Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts.

abstract：:Colorectal cancer cells with stem-like properties, referred to as colon cancer-initiating cells (CCIC), have high tumorigenic potential. While CCIC can differentiate to promote cellular heterogeneity, it remains unclear whether CCIC within a tumor contain distinct subpopulations. Here, we describe the co-existence of ...

journal_title：Cancer research

authors： Srinivasan T,Walters J,Bu P,Than EB,Tung KL,Chen KY,Panarelli N,Milsom J,Augenlicht L,Lipkin SM,Shen X

更新日期：2016-06-01 00:00:00

abstract：:Peripheral blood monocytes were isolated from normal human donors by separation on a continuous Percoll gradient and adherence to yield preparations of blood monocytes with a high degree of purity (greater than 99%). The monocytes were incubated in vitro with medium alone or with multilamellar liposomes that contained...

journal_title：Cancer research

authors： Kleinerman ES,Erickson KL,Schroit AJ,Fogler WE,Fidler IJ

更新日期：1983-05-01 00:00:00

abstract：:Overexpression of interleukin 6, a downstream target of the GBX2 homeobox gene, has been linked to the progression of prostate cancer. The Janus kinase-signal transducers and activators of transcription signaling pathway transmits interleukin 6-mediated signals from cell surface receptors to the target genes in the nu...

journal_title：Cancer research

authors： Ni Z,Lou W,Leman ES,Gao AC

更新日期：2000-03-01 00:00:00

abstract：:Metronomic chemotherapy refers to the close, regular administration of comparatively low doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is thought to have an antiangiogenic basis. However, whereas surprisingly durable and potent tumor responses have been observed in a number ...

journal_title：Cancer research

authors： Shaked Y,Emmenegger U,Francia G,Chen L,Lee CR,Man S,Paraghamian A,Ben-David Y,Kerbel RS

更新日期：2005-08-15 00:00:00

abstract：:We previously reported that bone marrows of breast cancer patients contained tumor antigen-specific CD8(+) T cells with central or effector memory phenotype. Using a recently developed ret transgenic mouse melanoma model, we now show that bone marrows and tumors of transgenic mice contain high frequencies of CD8(+) T ...

journal_title：Cancer research

authors： Umansky V,Abschuetz O,Osen W,Ramacher M,Zhao F,Kato M,Schadendorf D

更新日期：2008-11-15 00:00:00

abstract：:T-cell adoptive immunotherapy for stringent murine tumor models, such as intracranial, s.c., or advanced pulmonary metastases, routinely uses lymphodepletive conditioning regimens before T-cell transfer, like recent clinical protocols. In this study, we examined whether host lymphodepletion is an obligatory component ...

journal_title：Cancer research

authors： Wang LX,Shu S,Plautz GE

更新日期：2005-10-15 00:00:00

abstract：:Intestinal radiation injury is dose limiting during abdominal and pelvic radiotherapy and critical for the outcome after accidental whole-body radiation exposure. The multifunctional cytokine, interleukin-11 (IL-11), ameliorates the intestinal radiation response, but its clinical use is hampered by severe toxicity aft...

journal_title：Cancer research

authors： Boerma M,Wang J,Burnett AF,Santin AD,Roman JJ,Hauer-Jensen M

更新日期：2007-10-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) is a potent growth-regulatory and immunomodulatory cytokine that exerts a diverse range of effects on many types of cells. High levels of TGF-beta are produced by several human and mouse malignant mesothelioma (MM) cell lines, and it is known to act as a growth factor for the...

journal_title：Cancer research

authors： Marzo AL,Fitzpatrick DR,Robinson BW,Scott B

更新日期：1997-08-01 00:00:00

abstract：:Most patients with lung cancer still die from their disease, necessitating additional options to improve treatment. Here, we provide evidence for targeting CD22, a cell adhesion protein known to influence B-cell survival that we found is also widely expressed in lung cancer cells. In characterizing the antitumor activ...

journal_title：Cancer research

authors： Tuscano JM,Kato J,Pearson D,Xiong C,Newell L,Ma Y,Gandara DR,O'Donnell RT

更新日期：2012-11-01 00:00:00

abstract：:The expression of epidermal growth factor (EGF) receptor was examined immunohistochemically in a total of 122 gastric and 61 colonic carcinomas, out of which 16 gastric and 8 colonic carcinomas were also examined by 125I-labeled EGF binding analysis and Western blotting. The values of EGF binding were 12.68 +/- 1.98 (...

journal_title：Cancer research

authors： Yasui W,Sumiyoshi H,Hata J,Kameda T,Ochiai A,Ito H,Tahara E

更新日期：1988-01-01 00:00:00

abstract：:Targeted therapies can be defined as drugs developed against a specific target based on its important biological function in cancer. In contrast, nontargeted therapies are drugs identified by phenotypic screening of natural products or chemical libraries against established cancer cell lines or preclinical animal mode...

