Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation.

abstract：:Antiestrogen resistance is frequently observed in patients after longterm treatment with tamoxifen, a nonsteroidal antiestrogen widely used for endocrine therapy of breast cancer. In vitro studies in resistant cells showed that the expression of natural estrogen-responsive genes is frequently altered. Using MVLN cells...

journal_title：Cancer research

authors： Badia E,Duchesne MJ,Semlali A,Fuentes M,Giamarchi C,Richard-Foy H,Nicolas JC,Pons M

更新日期：2000-08-01 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has been shown to induce apoptosis specifically in cancer cells while sparing normal tissues. Unfortunately not all cancer cells respond to TRAIL; therefore, TRAIL sensitizing agents are currently being explored. We have identified synthetic trit...

journal_title：Cancer research

authors： Hyer ML,Croxton R,Krajewska M,Krajewski S,Kress CL,Lu M,Suh N,Sporn MB,Cryns VL,Zapata JM,Reed JC

更新日期：2005-06-01 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:The introduction of normal chromosomes into tumor cells by microcell fusion-mediated transfer is a powerful technique to identify putative tumor suppressor genes. We have used this approach to independently transfer human chromosomes 3 and 12 into a human prostate cancer cell line, DU 145. We showed that while the ext...

journal_title：Cancer research

authors： Bérubé NG,Speevak MD,Chevrette M

更新日期：1994-06-15 00:00:00

abstract：:Akt activation has been implicated broadly in tumorigenesis, but the basis for its dysregulation in cancer cells is incompletely understood. In this study, we sought to clarify a regulatory role for the Akt-binding carboxy-terminal modulator protein (CTMP), which has been controversial. In evaluating CTMP expression i...

journal_title：Cancer research

authors： Liu YP,Liao WC,Ger LP,Chen JC,Hsu TI,Lee YC,Chang HT,Chen YC,Jan YH,Lee KH,Zeng YH,Hsiao M,Lu PJ

更新日期：2013-10-15 00:00:00

abstract：:An anemia-inducing substance was isolated from the human placenta and designated placental anemia-inducing factor (PAIF). An amount of 2.8 mg was purified from about 70 total placentas (total wet weight, 42 kg). PAIF caused hemolysis of human erythrocytes in vitro and reduced the number of erythrocytes in rabbits to 8...

journal_title：Cancer research

authors： Oh-Uti K,Inoue S,Minato S

更新日期：1980-05-01 00:00:00

abstract：:The level of nonspecific lipid transfer protein in three Morris hepatomas of varying degrees of differentiation has been found to be less than 10% of the level in either host or control livers, whereas phosphatidylcholine transfer activity is slightly reduced for hepatomas compared to host livers (20 to 40%), though n...

journal_title：Cancer research

authors： Crain RC,Clark RW,Harvey BE

更新日期：1983-07-01 00:00:00

abstract：:Mutation in either TSC1 or TSC2 causes the autosomal dominant disorder tuberous sclerosis, in which widespread hamartomas are seen, some of which have a high level of vascularization. Tuberous sclerosis complex (TSC) gene products negatively regulate mammalian target of rapamycin (mTOR) activity. We found that vascula...

journal_title：Cancer research

authors： El-Hashemite N,Walker V,Zhang H,Kwiatkowski DJ

更新日期：2003-09-01 00:00:00

abstract：:Claudin proteins form a large family of integral membrane proteins crucial for tight junction formation and function. Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpressed in ovarian cancer. To clarify the roles of claudins in ovarian tumorigenesis, we have generated human o...

journal_title：Cancer research

authors： Agarwal R,D'Souza T,Morin PJ

更新日期：2005-08-15 00:00:00

abstract：:A role for proteolysis during chemical induction of endogenous xenotropic Type C virus from Kirsten sarcoma virus-transformed mouse cells was examined. Two distinct classes of protease inhibitors, the trypsin inhibitor, alpha-N-tosyl-L-lysine chloromethyl ketone, and two naturally occurring oligopeptide inhibitors, an...

journal_title：Cancer research

authors： Long CW,Bruszewski JA,Christensen WL,Suk WA

更新日期：1979-08-01 00:00:00

abstract：:The gadd45 gene, a growth arrest and DNA damage (gadd)-induced gene, is transcriptionally activated by UV irradiation through two distinct pathways. One requires the sequence-specific binding of the p53 tumor suppressor protein to a responsive element within the third intron of the gadd45 gene, and the other is p53-in...

