Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:An increased level of chondroitin sulfate (CS) expression on the cell surface is often associated with malignant transformation and the progression of tumor cells. In this study, CSs expressed on highly metastatic tumor cells were used as a target for the selective delivery of anticancer drugs by polyethylene glycol (...

journal_title：Cancer research

authors： Lee CM,Tanaka T,Murai T,Kondo M,Kimura J,Su W,Kitagawa T,Ito T,Matsuda H,Miyasaka M

更新日期：2002-08-01 00:00:00

abstract：:PRL-3, an oncogenic dual-specificity phosphatase, is overexpressed in 50% of acute myelogenous leukemia (AML) and associated with poor survival. We found that stable expression of PRL-3 confers cytokine independence and growth advantage of AML cells. However, how PRL-3 mediates these functions in AML is not known. To ...

journal_title：Cancer research

authors： Chong PS,Zhou J,Cheong LL,Liu SC,Qian J,Guo T,Sze SK,Zeng Q,Chng WJ

更新日期：2014-06-01 00:00:00

abstract：:Using the principle of functional polarization of dendritic cells (DCs), we have developed a novel protocol to generate human DCs combining the three features critical for the induction of type-1 immunity: (a) fully mature status; (b) responsiveness to secondary lymphoid organ chemokines; and (c) high interleukin-12p7...

journal_title：Cancer research

authors： Mailliard RB,Wankowicz-Kalinska A,Cai Q,Wesa A,Hilkens CM,Kapsenberg ML,Kirkwood JM,Storkus WJ,Kalinski P

更新日期：2004-09-01 00:00:00

abstract：:Cigarette smoke contains low levels of agonists for the aryl hydrocarbon receptor (AhR; also called the dioxin receptor). However, little is understood about the whole potential of cigarette smoke for activating AhR. In this report, we evaluated the total "dioxin-like" activity of cigarette smoke using in vitro and in...

journal_title：Cancer research

authors： Kasai A,Hiramatsu N,Hayakawa K,Yao J,Maeda S,Kitamura M

更新日期：2006-07-15 00:00:00

abstract：:The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. The degree of inhibition depended on both the dose and t...

journal_title：Cancer research

authors： Weekes RG,Verma AK,Boutwell RK

更新日期：1980-11-01 00:00:00

abstract：:Calcium is universally required for cell growth and proliferation. Calmodulin is the main intracellular receptor for calcium. Although calcium and calmodulin are well known to be required for cell cycle regulation, the target pathways for their action remain poorly defined. Potential targets include the calcium/calmod...

journal_title：Cancer research

authors： Rodriguez-Mora OG,LaHair MM,McCubrey JA,Franklin RA

更新日期：2005-06-15 00:00:00

abstract：:Heparanase is overexpressed in many solid tumor cells and is capable of specifically cleaving heparan sulfate, and this activity is associated with the metastatic potential of tumor cells; however, the activation mechanism of heparanase has remained unknown. In this study, we investigated the link between disulfide bo...

journal_title：Cancer research

authors： Simizu S,Suzuki T,Muroi M,Lai NS,Takagi S,Dohmae N,Osada H

更新日期：2007-08-15 00:00:00

abstract：:Specific binding sites for prolactin (PRL) were present in membrane preparations from 7,12-dimethylbenz(a)-anthracene-induced rat mammary tumors. The specific binding of PRL was time and temperature dependent. A significant negative correlation was noted between administered doses of estrogen and the subsequent bindin...

journal_title：Cancer research

authors： Kledzik GS,Bradley CJ,Marshall S,Campbell GA,Meites J

更新日期：1976-09-01 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Most squamous cell carcinomas of the head and neck (HNSCC) overexpress ERBB1/EGFR, but EGF receptor (EGFR)-targeted therapies have yielded disappointing clinical results in treatment of this cancer. Here, we describe a novel interaction between EGFR and the ligand EphrinB1 (EFNB1), and we show that EFNB1 phosphorylati...

journal_title：Cancer research

authors： Vermeer PD,Colbert PL,Wieking BG,Vermeer DW,Lee JH

更新日期：2013-09-15 00:00:00

abstract：:Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The expression of claudin-1, activity ...

