Abstract：
:The interleukin-11 receptor alpha (IL-11Ralpha) is a functional target in bone metastasis. However, its role in primary bone tumors has not been established. As such, here, we evaluated IL-11Ralpha as a candidate target in primary and metastatic human osteosarcoma. First, in an orthotopic mouse model, we showed that IL-11Ralpha protein is markedly expressed in primary osseus and pulmonary metastatic osteosarcoma but absent from control normal tibia and lung. Moreover, systemic administration of an IL-11Ralpha-targeting phage displaying the cyclic nonapeptide CGRRAGGSC resulted in strong and selective accumulation of IL-11Ralpha-homing phage particles in the osteosarcoma but not in several control organs. Finally, IL-11Ralpha expression in a large panel of human primary and metastatic osteosarcoma samples was remarkably consistent with the observations in the orthotopic mouse model. These data establish IL-11Ralpha as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Lewis VO,Ozawa MG,Deavers MT,Wang G,Shintani T,Arap W,Pasqualini Rdoi
10.1158/0008-5472.CAN-08-4845subject
Has Abstractpub_date
2009-03-01 00:00:00pages
1995-9issue
5eissn
0008-5472issn
1538-7445pii
0008-5472.CAN-08-4845journal_volume
69pub_type
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