Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.

abstract：:Borderline ovarian tumors possess many of the same morphological features as their malignant counterparts, but they do not destructively invade the ovarian stroma, and the women in whom they develop generally have a favorable prognosis. Female residents of three urban counties of western Washington diagnosed with sero...

journal_title：Cancer research

authors： Harlow BL,Weiss NS,Roth GJ,Chu J,Daling JR

更新日期：1988-10-15 00:00:00

abstract：:Checkpoint pathways help cells maintain genomic integrity, delaying cell cycle progression in response to various risks of fidelity, such as genotoxic stresses, compromised DNA replication, and impaired spindle control. Cancer cells frequently exhibit genomic instability, and recent studies showed that checkpoint path...

journal_title：Cancer research

authors： Ray D,Terao Y,Fuhrken PG,Ma ZQ,DeMayo FJ,Christov K,Heerema NA,Franks R,Tsai SY,Papoutsakis ET,Kiyokawa H

更新日期：2007-02-01 00:00:00

abstract：:The intracellular translocation of protein kinase C (PKC) from the soluble to the membranous fraction has been shown previously to correlate with biological activity of phorbol esters in several systems. In this paper, we describe that PKC translocation was a general phenomenon in all PKC containing cell types when fi...

journal_title：Cancer research

authors： Forsbeck K,Nilsson K,Hansson A,Skoglund G,Ingelman-Sundberg M

更新日期：1985-12-01 00:00:00

abstract：:Multicellular spheroids composed of transformed cells are known to mimic the growth characteristics of tumors and to develop gradients in proliferation with increasing size. This progressive accumulation of quiescent cells is presumably an active process that occurs in response to the microenvironmental stresses that ...

journal_title：Cancer research

authors： LaRue KE,Khalil M,Freyer JP

更新日期：2004-03-01 00:00:00

abstract：:In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data. Selective toxicity of antitumor drugs has been demonstrated for rapidly growing large growth fraction tumors occurring in patients under age 30. In these tumors curative schedu...

journal_title：Cancer research

authors： Zubrod CG

更新日期：1978-12-01 00:00:00

abstract：:Inactivation of the p53 tumor suppressor gene is a common finding in human cancer. In most cases, inactivation is due to a point mutation in the gene, but rearrangement of the p53 gene is sometimes observed. We analyzed the inactivation of p53 in the human pancreas cancer cell line Hs766T, which harbors a structural a...

journal_title：Cancer research

authors： Slebos RJ,Resnick MA,Taylor JA

更新日期：1998-12-01 00:00:00

abstract：:There is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these events. In this study, we identified genes in rat esophagus that were differentially expressed in response to short-te...

journal_title：Cancer research

authors： Reen RK,Dombkowski AA,Kresty LA,Cukovic D,Mele JM,Salagrama S,Nines R,Stoner GD

更新日期：2007-07-01 00:00:00

abstract：:In view of advancements in treatment of certain hormone-dependent cancers with analogues of luteinizing hormone-releasing hormone (LH-RH), this study was undertaken to establish the presence and characteristics of receptors for [D-Trp6]LH-RH on the membranes of human endometrial cancer. Specific binding of [125I,D-Trp...

journal_title：Cancer research

authors： Srkalovic G,Wittliff JL,Schally AV

更新日期：1990-03-15 00:00:00

abstract：:For two decades, the antigen recognized by the Pathologische Anatomie Leiden-Endothelium (PAL-E) monoclonal antibody, a standard vascular endothelial cell marker, has remained elusive. Here, we used a combinatorial phage display-based approach ("epitope mapping") to select peptides binding to the original PAL-E antibo...

journal_title：Cancer research

authors： Jaalouk DE,Ozawa MG,Sun J,Lahdenranta J,Schlingemann RO,Pasqualini R,Arap W

更新日期：2007-10-15 00:00:00

abstract：:Expression of the pro-oncogenic mucin MUC1 is elevated by inflammation in airway epithelial cells, but the contributions of MUC1 to the development of lung cancer are uncertain. In this study, we developed our finding that cigarette smoke increases Muc1 expression in mouse lung macrophages, where we hypothesized MUC1 ...

journal_title：Cancer research

authors： Xu X,Padilla MT,Li B,Wells A,Kato K,Tellez C,Belinsky SA,Kim KC,Lin Y

更新日期：2014-01-15 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) functions primarily as an inhibitory neurotransmitter in the mature central nervous system, and GABA/GABA receptors are also present in nonneural tissues, including cancer, but their precise function in nonneuronal or cancerous cells has thus far been poorly defined. Through the genome-w...

