当前位置： SCI文献检索 > CANCER RESEARCH期刊下所有文献 > The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.

The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.

Abstract：

:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not only reduce osteolysis associated with metastatic breast cancer, but also decrease tumor burden in bone. The mechanisms by which tumor burden is decreased following BP administration are unknown. Here we examined the effects of the BP ibandronate on MDA-231 human breast cancer cells in bone metastases in a well-characterized animal model of bone metastasis. Ibandronate, which was administered (s.c. daily; 4 microg/mouse/day) after bone metastases were established, inhibited the progression of established osteolytic bone metastases as assessed by radiographic analysis. Histological and histomorphometrical examination revealed that ibandronate reduced osteoclastic bone resorption, with increased apoptosis in osteoclasts. Furthermore, ibandronate also significantly decreased the MDA-231 tumor burden, with increased apoptosis in MDA-231 breast cancer cells in bone metastases. In contrast, ibandronate failed to inhibit MDA-231 tumor formation with no effects on apoptosis in MDA-231 breast cancer cells in the orthotopic mammary fat pads. These data suggest that the effects of ibandronate on apoptosis in MDA-231 breast cancer cells are restricted in bone in which ibandronate selectively deposits. Consistent with these in vivo results, a relatively high concentration of ibandronate (100 microM) increased caspase-3 activity and induced DNA fragmentation in MDA-231 breast cancer cells in culture. Moreover, a caspase inhibitor, z-Val-Ala-Asp-fluoromethyl ketone, blocked ibandronate-induced DNA fragmentation in MDA-231 cells, suggesting an involvement of caspase-3 in ibandronate-induced apoptosis. Our results suggest that BP suppresses bone metastases through promotion of apoptosis in metastatic cancer cells as well as in osteoclasts. However, it still remains open whether BP has direct anticancer actions in vivo.

journal_name

Cancer Res

journal_title

Cancer research

authors

Hiraga T,Williams PJ,Mundy GR,Yoneda T

subject

Has Abstract

pub_date

2001-06-01 00:00:00

pages

4418-24

issue

11

eissn

0008-5472

issn

1538-7445

journal_volume

61

pub_type

杂志文章

相关文献

CANCER RESEARCH文献大全
  • Susceptibilities of normal and malignant human lung cells in culture to the cytocidal action of antitumor agents.

    abstract：:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Tsukeda H,Mizuno S,Nitta K

    更新日期：1978-08-01 00:00:00

  • Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.

    abstract：:DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound is expected to be a clinically useful antitumor agent. Three human tumor cell lines resistant to CPT (A549/CPT, HT-29/CPT, St-4/CPT) were isolated in vitro, and...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sugimoto Y,Tsukahara S,Oh-hara T,Isoe T,Tsuruo T

    更新日期：1990-11-01 00:00:00

  • Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland.

    abstract：:Thyroid neoplasms show a wide variety of lesions varying from slowly growing differentiated adenocarcinomas to rapidly proliferating undifferentiated carcinomas. There has been some histopathological evidence that the undifferentiated thyroid carcinomas are derived from differentiated carcinomas. Moreover, it is suspe...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Ito T,Seyama T,Mizuno T,Tsuyama N,Hayashi T,Hayashi Y,Dohi K,Nakamura N,Akiyama M

    更新日期：1992-03-01 00:00:00

  • Anti-PD-L1 Treatment Results in Functional Remodeling of the Macrophage Compartment.

    abstract：:Checkpoint inhibitors like anti-PD1/PD-L1 have demonstrated significant therapeutic efficacy in a subset of patients partly through reinvigoration of CD8 T cells. However, their impact on myeloid cells remains largely unknown. Here, we report that anti-PD-L1 treatment favorably impacts the phenotype and function of tu...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-18-3208

    authors： Xiong H,Mittman S,Rodriguez R,Moskalenko M,Pacheco-Sanchez P,Yang Y,Nickles D,Cubas R

    更新日期：2019-04-01 00:00:00

  • Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.

    abstract：:5'-Deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine, which are metabolized to the methionine precursor, 5-methylthioribose-1-phosphate, by 5'-deoxy-5'-methylthioadenosine phosphorylase and purine nucleoside phosphorylase, respectively, can serve as sources of methionine for cultured HL-60 promyelocytic l...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Savarese TM,Ghoda LY,Dexter DL,Parks RE Jr