journal_title：Cancer research

authors： Takahashi S,Saito S,Ohtani N,Sakai T

更新日期：2001-02-01 00:00:00

abstract：:We have explored the therapeutic effects of anti-epidermal growth factor receptor monoclonal antibodies (MAbs) 225 and 528 on well established A431 epidermoid carcinoma xenografts, approximately 400 mm3 (1 cm in diameter) at the start of treatment. In previous reports we demonstrated that MAbs 225 and 528 prevented th...

journal_title：Cancer research

authors： Fan Z,Baselga J,Masui H,Mendelsohn J

更新日期：1993-10-01 00:00:00

abstract：:MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we estab...

journal_title：Cancer research

authors： Reinert LS,Shi B,Nandi S,Mazan-Mamczarz K,Vitolo M,Bachman KE,He H,Gartenhaus RB

更新日期：2006-09-15 00:00:00

abstract：:The effect of 17beta-estradiol on an estrogen receptor-positive human breast cancer cell line (MCF-7) was studied. Low concentrations (10(-9) M) of 17beta-estradiol enhanced the rate of cell proliferation; the overall cell cycle time was shortened; and the proportion of cells in the S phase increased. Higher concentra...

journal_title：Cancer research

authors： Weichselbaum RR,Hellman S,Piro AJ,Nove JJ,Little JB

更新日期：1978-08-01 00:00:00

abstract：:This report describes the development and validation of quantitative microsatellite analysis (QuMA) for rapid measurement of relative DNA sequence copy number. In QuMA, the copy number of a test locus relative to a pooled reference is assessed using quantitative, real-time PCR amplification of loci carrying simple seq...

journal_title：Cancer research

authors： Ginzinger DG,Godfrey TE,Nigro J,Moore DH 2nd,Suzuki S,Pallavicini MG,Gray JW,Jensen RH

更新日期：2000-10-01 00:00:00

abstract：:Cancer-secreted, extracellular vesicle (EV)-encapsulated miRNAs enable cancer cells to communicate with each other and with noncancerous cells in tumor pathogenesis and response to therapies. Here, we show that treatment with a sublethal dose of chemotherapeutic agents induces breast cancer cells to secrete EV with th...

journal_title：Cancer research

authors： Shen M,Dong C,Ruan X,Yan W,Cao M,Pizzo D,Wu X,Yang L,Liu L,Ren X,Wang SE

更新日期：2019-07-15 00:00:00

abstract：:Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2 (FERMT2) promotes metastatic progressi...

journal_title：Cancer research

authors： Sossey-Alaoui K,Pluskota E,Bialkowska K,Szpak D,Parker Y,Morrison CD,Lindner DJ,Schiemann WP,Plow EF

更新日期：2017-09-15 00:00:00

abstract：:The relatively recent clinical success of bortezomib, particularly in multiple myeloma, has established the validity of the proteasome as a viable target for anticancer drug development. This highly cited 1999 Cancer Research article from Adams and colleagues was published during the period when this drug was transiti...

journal_title：Cancer research

authors： Tew KD

更新日期：2016-09-01 00:00:00

abstract：:Samples of three nonmalignant and seven leukemic human cells were examined for DNA polymerase activity that could be identified as RNA tumor virus reverse transcriptase. Experiments on virus-infected model animal cells provided the basis for cell fractionation procedures, and reconstituted systems of known virus, adde...

journal_title：Cancer research

authors： Kiessling AA,Goulian M

更新日期：1979-06-01 00:00:00

abstract：:The importance of invasion in the complex process of metastasis, although now well established, has been studied with increasing molecular detail due to the development of robust in vitro experimental assays. In this issue of Cancer Research, we highlight a paper published by George Poste and colleagues that compared ...

journal_title：Cancer research

authors： Welch DR

更新日期：2016-04-01 00:00:00

abstract：:The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates bi...

journal_title：Cancer research

authors： Wilson S,Fitzsimons M,Ferguson M,Heath A,Jensen M,Miller J,Murphy MW,Porter J,Sahni H,Staudt L,Tang Y,Wang Z,Yu C,Zhang J,Ferretti V,Grossman RL,GDC Project.

