IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma.

abstract：:Cancer cells with germline deleterious mutations of BRCA1 or BRCA2 are deficient in homologous recombination repair and therefore sensitive to PARP inhibitor treatment. However, wild-type BRCA1/2-expressing cells with defects in other DNA damage repair pathway components may also exhibit "BRCAness," which in combinati...

journal_title：Cancer research

authors： Cai C

更新日期：2020-07-15 00:00:00

abstract：:Membrane-bound complement inhibitors protect host cells from inadvertent complement attack, and complement inhibitors are often up-regulated on tumors, possibly representing a selective adaptation by tumors to escape elimination by a host antitumor immune response. Relevant in vivo studies using rodent models of human...

journal_title：Cancer research

authors： Caragine TA,Okada N,Frey AB,Tomlinson S

更新日期：2002-02-15 00:00:00

abstract：:An immunosuppressive peptide fraction was isolated by means of gel filtration, membrane partition, and ion-exchange chromatography from the sera of patients hospitalized for cancer. The resulting peptide fraction, which was heterogeneous as judged by high-voltage electrophoresis, was found to suppress both phytohemagg...

journal_title：Cancer research

authors： Nimberg RB,Glasgow AH,Menzoian JO,Constantian MB,Cooperband SR,Mannick JA,Schmid K

更新日期：1975-06-01 00:00:00

abstract：:Modern cancer therapy/care involves the integration of basic, clinical, and population-based research professionals using state-of-the-art science to achieve the best possible patient outcomes. A well-integrated team of basic, clinical, and population science professionals and educators working with a fully engaged gr...

journal_title：Cancer research

authors： Welch DR,Antalis TM,Burnstein K,Vona-Davis L,Jensen RA,Nakshatri H,Riegel AT,Spitz DR,Watson DK,Weiner GJ,Cancer Biology Training Consortium.

更新日期：2015-12-15 00:00:00

abstract：:S49 cyc- lymphoma cells contain a mutation resulting in loss of a functional guanine nucleotide regulatory protein rendering their adenylate cyclase refractory to most stimuli. S49 wild-type and cyc- clones were used in the present study to investigate the possible association of altered cAMP metabolism with tumorigen...

journal_title：Cancer research

authors： Stadel JM,Johnson RK,Mirabelli CK,Powers DA,Sung CM,Faucette LF,McCabe FL,Crooke ST

更新日期：1988-02-01 00:00:00

abstract：:Activation of activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB)-dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFkappaB activation by intera...

journal_title：Cancer research

authors： Matthews CP,Birkholz AM,Baker AR,Perella CM,Beck GR Jr,Young MR,Colburn NH

更新日期：2007-03-15 00:00:00

abstract：:Abnormalities of chromosome 1, including trisomy for all or a portion of the long arm, have been frequently reported in many cancers. Anomalies of chromosome 19 are far less common, although a t(1;19)(q23;p13) translocation has been reported in association with pre-B-cell leukemia. We have observed a t(1;19)(q12;p13) ...

journal_title：Cancer research

authors： Parmiter AH,Balaban G,Herlyn M,Clark WH Jr,Nowell PC

更新日期：1986-03-01 00:00:00

abstract：:The unresponsiveness of metastatic melanoma to conventional chemotherapeutic and biological agents is largely due to the development of resistance to apoptosis. Pyrimethamine belongs to the group of antifolate drugs, and in addition to antiprotozoan effects, it exerts a strong proapoptotic activity, which we recently ...

journal_title：Cancer research

authors： Giammarioli AM,Maselli A,Casagrande A,Gambardella L,Gallina A,Spada M,Giovannetti A,Proietti E,Malorni W,Pierdominici M

更新日期：2008-07-01 00:00:00

abstract：:We have previously reported that several biological agents, when given simultaneously with cytosine arabinoside or cytoxan, will protect from cytosine arabinoside-induced but not from cytoxan-induced alopecia. In the present study we used the secosteroid 1,25-dihydroxyvitamin D3 in a different timing schedule to prote...

journal_title：Cancer research

authors： Jimenez JJ,Yunis AA

更新日期：1992-09-15 00:00:00

abstract：:Triple-negative breast cancers (TNBC) are highly aggressive, lack FDA-approved targeted therapies, and frequently recur, making the discovery of novel therapeutic targets for this disease imperative. Our previous analysis of the molecular mechanisms of action of bromodomain and extraterminal protein inhibitors (BETi) ...

journal_title：Cancer research

authors： Sahni JM,Gayle SS,Webb BM,Weber-Bonk KL,Seachrist DD,Singh S,Sizemore ST,Restrepo NA,Bebek G,Scacheri PC,Varadan V,Summers MK,Keri RA

