Abstract:
:Defects in cell cycle control and increased genomic instability, including gene amplification, often occur during cancer development. Cyclin D1 plays a pivotal role in G1, and this gene is frequently amplified and overexpressed in several types of human cancer. This study demonstrates that ectopic overexpression of cyclin D1 in a rat liver epithelial cell line markedly increased the yield of cells containing amplified copies of the CAD gene. This effect was associated with a loss of G1-S checkpoint control, although the cyclin D1-overexpressing cells had a normal p53 gene. The capacity of cyclin D1 to enhance gene amplification may contribute to the process of genomic instability during tumor development.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Zhou P,Jiang W,Weghorst CM,Weinstein IBsubject
Has Abstractpub_date
1996-01-01 00:00:00pages
36-9issue
1eissn
0008-5472issn
1538-7445journal_volume
56pub_type
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