Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines.

abstract：:We have obtained evidence for the existence of genes controlling invasion and metastasis by somatic cell fusion studies. Noninvasive, nonmetastatic mouse BW5147 T-lymphoma cells were fused with invasive human T-cells. The human cells were either activated normal peripheral blood lymphocytes or leukemic T-lymphoblasts....

journal_title：Cancer research

authors： Collard JG,van de Poll M,Scheffer A,Roos E,Hopman AH,Geurts van Kessel AH,van Dongen JJ

更新日期：1987-12-15 00:00:00

abstract：:SOX9 is a member of the SOX [Sry-related high-mobility group (HMG) box] family of HMG DNA-binding domain transcription factors and is required for the development and differentiation of multiple cell lineages. This report shows that basal epithelial cells express SOX9 in normal prostate, with no detectable expression ...

journal_title：Cancer research

authors： Wang H,McKnight NC,Zhang T,Lu ML,Balk SP,Yuan X

更新日期：2007-01-15 00:00:00

abstract：:Microarray gene expression profiling is a powerful tool for generating molecular cancer classifications. However, elucidating biological insights from these large data sets has been challenging. Previously, we identified a gene expression-based classification of primary uveal melanomas that accurately predicts metasta...

journal_title：Cancer research

authors： Onken MD,Ehlers JP,Worley LA,Makita J,Yokota Y,Harbour JW

更新日期：2006-05-01 00:00:00

abstract：:Solid human tumors and their surrounding microenvironment are hypothesized to coevolve in a manner that promotes tumor growth, invasiveness, and spread. Mouse models of cancer have focused on genetic changes in the epithelial tumor cells and therefore have not robustly tested this hypothesis. We have recently develope...

journal_title：Cancer research

authors： Wallace JA,Li F,Leone G,Ostrowski MC

更新日期：2011-02-15 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:Human polymorphic N-acetyltransferase (NAT2) catalyzes the N-acetylation of arylamine carcinogens and the metabolic activation of N-hydroxyarylamine and N-hydroxyarylamide carcinogens by O- and N,O-acetylation, respectively. Rapid and slow acetylator phenotype is regulated at the NAT2 locus, and each has been associat...

journal_title：Cancer research

authors： Hein DW,Doll MA,Rustan TD,Ferguson RJ

更新日期：1995-08-15 00:00:00

abstract：:MSN-1 is a monoclonal antibody, which was raised by immunizing mice with a human endometrial cancer cell line, SNG-II. The MSN-1 specifically recognizes a blood group carbohydrate antigen, Leb. We investigated the subcellular and suborganellar localization of the MSN-1-reactive carbohydrate antigens in the endometrial...

journal_title：Cancer research

authors： Susumu N,Kawakami H,Aoki D,Hirano H,Nozawa S

更新日期：1993-08-01 00:00:00

abstract：:The WWOX (WW domain containing oxidoreductase) gene was recently identified as a candidate tumor suppressor gene at 16q23.3-24.1, a chromosome region that spans the common fragile site FRA16D. To evaluate the potential role of the WWOX gene in esophageal squamous cell carcinomas, we examined 36 tumors for genetic alte...

journal_title：Cancer research

authors： Kuroki T,Trapasso F,Shiraishi T,Alder H,Mimori K,Mori M,Croce CM

更新日期：2002-04-15 00:00:00

abstract：:Murine fibrosarcoma UV-2237MM cells were implanted into different organs of syngeneic C3H/HeN mice. The resultant tumors were treated by i.v. administration of Adriamycin (ADR). Despite the high sensitivity of the fibrosarcoma cells to ADR in vitro, the established tumors growing in vivo exhibited marked differences i...

journal_title：Cancer research

authors： Staroselsky AN,Fan D,O'Brian CA,Bucana CD,Gupta KP,Fidler IJ

更新日期：1990-12-15 00:00:00

abstract：:Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested pa...

journal_title：Cancer research

authors： Sairenji T,Sullivan JL,Sakamoto K,Spiro RC,Katayama I,Humphreys RE

更新日期：1985-01-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:SPARC is an extracellular matrix protein that exerts pleiotropic effects on extracellular matrix organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer. Chronic myelogenous leukemia (CML) cells resistant to the BCR-ABL inhibitor imatinib (IM-R cells) were found to overexpress ...

