Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

abstract：:Prostate cancer is the most commonly diagnosed noncutaneous neoplasm and second most common cause of cancer-related mortality in western men. To investigate the mechanisms of prostate cancer development and progression, we did expression profiling of human prostate cancer and benign tissues. We show that the SOX4 is o...

journal_title：Cancer research

authors： Liu P,Ramachandran S,Ali Seyed M,Scharer CD,Laycock N,Dalton WB,Williams H,Karanam S,Datta MW,Jaye DL,Moreno CS

更新日期：2006-04-15 00:00:00

abstract：:The majority of colorectal cancers have lost/inactivated the p53 tumor suppressor gene. Using isogenic human colon cancer cells that differ only in their p53 status, we demonstrate that loss of p53 renders tumor cells relatively resistant to the topoisomerase I inhibitor, irinotecan. Whereas irinotecan-induced up-regu...

journal_title：Cancer research

authors： Ravi R,Jain AJ,Schulick RD,Pham V,Prouser TS,Allen H,Mayer EG,Yu H,Pardoll DM,Ashkenazi A,Bedi A

更新日期：2004-12-15 00:00:00

abstract：:Intracavitary instillation of radioantibodies has been proposed as therapy for anatomically confined malignant disease. To evaluate this therapeutic strategy, a monoclonal antibody reactive with human transferrin receptor (7D3) was evaluated for localization in a human malignant mesothelioma transplanted i.p. in athym...

journal_title：Cancer research

authors： Griffin TW,Collins J,Bokhari F,Stochl M,Brill AB,Ito T,Emond G,Sands H

更新日期：1990-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies human gastric carcinogenesis, though the contribution of EBV to such somatic methylation changes has n...

journal_title：Cancer research

authors： Matsusaka K,Kaneda A,Nagae G,Ushiku T,Kikuchi Y,Hino R,Uozaki H,Seto Y,Takada K,Aburatani H,Fukayama M

更新日期：2011-12-01 00:00:00

abstract：:mtCLIC/CLIC4 is a p53 and tumor necrosis factor alpha (TNFalpha) regulated intracellular chloride channel protein that localizes to cytoplasm and organelles and induces apoptosis when overexpressed in several cell types of mouse and human origin. CLIC4 is elevated during TNFalpha-induced apoptosis in human osteosarcom...

journal_title：Cancer research

authors： Suh KS,Mutoh M,Gerdes M,Crutchley JM,Mutoh T,Edwards LE,Dumont RA,Sodha P,Cheng C,Glick A,Yuspa SH

更新日期：2005-01-15 00:00:00

abstract：:The capacity of lymph nodes to eradicate cancer is a controversial issue. The purpose of this study was to determine the interplay between tumor growth and host resistance at early stages of lymph node metastasis. A metastasis model was made in the rat mesenteric lymph node, and migration of cancer cells was visualize...

journal_title：Cancer research

authors： Nagata H,Arai T,Soejima Y,Suzuki H,Ishii H,Hibi T

更新日期：2004-11-15 00:00:00

abstract：:Treatment of mice with the immunomodulator pyran copolymer inhibited leukemogenesis produced by Friend leukemia virus (FLV) complex, as evidenced by inhibition of the spleen focus-forming virus and lymphatic leukemia virus, as well as by a significant decrease in splenomegaly. In this report we present data suggesting...

journal_title：Cancer research

authors： Schuller GB,Morahan PS

更新日期：1977-11-01 00:00:00

abstract：:Protein synthesis is a vital cellular process that regulates growth and metabolism. It is controlled via signaling networks in response to environmental changes, including the presence of nutrients, mitogens, or starvation. The phosphorylation state of proteins involved in translation initiation is a limiting factor t...

journal_title：Cancer research

authors： Grzmil M,Hemmings BA

更新日期：2012-08-15 00:00:00

abstract：:Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested pa...

journal_title：Cancer research

authors： Sairenji T,Sullivan JL,Sakamoto K,Spiro RC,Katayama I,Humphreys RE

更新日期：1985-01-01 00:00:00

abstract：:Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44(+) subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. miR-708 w...

journal_title：Cancer research

authors： Saini S,Majid S,Shahryari V,Arora S,Yamamura S,Chang I,Zaman MS,Deng G,Tanaka Y,Dahiya R

