988-01-01 00:00:00

abstract：:I have attempted to illustrate the many different properties of retroviruses and their presence in a wide variety of animal species including humans. Since the turn of this century, progress in the field of retrovirology has been noteworthy and many new and important scientific observations have been made (Table 7). A...

journal_title：Cancer research

authors： Levy JA

更新日期：1986-11-01 00:00:00

abstract：:Prostate cancer biology varies from locally confined tumors with low risk for relapse to tumors with high risk for progression even after radical prostatectomy. Currently, there are no reliable biomarkers to predict tumor relapse and poor clinical outcome. In this study, we correlated expression patterns of the androg...

journal_title：Cancer research

authors： Kahl P,Gullotti L,Heukamp LC,Wolf S,Friedrichs N,Vorreuther R,Solleder G,Bastian PJ,Ellinger J,Metzger E,Schüle R,Buettner R

更新日期：2006-12-01 00:00:00

abstract：:The ErbB2 receptor tyrosine kinase is overexpressed in approximately 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer. We observe that LRIG1 protein levels are signific...

journal_title：Cancer research

authors： Miller JK,Shattuck DL,Ingalla EQ,Yen L,Borowsky AD,Young LJ,Cardiff RD,Carraway KL 3rd,Sweeney C

更新日期：2008-10-15 00:00:00