Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3.

abstract：:Interleukin-6 (IL-6) and the subsequent Janus-activated kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of multiple myeloma. Here, we compared the sensitivity and specificity of a novel pan-JAK inhibitor, tetracyclic pyridone 6 (P6), with that of AG490 in a panel of myeloma-derived c...

journal_title：Cancer research

authors： Pedranzini L,Dechow T,Berishaj M,Comenzo R,Zhou P,Azare J,Bornmann W,Bromberg J

更新日期：2006-10-01 00:00:00

abstract：:The induction of phase 2 detoxifying enzymes, such as UDP-glucuronosyltransferases (UGTs), in response to an array of naturally occurring and synthetic agents, such as oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione), provides an effective means of protection against a variety of carcinogens. Transcription fa...

journal_title：Cancer research

authors： Iida K,Itoh K,Kumagai Y,Oyasu R,Hattori K,Kawai K,Shimazui T,Akaza H,Yamamoto M

更新日期：2004-09-15 00:00:00

abstract：:The uptake of m-[125I]iodobenzylguanidine (mIBG), a compound structurally analogous to the antihypertensive drug guanethidine, was examined in various human cell lines. Of three neuroblastoma lines, SK-N-LO, IMR-32, and SK-N-SH, only the last showed specific uptake of the compound. In contrast, only a nonspecific upta...

journal_title：Cancer research

authors： Buck J,Bruchelt G,Girgert R,Treuner J,Niethammer D

更新日期：1985-12-01 00:00:00

abstract：:Chemotherapy with 4'-O-tetrahydropyranyladriamycin (THP-ADM), a new derivative of Adriamycin, was equally or more effective against several experimental mouse tumors than it was with Adriamycin (ADM). When mice with P388 leukemia were given i.p. injections of THP-ADM or ADM daily for 9 consecutive days, the maximum in...

journal_title：Cancer research

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1982-04-01 00:00:00

abstract：:L-Histidinol, an analogue of the amino acid L-histidine, has been reported to be able to increase the specificity of 5-fluorouracil (FUra), through both protection of normal tissues at risk and potentiation of leukemic cell killing. It is postulated that this occurs through prevention of the entry of normal cells into...

journal_title：Cancer research

authors： Edelstein MB,Heilbrun LK

更新日期：1988-03-15 00:00:00

abstract：:We have examined the time course and patterns of covalent aflatoxin B1:DNA adducts produced within the ribosomal RNA gene sequences isolated from the liver nuclear DNA of aflatoxin B1-treated animals. Liver nuclear DNA was initially enriched in ribosomal DNA by cesium salt density centrifugation, and incubated under a...

journal_title：Cancer research

authors： Irvin TR,Wogan GN

更新日期：1985-08-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infi...

journal_title：Cancer research

authors： Marsh T,Wong I,Sceneay J,Barakat A,Qin Y,Sjödin A,Alspach E,Nilsson B,Stewart SA,McAllister SS

更新日期：2016-05-15 00:00:00

abstract：:Tumor-associated macrophages (TAM) are a major inflammatory infiltrate in tumors and a major component of the protumor function of inflammation. TAM in established tumors generally have an M2 phenotype with defective production of interleukin-12 (IL-12) and high IL-10. Here, we report that defective responsiveness of ...

journal_title：Cancer research

authors： Saccani A,Schioppa T,Porta C,Biswas SK,Nebuloni M,Vago L,Bottazzi B,Colombo MP,Mantovani A,Sica A

更新日期：2006-12-01 00:00:00

abstract：:We have recently reported that apoptosis of T cells induced by squamous cell carcinoma of the head and neck (SCCHN) is partly Fas dependent. This tumor-induced T-cell death is mediated by the activities of caspase-8 and caspase-3 and is partially inhibited by antibodies to either Fas or Fas ligand. We report here that...

journal_title：Cancer research

authors： Gastman BR,Yin XM,Johnson DE,Wieckowski E,Wang GQ,Watkins SC,Rabinowich H

更新日期：2000-12-15 00:00:00

abstract：:Inflammation affects tumor immune surveillance and resistance to therapy. Here, we show that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells. IL1β production is triggered by cancer cell membrane-derived TGFβ. Neutralizing TG...

journal_title：Cancer research

authors： Wu TC,Xu K,Martinek J,Young RR,Banchereau R,George J,Turner J,Kim KI,Zurawski S,Wang X,Blankenship D,Brookes HM,Marches F,Obermoser G,Lavecchio E,Levin MK,Bae S,Chung CH,Smith JL,Cepika AM,Oxley KL,Snipes GJ,B