更新日期：2012-07-15 00:00:00

abstract：:The radiation response of autochthonous tumors induced by s.c. injection of 3-methylcholanthrene in ICR/JCL mice was studied. The tumors were mostly fibrosarcomas and grew with an average volume-doubling time of 2.6 days, independently of the time tumor appearance or dose of the chemical used. The tumors were locally ...

journal_title：Cancer research

authors： Tanooka H,Hoshino H,Tanaka K,Nagase M

更新日期：1980-07-01 00:00:00

abstract：:MHC class I-restricted tumor antigen can be presented to CD8+ T cells by two distinct mechanisms. Direct presentation involves degradation of cytosolic proteins by the proteosome into peptides, transport of the peptides across the endoplasmic reticulum membrane, and expression of the MHC-peptide complex on the tumor c...

journal_title：Cancer research

authors： Guilloux Y,Bai XF,Liu X,Zheng P,Liu Y

更新日期：2001-02-01 00:00:00

abstract：:Chicken chondrocytes isolated from 11-day-old chicken vertebrate cartilage were transformed by Rous sarcoma virus ts LA24 of the Prague strain as well as by the wild-type Prague strain of Rous sarcoma virus. The morphology of chondrocytes transformed by Rous sarcoma virus ts LA 24 was dependent on the temperature, and...

journal_title：Cancer research

authors： Okayama M,Yoshimura M,Muto M,Chi J,Roth S,Kaji A

更新日期：1977-03-01 00:00:00

abstract：:Variation in colorectal cancer rates between countries and within ethnic groups upon migration and/or Westernization suggests a role for some aspects of Western lifestyle in the etiology of this disease. We conducted a population-based case-control study in the multiethnic population of Hawaii to evaluate associations...

journal_title：Cancer research

authors： Le Marchand L,Wilkens LR,Kolonel LN,Hankin JH,Lyu LC

更新日期：1997-11-01 00:00:00

abstract：:The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/...

journal_title：Cancer research

authors： Miller WR

更新日期：1976-02-01 00:00:00

abstract：:Despite our improved understanding of cancer, the 5-year survival rate for head and neck squamous cell carcinomas (HNSCC) patients remains relatively unchanged at 50% for the past three decades. HNSCCs often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important progno...

journal_title：Cancer research

authors： Patel V,Marsh CA,Dorsam RT,Mikelis CM,Masedunskas A,Amornphimoltham P,Nathan CA,Singh B,Weigert R,Molinolo AA,Gutkind JS

更新日期：2011-11-15 00:00:00

abstract：:We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX), the inhibition of DNA synthesis in L1210 murine leukemia cel...

journal_title：Cancer research

authors： Chang BK,Huang AT,Joines WT

更新日期：1980-04-01 00:00:00

abstract：:Partially purified preparations of mouse interferon, administered during the 2-day period following the administration of a toxic dose of 5-fluorouracil (FUra), yielded significant protection from mortality in BALB/c X DBA/2 F1 mice. Protection against FUra-induced toxicity was also observed when the interferon induce...

journal_title：Cancer research

authors： Stolfi RL,Martin DS,Sawyer RC,Spiegelman S

更新日期：1983-02-01 00:00:00

abstract：:Somatostatin receptors (SSTR) are highly expressed in well-differentiated neuroendocrine tumors (NET). Octreotide, an SSTR agonist, has been used to suppress the production of vasoactive hormones and relieve symptoms of hormone hypersecretion with functional NETs. In a clinical trial, an empiric dose of octreotide tre...

journal_title：Cancer research

authors： Heidari P,Wehrenberg-Klee E,Habibollahi P,Yokell D,Kulke M,Mahmood U

更新日期：2013-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers largely due to disseminated disease at the time of presentation. Here, we investigated the role and mechanism of action of the metastasis-associated protein anterior gradient 2 (AGR2) in the pathogenesis of pancreatic cancer. AGR2 was induc...

journal_title：Cancer research

authors： Dumartin L,Whiteman HJ,Weeks ME,Hariharan D,Dmitrovic B,Iacobuzio-Donahue CA,Brentnall TA,Bronner MP,Feakins RM,Timms JF,Brennan C,Lemoine NR,Crnogorac-Jurcevic T

