Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

abstract：:Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for t...

journal_title：Cancer research

authors： Shibata T,Watari K,Izumi H,Kawahara A,Hattori S,Fukumitsu C,Murakami Y,Takahashi R,Toh U,Ito KI,Ohdo S,Tanaka M,Kage M,Kuwano M,Ono M

更新日期：2017-01-15 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association between single-nucleotide polymorphisms (SNP) in PI3K genes and prostate cancer. Pooled data f...

journal_title：Cancer research

authors： Koutros S,Schumacher FR,Hayes RB,Ma J,Huang WY,Albanes D,Canzian F,Chanock SJ,Crawford ED,Diver WR,Feigelson HS,Giovanucci E,Haiman CA,Henderson BE,Hunter DJ,Kaaks R,Kolonel LN,Kraft P,Le Marchand L,Riboli E,Siddi

更新日期：2010-03-15 00:00:00

abstract：:PTEN phosphatase is a potent tumor suppressor that regulates multiple cellular functions. In the cytoplasm, PTEN dephosphorylates its primary lipid substrate, phosphatidylinositol 3,4,5-trisphosphate, to antagonize the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway. It has also become increasingly evident ...

journal_title：Cancer research

authors： Gu T,Zhang Z,Wang J,Guo J,Shen WH,Yin Y

更新日期：2011-04-15 00:00:00

abstract：:We generated DNA expression vectors encoding the full-length neu cDNA (designated pNeuN), the neu extracellular domain (pNeuE), or the neu extracellular and transmembrane domains (pNeuTM). The 293 cells transfected with pNeuN or pNeuTM expressed the neu extracellular domain on the surface membrane, whereas 293 cells t...

journal_title：Cancer research

authors： Chen Y,Hu D,Eling DJ,Robbins J,Kipps TJ

更新日期：1998-05-01 00:00:00

abstract：:Meningiomas are rich in progestin receptors, whereas estrogen receptors (ER) are virtually undetectable. The present experiments were performed to evaluate whether the absence of ER from the majority of human meningioma cytosols can be attributed to: occurrence of only a small number of ER-positive cells in an otherwi...

journal_title：Cancer research

authors： Blankenstein MA,Berns PM,Blaauw G,Mulder E,Thijssen JH

更新日期：1986-08-01 00:00:00

abstract：:The distribution and localization of a glioma-associated antigen defined by monoclonal antibody 81C6 has been examined using human cultured cell lines and tissues. Monoclonal antibody 81C6 was selected from a hybridoma fusion of spleen cells of mice immunized with the glial fibrillary acidic protein-positive human gli...

journal_title：Cancer research

authors： Bourdon MA,Wikstrand CJ,Furthmayr H,Matthews TJ,Bigner DD

更新日期：1983-06-01 00:00:00

abstract：:Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), but the mechanism by ...

journal_title：Cancer research

authors： Wu X,Mondal G,Wang X,Wu J,Yang L,Pankratz VS,Rowley M,Couch FJ

更新日期：2009-07-01 00:00:00

abstract：:Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors of phosphatidylinositol-3-kinase. The 50% inhibitory concentration for inhibition by wortmannin is 2 to 4 nM. Kinetic analysis demonstrate...

journal_title：Cancer research

authors： Powis G,Bonjouklian R,Berggren MM,Gallegos A,Abraham R,Ashendel C,Zalkow L,Matter WF,Dodge J,Grindey G

更新日期：1994-05-01 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:In a study of human breast carcinomas in short-term organ culture, in which plasminogen activator modulation by estrogen was used as a test of estrogen sensitivity (R. Mira-y-Lopez and L. Ossowski, Cancer Res., 47: 3558-3564, 1987), we found that the number of estrogen and progesterone receptor-positive cancers showin...

journal_title：Cancer research

authors： Mira-y-Lopez R,Ossowski L

更新日期：1990-01-01 00:00:00

abstract：:Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair pathways, has been suggested to contribute to the pathogenicity of various human cancers, including gastric cancer. In this study, we addressed the prognostic and chemotherapeutic significance of RECQL4 in human gastric cancer, wh...

journal_title：Cancer research

authors： Mo D,Fang H,Niu K,Liu J,Wu M,Li S,Zhu T,Aleskandarany MA,Arora A,Lobo DN,Madhusudan S,Balajee AS,Chi Z,Zhao Y