更新日期：2018-09-15 00:00:00

abstract：:The present work is a continuation of our studies to improve the graft versus leukemia (GVL) effect in autologous bone marrow transplantation. We have recently shown that the GVL effect of bone marrow transplantation (BMT) with interleukin 2 (IL-2)-activated bone marrow (ABM) followed by IL-2 therapy immediately after...

journal_title：Cancer research

authors： Charak BS,Brynes RK,Katsuda S,Groshen S,Chen SC,Mazumder A

更新日期：1991-04-15 00:00:00

abstract：:The basal layer of the epidermis and hair follicles is composed of actively cycling, transit-amplifying cells and quiescent cells including stem cells. To determine which population is the target of carcinogenic chemicals, we treated CD-1 female mice topically with 5-fluorouracil (5-FU), an agent known to kill cycling...

journal_title：Cancer research

authors： Morris RJ,Coulter K,Tryson K,Steinberg SR

更新日期：1997-08-15 00:00:00

abstract：:The estrogen receptor (ER) is a nuclear protein with a hormone- and a DNA-binding domain. We examined the DNA binding of ER in MCF-7 cells and 79 primary breast cancers by gel mobility shift assay using as a probe the estrogen response element (ERE). The mobility shift assay showed saturable, specific binding of ER to...

journal_title：Cancer research

authors： Foster BD,Cavener DR,Parl FF

更新日期：1991-07-01 00:00:00

abstract：:The difficulty to dissect a complex phenotype of established malignant cells to several critical transcriptional programs greatly impedes our understanding of the malignant transformation. The genetic elements required to transform some primary human cells to a tumorigenic state were described in several recent studie...

journal_title：Cancer research

authors： Milyavsky M,Tabach Y,Shats I,Erez N,Cohen Y,Tang X,Kalis M,Kogan I,Buganim Y,Goldfinger N,Ginsberg D,Harris CC,Domany E,Rotter V

更新日期：2005-06-01 00:00:00

abstract：:The p53 mutant 143Ala is a human temperature-sensitive mutant with two conformational states. To definitively determine whether the Fas signal transduction pathway and the function of the pathway are dependent on p53 status, we have established stable transfectants of p53 mutant 143Ala in two human cancer cell lines: ...

journal_title：Cancer research

authors： Li Y,Raffo AJ,Drew L,Mao Y,Tran A,Petrylak DP,Fine RL

更新日期：2003-04-01 00:00:00

abstract：:We obtained seven monoclonal antibodies (MAb) against a gastric mucin of an ALeb patient. By immunoperoxidase on normal gastric mucosae, two MAbs (3-3A and 2-25 LE) reacted exclusively with the A and Lewis-positive individuals, respectively; the five other MAbs (1-13 M1, 2-11 M1, 2-12 M1, 9-13 M1, and 58 M1) stained t...

journal_title：Cancer research

authors： Bara J,Gautier R,Daher N,Zaghouani H,Decaens C

更新日期：1986-08-01 00:00:00

abstract：:The development of molecular dosimetry methods will simplify the identification of people at high risk for cancer. A combined monoclonal antibody immunoaffinity chromatography/high performance liquid chromatography method has been devised to isolate and quantify aflatoxin-DNA adducts and other metabolites in rat urine...

journal_title：Cancer research

authors： Groopman JD,Hasler JA,Trudel LJ,Pikul A,Donahue PR,Wogan GN

更新日期：1992-01-15 00:00:00

abstract：:Treatment of L1210 cells with glucose, 1-methyl-3-isobutylxanthine, theophylline, and prostaglandins E1 and E2 was used to increase to varying degrees the endogenous level of cyclic adenosine 3':5'-monophosphate (cAMP). In an inverse manner these agents decreased the rate of methotrexate (MTX) transport into the cells...

journal_title：Cancer research

authors： Henderson GB,Zevely EM,Huennekens FM

更新日期：1978-03-01 00:00:00

abstract：:We have identified RGS17 as a commonly induced gene in lung and prostate tumors. Through microarray and gene expression analysis, we show that expression of RGS17 is up-regulated in 80% of lung tumors, and also up-regulated in prostate tumors. Through knockdown and overexpression of RGS17 in tumor cells, we show that ...