更新日期：2011-11-15 00:00:00

abstract：:Using 21 microsatellite polymorphic markers spanning both p and q arms, we have performed detailed deletion mapping on chromosome 9 in 18 primary nasopharyngeal carcinomas. All 18 tumors were informative at multiple loci. Eleven of the 18 cases (61%) demonstrated allelic deletion of chromosome 9. Among these 11, 6 cas...

journal_title：Cancer research

authors： Huang DP,Lo KW,van Hasselt CA,Woo JK,Choi PH,Leung SF,Cheung ST,Cairns P,Sidransky D,Lee JC

更新日期：1994-08-01 00:00:00

abstract：:Nickel is a toxic, mutagenic, and carcinogenic metal of significant occupational and environmental concern. Although several cellular targets of nickel have been identified, considerable evidence suggests that it can act indirectly upon DNA by inducing the formation of oxidized purines or pyrimidines that constitute p...

journal_title：Cancer research

authors： Higinbotham KG,Rice JM,Diwan BA,Kasprzak KS,Reed CD,Perantoni AO

更新日期：1992-09-01 00:00:00

abstract：:The expression of human leukocyte antigen (HLA) class I alleles was analyzed in 65 renal cell carcinomas using one-dimensional isoelectric focusing. Normal organ tissue and peripheral blood lymphocytes were used as controls. The patients were serologically typed using the standard microcytotoxicity test. Forty-two pat...

journal_title：Cancer research

authors： Luboldt HJ,Kubens BS,Rübben H,Grosse-Wilde H

更新日期：1996-02-15 00:00:00

abstract：:Several responses of 10T 1/2 cells and of cells from strains transformed by X-irradiation or by methylcholanthrene exposure were examined. Malignant potential, as determined by the ability of the cells to initiate tumors in syngeneic hosts, either normal or rendered immunodeficient, varied by a factor of 10(6). The gr...

journal_title：Cancer research

authors： Hahn GM

更新日期：1980-10-01 00:00:00

abstract：:Although African-American (AA) patients with prostate cancer tend to develop greater therapeutic resistance and faster prostate cancer recurrence compared with Caucasian-American (CA) men, the molecular mechanisms of this racial prostate cancer disparity remain undefined. In this study, we provide the first comprehens...

journal_title：Cancer research

authors： Kumar R,Bhat TA,Walsh EM,Chaudhary AK,O'Malley J,Rhim JS,Wang J,Morrison CD,Attwood K,Bshara W,Mohler JL,Yadav N,Chandra D

更新日期：2019-04-01 00:00:00

abstract：:Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

journal_title：Cancer research

authors： Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

更新日期：1981-07-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:Two opposing clusters of transcription factors (TF) have been associated with the differential risks of estrogen receptor positive or negative breast cancers, but the mechanisms underlying the opposing functions of the two clusters are undefined. In this study, we identified NFIB and YBX1 as novel interactors of the e...

journal_title：Cancer research

authors： Campbell TM,Castro MAA,de Oliveira KG,Ponder BAJ,Meyer KB

更新日期：2018-01-15 00:00:00

abstract：:The receptor tyrosine kinase ErbB-2 plays an important role in the regulation of growth factor-induced signal transduction cascades in the epithelium, and ErbB-2 is frequently overexpressed in epithelial tumors. Our previous studies on clinical prostate cancer specimens indicated that ErbB-2 expression was increased i...

journal_title：Cancer research

authors： Casimiro M,Rodriguez O,Pootrakul L,Aventian M,Lushina N,Cromelin C,Ferzli G,Johnson K,Fricke S,Diba F,Kallakury B,Ohanyerenwa C,Chen M,Ostrowski M,Hung MC,Rabbani SA,Datar R,Cote R,Pestell R,Albanese C

更新日期：2007-05-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis of transformed and cancer cells but not of most normal cells. Recent studies have revealed an unforeseen toxicity of TRAIL toward normal human hepatocytes, thereby bringing into question the safety of systemic administrati...

journal_title：Cancer research

authors： Ozoren N,Kim K,Burns TF,Dicker DT,Moscioni AD,El-Deiry WS

更新日期：2000-11-15 00:00:00