Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:Despite significant advances in cancer precision medicine, a significant hurdle to its broader adoption remains the multitude of variants of unknown significance identified by clinical tumor sequencing and the lack of biologically validated methods to distinguish between functional and benign variants. Here we used fu...

journal_title：Cancer research

authors： Hanrahan AJ,Sylvester BE,Chang MT,Elzein A,Gao J,Han W,Liu Y,Xu D,Gao SP,Gorelick AN,Jones AM,Kiliti AJ,Nissan MH,Nimura CA,Poteshman AN,Yao Z,Gao Y,Hu W,Wise HC,Gavrila EI,Shoushtari AN,Tiwari S,Viale A,Abd

更新日期：2020-10-01 00:00:00

abstract：:DNA content and in situ sensitivity to denaturation were analyzed by flow cytometry of individual cell nuclei isolated from 40 breast carcinomas, nine fibroadenomas, and 14 samples of normal breast tissue. The extent of DNA denaturation induced by acid was expressed as alpha t, which represents the fraction of DNA sta...

journal_title：Cancer research

authors： Kunicka JE,Olszewski W,Rosen PP,Kimmel M,Melamed MR,Darzynkiewicz Z

更新日期：1989-11-15 00:00:00

abstract：:The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irrever...

journal_title：Cancer research

authors： Howard RA,Spring TG,Bear JL

更新日期：1976-12-01 00:00:00

abstract：:Increased age is regularly linked with heightened cancer risk, but recent research suggests a flattening around age 80. We report that, independent of cancer site or time period, most incidence rates decrease in the more elderly and drop to or toward zero near the ceiling of human life span. For all major organ sites,...

journal_title：Cancer research

authors： Harding C,Pompei F,Lee EE,Wilson R

更新日期：2008-06-01 00:00:00

abstract：:Busulfan (1,4-butanediol dimethanesulfonate, BU) is relatively unique among other standard chemotherapy compounds in its ability to deplete noncycling primitive stem cells in the host and consequently to allow for high levels of long-term, donor-type engraftment after bone marrow transplantation (BMT). Such a property...

journal_title：Cancer research

authors： Westerhof GR,Ploemacher RE,Boudewijn A,Blokland I,Dillingh JH,McGown AT,Hadfield JA,Dawson MJ,Down JD

更新日期：2000-10-01 00:00:00

abstract：:In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes as were observed to increase, suggesting a previously unknown mechanism for epigenetic regulation. To address this idea, the expression of the BAG family genes...

journal_title：Cancer research

authors： Sun L,Huang L,Nguyen P,Bisht KS,Bar-Sela G,Ho AS,Bradbury CM,Yu W,Cui H,Lee S,Trepel JB,Feinberg AP,Gius D

更新日期：2008-04-15 00:00:00

abstract：:Among the many proteases associated with human cancer, seprase or fibroblast activation protein alpha, a type II transmembrane glycoprotein, has two types of EDTA-resistant protease activities: dipeptidyl peptidase and a 170-kDa gelatinase activity. To test if activation of gelatinases associated with seprase could be...

journal_title：Cancer research

authors： Chen D,Kennedy A,Wang JY,Zeng W,Zhao Q,Pearl M,Zhang M,Suo Z,Nesland JM,Qiao Y,Ng AK,Hirashima N,Yamane T,Mori Y,Mitsumata M,Ghersi G,Chen WT

更新日期：2006-10-15 00:00:00

abstract：:It is known that Wnt-1 signaling inhibits apoptosis by activating beta-catenin/tcf-mediated transcription. Here, we show that blocking Wnt-1 signaling in beta-catenin-deficient mesothelioma cell lines H28 and MS-1 induces apoptotic cell death. Both Wnt-1 small interfering RNA (siRNA) and Dishevelled siRNA induced sign...

journal_title：Cancer research

authors： You L,He B,Uematsu K,Xu Z,Mazieres J,Lee A,McCormick F,Jablons DM

更新日期：2004-05-15 00:00:00

abstract：:Sulfated macromolecules synthesized in tumor and mucosa tissues derived from colorectal cancer patients were labeled with [35S]sulfate and separated into two fractions on DEAE-Sephacel: the slightly acidic peak (peak I) was eluted with 0.2 M NaCl and the highly acidic peak (peak II) was eluted with 0.5 M NaCl. A total...