更新日期：2016-05-15 00:00:00

abstract：:Human peripheral blood lymphocytes (PBL), obtained from patients with a variety of cancers, were incubated in vitro with phytohemagglutinin, concanavalin A, and crude or lectin-free T-cell growth factors. The lectin-activated PBL of nine patients were capable of lysing fresh autologous tumor during a 4-hr 51Cr release...

journal_title：Cancer research

authors： Mazumder A,Grimm EA,Zhang HZ,Rosenberg SA

更新日期：1982-03-01 00:00:00

abstract：:The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent carcinogen in adult laboratory rodents. Our previous studies have shown that NNK crosses the placenta in pregnant hamsters and is metabolized into DNA-methylating and clastogenic intermediates by fetal respiratory tract t...

journal_title：Cancer research

authors： Correa E,Joshi PA,Castonguay A,Schüller HM

更新日期：1990-06-01 00:00:00

abstract：:Apoptosis is a critical early cellular event in the development of polycystic kidney disease (PKD) in humans and mice. In the SBM transgenic model of PKD, both apoptosis and proliferation are c-myc driven and are independent of p53 and Bcl-2 pathways. On the basis of recent evidence implicating the FasL/Fas pathway in...

journal_title：Cancer research

authors： Couillard M,Guillaume R,Tanji N,D'Agati V,Trudel M

更新日期：2002-04-15 00:00:00

abstract：:Somatic copy number variations (CNV) may drive cancer progression through both coding and noncoding transcripts. However, noncoding transcripts resulting from CNV are largely unknown, especially for circular RNAs. By integrating bioinformatics analyses of alerted circRNAs and focal CNV in lung adenocarcinoma, we ident...

journal_title：Cancer research

authors： Qiu M,Xia W,Chen R,Wang S,Xu Y,Ma Z,Xu W,Zhang E,Wang J,Fang T,Hu J,Dong G,Yin R,Wang J,Xu L

更新日期：2018-06-01 00:00:00

abstract：:A simple method is described for quantitating pulmonary metastases in C57BL/6J mice implanted with the Lewis T241 fibrosarcoma. Lungs were removed from tumor-bearing mice, homogenized, and diluted to 14 ml with supplemented Roswell Park Memorial Institute Tissue Culture Medium 1640 (+5% fetal calf serum). Twenty-five ...

journal_title：Cancer research

authors： Jones CE,Lee CT,Deodhar SD

更新日期：1983-12-01 00:00:00

abstract：:Transcriptional regulator YAP is activated in multiple human cancers and plays critical roles in tumor initiation, progression, metastasis, and drug resistance. However, therapeutic targeting of the Hippo-YAP pathway has been challenging due to its low druggability and limited knowledge of YAP regulation in cancer. He...

journal_title：Cancer research

authors： Seo J,Kim MH,Hong H,Cho H,Park S,Kim SK,Kim J

更新日期：2019-12-15 00:00:00

abstract：:The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bear...

journal_title：Cancer research

authors： Barbazán J,Alonso-Alconada L,Elkhatib N,Geraldo S,Gurchenkov V,Glentis A,van Niel G,Palmulli R,Fernández B,Viaño P,Garcia-Caballero T,López-López R,Abal M,Vignjevic DM

更新日期：2017-07-01 00:00:00

abstract：:The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP). Coexpression of MT1-MMP with lumican in HEK293T cells reduced the concentration of lumican secreted in...

journal_title：Cancer research

authors： Li Y,Aoki T,Mori Y,Ahmad M,Miyamori H,Takino T,Sato H

更新日期：2004-10-01 00:00:00

abstract：:Two populations of nuclear androgen receptors have been characterized in human prostatic tissue, and the levels and proportions of each were found to differ in normal prostates, benign hyperplastic prostates (BPH), and malignant prostates. A significant percentage (35 to 50%) of total nuclear androgen receptors was as...

journal_title：Cancer research

authors： Barrack ER,Bujnovszky P,Walsh PC

更新日期：1983-03-01 00:00:00

abstract：:Development of novel approaches for quantitative analysis of gene expression in intact tumor cells should provide new means for cancer detection and for studying the response of cancer cells to biological and therapeutic reagents. We developed procedures for detecting the levels of expression of multiple genes in fixe...