    更新日期：1983-10-01 00:00:00

  • Melanoma-specific memory T cells are functionally active in Ret transgenic mice without macroscopic tumors.

    abstract：:We previously reported that bone marrows of breast cancer patients contained tumor antigen-specific CD8(+) T cells with central or effector memory phenotype. Using a recently developed ret transgenic mouse melanoma model, we now show that bone marrows and tumors of transgenic mice contain high frequencies of CD8(+) T ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-08-1464

    authors： Umansky V,Abschuetz O,Osen W,Ramacher M,Zhao F,Kato M,Schadendorf D

    更新日期：2008-11-15 00:00:00

  • Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells.

    abstract：:Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional cell surface aminopeptidase that is widely expressed in different cell types. Our previous study demonstrated a possible link between DPPIV expression and decreased i.p. dissemination and loss of invasive potential of ovarian carcinoma. In this report, we exami...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Kajiyama H,Kikkawa F,Khin E,Shibata K,Ino K,Mizutani S

    更新日期：2003-05-01 00:00:00

  • Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells.

    abstract：:Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown to be the essential mediator of most Smad-dependent TGF-beta responses, including control...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-08-3961

    authors： Yang J,Wahdan-Alaswad R,Danielpour D

    更新日期：2009-03-15 00:00:00

  • A Novel Mechanism to Induce BRCAness in Cancer Cells.

    abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

    journal_title：Cancer research

    pub_type： 评论,杂志文章

    doi：10.1158/0008-5472.CAN-20-1451

    authors： Cai C

    更新日期：2020-07-15 00:00:00

  • Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents.

    abstract：:Monocytes and dendritic cells are key players in the immune response. Because dendritic cells drive the tumor host defense, it is important that monocytes and dendritic cells survive cytotoxic tumor therapy. Although most of the anticancer drugs target DNA, the DNA repair capacity of monocytes and dendritic cells has ...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-06-3712

    authors： Briegert M,Kaina B

    更新日期：2007-01-01 00:00:00

  • Relationship between Rous sarcoma virus-induced expression of membrane antigen and phenotypic transformation.

    abstract：:Rous sarcoma virus-transformed hamster BHK fibroblasts express a virus-induced cell surface antigen undetectable in cells either transformed by unrelated viruses or infected by transformation-defective strains of Rous sarcoma virus. To clarify whether this antigen plays any role in the process of malignant transformat...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Comoglio PM,Pani B,Prat M,Tarone G,Monti-Bragadin C

    更新日期：1979-11-01 00:00:00

  • Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha.

    abstract：:Mutagenesis of protooncogenes has been postulated to contribute to the initiation and progression of human cancer. Activating mutations in the H-ras gene are predominantly single-base substitutions and are most frequently identified at codons 12, 13, and 61. We have analyzed the effects of DNA sequence context at spec...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Hoffmann JS,Fry M,Ji J,Williams KJ,Loeb LA

    更新日期：1993-06-15 00:00:00

  • Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase.

    abstract：:S49 cyc- lymphoma cells contain a mutation resulting in loss of a functional guanine nucleotide regulatory protein rendering their adenylate cyclase refractory to most stimuli. S49 wild-type and cyc- clones were used in the present study to investigate the possible association of altered cAMP metabolism with tumorigen...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Stadel JM,Johnson RK,Mirabelli CK,Powers DA,Sung CM,Faucette LF,McCabe FL,Crooke ST

    更新日期：1988-02-01 00:00:00

  • Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.

    abstract：:Sustained proliferation of cancer cells requires telomerase to maintain telomeres that regulate chromosomal stability and cellular mitosis. Expression of human telomerase reverse transcriptase (hTERT) catalytic subunit, which modulates telomerase activity, is regulated at both the transcriptional level and via phospho...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Akiyama M,Hideshima T,Hayashi T,Tai YT,Mitsiades CS,Mitsiades N,Chauhan D,Richardson P,Munshi NC,Anderson KC

    更新日期：2003-01-01 00:00:00

  • Effects of transferrin-indium on cellular proliferation of a human leukemia cell line.

