ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.

abstract：:Metastasis via the lymphatic vasculature is an important step in cancer progression. The formation of new lymphatic vessels (lymphangiogenesis), or remodeling of existing lymphatics, is thought to facilitate the entry and transport of tumor cells into lymphatic vessels and on to distant organs. The migration of lympha...

journal_title：Cancer research

authors： Karnezis T,Farnsworth RH,Harris NC,Williams SP,Caesar C,Byrne DJ,Herle P,Macheda ML,Shayan R,Zhang YF,Yazar S,Takouridis SJ,Gerard C,Fox SB,Achen MG,Stacker SA

更新日期：2019-04-01 00:00:00

abstract：:Sporadic colorectal cancer (CRC) is characterized by genetic and epigenetic changes such as regional DNA hypermethylation and global DNA hypomethylation. Epidemiological and animal studies suggest that aberrant DNA methylation is associated with low dietary folate intake, which is aggravated by high alcohol intake. Th...

journal_title：Cancer research

authors： van Engeland M,Weijenberg MP,Roemen GM,Brink M,de Bruïne AP,Goldbohm RA,van den Brandt PA,Baylin SB,de Goeij AF,Herman JG

更新日期：2003-06-15 00:00:00

abstract：:Administration of methylating carcinogens such as methyl methanesulfonate (120 mg/kg), dimethylnitrosamine (5 mg/kg), or methylnitrosourea (80 mg/kg) to rats resulted in an increased ellipticity in circular dichroism spectra and in an enhanced ability to bind ethidium bromide in the liver chromatin. Although shearing ...

journal_title：Cancer research

authors： Nicolini C,Ramanathan R,Kendall F,Murphy J,Parodi S,Sarma DS

更新日期：1976-05-01 00:00:00

abstract：:Using OST6 and OST7 monoclonal antibodies against human osteosarcoma cells, a solid-phase radioimmunosandwich assay was developed to quantitate a human osterosarcoma-associated antigen in a total of 242 sera from healthy adults and patients with various diseases. The levels of the antigen in sera were high in patients...

journal_title：Cancer research

authors： Tanaka C,Yamamuro T,Masuda T,Tanaka H,Matsumoto M,Kotoura Y,Tsuji T,Toguchida J,Miyama-Inaba M,Ueda M

更新日期：1986-09-01 00:00:00

abstract：:Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

journal_title：Cancer research

authors： Kelly SA,Gschmeissner S,East N,Balkwill FR

更新日期：1991-08-01 00:00:00

abstract：:Epidemiological studies have shown a positive association of colon cancer with hyperlipidemia. Furthermore, signaling generated by peroxisome proliferator-activated receptor (PPAR) alpha and gamma ligands, suggested to be candidate tumor preventive agents, has been shown to lower serum triglyceride levels. In the pres...

journal_title：Cancer research

authors： Niho N,Takahashi M,Kitamura T,Shoji Y,Itoh M,Noda T,Sugimura T,Wakabayashi K

更新日期：2003-09-15 00:00:00

abstract：:Human carcinoembryonic antigen (CEA) is an oncofetal glycoprotein overexpression of which by gastrointestinal carcinomas is well known. Expression of CEA in head and neck cancer (HNC) is not widely recognized. It is important to note that most of these studies used polyclonal antibodies that may have cross-reactivity ...

journal_title：Cancer research

authors： Kass ES,Greiner JW,Kantor JA,Tsang KY,Guadagni F,Chen Z,Clark B,De Pascalis R,Schlom J,Van Waes C

更新日期：2002-09-01 00:00:00

abstract：:DNA mismatch binding in vitro, resistance to DNA methylation damage, and spontaneous mutation rates were examined in human colorectal adenocarcinoma cell lines. Of 11 cell lines, 3 (DLD1, HCT15, and LoVo) were defective in mismatch binding. All three lines had a mutator phenotype. These properties indicate that DLD1 a...

journal_title：Cancer research

authors： Branch P,Hampson R,Karran P

更新日期：1995-06-01 00:00:00

abstract：:Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and astrocytomas. Using si...

journal_title：Cancer research

authors： Rubio MP,Correa KM,Ramesh V,MacCollin MM,Jacoby LB,von Deimling A,Gusella JF,Louis DN

更新日期：1994-01-01 00:00:00

abstract：:Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit i...