journal_title：Cancer research

authors： Peng XH,Cao ZH,Xia JT,Carlson GW,Lewis MM,Wood WC,Yang L

更新日期：2005-03-01 00:00:00

abstract：:The ability of culture dishes coated with an extracellular matrix (ECM) to act as a suitable substrate for human ovarian carcinoma cells in vitro has been examined. The plating efficiency on ECM was 30 to 80% (dispersed tumor cells from solid tumor tissue and effusions) with active proliferation of tumor cells being o...

journal_title：Cancer research

authors： Crickard K,Crickard U,Yoonessi M

更新日期：1983-06-01 00:00:00

abstract：:The level of steroid receptors in target cells affects the responsiveness of the cell to the hormone. In mouse AtT-20 cells, it has been shown that chronic glucocorticoid treatment causes a down-regulation of glucocorticoid receptor (GR) levels (F. Svec and M. Rudis, J. Biol. Chem., 256:5984-5987, 1981). The current s...

journal_title：Cancer research

authors： Vedeckis WV,Ali M,Allen HR

更新日期：1989-04-15 00:00:00

abstract：:Small hydrophobic peptides were studied as possible substrates of the multidrug resistance protein (MRP)-1 (ABCC1) transmembrane transporter molecule. As observed earlier for P-glycoprotein- (Pgp; ABCB1) overexpressing cells, MRP1-overexpressing cells, including cells stably transfected with the MRP1 cDNA, showed dist...

journal_title：Cancer research

authors： de Jong MC,Slootstra JW,Scheffer GL,Schroeijers AB,Puijk WC,Dinkelberg R,Kool M,Broxterman HJ,Meloen RH,Scheper RJ

更新日期：2001-03-15 00:00:00

abstract：:DAB389 GRP is composed of the catalytic and transmembrane domains of diphtheria toxin fused to gastrin-releasing peptide (GRP). DAB389 GRP is selectively targeted to, and inhibits protein synthesis in, cell lines expressing GRP receptors. Protein synthesis in 5'ET4 cells (BALB/3T3 fibroblasts transfected with the gene...

journal_title：Cancer research

authors： vanderSpek JC,Sutherland JA,Zeng H,Battey JF,Jensen RT,Murphy JR

更新日期：1997-01-15 00:00:00

abstract：:The nevoid basal cell carcinoma (Gorlin) syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple developmental defects and cancer susceptibility. NBCCS is caused by mutations in the human homologue (PTCH) of the Drosophila patched gene, a developmental regulator implicated in signaling of hedgehog...

journal_title：Cancer research

authors： Vorechovský I,Undén AB,Sandstedt B,Toftgård R,Ståhle-Bäckdahl M

更新日期：1997-11-01 00:00:00

abstract：:Aromatase plays a critical role in breast cancer development by converting androgen to estrogen. In this report, results are presented to demonstrate that estrogen, the product of aromatase, can up-regulate its expression. Estrogen receptor (ER) transient transfection experiments were performed using the SK-BR-3 breas...

journal_title：Cancer research

authors： Kinoshita Y,Chen S

更新日期：2003-07-01 00:00:00

abstract：:XRCC1 is a key component of DNA base excision repair, single strand break repair, and backup nonhomologous end-joining pathway. XRCC1 (X-ray repair cross-complementing gene 1) deficiency promotes genomic instability, increases cancer risk, and may have clinical application in breast cancer. We investigated XRCC1 expre...

journal_title：Cancer research

authors： Sultana R,Abdel-Fatah T,Abbotts R,Hawkes C,Albarakati N,Seedhouse C,Ball G,Chan S,Rakha EA,Ellis IO,Madhusudan S

更新日期：2013-03-01 00:00:00

abstract：:Published studies of the cancer experiences of children vaccinated with Bacillus Calmette-Guérin in antituberculosis programs were reviewed and the strengths and weaknesses of each evaluated. There is little evidence that vaccination outside of the neonatal period is effective. If there is an effect of neonatal vaccin...

journal_title：Cancer research

authors： Hoover RN

更新日期：1976-02-01 00:00:00

abstract：:The major heat shock protein Hsp72 is constitutively expressed in many tumor cell lines and biopsies, and its expression correlates with poor prognosis in several types of cancer. Hsp72 was suggested to play an important role in neoplastic transformation and tumor development. We addressed the role of Hsp72 in cancer ...

journal_title：Cancer research

authors： Yaglom JA,Gabai VL,Sherman MY

更新日期：2007-03-01 00:00:00