journal_title：Cancer research

authors： Oku N,Sasabe E,Ueta E,Yamamoto T,Osaki T

更新日期：2006-05-15 00:00:00

abstract：:Acute myeloid leukemia (AML) is a malignancy of stem cells with an unlimited capacity for self-renewal. MUC1 is a secreted, oncogenic mucin that is expressed aberrantly in AML blasts, but its potential uses to target AML stem cells have not been explored. Here, we report that MUC1 is highly expressed on AML CD34(+)/li...

journal_title：Cancer research

authors： Stroopinsky D,Rosenblatt J,Ito K,Mills H,Yin L,Rajabi H,Vasir B,Kufe T,Luptakova K,Arnason J,Nardella C,Levine JD,Joyce RM,Galinsky I,Reiter Y,Stone RM,Pandolfi PP,Kufe D,Avigan D

更新日期：2013-09-01 00:00:00

abstract：:It is becoming increasingly clear that tumor growth and progression is not entirely due to genetic aberrations but also reflective of tumor cell plasticity. It follows therefore that proteins contributing to tumor progression oscillate in their expression a contention yet to be shown. Because the urokinase-type plasmi...

journal_title：Cancer research

authors： Yang L,Avila H,Wang H,Trevino J,Gallick GE,Kitadai Y,Sasaki T,Boyd DD

更新日期：2006-08-15 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Initially isolated as the dominant suppressor of the mutant epidermal growth factor receptor (ellipse), the Dachshund gene plays a key role in metazoan development regulating the Retinal Determination Gene Network. Herein, the DACH1 gene was expressed in normal prostate epithelial cells with reduced expression in huma...

journal_title：Cancer research

authors： Wu K,Katiyar S,Witkiewicz A,Li A,McCue P,Song LN,Tian L,Jin M,Pestell RG

更新日期：2009-04-15 00:00:00

abstract：:The pH of solid tumors is acidic due to increased fermentative metabolism and poor perfusion. It has been hypothesized that acid pH promotes local invasive growth and metastasis. The hypothesis that acid mediates invasion proposes that H(+) diffuses from the proximal tumor microenvironment into adjacent normal tissues...

journal_title：Cancer research

authors： Estrella V,Chen T,Lloyd M,Wojtkowiak J,Cornnell HH,Ibrahim-Hashim A,Bailey K,Balagurunathan Y,Rothberg JM,Sloane BF,Johnson J,Gatenby RA,Gillies RJ

更新日期：2013-03-01 00:00:00

abstract：:Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein that is believed to play a major role in cervical neoplasia. Anti-HPV16 E7 intracellular single-chain antibodies (scFvs) were constructed to down-regulate HPV16 E7 oncoprotein in HPV DNA-containing cell lines. In these studies, we transfected anti-E7 scFvs...

journal_title：Cancer research

authors： Wang-Johanning F,Gillespie GY,Grim J,Rancourt C,Alvarez RD,Siegal GP,Curiel DT

更新日期：1998-05-01 00:00:00

abstract：:The ability of tumor cells to express elevated levels of proteinases capable of degrading tissue matrix and basement membrane components in vitro has been correlated to their invasive and metastatic potential. Many in vitro invasion assays have been performed either in the presence of serum or with tumor cells that ha...

journal_title：Cancer research

authors： Neri A,Bohoslawec O,Anderson TD,Tokes ZA

更新日期：1991-02-15 00:00:00

abstract：:We report on the identification of autoantigens commonly recognized by sera from patients with breast cancer. We selected ten sera from patients with invasive ductal carcinoma (IDC) of the breast with high titer IgG autoantibodies for biopanning of a T7 phage breast cancer cDNA display library. A high throughput metho...

journal_title：Cancer research

authors： Fernández-Madrid F,Tang N,Alansari H,Granda JL,Tait L,Amirikia KC,Moroianu M,Wang X,Karvonen RL

更新日期：2004-08-01 00:00:00

abstract：:The effect of intragastric gavage administration of docosahexaenoic acid (DHA) on the formation of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci in rat colon was investigated. Male F344 rats were treated three times s.c. with 20 mg/kg of DMH and were given either 0.7 ml of DHA or water intragastrically 5 tim...