    abstract：:In previous studies, we have demonstrated that transferrin-gallium inhibits cellular proliferation by a mechanism whereby cellular iron utilization is impaired. Since indium, a similar class 3A metal, has not been well studied, we examined its effects on cellular iron uptake and cellular proliferation. In these studie...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Moran PL,Seligman PA

    更新日期：1989-08-01 00:00:00

  • Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients.

    abstract：:Activation of c-src, a cellular human gene homologous in sequence to the v-src gene of Rous sarcoma virus, had been thought to play an important role in the progression of several types of human cancers, without having undergone any genetic changes. However, recently truncating mutations at codon 531 of the c-src gene...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Daigo Y,Furukawa Y,Kawasoe T,Ishiguro H,Fujita M,Sugai S,Nakamori S,Liefers GJ,Tollenaar RA,van de Velde CJ,Nakamura Y

    更新日期：1999-09-01 00:00:00

  • Development of a murine lymphoma model system for the characterization of natural killer:tumor cell interactions.

    abstract：:We have developed a model system which can be utilized for characterizing both the molecular basis of natural killer (NK):tumor interactions and the consequences of these interactions on tumor growth in vivo. This model system consists of several tumor lines which were derived from the murine lymphoma ASL1w under cond...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Smithson G,Wolcott RM,Chervenak R

    更新日期：1992-08-01 00:00:00

  • Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor.

    abstract：:We previously reported that both sodium butyrate and trichostatin A (TSA), both of which are known as inhibitors of histone deacetylase, arrest human tumor cells at G1 and G2-M and activate the cyclin-dependent kinase inhibitor, the p21/WAF1/Cip1 gene promoter, through the Sp1 sites. In this study, we identified Sp1 a...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Sowa Y,Orita T,Minamikawa-Hiranabe S,Mizuno T,Nomura H,Sakai T

    更新日期：1999-09-01 00:00:00

  • N-ras mutation in ultraviolet radiation-induced murine skin cancers.

    abstract：:UV radiation is a potent DNA-damaging agent and a known inducer of skin cancer in experimental animals. To elucidate the role of oncogenes in UV carcinogenesis, we analyzed UV-induced murine skin tumors for mutations in codon 12, 13, or 61 of Ha-ras, Ki-ras, and N-ras oncogenes by amplification of genomic tumor DNAs b...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Pierceall WE,Kripke ML,Ananthaswamy HN

    更新日期：1992-07-15 00:00:00

  • SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.

    abstract：:BRAF mutations result in constitutively active BRAF kinase activity and increased extracellular signal-regulated kinase (ERK) signaling and cell proliferation. Initial studies have shown that BRAF mutations occur at a high frequency in melanocytic nevi and metastatic lesions, but recent data have revealed much lower i...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-04-1669

    authors： Tsavachidou D,Coleman ML,Athanasiadis G,Li S,Licht JD,Olson MF,Weber BL

    更新日期：2004-08-15 00:00:00

  • Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.

    abstract：:T-cell exhaustion in cancer is linked to poor clinical outcomes, where evidence suggests T-cell metabolic changes precede functional exhaustion. Direct competition between tumor-infiltrating lymphocytes (TIL) and cancer cells for metabolic resources often renders T cells dysfunctional. Environmental stress produces ep...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-20-0524

    authors： Koss B,Shields BD,Taylor EM,Storey AJ,Byrum SD,Gies AJ,Washam CL,Choudhury SR,Hyun Ahn J,Uryu H,Williams JB,Krager KJ,Chiang TC,Mackintosh SG,Edmondson RD,Aykin-Burns N,Gajewski TF,Wang GG,Tackett AJ

    更新日期：2020-11-01 00:00:00

  • Human ovarian carcinoma cells maintained on extracellular matrix versus plastic.

    abstract：:The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Crickard K,Crickard U,Yoonessi M

    更新日期：1983-06-01 00:00:00

  • Increase in type I cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity and specific accumulation of type I regulatory subunits in adenovirus type 12-transformed cells.

    abstract：:Types I and II cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinases were compared in extracts from untransformed rat 3Y1 cells and 3Y1 cells transformed by the highly oncogenic human adenovirus type 12. Analysis of the kinases through diethylaminoethyl Sepharose column chromatography showed a signific...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Ledinko N,Chan IJ