journal_title：Cancer research

authors： Hait WN,Hambley TW

更新日期：2009-02-15 00:00:00

abstract：:Radioimmunoassay has been used to measure acetylated and deacetylated deoxyguanosine C-8 DNA adducts of 2-acetylaminofluorene in liver and kidney DNA of male Wistar-Furth rats fed a dietary regimen of 0.02 or 0.04% 2-acetylaminofluorene. When adduct formation was monitored during continuous feeding up to 60 days, subs...

journal_title：Cancer research

authors： Poirier MC,True B,Laishes BA

更新日期：1982-04-01 00:00:00

abstract：:Human polynucleotide phosphorylase (hPNPase(old-35)) is a type I IFN-inducible 3',5' exoribonuclease that mediates mRNA degradation. In melanoma cells, slow and sustained overexpression of hPNPase(old-35) induces G(1) cell cycle arrest ultimately culminating in apoptosis, whereas rapid overexpression of hPNPase(old-35...

journal_title：Cancer research

authors： Sarkar D,Park ES,Barber GN,Fisher PB

更新日期：2007-09-01 00:00:00

abstract：:The effects of combined administration of cimetidine and tetragastrin on gastric acid secretion, the labeling index of the gastric mucosa, and the incidence of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine were investigated in inbred Wistar rats. Prolonged administration of tetragastrin in de...

journal_title：Cancer research

authors： Tatsuta M,Iishi H,Yamamura H,Baba M,Yamamoto R,Taniguchi H

更新日期：1988-03-15 00:00:00

abstract：:In the vascular system, circulating tumor cells interact with endothelial cells. Tumor-endothelial cross-talk transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state called endothelial cell activation (ECA). In the present study, we analyze the potential of metastatic tumor-der...

journal_title：Cancer research

authors： Goerge T,Barg A,Schnaeker EM,Poppelmann B,Shpacovitch V,Rattenholl A,Maaser C,Luger TA,Steinhoff M,Schneider SW

更新日期：2006-08-01 00:00:00

abstract：:The failure and/or toxicity of conventional therapies for many types of human cancers underscore the need for development of safe and effective alternative treatments. Toward this goal, we describe the direct oncolytic activity of RNA-based vectors derived from poliovirus, termed replicons, which are genetically incap...

journal_title：Cancer research

authors： Ansardi DC,Porter DC,Jackson CA,Gillespie GY,Morrow CD

更新日期：2001-12-01 00:00:00

abstract：:The semisynthetic anthracycline, 5-iminodaunorubicin (IM), was investigated to see whether modification of the benzoquinone moiety to produce a drug with low free radical potential would alter the cytotoxic and biochemical characteristics of this drug in comparison to Adriamycin (ADR), an agent with high free radical ...

journal_title：Cancer research

authors： Glazer RI,Hartman KD,Richardson CL

更新日期：1982-01-01 00:00:00

abstract：:Vinblastine (VLB) is moderately active clinically against advanced breast cancer. Since VLB is extensively taken up by platelets and thus only partially available to tumor cells, to enhance the therapeutic index of VLB we have therefore administered this agent by continuous i.v. infusion to patients with advanced brea...

journal_title：Cancer research

authors： Lu K,Yap HY,Loo TL

更新日期：1983-03-01 00:00:00

abstract：:Although obesity is one of the strongest risk factors for esophageal adenocarcinoma (EAC), the molecular mechanisms underlying this association remain unclear. We recently identified 4 EAC-specific master regulator transcription factors (MRTF) ELF3, KLF5, GATA6, and EHF. In the present study, Gene Set Enrichment Analy...

journal_title：Cancer research

authors： Ma S,Zhou B,Yang Q,Pan Y,Yang W,Freedland SJ,Ding LW,Freeman MR,Breunig JJ,Bhowmick NA,Pan J,Koeffler HP,Lin DC

更新日期：2021-01-05 00:00:00

abstract：:Aberrant signal transduction has been implicated in malignant transformation, growth, and progression. This has led to the proposal to use inhibitors of signal transduction pathways to treat cancer. One approach to circumventing potential toxicity and improving efficacy would be to target pathways upon which cancer ce...

journal_title：Cancer research

authors： Kohn EC,Sandeen MA,Liotta LA

更新日期：1992-06-01 00:00:00

abstract：:The chemotherapeutic agent paclitaxel disrupts microtubule dynamics causing mitotic arrest, which leads to cell death. However, in paclitaxel-resistant tumor cells, treatment with paclitaxel induces abnormal progression through prophase resulting in a multimininucleated phenotype. Multimininucleation and subsequent po...