更新日期：2017-10-01 00:00:00

abstract：:We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG-72) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases using monoclonal antibodies (MAbs) B72.3, CC-49, and CC-83, which recognize distinct carbohydrate antigenic de...

journal_title：Cancer research

authors： Muraro R,Frati L,Bei R,Ficari F,Valli C,French D,Mammarella S,Caramia F,Fegiz G,Mariani-Costantini R

更新日期：1991-10-01 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:Sequence alterations of mitotic checkpoint genes, hBUB1 and hBUBR1, were examined, and their gene transcripts were quantified using on-line, real-time quantitative reverse transcription-PCR in surgically resected human colorectal cancers and their neighboring normal tissues. Our results reveal a new hBUB1 missense mut...

journal_title：Cancer research

authors： Shichiri M,Yoshinaga K,Hisatomi H,Sugihara K,Hirata Y

更新日期：2002-01-01 00:00:00

abstract：:We report that tumor necrosis factor (TNF) alpha induced a strong antitumor immune reaction when it was produced in arteries leading to tumors by gene transfer in vivo. We used a mouse model carrying a sarcoma-180 tumor in the right footpad and injected the fusogenic liposomes encapsulating the human TNF-alpha gene in...

journal_title：Cancer research

authors： Mizuguchi H,Nakagawa T,Toyosawa S,Nakanishi M,Imazu S,Nakanishi T,Tsutsumi Y,Nakagawa S,Hayakawa T,Ijuhin N,Mayumi T

更新日期：1998-12-15 00:00:00

abstract：:Antibodies were produced against 220,000-molecular-weight proteins of Syrian hamster embryo cells. The antiserum containing these antibodies is capable of immunologically staining the surfaces and a fibrillar network around untransformed Syrian hamster embryo cells. The staining is removed by adsorption of the antiser...

journal_title：Cancer research

authors： Clarke SM,Fink LM

更新日期：1977-09-01 00:00:00

abstract：:The tumor suppressor protein BRCA1 localizes to sites of DNA double-strand breaks (DSB), promoting repair by homologous recombination through the recruitment of DNA damage repair proteins. In normal cells, homologous recombination largely depends on BRCA1. However, assembly of the pivotal homologous recombination regu...

journal_title：Cancer research

authors： Nakada S,Yonamine RM,Matsuo K

更新日期：2012-10-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAID) are effective in suppressing the formation of colorectal tumors. However, the mechanisms underlying the antineoplastic effects of NSAIDs remain unclear. The effects of NSAIDs are incomplete, and resistance to NSAIDs is often developed. Growing evidence has indicated that th...

journal_title：Cancer research

authors： Bank A,Wang P,Du C,Yu J,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with breast cancer. It is well recognized that BP reduces osteolysis by promoting apoptosis in osteoclasts. However, recent animal and human data suggest that BPs not on...

journal_title：Cancer research

authors： Hiraga T,Williams PJ,Mundy GR,Yoneda T

更新日期：2001-06-01 00:00:00

abstract：:Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitigated and uncertain. Here, we report that PACE4 pre-mRNA undergoes DNA...

journal_title：Cancer research

authors： Couture F,Sabbagh R,Kwiatkowska A,Desjardins R,Guay SP,Bouchard L,Day R

更新日期：2017-12-15 00:00:00

abstract：:We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated with clinical parameters relevant to tumor metastasis, and we report here on the identification of N-myc downstream regulated gene 2...

journal_title：Cancer research

authors： Lee DC,Kang YK,Kim WH,Jang YJ,Kim DJ,Park IY,Sohn BH,Sohn HA,Lee HG,Lim JS,Kim JW,Song EY,Kim DM,Lee MN,Oh GT,Kim SJ,Park KC,Yoo HS,Choi JY,Yeom YI

更新日期：2008-06-01 00:00:00

abstract：:A potential tumor suppressor gene, STK11 , encoding a serine threonine kinase, has recently been identified on chromosome 19p13. Germ-line mutations of this gene have been found in patients with Peutz-Jeghers syndrome (PJS). To further investigate the relevance of STK11 mutations in PJS, we analyzed its coding sequenc...

journal_title：Cancer research

authors： Resta N,Simone C,Mareni C,Montera M,Gentile M,Susca F,Gristina R,Pozzi S,Bertario L,Bufo P,Carlomagno N,Ingrosso M,Rossini FP,Tenconi R,Guanti G

更新日期：1998-11-01 00:00:00

abstract：:Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may be correlated with tumor progression and/or poor clinical outcome. Therefore, neoplasias potentially sensitive to immunotherapy should be checked for their IL-15 expres...

