Human uterine endometrial adenocarcinoma: characteristic acquirement of synthetic potentials for II3SO3-LacCer and ganglio series sulfoglycosphingolipids after transfer of the cancer cells to culture.

abstract：:Gene expression signatures generated from DNA microarray analyses have shown promise as predictive biomarkers of clinical outcome. In this study, we determined a high-risk signature for disease recurrence using formalin-fixed head and neck squamous cell carcinoma (HNSCC) tumors and compared the results with an indepen...

journal_title：Cancer research

authors： Chung CH,Parker JS,Ely K,Carter J,Yi Y,Murphy BA,Ang KK,El-Naggar AK,Zanation AM,Cmelak AJ,Levy S,Slebos RJ,Yarbrough WG

更新日期：2006-08-15 00:00:00

abstract：:Calmodulin contents of normal rat liver, host liver [bearing hepatoma 5123t.c.(h)], regenerating liver, and Morris hepatomas 7800, 5123t.c.(h), and 7794A were determined by phosphodiesterase assay and by radioimmunoassay. The calmodulin levels determined by both assays were significantly increased in three hepatomas w...

journal_title：Cancer research

authors： Wei JW,Morris HP,Hickie RA

更新日期：1982-07-01 00:00:00

abstract：:Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome characterized by early age of onset colorectal cancer (mean 45 years) as well as endometrial, urinary tract, and upper gastrointestinal adenocarcinomas. The HNPCC phenotype has been shown to segregate with germline mutations in ...

journal_title：Cancer research

authors： Weber TK,Conlon W,Petrelli NJ,Rodriguez-Bigas M,Keitz B,Pazik J,Farrell C,O'Malley L,Oshalim M,Abdo M,Anderson G,Stoler D,Yandell D

更新日期：1997-09-01 00:00:00

abstract：:We tested the ability of a serum-free medium containing insulin, transferrin, 17 beta-estradiol, dexamethasone, triiodothyronine, prostaglandin F2 alpha, and fibronectin (HBCA medium) to support the continuous growth and passage of five human breast carcinoma cell lines on a collagen matrix. Doubling times of the cell...

journal_title：Cancer research

authors： Calvo F,Brower M,Carney DN

更新日期：1984-10-01 00:00:00

abstract：:Chromatin was isolated from 0.025 M citric acid nuclei of regenerating rat liver at 1,5,18,24, and 48 hr posthepatectomy. The total protein to DNA ratios did not change significantly during this time period. However, 2-dimensional polyacrylamide gel electrophoresis of nonhistone proteins of "Chromatin Fraction II" rev...

journal_title：Cancer research

authors： Yeoman LC,Taylor CW,Jordan JJ,Busch H

更新日期：1975-05-01 00:00:00

abstract：:Human glandular kallikrein (hK2) and prostate-specific antigen (PSA) are related members of the human kallikrein gene family. The genes for hK2 and PSA are expressed predominately in the prostate, are transcriptionally up-regulated by androgens, and share 78% homology. Previously, one functional androgen response elem...

journal_title：Cancer research

authors： Yu DC,Sakamoto GT,Henderson DR

更新日期：1999-04-01 00:00:00

abstract：:The immune reactivity to partially purified Thomsen-Friedenreich antigen was investigated in patients with lung cancer. The modified method of original leukocyte adherence inhibition test, termed superoxide assay-leukocyte adherence inhibition test, was used to detect the reactivity. The coded peripheral mononuclear c...

journal_title：Cancer research

authors： Ichinose Y,Yagawa K,Kaku M,Hara N,Ohta M

更新日期：1985-09-01 00:00:00

abstract：:The in vivo activation of aflatoxin B1 (AFB1) was assessed by using two transgenic mouse lines, M2 and M10, in which the human fetus-specific CYP3A7 was expressed in the kidney (M2) and the liver (M10), respectively. Male mice of 8 weeks old from these two lines were treated with a single i.p. injection of AFB1 (4 mg/...

journal_title：Cancer research

authors： Li Y,Yokoi T,Katsuki M,Wang JS,Groopman JD,Kamataki T

更新日期：1997-02-15 00:00:00

abstract：:One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling, such that tamoxifen nonresponsiveness or resi...

journal_title：Cancer research

authors： Busch S,Sims AH,Stål O,Fernö M,Landberg G

更新日期：2015-04-01 00:00:00

abstract：:The expression of the chemokine CC-chemokine ligand 20 (CCL20)/macrophage inflammatory protein (MIP)-3alpha and its receptor CC-chemokine receptor 6 (CCR6) by multiple myeloma (MM) and microenvironment cells and their potential relationship with osteoclast (OC) formation and osteolytic bone lesions in MM patients was ...

journal_title：Cancer research

authors： Giuliani N,Lisignoli G,Colla S,Lazzaretti M,Storti P,Mancini C,Bonomini S,Manferdini C,Codeluppi K,Facchini A,Rizzoli V