journal_title：Cancer research

authors： Takehara A,Hosokawa M,Eguchi H,Ohigashi H,Ishikawa O,Nakamura Y,Nakagawa H

更新日期：2007-10-15 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00

abstract：:Constitutive tyrosine kinase activity of Bcr-Abl promotes proliferation and survival of chronic myelogenous leukemia (CML) cells. Inhibition of Bcr-Abl tyrosine kinase activity or signaling proteins activated by Bcr-Abl in CML cells blocks proliferation and causes apoptotic cell death. The selective Abl kinase inhibit...

journal_title：Cancer research

authors： Golas JM,Arndt K,Etienne C,Lucas J,Nardin D,Gibbons J,Frost P,Ye F,Boschelli DH,Boschelli F

更新日期：2003-01-15 00:00:00

abstract：:The primary role of the mismatch repair (MMR) system is the avoidance of mutations caused by replication and recombination errors. Furthermore, the lethality of methylating agents has been attributed to the processing of O(6)-methylguanine lesions in DNA by MMR. Loss of the MSH2 protein completely abolishes repair fun...

journal_title：Cancer research

authors： Claij N,van der Wal A,Dekker M,Jansen L,te Riele H

更新日期：2003-05-01 00:00:00

abstract：:In our previous studies we showed that motility related protein 1 (MRP-1) is a glycoprotein recognized by mAb M31-15, and that the sequence of MRP-1 is identical to that of CD9, a WBC differentiation antigen. Transfection of MRP-1/CD9 cDNA into cultured nonhematopoietic cells suppresses cell motility. The extent of su...

journal_title：Cancer research

authors： Miyake M,Nakano K,Ieki Y,Adachi M,Huang CL,Itoi S,Koh T,Taki T

更新日期：1995-09-15 00:00:00

abstract：:Tumor development relies upon essential contributions from the tumor microenvironment and host immune alterations. These contributions may inform the plasma proteome in a manner that could be exploited for cancer diagnosis and prognosis. In this study, we employed a systems biology approach to characterize the plasma ...

journal_title：Cancer research

authors： Pitteri SJ,Kelly-Spratt KS,Gurley KE,Kennedy J,Buson TB,Chin A,Wang H,Zhang Q,Wong CH,Chodosh LA,Nelson PS,Hanash SM,Kemp CJ

更新日期：2011-08-01 00:00:00

abstract：:Iodine-131-labeled anti-CD45 antibody has been added to conventional hematopoietic stem cell transplant preparative regimens to deliver targeted radiation to hematopoietic tissues, with the goal of decreasing relapse rates without increasing toxicity. However, higher radiation doses could be delivered to leukemia cell...

journal_title：Cancer research

authors： Ruffner KL,Martin PJ,Hussell S,Nourigat C,Fisher DR,Bernstein ID,Matthews DC

更新日期：2001-07-01 00:00:00

abstract：:A number of biochemical aspects of melanogenesis were studied in 15 variously melanized human melanomas. The tryosinase activity was correlated with the degree of melanoma varied from 3,667 to 46,183 tryosinase units, in partially melanotic melanoma it varied from 14 to 75 tryrosinase units. The subcellular distributi...

journal_title：Cancer research

authors： Chen YM,Chavin W

更新日期：1975-03-01 00:00:00

abstract：:5-lodo-2'-deoxyuridine (lUdR) significantly increases the total number of spleen cells on the fourth day after administration of 100 mg/kg in normal C3HeB/FeJ male mice. The number of splenic B-cells [cells sensitive to the cytotoxic activity of a rabbit antiserum to mouse F(ab)2, plus complement] increases on the sam...

journal_title：Cancer research

authors： Anaclerio A,Leitman S,Galiette R,Heppner G,Calabresi P

更新日期：1976-01-01 00:00:00

abstract：:To investigate the mechanisms underlying contraction of the stomach wall in cases of gastric scirrhous carcinoma, we have developed an in vitro model for gastric cancer, in which both fibroblasts and gastric carcinoma cells are embedded within a collagen matrix. Gastric carcinoma cells of the scirrhous type (KATO-III)...

journal_title：Cancer research

authors： Ura H,Obara T,Yokota K,Shibata Y,Okamura K,Namiki M

更新日期：1991-07-01 00:00:00

abstract：:Infection by human papillomaviruses (HPV) leads to the formation of benign lesions, warts, and in some cases, cervical cancer. The formation of these lesions is dependent upon increased expression of proangiogenic factors. Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-in...