journal_title：Cancer research

authors： Fenouille N,Puissant A,Dufies M,Robert G,Jacquel A,Ohanna M,Deckert M,Pasquet JM,Mahon FX,Cassuto JP,Raynaud S,Tartare-Deckert S,Auberger P

更新日期：2010-12-01 00:00:00

abstract：:High levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, suggesting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. To test this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two independe...

journal_title：Cancer research

authors： Xiong S,Pant V,Suh YA,Van Pelt CS,Wang Y,Valentin-Vega YA,Post SM,Lozano G

更新日期：2010-09-15 00:00:00

abstract：:The acidic glycosphingolipid composition of human uterine endometrial adenocarcinoma was compared with those of normal uterine endometrium at the proliferative and the secretory phases. Upon chemical composition analysis, no significant transformation-associated change of these glycolipids was observed. However, when ...

journal_title：Cancer research

authors： Kubushiro K,Tsukazaki K,Tanaka J,Takamatsu K,Kiguchi K,Mikami M,Nozawa S,Nagai Y,Iwamori M

更新日期：1992-02-15 00:00:00

abstract：:We have previously described the neoplastic transformation of immortalized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Natl. Acad. Sci. USA, 86: 10075-10079, 1989...

journal_title：Cancer research

authors： Pfeifer AM,Jones RT,Bowden PE,Mann D,Spillare E,Klein-Szanto AJ,Trump BF,Harris CC

更新日期：1991-07-15 00:00:00

abstract：:Transduction of malignant cells with toxin genes provides a novel means to promote tumor cell destruction. The efficacy of a toxin gene is dependent on the cell type targeted, the quantity of exogenous protein synthesized, and the mechanisms of growth inhibition and bystander killing. To develop gene therapy for targe...

journal_title：Cancer research

authors： Hoganson DK,Batra RK,Olsen JC,Boucher RC

更新日期：1996-03-15 00:00:00

abstract：:We tested the ability of a serum-free medium containing insulin, transferrin, 17 beta-estradiol, dexamethasone, triiodothyronine, prostaglandin F2 alpha, and fibronectin (HBCA medium) to support the continuous growth and passage of five human breast carcinoma cell lines on a collagen matrix. Doubling times of the cell...

journal_title：Cancer research

authors： Calvo F,Brower M,Carney DN

更新日期：1984-10-01 00:00:00

abstract：:Unscheduled DNA synthesis (UDS) indicated by melphalan was studied in freshly collected tumor cells from human melanoma metastases. Comparative studies were done on human bone marrow blast cells. Significant levels of UDS comparable with those in myeloblasts were found in only two of eight melanoma cell populations. T...

journal_title：Cancer research

authors： Lewensohn R,Ringborg U,Hansson J

更新日期：1982-01-01 00:00:00

abstract：:Patient-derived xenografts (PDX) are tumor-in-mouse models for cancer. PDX collections, such as the NCI PDXNet, are powerful resources for preclinical therapeutic testing. However, variations in experimental and analysis procedures have limited interpretability. To determine the robustness of PDX studies, the PDXNet t...

journal_title：Cancer research

authors： Evrard YA,Srivastava A,Randjelovic J,Doroshow JH,Dean DA 2nd,Morris JS,Chuang JH,NCI PDXNet Consortium.

更新日期：2020-06-01 00:00:00

abstract：:In most patients with chronic myeloid leukemia (CML), the disease can be kept under control using the BCR/ABL kinase inhibitor imatinib. Nevertheless, resistance or intolerance to imatinib and other BCR/ABL inhibitors may occur during therapy. Therefore, CML research is focusing on novel targets and targeted drugs. Po...

journal_title：Cancer research

authors： Gleixner KV,Ferenc V,Peter B,Gruze A,Meyer RA,Hadzijusufovic E,Cerny-Reiterer S,Mayerhofer M,Pickl WF,Sillaber C,Valent P

更新日期：2010-02-15 00:00:00

abstract：:A high-affinity localization of [2H]methylcholanthrene and/or its metabolites to a specific nuclear fraction (Fraction l) between 4 and 72 hr of exposure is described. Other carcinogenic hydrocarbons, such as benzo(a)pyrene and dibenz(a,h)anthracene, demonstrate a similar markded localization in Fraction l after 24 hr...

journal_title：Cancer research

authors： Spelsberg TC,Zytkovicz TH,Moses HL

更新日期：1977-05-01 00:00:00

abstract：:Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied multidimensional proteomics, sensitivity correlation analysis, and transcriptomics to identify a common...