更新日期：2008-08-15 00:00:00

abstract：:Cholangiocarcinoma is a devastating cancer of biliary origin with limited treatment options. Symptoms are usually evident after blockage of the bile duct by the tumor, and at this late stage, they are relatively resistant to chemotherapy and radiation therapy. Therefore, it is imperative that alternative treatment opt...

journal_title：Cancer research

authors： Alpini G,Invernizzi P,Gaudio E,Venter J,Kopriva S,Bernuzzi F,Onori P,Franchitto A,Coufal M,Frampton G,Alvaro D,Lee SP,Marzioni M,Benedetti A,DeMorrow S

更新日期：2008-11-15 00:00:00

abstract：:Neuroblastomas are histopathologically heterogeneous, ranging from immature malignant tumors to benign ganglioneuromas. The amount of Schwann cell stroma greatly increases with neuroblastoma differentiation, and these Schwann cells appear to be normal cells that infiltrate the tumor. To determine whether Schwann cells...

journal_title：Cancer research

authors： Kwiatkowski JL,Rutkowski JL,Yamashiro DJ,Tennekoon GI,Brodeur GM

更新日期：1998-10-15 00:00:00

abstract：:Communication between cancer cells and the tumor microenvironment results in the modulation of complex signaling networks that facilitate tumor progression. Here, we describe a new mechanism of intercellular communication originating from large oncosomes (LO), which are cancer cell-derived, atypically large (1-10 μm) ...

journal_title：Cancer research

authors： Minciacchi VR,Spinelli C,Reis-Sobreiro M,Cavallini L,You S,Zandian M,Li X,Mishra R,Chiarugi P,Adam RM,Posadas EM,Viglietto G,Freeman MR,Cocucci E,Bhowmick NA,Di Vizio D

更新日期：2017-05-01 00:00:00

abstract：:Immunodiffusion, immunofluorescence, and flow cytometric techniques were used to characterize the expression of murine gamma-glutamyltranspeptidase (gamma GT) on normal and cervical cancer tissue. In immunodiffusion tests, the rabbit antiserum produced against highly purified murine kidney gamma GT formed two lines ag...

journal_title：Cancer research

authors： Chen YF,Haskill S

更新日期：1984-10-01 00:00:00

abstract：:Irinotecan hydrochloride (CPT-11), an antitumor camptothecin derivative, causes severe forms of diarrhea clinically. We characterized CPT-11-induced diarrhea histologically and enzymologically and assessed the relationships between intestinal toxicity and the activity of the enzymes that play a key role in the major m...

journal_title：Cancer research

authors： Takasuna K,Hagiwara T,Hirohashi M,Kato M,Nomura M,Nagai E,Yokoi T,Kamataki T

更新日期：1996-08-15 00:00:00

abstract：:We have previously reported that rodent tumor cell lines secrete a potent vascular permeability factor with a molecular weight of 34,000-42,000 (Senger et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science (Wash. DC), 219: 983-985, 1983). This tumor-secreted vas...

journal_title：Cancer research

authors： Senger DR,Perruzzi CA,Feder J,Dvorak HF

更新日期：1986-11-01 00:00:00

abstract：:Inactivation of p53 signaling by mutation of p53 itself or abrogation of its normal function by other transfactors, such as MDM2, is a key event in the development of most human cancers. To identify novel regulators of p53, we have used a phenotype-based selection in which a total cDNA library in a retroviral vector h...

journal_title：Cancer research

authors： Agarwal MK,Ruhul Amin AR,Agarwal ML

更新日期：2007-01-01 00:00:00

abstract：:A body of evidence has shown the existence of a nuclear phosphoinositide cycle in different cell types. The cycle is endowed with kinases as well as phosphatases and phospholipase C (PLC). Among the PLC isozymes, the beta family is characterized by a long COOH-terminal tail that contains a cluster of lysine residues r...

journal_title：Cancer research

authors： Matteucci A,Faenza I,Gilmour RS,Manzoli L,Billi AM,Peruzzi D,Bavelloni A,Rhee SG,Cocco L

更新日期：1998-11-15 00:00:00

abstract：:When Shionogi carcinoma 115 (SC115, an undifferentiated medullary carcinoma showing a compact cell pattern and containing androgen receptor) was transplanted into male and female DS mice, it grew only in males. In contrast with this strict androgen dependency in DS hosts, SC115 tumors grew in male and female nude athy...

journal_title：Cancer research

authors： Kitamura Y,Uchida N,Hayata I,Yamaguchi K,Okamoto S,Narita N,Matsumoto K

更新日期：1980-12-01 00:00:00

abstract：:Human malignant mesothelioma of the pleura was successfully transplanted s.c. into athymic nude mice and grew as a solid neoplastic mass. Tumor growth resulted in death of the animals between 98 and 161 days after implantation. Minced samples of the growing tumor were propagated as a malignant peritoneal effusion. Ani...

