Antibody microarray profiling reveals individual and combined serum proteins associated with pancreatic cancer.

abstract：:PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate cancer progression and metastasis. However, in preclinical murine models, deletion of Pten alone fails to mimic the significant metastatic burden that frequently accompanies the end stage of human disease. To identify additional pathway ...

journal_title：Cancer research

authors： Mulholland DJ,Kobayashi N,Ruscetti M,Zhi A,Tran LM,Huang J,Gleave M,Wu H

更新日期：2012-04-01 00:00:00

abstract：:Glioblastoma (GBM) is often treated with the cytotoxic drug temozolomide, but the disease inevitably recurs in a drug-resistant form after initial treatment. Here, we report that in GBM cells, even a modest decrease in the mismatch repair (MMR) components MSH2 and MSH6 have profound effects on temozolomide sensitivity...

journal_title：Cancer research

authors： McFaline-Figueroa JL,Braun CJ,Stanciu M,Nagel ZD,Mazzucato P,Sangaraju D,Cerniauskas E,Barford K,Vargas A,Chen Y,Tretyakova N,Lees JA,Hemann MT,White FM,Samson LD

更新日期：2015-08-01 00:00:00

abstract：:Although accumulating evidence indicates that chronic lymphocytic leukemia (CLL) is a disease with appreciable cell dynamics, it remains uncertain whether this also applies to patients with stable disease. In this study, (2)H(2)O was administered to a clinically homogeneous cohort of nine stable, untreated CLL patient...

journal_title：Cancer research

authors： van Gent R,Kater AP,Otto SA,Jaspers A,Borghans JA,Vrisekoop N,Ackermans MA,Ruiter AF,Wittebol S,Eldering E,van Oers MH,Tesselaar K,Kersten MJ,Miedema F

更新日期：2008-12-15 00:00:00

abstract：:Some, but not all, epidemiological studies have suggested that dichlorodiphenyltrichloroethane (DDT) may play a role in the development of breast cancer. These investigations have been conducted in countries where this substance has been banned for at least 20 years. We conducted a study in Mexico, a country in which ...

journal_title：Cancer research

authors： López-Carrillo L,Blair A,López-Cervantes M,Cebrián M,Rueda C,Reyes R,Mohar A,Bravo J

更新日期：1997-09-01 00:00:00

abstract：:cis-Diammine(1,1-cyclobutanedicarboxylato)platinum (CBDCA) is a nonnephrotoxic but myelosuppressive analogue of cisplatin (DDP) with greatly reduced protein binding and greatly increased renal excretion. Thus, CBDCA might produce undue toxicity in patients with decreased renal function. Twenty-two patients [14 females...

journal_title：Cancer research

authors： Egorin MJ,Van Echo DA,Tipping SJ,Olman EA,Whitacre MY,Thompson BW,Aisner J

更新日期：1984-11-01 00:00:00

abstract：:BCL2 suppresses apoptosis by binding the BH3 domain of proapoptotic factors and thereby regulating outer mitochondrial membrane permeabilization. Many tumor types, including B-cell lymphomas and chronic lymphocytic leukemia, are dependent on BCL2 for survival but become resistant to apoptosis after treatment. Here, we...

journal_title：Cancer research

authors： Dutta C,Day T,Kopp N,van Bodegom D,Davids MS,Ryan J,Bird L,Kommajosyula N,Weigert O,Yoda A,Fung H,Brown JR,Shapiro GI,Letai A,Weinstock DM

更新日期：2012-08-15 00:00:00

abstract：:We have previously reported that abdominal irradiation prior to i.v. injection of syngeneic tumor cells reduced metastases in lung. Our report described an investigation of the significance of intestinal organisms in the radiation effect. We found that eliminating intestinal organisms with antibiotics totally abolishe...

journal_title：Cancer research

authors： Matsumoto T,Ando K,Koike S

更新日期：1988-06-01 00:00:00

abstract：:We have carried out a series of complementary in vivo and in vitro studies to better understand the metabolism of vitamin A by the prostate gland. Male Sprague-Dawley rats were fed either a control diet sufficient in vitamin A [CON group; 0.8 microg retinol equivalents (RE)/g diet] or a CON diet supplemented with the ...

journal_title：Cancer research

authors： Lewis KC,Hochadel JF

更新日期：1999-12-01 00:00:00

abstract：:KLF4/GLKF4 is a transcription factor that can have divergent functions in different malignancies. The role of KLF4 in prostate cancer etiology remains unclear. We have recently reported that small double-stranded RNA can induce gene expression by targeting promoter sequence in a phenomenon referred to as RNA activatio...

journal_title：Cancer research

authors： Wang J,Place RF,Huang V,Wang X,Noonan EJ,Magyar CE,Huang J,Li LC

更新日期：2010-12-15 00:00:00

abstract：:Between 5% and 10% of women who survive a first primary breast cancer will subsequently develop a second primary cancer in the contralateral breast. The Women's Environment, Cancer, and Radiation Epidemiology Study was designed to identify genetic and environmental determinants of contralateral breast cancer (CBC). In...