更新日期：2017-11-01 00:00:00

abstract：:Detecting the presence and diversity of low-level mutations in human tumors undergoing genomic instability is desirable due to their potential prognostic value and their putative influence on the ability of tumors to resist drug treatment and/or metastasize. However, direct measurement of these genetic alterations in ...

journal_title：Cancer research

authors： Liu WH,Kaur M,Wang G,Zhu P,Zhang Y,Makrigiorgos GM

更新日期：2004-04-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell renal cell carcinoma (ccRCC) representing approximately 75% of all RCCs. Increased expression of the hypoxia-induced factors-1α (HIF1α) and HIF2α has been suggested as a pivotal step in ccRCC carcinogenesis,...

journal_title：Cancer research

authors： Fu L,Wang G,Shevchuk MM,Nanus DM,Gudas LJ

更新日期：2013-05-01 00:00:00

abstract：:A radioimmunoassay for transforming growth factor alpha (TGF-alpha) using synthetic rat sarcoma transforming growth factor and its rabbit polyclonal antibody has been developed. Using radioimmunoassays, the urinary TGF-alpha and epidermal growth factor (EGF) concentrations in 31 patients with hepatocellular carcinoma ...

journal_title：Cancer research

authors： Yeh YC,Tsai JF,Chuang LY,Yeh HW,Tsai JH,Florine DL,Tam JP

更新日期：1987-02-01 00:00:00

abstract：:In this study of breast cancer specimens, the relationship between cytosolic estrogen (ER) and progesterone receptor (PR) content to the size of the respective growth fraction (GF) (expressed as percentage of proliferating tumor cells) was investigated. We applied the recently developed ligand-binding assay for extrac...

journal_title：Cancer research

authors： Vollmer G,Gerdes J,Knuppen R

更新日期：1989-07-15 00:00:00

abstract：:The relative amounts of HLA-A,B,C antigens, beta 2-microglobulin (beta 2m), and trophoblast antigens (Trop-1 and Trop-2) were determined on nine choriocarcinoma cell lines including seven lines of gestational origin and two lines of nongestational origin (from ovary and stomach) by quantitative immunofluorescence anal...

journal_title：Cancer research

authors： Kawata M,Sizer K,Sekiya S,Parnes JR,Herzenberg LA

更新日期：1984-09-01 00:00:00

abstract：:Angiogenesis is a crucial step in tumor growth and progression. Its quantitation by microvessel counting is of prognostic value in several types of malignancies. Scarce data are available on angiogenesis in gastrointestinal tumors. We studied 36 adenomas and 178 large bowel carcinomas to evaluate the onset of angiogen...

journal_title：Cancer research

authors： Bossi P,Viale G,Lee AK,Alfano R,Coggi G,Bosari S

更新日期：1995-11-01 00:00:00

abstract：:Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1,511 cases and 1,457 con...

journal_title：Cancer research

authors： Canova C,Hashibe M,Simonato L,Nelis M,Metspalu A,Lagiou P,Trichopoulos D,Ahrens W,Pigeot I,Merletti F,Richiardi L,Talamini R,Barzan L,Macfarlane GJ,Macfarlane TV,Holcátová I,Bencko V,Benhamou S,Bouchardy C,Kjaerheim

更新日期：2009-04-01 00:00:00

abstract：:With the increasing generation of new cancer vaccine strategies, there is also an increasing demand for preclinical models that can carefully predict the efficacy of these vaccines in humans. However, the only tumor models available to study vaccines against human papillomavirus (HPV) 16 have been developed in C57BL/6...

journal_title：Cancer research

authors： Eiben GL,Velders MP,Schreiber H,Cassetti MC,Pullen JK,Smith LR,Kast WM

更新日期：2002-10-15 00:00:00

abstract：:MCF-7 cells have been shown to contain estrogen receptor in several cell fractions following homogenization: nuclei, microsomes, and cytosol. The amount of 17 beta-estradiol-binding capacity found in each cellular compartment depended on the inclusion of detergent in homogenization buffers and on the use of 0.25 M suc...

journal_title：Cancer research

authors： Brooks SC,Hansen ER,Saunders DE,Battelli MG,Shafie SM

更新日期：1984-09-01 00:00:00