    更新日期：1984-06-01 00:00:00

  • The synthetic heteroarotinoid SHetA2 induces apoptosis in squamous carcinoma cells through a receptor-independent and mitochondria-dependent pathway.

    abstract：:Retinoids that regulate cell growth, differentiation, and apoptosis have shown promising results in preclinical studies and in a few clinical trials of cancer chemoprevention and therapy. However, the clinical use of retinoids is limited by resistance of certain malignant cells to their antitumor effects and by side e...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Chun KH,Benbrook DM,Berlin KD,Hong WK,Lotan R

    更新日期：2003-07-01 00:00:00

  • Distal nephron renal tumors: microsatellite allelotype.

    abstract：:Tumors of varying malignant potential arise from the complex epithelial lining of the nephron. Although the molecular characteristics of renal clear cell carcinomas, which arise from the proximal tubule, have been studied, little is known about tumors that develop from other parts of the renal tubular system. To eluci...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Polascik TJ,Cairns P,Epstein JI,Fuzesi L,Ro JY,Marshall FF,Sidransky D,Schoenberg M

    更新日期：1996-04-15 00:00:00

  • Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease.

    abstract：:Galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, contributes to the creation of an immunosuppressed microenvironment at sites of tumor growth. In spite of considerable progress in elucidating its role in tumor-immune escape, the mechanisms underlying the inhibitory functions of Gal1 remain obscur...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-12-2418

    authors： Dalotto-Moreno T,Croci DO,Cerliani JP,Martinez-Allo VC,Dergan-Dylon S,Méndez-Huergo SP,Stupirski JC,Mazal D,Osinaga E,Toscano MA,Sundblad V,Rabinovich GA,Salatino M

    更新日期：2013-02-01 00:00:00

  • Detection of mutant-specific responses by macrophage migration inhibition reactions induced by wild-type and mutant polyoma viruses and polyoma virus-infected cells.

    abstract：:Macrophage migration inhibition responses of mice immunized with mutant polyoma viruses or with cells transformed and/or infected by them have been studied. The macrophage migration inhibition reaction revealed individual differences. In several cases, mice immunized with a mutant virus responded preferentially or exc...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：

    authors： Szigeti R,Dalianis T,Ramqvist T,Ito Y,Klein G

    更新日期：1984-03-01 00:00:00

  • Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40.

    abstract：:SGN-40 is a humanized IgG1 antihuman CD40 that is currently in a phase I clinical trial for the treatment of multiple myeloma. As surface CD40 expression on B-lineage cells is maintained from pro-B cells to plasma cells, SGN-40 may be applicable to treatment of other B-cell neoplasias, including non-Hodgkin's lymphoma...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-0095

    authors： Law CL,Gordon KA,Collier J,Klussman K,McEarchern JA,Cerveny CG,Mixan BJ,Lee WP,Lin Z,Valdez P,Wahl AF,Grewal IS

    更新日期：2005-09-15 00:00:00

  • LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer.

    abstract：:We showed that the PEA3 transcriptional factor interacted with LKB1, a serine/threonine kinase, which is somatically mutated in lung cancer. This interaction occurred through the ETS domain of PEA3 and the kinase domain of LKB1. Mutation of LKB1 in lung cancer cells stabilized PEA3. Reintroduction of wild-type (WT) LK...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-05-2902

    authors： Upadhyay S,Liu C,Chatterjee A,Hoque MO,Kim MS,Engles J,Westra W,Trink B,Ratovitski E,Sidransky D

    更新日期：2006-08-15 00:00:00

  • Transforming growth factor-beta signaling in prostate stromal cells supports prostate carcinoma growth by up-regulating stromal genes related to tissue remodeling.

    abstract：:Increasing evidence points to an active stromal involvement in cancer initiation and progression. Cytokines derived from tumor cells are believed to modulate stromal cells to produce growth and angiogenic factors, which in turn provide the tumor with the necessary microenvironment for expansion and invasion. Transform...

    journal_title：Cancer research

    pub_type： 杂志文章

    doi：10.1158/0008-5472.CAN-07-0444

    authors： Verona EV,Elkahloun AG,Yang J,Bandyopadhyay A,Yeh IT,Sun LZ

    更新日期：2007-06-15 00:00:00