Abstract：
:Cultured normal and malignant human lung cells were examined for their different sensitivities to the cytocidal action of nine antitumor and three non-antitumor agents. The malignant cells were killed preferentially at lower concentrations and in a shorter time with each antitumor agent, Adriamycin, neocarzinostatin, bleomycin, actinomycin D, mitomycin C, carboquone, 1-beta-D-arabinofuranosylcytosine, 5-fluorouracil, and 5-fluorodeoxyuridine. Among these, Adriamycin, 5-fluorouracil, and 5-fluoro-deoxyuridine exhibited a higher differential lethal action on the malignant cells than did the other antitumor agents. The two cell lines exhibited little difference in cytolytic sensitivity to non-antitumor cytotoxic agents such as amphotericin B, G-strophanthin, and alph-amanitin.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Tsukeda H,Mizuno S,Nitta Ksubject
Has Abstractpub_date
1978-08-01 00:00:00pages
2529-32issue
8eissn
0008-5472issn
1538-7445journal_volume
38pub_type
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