journal_title：Cancer research

authors： Peuget S,Zhu J,Sanz G,Singh M,Gaetani M,Chen X,Shi Y,Saei AA,Visnes T,Lindström MS,Rihani A,Moyano-Galceran L,Carlson JW,Hjerpe E,Joneborg U,Lehti K,Hartman J,Helleday T,Zubarev R,Selivanova G

更新日期：2020-04-01 00:00:00

abstract：:To understand the involvement of allelic losses and inactivation of tumor suppressor genes for the development of endometrial carcinoma of the uterus (EC), 24 cases of EC were examined for loss of heterozygosity (LOH) using a total of 57 polymorphic DNA markers covering all 23 pairs of chromosomes. LOH was observed at...

journal_title：Cancer research

authors： Okamoto A,Sameshima Y,Yamada Y,Teshima S,Terashima Y,Terada M,Yokota J

更新日期：1991-10-15 00:00:00

abstract：:We examined in vivo DNA repair synthesis in liver and lung of A/HeJ mice treated with benzo(a)pyrene (BP) or 4-nitroquinoline 1-oxide. To differentiate between the removal of carcinogen metabolite:DNA adducts due to cell turnover and DNA repair, we measured unscheduled DNA synthesis (UDS) in the nonreplicating DNA fra...

journal_title：Cancer research

authors： Kulkarni MS,Angerman-Stewart J,Anderson MW

更新日期：1984-04-01 00:00:00

abstract：:DDX3 is a DEAD box RNA helicase with diverse biological functions. Using colony formation assay, our results revealed that DDX3 inhibited the colony formation ability of various tumor cells, and this inhibition might be due to a reduced growth rate caused by DDX3. Additionally, we identified p21(waf1/cip1), a cyclin-d...

journal_title：Cancer research

authors： Chao CH,Chen CM,Cheng PL,Shih JW,Tsou AP,Lee YH

更新日期：2006-07-01 00:00:00

abstract：:Tumor cell-derived selectin ligands mediate contact to the endothelium, platelets, and leukocytes through binding to selectins that facilitates metastasis. Here, we describe the mechanism of how endogenous (non-tumor derived) selectin ligands contribute to metastasis using α(1,3)fucosyltransferase 7 (Fuc-TVII(-/-))-de...

journal_title：Cancer research

authors： Hoos A,Protsyuk D,Borsig L

更新日期：2014-02-01 00:00:00

abstract：:TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL ratio as one such biomarker, based on its association with other suppressor...

journal_title：Cancer research

authors： Grawenda AM,Møller EK,Lam S,Repapi E,Teunisse AF,Alnæs GI,Børresen-Dale AL,Kristensen VN,Goding CR,Jochemsen AG,Edvardsen H,Bond GL

更新日期：2015-02-15 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily of structurally related cytokines. TWEAK acts on responsive cells via binding to a cell surface receptor named Fn14. Recent studies have demonstrated that TWEAK can stimulate numerous cellular responses in...

journal_title：Cancer research

authors： Ho DH,Vu H,Brown SA,Donohue PJ,Hanscom HN,Winkles JA

更新日期：2004-12-15 00:00:00

abstract：:Overexpression of PRL-3, an oncogenic phosphatase, was identified as a novel cluster in patients with newly diagnosed multiple myeloma. However, the regulation and oncogenic activities of PRL-3 in multiple myeloma warrant further investigation. Here, we report that IL6 activates STAT3, which acts as a direct transcrip...

journal_title：Cancer research

authors： Chong PSY,Zhou J,Lim JSL,Hee YT,Chooi JY,Chung TH,Tan ZT,Zeng Q,Waller DD,Sebag M,Chng WJ

更新日期：2019-09-15 00:00:00

abstract：:Topical 5-aminolevulinic acid-based photodynamic therapy (PDT) has produced complete response rates of >90% for nonmelanoma skin carcinomas, which are mostly human papillomavirus (HPV) negative. Using a similar treatment protocol, we observed a short-term response in only one third (10 of 32) of high-grade vulval intr...

journal_title：Cancer research

authors： Abdel-Hady ES,Martin-Hirsch P,Duggan-Keen M,Stern PL,Moore JV,Corbitt G,Kitchener HC,Hampson IN

更新日期：2001-01-01 00:00:00