journal_title：Cancer research

authors： James MA,Lu Y,Liu Y,Vikis HG,You M

更新日期：2009-03-01 00:00:00

abstract：:A translationally regulated, dominant-negative isoform of CCAAT/enhancer-binding protein beta is expressed in transplantable and primary mouse mammary tumors of different etiologies but is not expressed in preneoplastic mammary hyperplasias or in primary prostate, lung, lens, ovary or lymphoid tumors. The eukaryotic i...

journal_title：Cancer research

authors： Raught B,Gingras AC,James A,Medina D,Sonenberg N,Rosen JM

更新日期：1996-10-01 00:00:00

abstract：:Antiestrogen resistance is frequently observed in patients after longterm treatment with tamoxifen, a nonsteroidal antiestrogen widely used for endocrine therapy of breast cancer. In vitro studies in resistant cells showed that the expression of natural estrogen-responsive genes is frequently altered. Using MVLN cells...

journal_title：Cancer research

authors： Badia E,Duchesne MJ,Semlali A,Fuentes M,Giamarchi C,Richard-Foy H,Nicolas JC,Pons M

更新日期：2000-08-01 00:00:00

abstract：:A high-affinity localization of [2H]methylcholanthrene and/or its metabolites to a specific nuclear fraction (Fraction l) between 4 and 72 hr of exposure is described. Other carcinogenic hydrocarbons, such as benzo(a)pyrene and dibenz(a,h)anthracene, demonstrate a similar markded localization in Fraction l after 24 hr...

journal_title：Cancer research

authors： Spelsberg TC,Zytkovicz TH,Moses HL

更新日期：1977-05-01 00:00:00

abstract：:Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of ...

journal_title：Cancer research

authors： Dalton JT,Wientjes MG,Badalament RA,Drago JR,Au JL

更新日期：1991-10-01 00:00:00

abstract：:alphaVbeta3 integrin complexes are overexpressed in the growing, invading margins of human glioblastoma multiforme (GBM) and in the GBM vasculature, suggesting a key role for alphaVbeta3 in GBM growth and invasion. The function of alphaVbeta3 complexes in tumor formation, however, has been challenged by studies showin...

journal_title：Cancer research

authors： Kanamori M,Vanden Berg SR,Bergers G,Berger MS,Pieper RO

更新日期：2004-04-15 00:00:00

abstract：:Luzopeptins consist of two identical, substituted quinolines linked to a cyclic decadepsipeptide, with a 2-fold symmetry. Luzopeptin A, with two acetylated sites in its peptide ring, is active against several experimental animal tumor systems. Luzopeptin B (one acetylated site) is less active, and luzopeptin C (no ace...

journal_title：Cancer research

authors： Huang CH,Crooke ST

更新日期：1985-08-01 00:00:00

abstract：:Metastasis is the primary cause of death from breast cancer. A xenograft model was used to identify genes potentially involved with metastasis, comparing expression in the poorly metastatic GI101A human breast cancer cell line and a highly metastatic variant, GILM2. cDNA microarray analyses of these isogenic variants ...

journal_title：Cancer research

authors： Kluger HM,Chelouche Lev D,Kluger Y,McCarthy MM,Kiriakova G,Camp RL,Rimm DL,Price JE

更新日期：2005-07-01 00:00:00

abstract：:H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. Here, we show that H2...

journal_title：Cancer research

authors： Stiff T,O'Driscoll M,Rief N,Iwabuchi K,Löbrich M,Jeggo PA

更新日期：2004-04-01 00:00:00

abstract：:Maximum rates of nitrofuran reduction by intact mammalian cells and homogenates of mouse liver are obtained under anaerobic conditions, although significant reduction does occur with gas mixtures containing 5% oxygen and less. Single-strand breaks in DNA, measured as a decrease in the sedimentation constant on alkalin...

journal_title：Cancer research

authors： Olive PL,McCalla DR

更新日期：1975-03-01 00:00:00

abstract：:One of the greatest challenges in developing therapeutic regimens is the inability to rapidly and objectively assess tumor response due to treatment. Moreover, tumor response to therapeutic intervention in many cases is transient, and progressive alterations within the tumor may mask the effectiveness of an initially ...

journal_title：Cancer research

authors： Lee KC,Hall DE,Hoff BA,Moffat BA,Sharma S,Chenevert TL,Meyer CR,Leopold WR,Johnson TD,Mazurchuk RV,Rehemtulla A,Ross BD

更新日期：2006-05-01 00:00:00

abstract：:The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. Using viable cell membrane immunofluorescence, most established and early passage...

journal_title：Cancer research

authors： Cloyd MW,Bolognesi DP,Bigner DD

更新日期：1977-03-01 00:00:00