Selective toxicity of anticancer drugs: Presidential Address.

abstract：:Pancreatic cancer is highly resistant to current chemotherapy agents. We therefore examined the effects of triptolide (a diterpenoid triepoxide) on pancreatic cancer growth and local-regional tumor spread using an orthotopic model of pancreatic cancer. We have recently shown that an increased level of HSP70 in pancrea...

journal_title：Cancer research

authors： Phillips PA,Dudeja V,McCarroll JA,Borja-Cacho D,Dawra RK,Grizzle WE,Vickers SM,Saluja AK

更新日期：2007-10-01 00:00:00

abstract：:Virtually all patients with chronic myelogenous leukemia (CML) express an aberrant protein (p210 Bcr-Abl) that contains NH2-terminal sequences from Bcr fused to COOH-terminal sequences from Abl. In a yeast two-hybrid screen, we have identified TSG101 as a binding partner for Bcr. Because TSG101 is a subunit of the mam...

journal_title：Cancer research

authors： Olabisi OO,Mahon GM,Kostenko EV,Liu Z,Ozer HL,Whitehead IP

更新日期：2006-06-15 00:00:00

abstract：:The MAGE-1 gene codes for a tumor-specific antigen, MZ2-E, that elicited a cytotoxic T-lymphocyte response in the melanoma patient from whom it was derived. We have developed a simplified method, using polymerase chain reaction amplification of exon 3 followed by restriction enzyme pattern analysis, to distinguish exp...

journal_title：Cancer research

authors： Zakut R,Topalian SL,Kawakami Y,Mancini M,Eliyahu S,Rosenberg SA

更新日期：1993-01-01 00:00:00

abstract：:Myc transcriptional activity is frequently deregulated in human cancers, but a Myc-driven gene signature with prognostic ability across multiple tumor types remains lacking. Here, we selected 18 Myc-regulated genes from published studies of Myc family targets in epithelial ovarian cancer (EOC) and neuroblastoma. A Myc...

journal_title：Cancer research

authors： Jung M,Russell AJ,Liu B,George J,Liu PY,Liu T,DeFazio A,Bowtell DD,Oberthuer A,London WB,Fletcher JI,Haber M,Norris MD,Henderson MJ

更新日期：2017-02-15 00:00:00

abstract：:An increased level of chondroitin sulfate (CS) expression on the cell surface is often associated with malignant transformation and the progression of tumor cells. In this study, CSs expressed on highly metastatic tumor cells were used as a target for the selective delivery of anticancer drugs by polyethylene glycol (...

journal_title：Cancer research

authors： Lee CM,Tanaka T,Murai T,Kondo M,Kimura J,Su W,Kitagawa T,Ito T,Matsuda H,Miyasaka M

更新日期：2002-08-01 00:00:00

abstract：:Biomarkers for early detection of epithelial ovarian cancer (EOC) are urgently needed. Patients can generate antibodies to tumor-associated antigens (TAAs). We tested multiplex detection of antibodies to candidate ovarian TAAs and statistical modeling for discrimination of sera of EOC patients and controls. Binding of...

journal_title：Cancer research

authors： Erkanli A,Taylor DD,Dean D,Eksir F,Egger D,Geyer J,Nelson BH,Stone B,Fritsche HA,Roden RB

更新日期：2006-02-01 00:00:00

abstract：:Induction of T-cell activation requires multiple signals provided by cell surface receptor interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides an important initial activation event which, when combined with the proper costimulatory signals, results in an activated effector T ...

journal_title：Cancer research

authors： Kroesen BJ,Bakker A,van Lier RA,The HT,de Leij L

更新日期：1995-10-01 00:00:00

abstract：:Lactoperoxidase-catalyzed metabolism of N-hydroxy-N-2-fluorenylacetamide (N-OH-2-FAA) may be via one-electron oxidation to nitroxyl free radical which dismutates to equimolar N-acetoxy-N-2-fluorenylacetamide and 2-nitrosofluorene (2-NOF) and/or a Br(-)-dependent oxidative cleavage to 2-NOF. Hence, the 2-NOF:N-acetoxy-...

journal_title：Cancer research

authors： Malejka-Giganti D,Ritter CL,Decker RW,Suilman JM

更新日期：1986-12-01 00:00:00

abstract：:Dilantin (phenytoin) is a commonly used antiepileptic agent that is known to decrease conductance of sodium and calcium ions and delay outward potassium currents. Separate from its antiseizure activity, dilantin interferes with microtubule protein polymerization. It induces metaphase arrest and potentiates the effects...

journal_title：Cancer research

authors： Lobert S,Ingram JW,Correia JJ

更新日期：1999-10-01 00:00:00

abstract：:Mutations in the human adenomatous polyposis (APC) gene are causative for familial adenomatous polyposis (FAP), a rare condition in which numerous colonic polyps arise during puberty and, if left untreated, lead to colon cancer. The APC gene is a tumor suppressor that has been termed the "gatekeeper gene" for colon ca...