journal_title：Cancer research

authors： Bodily JM,Mehta KP,Laimins LA

更新日期：2011-02-01 00:00:00

abstract：:Maintenance of long term culture and conventional xenografting of early B-lineage acute lymphoblastic leukemia cells is most difficult. Matrigel, a solubilized attachment matrix shown to aid growth of anchorage dependent solid tumors, was studied in heterotransplantation. Material for xenografting was derived from 5 p...

journal_title：Cancer research

authors： Sterling-Levis K,White L,Trickett AE,Gramacho C,Pittman SM,Tobias V

更新日期：1993-03-15 00:00:00

abstract：:The incidence, distribution, size, and histopathology of colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed a chemically defined fiber-free diet or nutritionally and calorically equivalent diets containing either 4.5 or 9.0% purified cellulose or pectin. This double-...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1980-08-01 00:00:00

abstract：:Tn and sialylated Tn (sTn) are blood group-related epitopes expressed on mucins of colon carcinoma and other epithelial tumors and are, therefore, potential targets for immunological control. We have immunized 20 colorectal cancer patients at high risk for recurrence with a vaccine consisting of partially desialylated...

journal_title：Cancer research

authors： O'Boyle KP,Zamore R,Adluri S,Cohen A,Kemeny N,Welt S,Lloyd KO,Oettgen HF,Old LJ,Livingston PO

更新日期：1992-10-15 00:00:00

abstract：:In 1984, we reported that while immunoreactive levels of serum alpha-1 proteinase inhibitor (API) increased significantly in nine patients with advanced solid tumors, the functional activity of the inhibitor, as measured by the serum trypsin inhibitory capacity, did not increase proportionately. This suggested that a ...

journal_title：Cancer research

authors： Chawla RK,Lawson DH,Sarma PR,Nixon DW,Travis J

更新日期：1987-02-15 00:00:00

abstract：:Polo-like kinase 1 (Plk1) is a key regulator of progression through mitosis. Although Plk1 seems to be dispensable for entry into mitosis, its role in spindle formation and exit from mitosis is crucial. Recent evidence suggests that a major role of Plk1 in exit from mitosis is the regulation of inhibitors of the anaph...

journal_title：Cancer research

authors： Eckerdt F,Strebhardt K

更新日期：2006-07-15 00:00:00

abstract：:Two recent studies independently identified polymorphisms in the 8q24 region, including a single nucleotide polymorphism (rs1447295), strongly associated with prostate cancer risk. Here, we replicate the overall association in a large nested case-control study from the National Cancer Institute Breast and Prostate Can...

journal_title：Cancer research

authors： Schumacher FR,Feigelson HS,Cox DG,Haiman CA,Albanes D,Buring J,Calle EE,Chanock SJ,Colditz GA,Diver WR,Dunning AM,Freedman ML,Gaziano JM,Giovannucci E,Hankinson SE,Hayes RB,Henderson BE,Hoover RN,Kaaks R,Key T,Kol

更新日期：2007-04-01 00:00:00

abstract：:All mammalian cells express 3 closely related Ras proteins, termed H-Ras, K-Ras, and N-Ras, that promote oncogenesis when they are mutationally activated at codon 12, 13, or 61. Although there is a high degree of similarity among the isoforms, K-Ras mutations are far more frequently observed in cancer, and each isofor...

journal_title：Cancer research

authors： Prior IA,Lewis PD,Mattos C

更新日期：2012-05-15 00:00:00

abstract：:Protein kinases of the Raf family act as signal-transducing elements downstream of activated cell surface receptors and are involved in the regulation of proliferation, differentiation, and cell survival. Whereas the role of c-Raf-1 as a mitogen-activated protein/extracellular signal-regulated kinase activator within ...

journal_title：Cancer research

authors： Kalmes A,Hagemann C,Weber CK,Wixler L,Schuster T,Rapp UR

更新日期：1998-07-15 00:00:00

abstract：:Three groups of 6 to 8-week-old male mice with transplanted C57BL/6 X DBA/2F1 tumor were irradiated by a single dose of 60Co localized on the tumor in association with i.p. injections of lyophilized Bacillus Calmette-Guérin. When the animals were sacrificed, tumor parameters (weight, surface area, and volume) were det...

journal_title：Cancer research

authors： Dubois JB,Serrou B

更新日期：1976-05-01 00:00:00