Abstract：
:The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C gamma 2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C gamma 2 was proved to be derived from chromosome 11 by somatic cell hybrid study. The normal counterpart of chromosome 11 was also isolated. With a DNA probe near the breakpoint of chromosome 11, Southern blot analysis of RC-K8 and 10 other cases with translocation involving the 11q23 region was conducted, but no rearrangement bands have been observed thus far except for RC-K8.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Akao Y,Seto M,Takahashi T,Kubonishi I,Miyoshi I,Nakazawa S,Tsujimoto Y,Croce CM,Ueda Rsubject
Has Abstractpub_date
1991-03-01 00:00:00pages
1574-6issue
5eissn
0008-5472issn
1538-7445journal_volume
51pub_type
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