journal_title：Cancer research

authors： Oshima M,Murai N,Kargman S,Arguello M,Luk P,Kwong E,Taketo MM,Evans JF

更新日期：2001-02-15 00:00:00

abstract：:Elevated tumor cyclooxygenase-2 (COX-2) expression is associated with tumor invasion, metastasis, and poor prognosis in non-small cell lung cancer (NSCLC). Here, we report that COX-2-dependent pathways contribute to the modulation of E-cadherin expression in NSCLC. First, whereas genetically modified COX-2-sense (COX-...

journal_title：Cancer research

authors： Dohadwala M,Yang SC,Luo J,Sharma S,Batra RK,Huang M,Lin Y,Goodglick L,Krysan K,Fishbein MC,Hong L,Lai C,Cameron RB,Gemmill RM,Drabkin HA,Dubinett SM

更新日期：2006-05-15 00:00:00

abstract：:Oncogenic BRAF alleles are both necessary and sufficient for cellular transformation, suggesting that chemical inhibition of the activated mutant protein kinase may reverse the tumor phenotype. Here, we report the characterization of SB-590885, a novel triarylimidazole that selectively inhibits Raf kinases with more p...

journal_title：Cancer research

authors： King AJ,Patrick DR,Batorsky RS,Ho ML,Do HT,Zhang SY,Kumar R,Rusnak DW,Takle AK,Wilson DM,Hugger E,Wang L,Karreth F,Lougheed JC,Lee J,Chau D,Stout TJ,May EW,Rominger CM,Schaber MD,Luo L,Lakdawala AS,Adams JL,

更新日期：2006-12-01 00:00:00

abstract：:Antitumor type I T-cell responses involving IFN-γ production are critical to control cancer, but the efficacy of this response is limited by a variety of immunosuppressive mechanisms that promote tumoral immune escape. One critical mechanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of s...

journal_title：Cancer research

authors： Redjimi N,Raffin C,Raimbaud I,Pignon P,Matsuzaki J,Odunsi K,Valmori D,Ayyoub M

更新日期：2012-09-01 00:00:00

abstract：:The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

journal_title：Cancer research

authors： Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

更新日期：2016-08-15 00:00:00

abstract：:Because efficient i.v. administration of interleukin 2 (IL-2) in tumor patients leads to severe cardiopulmonary side effects, we developed a new form of IL-2 application that allows activation of all IL-2-responsive immune cells directly at the tumor site. In five patients with T4N0M0 transitional cell carcinoma of th...

journal_title：Cancer research

authors： Huland E,Huland H

更新日期：1989-10-01 00:00:00

abstract：:Normal bone marrow progenitors and some leukemic cells develop only a limited amount of thermotolerance. Further, once developed, thermotolerance decays at a faster rate than that normally observed in cells of nonhemopoietic origin. Thermotolerance induction and maintenance correlates with reduced levels of expression...

journal_title：Cancer research

authors： Mivechi NF,Ouyang H,Hahn GM

更新日期：1992-12-15 00:00:00

abstract：:MHC class I-restricted tumor antigen can be presented to CD8+ T cells by two distinct mechanisms. Direct presentation involves degradation of cytosolic proteins by the proteosome into peptides, transport of the peptides across the endoplasmic reticulum membrane, and expression of the MHC-peptide complex on the tumor c...

journal_title：Cancer research

authors： Guilloux Y,Bai XF,Liu X,Zheng P,Liu Y

更新日期：2001-02-01 00:00:00

abstract：:This study shows that it is not possible to cause regression of the immunogenic SA-1 sarcoma by adoptive immunotherapy with tumor-sensitized T-cells, unless the tumor-bearing recipient is exposed to a sublethal dose of gamma-irradiation to remove a barrier that prevents adoptive immunity from being expressed. This bar...

journal_title：Cancer research

authors： Awwad M,North RJ

更新日期：1990-04-15 00:00:00

abstract：:Thymidine phosphorylase (dThdPase)/platelet-derived endothelial cell growth factor is expressed at higher levels in a variety of human carcinomas than it is in adjacent normal tissue. The higher expression is associated with an increase of intratumoral microvessel density (IMVD) and an unfavorable patient prognosis. W...

journal_title：Cancer research

authors： Matsuura T,Kuratate I,Teramachi K,Osaki M,Fukuda Y,Ito H

更新日期：1999-10-01 00:00:00

abstract：:Critical roles played by some protein kinases in neoplastic transformation and progression provide a rationale for developing selective, small-molecule kinase inhibitors as antineoplastic drugs. Protein kinase Cepsilon (PKCepsilon) is a rational target for cancer therapy, because it is oncogenic and prometastatic in t...