journal_title：Cancer research

authors： Takahashi M,Minamoto T,Yamashita N,Yazawa K,Sugimura T,Esumi H

更新日期：1993-06-15 00:00:00

abstract：:Transduction of malignant cells with toxin genes provides a novel means to promote tumor cell destruction. The efficacy of a toxin gene is dependent on the cell type targeted, the quantity of exogenous protein synthesized, and the mechanisms of growth inhibition and bystander killing. To develop gene therapy for targe...

journal_title：Cancer research

authors： Hoganson DK,Batra RK,Olsen JC,Boucher RC

更新日期：1996-03-15 00:00:00

abstract：:Obesity is associated with increased cancer incidence and mortality. We have previously found that obesity in children is associated with a 50% increased recurrence of acute lymphoblastic leukemia (ALL) in high-risk patients. We have therefore developed novel in vivo and in vitro preclinical models to study the mechan...

journal_title：Cancer research

authors： Behan JW,Yun JP,Proektor MP,Ehsanipour EA,Arutyunyan A,Moses AS,Avramis VI,Louie SG,Butturini A,Heisterkamp N,Mittelman SD

更新日期：2009-10-01 00:00:00

abstract：:Some of the possible mechanisms by which polyethylene glycol (PEG) augments the ability of MOPC-315 tumor bearer spleen cells to mediate in vitro antitumor cytotoxicity were evaluated. The level of antitumor cytotoxicity obtained in 5-day cultures of tumor bearer spleen cell suspensions correlated inversely with the p...

journal_title：Cancer research

authors： Mokyr MB,Przepiorka D,Dray S

更新日期：1982-07-01 00:00:00

abstract：:The kinetic properties of a soluble, magnesium-dependent 5'-nucleotidase from human malignant lymphocytes have been determined. The partially purified enzyme is distinct from plasma membrane-associated 5'-nucleotidase and is free of nonspecific phosphatase activity. Among purine ribonucleotides, it reacted efficiently...

journal_title：Cancer research

authors： Carson DA,Wasson DB

更新日期：1982-11-01 00:00:00

abstract：:Human embryonic lung fibroblasts (F-136-35-56) capable of growing in medium containing DL-homocysteine instead of L-methionine and human acute lymphoblastic leukemia cells (CCRF-HSB-2) with absolute methionine requirement exhibited dose-dependent growth inhibition when semipurified L-methionine-degrading enzyme (L-met...

journal_title：Cancer research

authors： Kreis W,Baker A,Ryan V,Bertasso A

更新日期：1980-03-01 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:Pheochromocytomas are tumors of the adrenal medulla originating in the chromaffin cells derived from the neural crest. Ten % of these tumors are associated with the familial cancer syndromes multiple endocrine neoplasia type 2, von Hippel-Lindau disease (VHL), and rarely, neurofibromatosis type 1, in which germ-line m...

journal_title：Cancer research

authors： Benn DE,Dwight T,Richardson AL,Delbridge L,Bambach CP,Stowasser M,Gordon RD,Marsh DJ,Robinson BG

更新日期：2000-12-15 00:00:00

abstract：:In vitro maturation was induced with 12-O-tetradecanoylphorbol-13-acetate in leukemic cell samples from patients with chronic lymphocytic leukemia (n = 10) and prolymphocytic leukemia (n = 4). The cells were studied for morphology, for immunological markers using the fluorescence activated cell sorter, and for acid ph...

journal_title：Cancer research

authors： Ziegler-Heitbrock HW,Munker R,Dörken B,Gaedicke G,Thiel E

更新日期：1986-04-01 00:00:00

abstract：:Primary central nervous system lymphoma (PCNSL) that arises in immune-deficient patients is an aggressive B-cell neoplasm that is universally associated with the EBV. Patients with EBV(+) PCNSL face a particularly poor prognosis with median survival times of 2-12 months despite aggressive management with radiation the...

journal_title：Cancer research

authors： Roychowdhury S,Peng R,Baiocchi RA,Bhatt D,Vourganti S,Grecula J,Gupta N,Eisenbeis CF,Nuovo GJ,Yang W,Schmalbrock P,Ferketich A,Moeschberger M,Porcu P,Barth RF,Caligiuri MA

更新日期：2003-03-01 00:00:00