journal_title：Cancer research

authors： Buhrman JD,Jordan KR,U'ren L,Sprague J,Kemmler CB,Slansky JE

更新日期：2013-01-01 00:00:00

abstract：:Chemical and biological studies are presented for a new series of platinum(II) antitumor agents that violate the classical structure-activity relationships established for platinum complexes. These new agents, which have demonstrated activity against murine and human tumor systems, are cis-[Pt(NH3)2(Am)Cl]+ cations, i...

journal_title：Cancer research

authors： Hollis LS,Sundquist WI,Burstyn JN,Heiger-Bernays WJ,Bellon SF,Ahmed KJ,Amundsen AR,Stern EW,Lippard SJ

更新日期：1991-04-01 00:00:00

abstract：:Malignant glioma is an often fatal type of cancer. Aberrant activation of STAT3 leads to glioma tumorigenesis. STAT3-induced transcription of protein-coding genes has been extensively studied; however, little is known about STAT3-regulated miRNA gene transcription in glioma tumorigenesis. In this study, we found that ...

journal_title：Cancer research

authors： Xue J,Zhou A,Wu Y,Morris SA,Lin K,Amin S,Verhaak R,Fuller G,Xie K,Heimberger AB,Huang S

更新日期：2016-07-15 00:00:00

abstract：:(-)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been shown to inhibit the growth of many cancer cell lines and to suppress the phosphorylation of epidermal growth factor receptor (EGFR). We observed similar effects of EGCG in esophageal squamous cell carcinoma KYSE 150 cells and epide...

journal_title：Cancer research

authors： Hou Z,Sang S,You H,Lee MJ,Hong J,Chin KV,Yang CS

更新日期：2005-09-01 00:00:00

abstract：:Metabolic reprogramming is a hallmark of cancer that includes increased glucose uptake and accelerated aerobic glycolysis. This phenotype is required to fulfill anabolic demands associated with aberrant cell proliferation and is often mediated by oncogenic drivers such as activated BRAF. In this study, we show that th...

journal_title：Cancer research

authors： Houles T,Gravel SP,Lavoie G,Shin S,Savall M,Méant A,Grondin B,Gaboury L,Yoon SO,St-Pierre J,Roux PP

更新日期：2018-05-01 00:00:00

abstract：:Merbarone, a novel DNA topoisomerase II (topo II) inhibitor, differs from teniposide (VM-26) in that it inhibits topo II activities without stabilizing topo II-DNA covalent complexes. Thus, while the cellular effects of VM-26 are the consequences of inhibition of topo II catalytic activities and generation of topo II-...

journal_title：Cancer research

authors： Chen M,Beck WT

更新日期：1995-04-01 00:00:00

abstract：:Galectin-3 (Gal-3), a pleiotropic carbohydrate-binding protein, is a selective binding partner of activated K-Ras-GTP. Because both proteins are antiapoptotic and associated with cancer progression, we questioned the possible functional role of Gal-3 in K-Ras activation. We found that overexpression of Gal-3 in human ...

journal_title：Cancer research

authors： Shalom-Feuerstein R,Cooks T,Raz A,Kloog Y

更新日期：2005-08-15 00:00:00

abstract：:Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative E...

journal_title：Cancer research

authors： Iljin K,Wolf M,Edgren H,Gupta S,Kilpinen S,Skotheim RI,Peltola M,Smit F,Verhaegh G,Schalken J,Nees M,Kallioniemi O

更新日期：2006-11-01 00:00:00

abstract：:A novel monoclonal antibody was raised by immunization of mice with colorectal tumor cell lines. The fusion was screened by immunohistochemistry for binding to primary colorectal tumors. Subsequent analysis on primary disaggregated colorectal tumors show that the antibody recognizes a cell surface antigen expressed by...

journal_title：Cancer research

authors： Durrant LG,Harding SJ,Green NH,Buckberry LD,Parsons T

更新日期：2006-06-01 00:00:00

abstract：:We investigated primary human lung cancers resected surgically or obtained at autopsy. Included were squamous cell carcinoma (SQC) (five cases), adenocarcinoma (ADC) (six cases), large cell carcinoma (LCC) (four cases), and small cell carcinoma (SCC) (two cases). The objective of the study was to search for the presen...

journal_title：Cancer research

authors： Shigematsu K,Kataoka Y,Kamio T,Kurihara M,Niwa M,Tsuchiyama H

更新日期：1990-04-15 00:00:00

abstract：:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not on...

