Abstract：
:Human malignant mesothelioma of the pleura was successfully transplanted s.c. into athymic nude mice and grew as a solid neoplastic mass. Tumor growth resulted in death of the animals between 98 and 161 days after implantation. Minced samples of the growing tumor were propagated as a malignant peritoneal effusion. Animals with malignant ascites died predictably at 32 to 33 days. Light and electron microscopy, and immunocytochemistry demonstrated a similarity of the transplanted solid and fluid malignancies with the human primary mesothelioma. Cytogenetic analysis demonstrated a predominance of cells with a triploid number of identifiable but abnormal human chromosomes. This model, which mimics the clinical behavior of malignant mesothelioma in the human, may be of value in animal trials of chemotherapy and immunotherapy.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Reale FR,Griffin TW,Compton JM,Graham S,Townes PL,Bogden Asubject
Has Abstractpub_date
1987-06-15 00:00:00pages
3199-205issue
12eissn
0008-5472issn
1538-7445journal_volume
47pub_type
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