Anti-BA46 monoclonal antibody Mc3: humanization using a novel positional consensus and in vivo and in vitro characterization.

abstract：:FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and increased tumorigenicity in vivo in...

journal_title：Cancer research

authors： Wang J,Yang L,Yang J,Kuropatwinski K,Wang W,Liu XQ,Hauser J,Brattain MG

更新日期：2008-05-01 00:00:00

abstract：:Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in cancer is largely unknown. By applying a multidisciplinary, high-throughput proteomic approach, we have recently identified a peptide ligand motif for targeted ...

journal_title：Cancer research

authors： Bartolini A,Di Paolo D,Noghero A,Murgia D,Sementa AR,Cilli M,Pasqualini R,Arap W,Bussolino F,Ponzoni M,Pastorino F,Marchiò S

更新日期：2015-10-15 00:00:00

abstract：:Chromosomal analysis of 16 rhabdomyosarcomas was done from four primary tumors and from 12 tumors after nude mouse passage. Seven tumors were alveolar; four of these had t(2;13)(q37;q14) and in two tumors it was the only structural abnormality. The other three alveolar tumors were near tetraploid with marker chromosom...

journal_title：Cancer research

authors： Wang-Wuu S,Soukup S,Ballard E,Gotwals B,Lampkin B

更新日期：1988-02-15 00:00:00

abstract：:TuAg.1 is a tumor-associated membrane glycoprotein first identified in rat hepatocellular carcinoma by monoclonal antibodies (mAbs) 324.5 and 324.9. This oncofetal antigen is also expressed by hepatocytes in cell culture but not normal adult hepatocytes in vivo. Affinity chromatography and preparative continuous eluti...

journal_title：Cancer research

authors： Lim YP,Fowler LC,Hixson DC,Wehbe T,Thompson NL

更新日期：1996-09-01 00:00:00

abstract：:Tumor-initiating properties of complete carcinogens such as 7,12-dimethylbenz(a)anthracene (DMBA) are well known but not the mechanism of DMBA-mediated tumor promotion. Our hypothesis is that interleukin (IL)-1alpha, an early proinflammatory cytokine that initiates a cascade of other cytokines and growth factors, is u...

journal_title：Cancer research

authors： Li X,Eckard J,Shah R,Malluck C,Frenkel K

更新日期：2002-01-15 00:00:00

abstract：:The operation of venereal factors in human cervical cancer is suggested by demographic and epidemiological data. Recent evidence supporting the genital herpesvirus hypothesis is consistent with this notion. A controlled epidemiological investigation has been undertaken on the role of the male coital partner in cervica...

journal_title：Cancer research

authors： Kessler II

更新日期：1976-02-01 00:00:00

abstract：:In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were treated by s.c. bolus once a day. However, it was not clear in the previo...

journal_title：Cancer research

authors： Kisker O,Becker CM,Prox D,Fannon M,D'Amato R,Flynn E,Fogler WE,Sim BK,Allred EN,Pirie-Shepherd SR,Folkman J

更新日期：2001-10-15 00:00:00

abstract：:Twenty-seven patients with advanced cancer were entered in a phase I study of bolus i.v. 5-fluorouracil at a dose of 370 mg/m2/day for 5 days combined with a continuous i.v. infusion of (6S)-folinic acid for 5.5 days, starting 24 h in advance of the first 5-fluorouracil dose. The dose of (6S)-folinic acid was escalate...

journal_title：Cancer research

authors： Newman EM,Akman SA,Harrison JS,Leong LA,Margolin KA,Morgan RJ,Raschko JW,Somlo G,Ahn CW,Doroshow JH

更新日期：1992-05-01 00:00:00

abstract：:Although African-American (AA) patients with prostate cancer tend to develop greater therapeutic resistance and faster prostate cancer recurrence compared with Caucasian-American (CA) men, the molecular mechanisms of this racial prostate cancer disparity remain undefined. In this study, we provide the first comprehens...

journal_title：Cancer research

authors： Kumar R,Bhat TA,Walsh EM,Chaudhary AK,O'Malley J,Rhim JS,Wang J,Morrison CD,Attwood K,Bshara W,Mohler JL,Yadav N,Chandra D

更新日期：2019-04-01 00:00:00

abstract：:Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment resistance, more recently it has been shown that cycling hypoxic regions acquire prosurvival pathw...

journal_title：Cancer research

authors： Matsumoto S,Batra S,Saito K,Yasui H,Choudhuri R,Gadisetti C,Subramanian S,Devasahayam N,Munasinghe JP,Mitchell JB,Krishna MC