journal_title：Cancer research

authors： Hiraga T,Williams PJ,Mundy GR,Yoneda T

更新日期：2001-06-01 00:00:00

abstract：:Human p29 is a newly identified nuclear protein whose function is largely undetermined. We found that p29 associated with chromatin, interacted with MCM3, and localized with proliferating cell nuclear antigen foci in the S phase. Silencing of p29 using small interfering RNA duplexes reduced DNA synthesis and increased...

journal_title：Cancer research

authors： Chu PC,Yang YC,Lu YT,Chen HT,Yu LC,Chang MS

更新日期：2006-09-01 00:00:00

abstract：:Death receptor Fas-mediated apoptosis not only eliminates nonspecific and autoreactive B cells but also plays a major role in antitumor immunity. However, the possible mechanisms underlying impairment of Fas-mediated induction of apoptosis during lymphomagenesis remain unknown. In this study, we employed our developed...

journal_title：Cancer research

authors： Sugihara E,Hashimoto N,Osuka S,Shimizu T,Ueno S,Okazaki S,Yaguchi T,Kawakami Y,Kosaki K,Sato TA,Okamoto S,Saya H

更新日期：2020-10-15 00:00:00

abstract：:We observed that photodynamic therapy (PDT) induces the expression and phosphorylation of the inhibitor of apoptosis (IAP) protein survivin in murine and human cancer cells and tumors. Survivin inhibits caspase-9, blocks apoptosis, and is associated with resistance to chemotherapy and radiation. Survivin is a client p...

journal_title：Cancer research

authors： Ferrario A,Rucker N,Wong S,Luna M,Gomer CJ

更新日期：2007-05-15 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

journal_title：Cancer research

authors： Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

更新日期：2004-01-01 00:00:00

abstract：:Using a microcytotoxicity assay we have studied the immune responses to the preneoplastic, hyperplastic alveolar nodule (HAN) lines D1 and D2 and to the mammary tumors arising spontaneously from them in BALB/c mice. Lymph node cells (LNC) from mice bearing HAN implants, or from mice whose implants had been removed gre...

journal_title：Cancer research

authors： Heppner GH,Kopp JS,Medina D

更新日期：1976-02-01 00:00:00

abstract：:Amino acid analysis of the culture medium was carried out in a human leukemic lymphoblastoid cell line (REH) established from the lymphoblasts of a patient with acute lymphoid leukemia. The results are compared with those of a reference cell line (LHN13) established from normal human lymphocytes. The most striking dif...

journal_title：Cancer research

authors： Lorans G,Rosenfeld C,Petitou M,Phan-Dinh-Tuy F,Mathé G

更新日期：1978-11-01 00:00:00

abstract：:The relationship between nitric oxide synthase II (NOS II) inducibility and the metastatic ability of UV-2237 murine fibrosarcoma cells was determined. Highly metastatic cells survived to produce numerous lung metastases after i.v. injection in syngeneic C3H/HeN mice, whereas poorly metastatic cells did not. Highly me...

journal_title：Cancer research

authors： Shi Q,Huang S,Jiang W,Kutach LS,Ananthaswamy HN,Xie K

更新日期：1999-05-01 00:00:00

abstract：:Human embryonal carcinoma (EC) cells are the stem cells of teratocarcinomas, and they are key components of germ cell tumors (GCTs). They express several high molecular weight glycoprotein antigens that are down-regulated upon differentiation. One of these antigens, defined by monoclonal antibody TRA-1-60, can be dete...

journal_title：Cancer research

authors： Badcock G,Pigott C,Goepel J,Andrews PW

更新日期：1999-09-15 00:00:00

abstract：:Homozygous deletion of the methylthioadenosine phosphorylase (MTAP) gene is a frequent event in a wide variety of human cancers and is a possible molecular target for therapy. One potential therapeutic strategy to target MTAP-deleted tumors involves combining toxic purine analogues such as 6'-thioguanine (6TG) or 2'-f...

journal_title：Cancer research

authors： Tang B,Lee HO,An SS,Cai KQ,Kruger WD

更新日期：2018-08-01 00:00:00

abstract：:The osteolytic bone destruction associated with breast cancer skeletal metastases represents a serious and incurable clinical condition. However, the molecular mechanisms regulating tumor cell expression of factors involved in the generation of osteolytic disease remain elusive. We demonstrated recently that breast ca...

journal_title：Cancer research

authors： Barnes GL,Hebert KE,Kamal M,Javed A,Einhorn TA,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2004-07-01 00:00:00