journal_title：Cancer research

authors： Khawam K,Giron-Michel J,Gu Y,Perier A,Giuliani M,Caignard A,Devocelle A,Ferrini S,Fabbi M,Charpentier B,Ludwig A,Chouaib S,Azzarone B,Eid P

更新日期：2009-02-15 00:00:00

abstract：:Noninvasive imaging techniques to image and characterize delivery and transport of macromolecules through the extracellular matrix (ECM) and supporting stroma of a tumor are necessary to develop treatments that alter the porosity and integrity of the ECM for improved delivery of therapeutic agents and to understand fa...

journal_title：Cancer research

authors： Pathak AP,Artemov D,Ward BD,Jackson DG,Neeman M,Bhujwalla ZM

更新日期：2005-02-15 00:00:00

abstract：:The Na+/I- symporter (NIS) present in the membranes of thyroid cells is responsible for the capacity of the thyroid to concentrate iodide. This allows treatment of thyroid cancers with 131I. We propose to enlarge this therapeutic strategy to nonthyroid tumors by using an adenoviral vector to deliver the NIS gene into ...

journal_title：Cancer research

authors： Boland A,Ricard M,Opolon P,Bidart JM,Yeh P,Filetti S,Schlumberger M,Perricaudet M

更新日期：2000-07-01 00:00:00

abstract：:Anti-idiotype monoclonal antibodies (Mabs) to mLL2, an anti-B-cell lymphoma and CD22-specific murine IgG2a-kappa Mab, were generated by hybridoma technology from splenocytes of Copenhagen rats immunized with mLL2 F(ab')2. Mab WN, an IgG2a-kappa, was selected based on its specific binding to mLL2 and not other IgG isot...

journal_title：Cancer research

authors： Losman MJ,Leung SO,Shih LB,Shevitz J,Shukla R,Haraga L,Goldenberg DM,Hansen HJ

更新日期：1995-12-01 00:00:00

abstract：:In this study, the mitochondrial phototoxicity of the cationic rhodacyanine MKT-077 was investigated by comparing its effects on the inhibition of mitochondrial respiration and the structural integrity of mitochondrial DNA (mtDNA) in the presence and absence of added high-intensity visible light (7.5 J/cm2). Results i...

journal_title：Cancer research

authors： Modica-Napolitano JS,Brunelli BT,Koya K,Chen LB

更新日期：1998-01-01 00:00:00

abstract：:Radiation exposure is related to risk of numerous types of cancer, but relatively little is known about its effect on risk of multiple primary cancers. Using follow-up data through 2002 from 77,752 Japanese atomic bomb survivors, we identified 14,048 participants diagnosed with a first primary cancer, of whom 1,088 we...

journal_title：Cancer research

authors： Li CI,Nishi N,McDougall JA,Semmens EO,Sugiyama H,Soda M,Sakata R,Hayashi M,Kasagi F,Suyama A,Mabuchi K,Davis S,Kodama K,Kopecky KJ

更新日期：2010-09-15 00:00:00

abstract：:The production of CD73-derived adenosine (Ado) by Tregs has been proposed as a resistance mechanism to anti-PD-1 therapy in murine tumor models. We reported that human Tregs express the ectonucleotidase CD39, which generates AMP from ATP, but do not express the AMPase CD73. In contrast, CD73 defined a subset of effect...

journal_title：Cancer research

authors： Gourdin N,Bossennec M,Rodriguez C,Vigano S,Machon C,Jandus C,Bauché D,Faget J,Durand I,Chopin N,Tredan O,Marie JC,Dubois B,Guitton J,Romero P,Caux C,Ménétrier-Caux C

更新日期：2018-07-01 00:00:00

abstract：:Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A ...

journal_title：Cancer research

authors： Al Absi A,Wurzer H,Guerin C,Hoffmann C,Moreau F,Mao X,Brown-Clay J,Petrolli R,Casellas CP,Dieterle M,Thiery JP,Chouaib S,Berchem G,Janji B,Thomas C

更新日期：2018-10-01 00:00:00

abstract：:HER-2/neu protooncogene amplification and protein expression were analyzed with slot blot and Western blot techniques, respectively, in more than 300 invasive primary breast tumors of all stages. Amplification (2- greater than 30 copies) was found in 17% of these tumors and high expression was seen in 19%. There was a...

journal_title：Cancer research

authors： Borg A,Tandon AK,Sigurdsson H,Clark GM,Fernö M,Fuqua SA,Killander D,McGuire WL

更新日期：1990-07-15 00:00:00