journal_title：Cancer research

authors： Concannon P,Haile RW,Børresen-Dale AL,Rosenstein BS,Gatti RA,Teraoka SN,Diep TA,Jansen L,Atencio DP,Langholz B,Capanu M,Liang X,Begg CB,Thomas DC,Bernstein L,Olsen JH,Malone KE,Lynch CF,Anton-Culver H,Bernstein JL,

更新日期：2008-08-15 00:00:00

abstract：:We have recently found that human pancreatic adenocarcinomas exhibit strong immunostaining for the three mammalian transforming growth factor beta (TGF-beta) isoforms. These important growth-regulating polypeptides bind to a number of proteins, including the type I TGF-beta receptor (T beta R-I), type II TGF-beta rece...

journal_title：Cancer research

authors： Friess H,Yamanaka Y,Büchler M,Berger HG,Kobrin MS,Baldwin RL,Korc M

更新日期：1993-06-15 00:00:00

abstract：:Oncomir-1 is an oncogenic cluster of microRNAs (miRNA) located on chromosome 13. Previous in vitro studies showed that it is transcriptionally regulated by the transcription factor E2F3. In this report, we combine expression profiling of both mRNA and miRNAs in Wilms' tumor (WT) samples to provide the first evidence t...

journal_title：Cancer research

authors： Kort EJ,Farber L,Tretiakova M,Petillo D,Furge KA,Yang XJ,Cornelius A,Teh BT

更新日期：2008-06-01 00:00:00

abstract：:To evaluate the role of the human T-cell-specific tyrosine kinase lck (YT16), we measured the levels of lck expression in thymocytes, peripheral T-cells, and leukemia T-cell lines which are arrested at different stages of thymic differentiation. The results indicate that higher levels of the lck message can be found i...

journal_title：Cancer research

authors： Koga Y,Kimura N,Minowada J,Mak TW

更新日期：1988-02-15 00:00:00

abstract：:Problems in the radioimmunodetection of cancer typically involve small lesions having low object contrast. As such, the imaging device utilized must have a high spatial resolution as well as high detection efficiency. In addition, the imaging device must be interfaced to a computer system to allow data manipulation to...

journal_title：Cancer research

authors： Rollo FD,Patton JA

更新日期：1980-08-01 00:00:00

abstract：:Growth rates of 7,12-dimethylbenz(a)anthracene-induced mammary tumors and the specific 125I-labeled prolactin binding to membrane fractions prepared from livers and tumors were studied in rats made diabetic by streptozotocin injection. Growth was inhibited in a majority of tumors and prolactin binding was reduced in b...

journal_title：Cancer research

authors： Smith RD,Hilf R,Senior AE

更新日期：1977-11-01 00:00:00

abstract：:The Aurora-A/STK15 gene encodes a kinase that is frequently amplified in cancer. Overexpression of Aurora-A in mammalian cells leads to centrosome amplification, genetic instability, and transformation. In this study, we show that Aurora-A activates nuclear factor-kappaB (NF-kappaB) via IkappaBalpha phosphorylation. I...

journal_title：Cancer research

authors： Briassouli P,Chan F,Savage K,Reis-Filho JS,Linardopoulos S

更新日期：2007-02-15 00:00:00

abstract：:The acute hemorrhagic necrosis of tumor nodules caused by the systemic administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) has been partially attributed to changes in tumor neovascularity. In this study, the effects of rhTNF-alpha were tested on primary autochthonous sarcomas induced in C57BL...

journal_title：Cancer research

authors： McIntosh JK,Mulé JJ,Travis WD,Rosenberg SA

更新日期：1990-04-15 00:00:00

abstract：:The metabolism of the rat esophageal carcinogen N-nitrosomethylbenzylamine (NMBzA) was studied using microsomes prepared from liver and esophageal mucosa of untreated male Sprague-Dawley rats. NMBzA was extensively metabolized to benzaldehyde, benzyl alcohol, and formaldehyde by hepatic microsomes. The rate of metabol...

journal_title：Cancer research

authors： Labuc GE,Archer MC

更新日期：1982-08-01 00:00:00

abstract：:EphA2 receptor tyrosine kinase is frequently overexpressed in different human cancers, suggesting that it may promote tumor development and progression. However, evidence also exists that EphA2 may possess antitumorigenic properties, raising a critical question on the role of EphA2 kinase in tumorigenesis in vivo. We ...

journal_title：Cancer research

authors： Guo H,Miao H,Gerber L,Singh J,Denning MF,Gilliam AC,Wang B

更新日期：2006-07-15 00:00:00

abstract：:A large number of poor prognosis neuroblastoma (NB) tumors constitutively express brain-derived neurotrophic factor (BDNF) and variably express the gene for its tyrosine kinase (Trk) receptor TrkB. Good prognosis NB tumors typically express high levels of TrkA mRNA, which encodes the signal transducing receptor for ne...