journal_title：Cancer research

authors： Chu F,Koomen JM,Kobayashi R,O'Brian CA

更新日期：2005-11-15 00:00:00

abstract：:An in vitro cell line (SGT) derived from a mouse submaxillary gland adenocarcinoma (TGS) containing A and B viral particles maintained its oncogenicity only for newborn isogeneic hosts (C3H/He mice) immunosuppressed with antithymocyte serum. Inoculation into adult isogeneic animals did not cause tumor but provided par...

journal_title：Cancer research

authors： Castelli L,Neri G,Frigola A,Di Fava FM,Giuliano MC

更新日期：1975-09-01 00:00:00

abstract：:Hybridoma-derived monoclonal anti-colorectal carcinoma antibodies suppressed the growth of colorectal carcinoma in nude mice as evidenced by a lower incidence of tumors, a longer latency period, and a smaller volume of tumors in antibody-treated than in control animals. The growth-inhibiting properties of monoclonal a...

journal_title：Cancer research

authors： Herlyn DM,Steplewski Z,Herlyn MF,Koprowski H

更新日期：1980-03-01 00:00:00

abstract：:Our recent allelic analysis of head and neck squamous cell carcinomas identified a high incidence of chromosomal loss on 13q. To further define an area of minimal loss, we tested 60 primary head and neck squamous cell carcinomas in 59 patients for loss of heterozygosity (LOH) by using 10 polymorphic microsatellite mar...

journal_title：Cancer research

authors： Yoo GH,Xu HJ,Brennan JA,Westra W,Hruban RH,Koch W,Benedict WF,Sidransky D

更新日期：1994-09-01 00:00:00

abstract：:In meningeal carcinomatosis, retroviral vector-producer cells can be introduced into the thecal sac and circulate in the cerebrospinal fluid to reach malignant tumor cells in the leptomeninges, release vector particles, and selectively infect and transfer a gene of interest to these cells. Gene transfer experiments wi...

journal_title：Cancer research

authors： Ram Z,Walbridge S,Oshiro EM,Viola JJ,Chiang Y,Mueller SN,Blaese RM,Oldfield EH

更新日期：1994-04-15 00:00:00

abstract：:Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pa...

journal_title：Cancer research

authors： Park EY,Chang E,Lee EJ,Lee HW,Kang HG,Chun KH,Woo YM,Kong HK,Ko JY,Suzuki H,Song E,Park JH

更新日期：2014-12-15 00:00:00

abstract：:Primary rat tracheal epithelial cells can be transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. The earliest recognizable morphological transformant is the enhanced growth variant (EGV), characterized by enhanced proliferative capacity. Transformed EGV colonies can progress to give rise to immortal cell lin...

journal_title：Cancer research

authors： Endo S,Nettesheim P,Oshimura M,Walker C

更新日期：1990-02-01 00:00:00

abstract：:Preexisting and acquired resistance to epidermal growth factor receptor (EGFR) inhibitors limits their clinical usefulness in patients with advanced non-small cell lung cancer (NSCLC). This study characterizes the efficacy and mechanisms of the combination of gefitinib or erlotinib with OSU-03012, a celecoxib-derived ...

journal_title：Cancer research

authors： Wang YC,Kulp SK,Wang D,Yang CC,Sargeant AM,Hung JH,Kashida Y,Yamaguchi M,Chang GD,Chen CS

更新日期：2008-04-15 00:00:00

abstract：:Multiple myeloma is a B-cell malignancy for which no curative therapies exist to date, despite enormous research efforts. The remarkable activity of the proteasome inhibitor bortezomib (PS-341, Velcade) observed in clinical trials of patients with relapsed refractory myeloma has led to investigations of the role of th...

journal_title：Cancer research

authors： Altun M,Galardy PJ,Shringarpure R,Hideshima T,LeBlanc R,Anderson KC,Ploegh HL,Kessler BM

更新日期：2005-09-01 00:00:00

abstract：:Chemotherapy, radiation, and growth inhibitory drugs preferentially eliminate actively growing cancer cells. Cancer recurrence is currently thought to be due to nondividing cancer stem/progenitor cells that are resistant to these therapies. Different therapeutic approaches need to be considered for the elimination of ...

journal_title：Cancer research

authors： Engelmann K,Shen H,Finn OJ

更新日期：2008-04-01 00:00:00

abstract：:Myc oncoproteins exert tumorigenic effects by regulating expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known histone methyltransferase that catalyzes...

journal_title：Cancer research

authors： Wong M,Tee AEL,Milazzo G,Bell JL,Poulos RC,Atmadibrata B,Sun Y,Jing D,Ho N,Ling D,Liu PY,Zhang XD,Hüttelmaier S,Wong JWH,Wang J,Polly P,Perini G,Scarlett CJ,Liu T

更新日期：2017-05-01 00:00:00