journal_title：Cancer research

authors： Yamori T,Kimura H,Stewart K,Ota DM,Cleary KR,Irimura T

更新日期：1987-05-15 00:00:00

abstract：:The ErbB2 receptor tyrosine kinase is overexpressed in approximately 25% of breast tumors and contributes to poor patient prognosis and therapeutic resistance. Here, we examine the role of the recently discovered ErbB negative regulator LRIG1 in ErbB2(+) breast cancer. We observe that LRIG1 protein levels are signific...

journal_title：Cancer research

authors： Miller JK,Shattuck DL,Ingalla EQ,Yen L,Borowsky AD,Young LJ,Cardiff RD,Carraway KL 3rd,Sweeney C

更新日期：2008-10-15 00:00:00

abstract：:The appearance of chemically induced mammary gland carcinomas in virgin female Sprague-Dawley rats was blocked by the administration of D,L-2-difluoromethylornithine (DFMO) in drinking water during the stage of tumor promotion. Rats were given injections s.c. at 50 days of age with either 35 mg of 1-methyl-1-nitrosour...

journal_title：Cancer research

authors： Thompson HJ,Meeker LD,Herbst EJ,Ronan AM,Minocha R

更新日期：1985-03-01 00:00:00

abstract：:A metastatic renal cell carcinoma (RCC) tumor model xenograft that expresses the targetable, membrane-bound tumor-associated antigen carbonic anhydrase type 9 (CA IX) is described. The xenograft, established from a high-grade type-2 chromophil RCC (cRCC), has been serially transplanted in immune compromised mice, in w...

journal_title：Cancer research

authors： Zisman A,Pantuck AJ,Bui MH,Said JW,Caliliw RR,Rao N,Shintaku P,Berger F,Gambhir SS,Belldegrun AS

更新日期：2003-08-15 00:00:00

abstract：:The cytotoxic activity of 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA), a novel acridine derivative with clinical antitumor activity, has been examined in multicellular spheroids grown from Chinese hamster V79-171b cells. m-AMSA is much less effective against cells within these tumor-like structures than it...

journal_title：Cancer research

authors： Wilson WR,Whitmore GF,Hill RP

更新日期：1981-07-01 00:00:00

abstract：:The current study is a continuation of our previous work showing that bone marrow activated in interleukin 2 has antitumor and antiviral activity in vitro. The antitumor efficacy of IL-2-activated bone marrow cells in vivo was assessed here. Our results indicated that bone marrow cells activated in IL-2 for 3 days (AB...

journal_title：Cancer research

authors： Agah R,Malloy B,Kerner M,Girgis E,Bean P,Twomey P,Mazumder A

更新日期：1989-11-01 00:00:00

abstract：:Using a microcytotoxicity assay we have studied the immune responses to the preneoplastic, hyperplastic alveolar nodule (HAN) lines D1 and D2 and to the mammary tumors arising spontaneously from them in BALB/c mice. Lymph node cells (LNC) from mice bearing HAN implants, or from mice whose implants had been removed gre...

journal_title：Cancer research

authors： Heppner GH,Kopp JS,Medina D

更新日期：1976-02-01 00:00:00

abstract：:The binding of the papillomavirus E6 protein to E6AP and the induction of p53 degradation are common features of high-risk genital human papillomaviruses (HPV); cutaneous HPVs, on the other hand, lack these capacities. Nevertheless, several cutaneous HPV types of the beta-genus, such as HPV38 are associated with tumor...

journal_title：Cancer research

authors： Muench P,Probst S,Schuetz J,Leiprecht N,Busch M,Wesselborg S,Stubenrauch F,Iftner T

更新日期：2010-09-01 00:00:00

abstract：:The ability of all-trans-retinoic acid (RA) to modulate the growth and squamous differentiation of four head and neck squamous cell carcinoma cell lines (183, 886, 1483, and SqCC/Y1) was examined, and the relationship of their state of squamous differentiation and RA responsiveness to the expression of cytosolic RA-bi...

journal_title：Cancer research

authors： Zou CP,Clifford JL,Xu XC,Sacks PG,Chambon P,Hong WK,Lotan R

更新日期：1994-10-15 00:00:00

abstract：:The study of two major risk factors in the development of hepatocellular carcinoma, namely persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an experimental system. To this end we have used a Pekin duck model to examine the effect of congenital duck hepatitis B virus...

journal_title：Cancer research

authors： Cova L,Wild CP,Mehrotra R,Turusov V,Shirai T,Lambert V,Jacquet C,Tomatis L,Trépo C,Montesano R