更新日期：2011-10-15 00:00:00

abstract：:Cultures of human mammary epithelial cells (HMECs) contain a subpopulation of variant cells with the capacity to propagate beyond an in vitro proliferation barrier. These variant HMECs, which contain hypermethylated and silenced p16(INK4a) (p16) promoters, eventually accumulate multiple chromosomal changes, many of wh...

journal_title：Cancer research

authors： Holst CR,Nuovo GJ,Esteller M,Chew K,Baylin SB,Herman JG,Tlsty TD

更新日期：2003-04-01 00:00:00

abstract：:Emerging studies indicate that DNA damage in cancer cells triggers antitumor immunity, but its intrinsic regulatory mechanism in breast cancer cells remains poorly understood. Here, we show that ZMYND8 is upregulated and inhibits micronucleus formation and DNA damage in breast cancer cells. Loss of ZMYND8 triggered ac...

journal_title：Cancer research

authors： Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

更新日期：2020-11-04 00:00:00

abstract：:Protein kinase C (PKC) has been implicated in enhancing cellular sensitivity to cis-diamminedichloroplatinum(II) (CP). We have synthesized a series of novel analogues of lyngbyatoxin A (7-linalylindolactam V), a natural tumor promoter and a potent activator of PKC, and investigated the effects of these synthetic compo...

journal_title：Cancer research

authors： Basu A,Kozikowski AP,Sato K,Lazo JS

更新日期：1991-05-15 00:00:00

abstract：:Treatment of human HL-60 or KG1A leukemia cells with the topoisomerase II inhibitor etoposide resulted in extensive DNA degradation. When DNA integrity was analyzed by agarose gel electrophoresis, a nucleosomal ladder became evident 1.5-2 h after addition of etoposide to cells, increased in intensity over 6 h, and per...

journal_title：Cancer research

authors： Kaufmann SH

更新日期：1989-11-01 00:00:00

abstract：:Neuroblastoma cells accumulate ascorbic acid and iron. It was hypothesized that these features could be exploited for sensitizing neuroblastoma cells for therapy in combination with reactive oxygen intermediates. In the present study the effects of 6-hydroxydopamine (6-OHDA) and H2O2 on metabolic parameters critical f...

journal_title：Cancer research

authors： Bruchelt G,Schraufstätter IU,Niethammer D,Cochrane CG

更新日期：1991-11-15 00:00:00

abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

journal_title：Cancer research

authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

更新日期：2017-11-01 00:00:00

abstract：:Focal adhesion kinase (FAK) functions downstream of integrins and growth factor receptors to promote tumor cell motility and invasion. In colorectal cancer, FAK is activated by amidated gastrin, a protumorigenic hormone. However, it is unclear how FAK receives signals from the gastrin receptor or other G-protein-coupl...

journal_title：Cancer research

authors： Yu HG,Nam JO,Miller NL,Tanjoni I,Walsh C,Shi L,Kim L,Chen XL,Tomar A,Lim ST,Schlaepfer DD

更新日期：2011-01-15 00:00:00

abstract：:Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins,...

journal_title：Cancer research

authors： Tome ME,Baker AF,Powis G,Payne CM,Briehl MM

更新日期：2001-03-15 00:00:00

abstract：:Rodent biliary glycoprotein (Bgp), also known as C-CAM, has recently been shown to function as a tumor suppressor in colon, prostate, and bladder cancers. This glycoprotein is a member of the carcinoembryonic antigen family and is one of the only proteins in this family to encode either a long (71-73 amino acids) or s...

journal_title：Cancer research

authors： Turbide C,Kunath T,Daniels E,Beauchemin N

更新日期：1997-07-01 00:00:00

abstract：:Mutations that alter normal splice patterns and genomic rearrangements are common causes of hereditary diseases including hereditary nonpolyposis colorectal cancer. However, abnormal transcripts can be difficult to detect and interpret because splicing patterns are often heterogeneous even in normal cells. Standard te...

journal_title：Cancer research

authors： Nakagawa H,Yan H,Lockman J,Hampel H,Kinzler KW,Vogelstein B,De La Chapelle A

更新日期：2002-08-15 00:00:00

abstract：:Recently the putative tumor suppressor gene p16INK4 was mapped to human chromosome 9p21, which is homologous to rat chromosome 5. Monosomy of rat chromosome 5 occurs with high frequency in rat kidney tumor-derived cell lines (ERC lines). Thus, we studied these lines in order to investigate the involvement of p15INK4B ...