journal_title：Cancer research

authors： Panvichian R,Orth K,Day ML,Day KC,Pilat MJ,Pienta KJ

更新日期：1998-10-15 00:00:00

abstract：:We developed a new simple enzymatic assay method for measuring urinary polyamines (total amount of putrescine, spermidine, and cadaverine), using an acylpolyamine amidohydrolase and a putrescine oxidase. First conjugated polyamines (putrescine, spermidine, and cadaverine) in urine were hydrolyzed by incubation with an...

journal_title：Cancer research

authors： Kubota S,Okada M,Imahori K,Ohsawa N

更新日期：1983-05-01 00:00:00

abstract：:Procarbazine, a chemotherapeutic hydrazine, is thought to be metabolized to an alkylating species similar to methyl carbonium ion by multistep reactions involving cytochrome P-450, monoamine oxidase, and cytosolic enzymes. The DNA-damaging and cytotoxic potential of procarbazine and its metabolites in murine L1210 leu...

journal_title：Cancer research

authors： Erikson JM,Tweedie DJ,Ducore JM,Prough RA

更新日期：1989-01-01 00:00:00

abstract：:The RNA-binding protein PNO1 is critical for ribosome biogenesis, but its potential role in cancer remains unknown. In this study, online data mining, cDNA, and tissue microarrays indicated that PNO1 expression was higher in colorectal cancer tissue than in noncancerous tissue, and its overexpression was associated wi...

journal_title：Cancer research

authors： Shen A,Chen Y,Liu L,Huang Y,Chen H,Qi F,Lin J,Shen Z,Wu X,Wu M,Li Q,Qiu L,Yu N,Sferra TJ,Peng J

更新日期：2019-05-01 00:00:00

abstract：:The inactivation of the tumor suppressor gene p53 has been demonstrated in a variety of human tumors. In this study, we present a p53 gene analysis of 13 uterine carcinoma cell lines. Sequencing analysis of the entire coding region revealed mutations changing the p53 amino acid composition in all six endometrial carci...

journal_title：Cancer research

authors： Yaginuma Y,Westphal H

更新日期：1991-12-15 00:00:00

abstract：:Determining to what degree chemicals and environmental agents contribute to the development of cancer would be materially enhanced by the ability to distinguish chemically induced tumors from those that arise spontaneously. Using DNA fingerprinting as an assay, we investigated whether somatic DNA rearrangements are mo...

journal_title：Cancer research

authors： Ledwith BJ,Storer RD,Prahalada S,Manam S,Leander KR,van Zwieten MJ,Nichols WW,Bradley MO

更新日期：1990-09-01 00:00:00

abstract：:In female nude mice, epidermal growth factor (EGF) was present at a mean concentration of 42.8 +/- 16.9 (SD) ng/mg wet tissue in the submandibular gland and 0.28 +/- 0.13 ng/ml in the plasma. Sialoadenectomy (removal of the submandibular glands) decreased circulating EGF to undetectable levels (less than 0.1 ng/ml). T...

journal_title：Cancer research

authors： Tsutsumi O,Tsutsumi A,Oka T

更新日期：1987-09-01 00:00:00

abstract：:The role of Janus-activated kinase (JAK) signaling in cell cycle transit and maintenance of genomic stability was determined in HL-60 myeloblastic leukemia cells. Inhibition of JAKs, all JAKs (JAK1, JAK2, JAK3, and tyrosine kinase 2), JAK2, or JAK3, caused a significant reduction in cell growth with a major G2-M arres...

journal_title：Cancer research

authors： Reiterer G,Yen A

更新日期：2006-09-15 00:00:00

abstract：:The presence of tumor cells in the circulation may predict disease recurrence and metastases. We have developed a sensitive technique for the detection of carcinoma cells in blood, using immunomagnetic beads to enrich for epithelial cells and the polymerase chain reaction to identify a tumor marker. The colon carcinom...

journal_title：Cancer research

authors： Hardingham JE,Kotasek D,Farmer B,Butler RN,Mi JX,Sage RE,Dobrovic A

更新日期：1993-08-01 00:00:00

abstract：:Gastrointestinal adenocarcinomas (GIAC) of the tubular gastrointestinal (GI) tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer...

journal_title：Cancer research

authors： Pan J,Silva TC,Gull N,Yang Q,Plummer JT,Chen S,Daigo K,Hamakubo T,Gery S,Ding LW,Jiang YY,Hu S,Xu LY,Li EM,Ding Y,Klempner SJ,Gayther SA,Berman BP,Koeffler HP,Lin DC

更新日期：2020-07-01 00:00:00