journal_title：Cancer research

authors： Matsumoto K,Wada RK,Yamashiro JM,Kaplan DR,Thiele CJ

更新日期：1995-04-15 00:00:00

abstract：:DNA topoisomerase I (topo I) has been identified as a principal target of a plant alkaloid camptothecin (CPT) and its derivative (CPT-11). The latter compound is expected to be a clinically useful antitumor agent. Three human tumor cell lines resistant to CPT (A549/CPT, HT-29/CPT, St-4/CPT) were isolated in vitro, and...

journal_title：Cancer research

authors： Sugimoto Y,Tsukahara S,Oh-hara T,Isoe T,Tsuruo T

更新日期：1990-11-01 00:00:00

abstract：:Adenylate cyclase responses to pituitary hormones including adrenocorticotropic hormone (ACTH), biogenetic amines, prostaglandin E1 (PGE1), angiotensin II, and glucagon were evaluated in adrenocortical tumors and hyperplastic adrenal tissues, obtained from patients with Cushing's syndrome at surgery, and in normal adr...

journal_title：Cancer research

authors： Matsukura S,Kakita T,Sueoka S,Yoshimi H,Hirata Y,Yokota M,Fujita T

更新日期：1980-10-01 00:00:00

abstract：:Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

journal_title：Cancer research

authors： Winkelhake JL,Elcombe BM,Hodach A

更新日期：1979-08-01 00:00:00

abstract：:Fluorescent-labeled hormones can be used to study hormone-receptor interactions by means of fluorescence polarization, visualization by fluorescence microscopy, or separation methods, e.g., dextran-coated charcoal. Subcellular fragments, single cells, and tissue preparations are amenable to study; in this work rat ute...

journal_title：Cancer research

authors： Dandliker WB,Brawn RJ,Hsu ML,Brawn PN,Levin J,Meyers CY,Kolb VM

更新日期：1978-11-01 00:00:00

abstract：:The effect of pretreatment with L-asparaginase on the cytotoxicity of methotrexate (MTX) was studied in L5178Y murine leukemic cells and L-929 cells grown in vitro. The results were correlated with the effects of L-asparaginase on DNA synthesis. At low concentrations of the enzyme, pretreatment of cells enhanced the e...

journal_title：Cancer research

authors： Chlopkiewicz B,Koziorowska J

更新日期：1975-06-01 00:00:00

abstract：:In vitro maturation was induced with 12-O-tetradecanoylphorbol-13-acetate in leukemic cell samples from patients with chronic lymphocytic leukemia (n = 10) and prolymphocytic leukemia (n = 4). The cells were studied for morphology, for immunological markers using the fluorescence activated cell sorter, and for acid ph...

journal_title：Cancer research

authors： Ziegler-Heitbrock HW,Munker R,Dörken B,Gaedicke G,Thiel E

更新日期：1986-04-01 00:00:00

abstract：:Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell-killing can produce a potent costimulatory danger signal and release of tumor epitopes fo...

journal_title：Cancer research

authors： Cerullo V,Pesonen S,Diaconu I,Escutenaire S,Arstila PT,Ugolini M,Nokisalmi P,Raki M,Laasonen L,Särkioja M,Rajecki M,Kangasniemi L,Guse K,Helminen A,Ahtiainen L,Ristimäki A,Räisänen-Sokolowski A,Haavisto E,Oksanen M,

更新日期：2010-06-01 00:00:00

abstract：:A novel chromosomal translocation, t(2;11)(q31;p15), was identified in a patient with therapy-related acute myelogenous leukemia (t-AML). Fluorescence in situ hybridization experiments mapped the breakpoint near NUP98; Southern blot analysis demonstrated that the nucleoporin gene NUP98 was disrupted by this translocat...

journal_title：Cancer research

authors： Raza-Egilmez SZ,Jani-Sait SN,Grossi M,Higgins MJ,Shows TB,Aplan PD

更新日期：1998-10-01 00:00:00

abstract：:We have established two new epithelial cell lines (NRP-152, NRP-154), with markedly different properties, from the dorsal-lateral prostate of Lobund/Wistar rats treated with N-methyl-N-nitrosourea and testosterone propionate. NRP-152 cells do not form tumors in athymic mice and retain many of the properties of normal ...

journal_title：Cancer research

authors： Danielpour D,Kadomatsu K,Anzano MA,Smith JM,Sporn MB

更新日期：1994-07-01 00:00:00

abstract：:A new type of monoclonal antibody (mAb)-based, highly specific phototherapy (photoimmunotherapy; PIT) that uses a near infrared (NIR) phthalocyanine dye, IRDye700DX (IR700) conjugated with a mAb, has recently been described. NIR light exposure leads to immediate, target-selective necrotic cell death in vitro. Detectin...

journal_title：Cancer research

authors： Nakajima T,Sano K,Mitsunaga M,Choyke PL,Kobayashi H

更新日期：2012-09-15 00:00:00