journal_title：Cancer research

authors： Reale FR,Griffin TW,Compton JM,Graham S,Townes PL,Bogden A

更新日期：1987-06-15 00:00:00

abstract：:Ewing's sarcoma is thought to arise after developmental arrest of primitive neural cells during embryogenesis. Because basic fibroblast growth factor (bFGF) has a critical role in the regulation of cell survival, proliferation, and differentiation during embryogenesis, we have tested the hypothesis that bFGF and FGF r...

journal_title：Cancer research

authors： Sturla LM,Westwood G,Selby PJ,Lewis IJ,Burchill SA

更新日期：2000-11-01 00:00:00

abstract：:Several well characterized murine T-lymphoma cell lines were used in somatic cell hybridization experiments to study the genetic regulation of glucocorticoid-induced lysis. Cell fusions were carried out among the SL12-derived cloned lines and between the W7 and SAK8 lines all of which have functional hormone receptors...

journal_title：Cancer research

authors： Weinroth SE,MacLeod CL,Minning L,Hays EF

更新日期：1985-10-01 00:00:00

abstract：:Proliferating cell nucleolar antigen P40 is a late G1-specific protein, which was found in a variety of human tumors (A. Chatterjee, J. W. Freeman, and H. Busch. Cancer Res., 47: 1123-1129, 1987). Two overlapping complementary DNA clones for antigen P40 were isolated by immunoscreening a lambda gt11 human expression l...

journal_title：Cancer research

authors： Reddy AB,Chatterjee A,Rothblum LI,Black A,Busch H

更新日期：1989-04-01 00:00:00

abstract：:Amphoterin has been suggested to regulate invasive process extension and cell migration in tumor cells and embryonic neurons through binding to receptor for advanced glycation end products (RAGE), a multiligand transmembrane receptor belonging to the immunoglobulin superfamily. In this study, we identify a COOH-termin...

journal_title：Cancer research

authors： Huttunen HJ,Fages C,Kuja-Panula J,Ridley AJ,Rauvala H

更新日期：2002-08-15 00:00:00

abstract：:Effective treatment of malignant carcinomas requires identification of proteins regulating epithelial cell proliferation. To this end, we compared gene expression profiles in murine colonocytes and their c-Myc-transformed counterparts, which possess enhanced proliferative potential. A surprisingly short list of deregu...

journal_title：Cancer research

authors： Thomas-Tikhonenko A,Viard-Leveugle I,Dews M,Wehrli P,Sevignani C,Yu D,Ricci S,el-Deiry W,Aronow B,Kaya G,Saurat JH,French LE

更新日期：2004-05-01 00:00:00

abstract：:A method was elaborated for high-yield 125I-trap labeling of rat colon carcinoma cells using conjugates of dichlorotriazine aminofluorescein and bovine serum albumin substituted with either N-acetylgalactosamine or N-acetylglucosamine as vehicles. Fluorescence microscopy revealed that the ligands accumulated in perinu...

journal_title：Cancer research

authors： Rushfeldt C,Smedsrød B

更新日期：1993-02-01 00:00:00

abstract：:Methodology for identifying tumor-associated antigens recognized by T cells has been successfully used to clone antigens from melanoma cells. Similar efforts for nonmelanoma tumors have had limited success with few antigens identified. To identify potentially relevant tumor-associated antigens expressed in renal cell ...

journal_title：Cancer research

authors： Hanada K,Perry-Lalley DM,Ohnmacht GA,Bettinotti MP,Yang JC

更新日期：2001-07-15 00:00:00

abstract：:The deregulation of several cell cycle-related genes participates in neoplastic transformation. Cell cycle progression is driven by cyclin-dependent kinases, which are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin-dependent kinases i...

journal_title：Cancer research

authors： Gasparotto D,Maestro R,Piccinin S,Vukosavljevic T,Barzan L,Sulfaro S,Boiocchi M

更新日期：1997-06-15 00:00:00

abstract：:Thymidine phosphorylase (TP) is an enzyme involved in the reversible conversion of thymidine to thymine and is identical to an angiogenic factor, platelet-derived endothelial cell growth factor. TP is expressed at higher levels in a wide variety of solid tumors than in the adjacent nonneoplastic tissues. Patients with...

journal_title：Cancer research

authors： Matsushita S,Nitanda T,Furukawa T,Sumizawa T,Tani A,Nishimoto K,Akiba S,Miyadera K,Fukushima M,Yamada Y,Yoshida H,Kanzaki T,Akiyama S

更新日期：1999-04-15 00:00:00

abstract：:Metastatic nonseminomatous testicular germ cell tumors are curable using combination chemotherapy in approximately 80% of patients. In contrast, most other patients with other types of cancer either present with or acquire drug-resistant disease following chemotherapy. Cell lines derived from testis tumors retain hype...

journal_title：Cancer research

authors： Parris CN,Walker MC,Masters JR,Arlett CF

更新日期：1990-12-01 00:00:00