journal_title：Cancer research

authors： Knapek DF,Serrano M,Beach D,Trono D,Walker CL

更新日期：1995-04-15 00:00:00

abstract：:Little is known about the genetic and molecular events leading to the early stages of human astrocytoma formation. To examine this issue, we analyzed the significance of sequential accumulation of two somatic point mutations (R267W and E258D) in the TP53 gene during the initiation of astrocytoma in a patient born with...

journal_title：Cancer research

authors： Fulci G,Ishii N,Maurici D,Gernert KM,Hainaut P,Kaur B,Van Meir EG

更新日期：2002-05-15 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a potent growth-regulatory and immunomodulatory cytokine that exerts a diverse range of effects on many types of cells. High levels of TGF-beta are produced by several human and mouse malignant mesothelioma (MM) cell lines, and it is known to act as a growth factor for the...

journal_title：Cancer research

authors： Marzo AL,Fitzpatrick DR,Robinson BW,Scott B

更新日期：1997-08-01 00:00:00

abstract：:Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer...

journal_title：Cancer research

authors： Jacobson RS,Becich MJ,Bollag RJ,Chavan G,Corrigan J,Dhir R,Feldman MD,Gaudioso C,Legowski E,Maihle NJ,Mitchell K,Murphy M,Sakthivel M,Tseytlin E,Weaver J

更新日期：2015-12-15 00:00:00

abstract：:In previous studies a clone of the gynogenetic fish, Poecilia formosa (the Amazon molly), was successfully used as a test animal to identify ultraviolet-induced damage. This work has been extended, and the fish system was used to detect damage caused byionizing radiation. Fish cells, exposed in vitro to 250 and 500 ra...

journal_title：Cancer research

authors： Woodhead D,Setlow RB,Hart RW

更新日期：1977-12-01 00:00:00

abstract：:Tumorigenic activities of the (+)- and (-)-enantiomers of the diastereomeric, bay-region benzo(c)phenanthrene 3,4-diol-1,2-epoxides were evaluated in two mouse tumor models. In an initiation-promotion experiment on mouse skin, a single topical application of 10, 25, or 75 nmol of the compounds was followed by 20 weeks...

journal_title：Cancer research

authors： Levin W,Chang RL,Wood AW,Thakker DR,Yagi H,Jerina DM,Conney AH

更新日期：1986-05-01 00:00:00

abstract：:Little is known about the molecular mechanisms responsible for the development of intracranial germ cell tumors (ICGTs). Recently, we demonstrated that the balance of the p53-mdm2 interactions is disrupted in ICGTs. The p14ARF product, a tumor suppresser gene located on the INK4a/ARF locus, acts as one of the major fa...

journal_title：Cancer research

authors： Iwato M,Tachibana O,Tohma Y,Arakawa Y,Nitta H,Hasegawa M,Yamashita J,Hayashi Y

更新日期：2000-04-15 00:00:00

abstract：:Human CYP2A6 has been recognized as being involved in the mutagenic activation of promutagens such as the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Methoxsalen (8-methoxypsoralen) was reported to inhibit CYP2A6. In the present study, the inhibitory effects of methoxsalen on NN...

journal_title：Cancer research

authors： Takeuchi H,Saoo K,Yokohira M,Ikeda M,Maeta H,Miyazaki M,Yamazaki H,Kamataki T,Imaida K

更新日期：2003-11-15 00:00:00

abstract：:While more than 70% of breast cancers express estrogen receptor-α (ER+), endocrine therapies targeting these receptors often fail. The molecular mechanisms that underlie treatment resistance remain unclear. We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrogen resistance. Hum...

journal_title：Cancer research

authors： Cook KL,Shajahan AN,Wärri A,Jin L,Hilakivi-Clarke LA,Clarke R

更新日期：2012-07-01 00:00:00

abstract：:The role of natural killer group 2, member D receptor (NKG2D)-expressing natural killer (NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor progression occurs despite tumor immunosurveillance, leading to cancer persistence in immunocompetent hosts. STAT3 plays a pivotal role both in onc...

journal_title：Cancer research

authors： Bedel R,Thiery-Vuillemin A,Grandclement C,Balland J,Remy-Martin JP,Kantelip B,Pallandre JR,Pivot X,Ferrand C,Tiberghien P,Borg C

更新日期：2011-03-01 00:00:00