更新日期：1990-04-01 00:00:00

abstract：:We have produced a panel of monoclonal antibodies directed against a dimethylbenzanthracene-induced murine mammary tumor. Five rat-mouse hybridomas produced antibodies that bound to some murine mammary tumors, but not to normal renal adherent cells, lymphocytes, 3T3 fibroblasts, red blood cells, or mammary gland. One ...

journal_title：Cancer research

authors： Johnson CW,Wei WZ,Barth RF,Tuttle SE,Andrews CA

更新日期：1985-08-01 00:00:00

abstract：:Human papillomavirus (HPV) type 18 DNA was introduced into epithelial cell strains derived from normal and cancer tissues of human prostatectomy specimens by the lipofection transfection method. Two cell lines were established: PZ-HPV-7 (transfected normal cell) and CA-HPV-10 (transfected cancer-derived cell). These l...

journal_title：Cancer research

authors： Weijerman PC,König JJ,Wong ST,Niesters HG,Peehl DM

更新日期：1994-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18-25 nucleotides) that are involved in diverse developmental and pathologic processes. Altered miRNA expression has been associated with several types of human cancer. However, most studies did not establish whether miRNA expression changes occurr...

journal_title：Cancer research

authors： Sempere LF,Christensen M,Silahtaroglu A,Bak M,Heath CV,Schwartz G,Wells W,Kauppinen S,Cole CN

更新日期：2007-12-15 00:00:00

abstract：:The ability to modulate DNA repair has been proposed as an effective method to overcome cytotoxic drug resistance in human tumors. However, no studies have shown that it is possible to achieve modulation of DNA repair in humans in vivo. This study analyzes modulation of O6-alkylguanine-DNA alkyltransferase, a DNA repa...

journal_title：Cancer research

authors： Gerson SL

更新日期：1989-06-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascer...

journal_title：Cancer research

authors： Santiago C,Pagán B,Isidro AA,Appleyard CB

更新日期：2007-11-15 00:00:00

abstract：:In vivo experiments performed with NIH (nu/nu, bg/bg, xid/xid) triple immunodeficient (TD) mice revealed the striking ability of i.v. injected B16-F1 and B16-F10 murine melanoma cells to colonize not only the lungs but also the liver of TD mice. Subsequently, B16 melanoma cell cultures, which express very low levels o...

journal_title：Cancer research

authors： Calorini L,Marozzi A,Byers HR,Waneck GL,Lee KW,Isselbacher KJ,Gattoni-Celli S

更新日期：1992-07-15 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00

abstract：:The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DL) is induced by the DNA damage response (DDR), which is often activated constitutively in cancer cells, revealing them to NK cells as a mechanism of imm...

journal_title：Cancer research

authors： Lam AR,Bert NL,Ho SS,Shen YJ,Tang LF,Xiong GM,Croxford JL,Koo CX,Ishii KJ,Akira S,Raulet DH,Gasser S

更新日期：2014-04-15 00:00:00

abstract：:The presence of common genomic deletions in the 19q13 chromosomal region in neuroblastomas and gliomas strongly suggests the presence of a putative tumor suppressor gene for these neoplasms in this region that, despite much effort, has not yet been identified. In an attempt to address this issue, we compared the expre...

journal_title：Cancer research

authors： Alaminos M,Dávalos V,Ropero S,Setién F,Paz MF,Herranz M,Fraga MF,Mora J,Cheung NK,Gerald WL,Esteller M

更新日期：2005-04-01 00:00:00

abstract：:The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal phenotype with increased migratory and invasive properties. This process has been well described...

journal_title：Cancer research

authors： Sannino G,Marchetto A,Kirchner T,Grünewald TGP

更新日期：2017-09-01 00:00:00

abstract：:XRCC1 is a key component of DNA base excision repair, single strand break repair, and backup nonhomologous end-joining pathway. XRCC1 (X-ray repair cross-complementing gene 1) deficiency promotes genomic instability, increases cancer risk, and may have clinical application in breast cancer. We investigated XRCC1 expre...

journal_title：Cancer research

authors： Sultana R,Abdel-Fatah T,Abbotts R,Hawkes C,Albarakati N,Seedhouse C,Ball G,Chan S,Rakha EA,Ellis IO,Madhusudan S

更新日期：2013-03-01 00:00:00