Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations.

abstract：:One hundred seven Chinese patients with primary hepatocellular carcinoma (PHC) were compared with 107 hospital controls for the presence of hepatitis B surface antigen and smoking, drinking, and dietary habits. Eighty-two % of PHC cases were hepatitis B surface antigen positive compared to 18% of controls (relative ri...

journal_title：Cancer research

authors： Lam KC,Yu MC,Leung JW,Henderson BE

更新日期：1982-12-01 00:00:00

abstract：:A dose-response study was conducted in Fischer rats with nitrosodiethylamine, which was administered in regulated amounts as a solution in drinking water. Groups of 20 female rats each received a different treatment, one group consisted of 12 animals; one of the groups was untreated. The concentrations of the solution...

journal_title：Cancer research

authors： Lijinsky W,Reuber MD,Riggs CW

更新日期：1981-12-01 00:00:00

abstract：:Vinblastine (VLB) is moderately active clinically against advanced breast cancer. Since VLB is extensively taken up by platelets and thus only partially available to tumor cells, to enhance the therapeutic index of VLB we have therefore administered this agent by continuous i.v. infusion to patients with advanced brea...

journal_title：Cancer research

authors： Lu K,Yap HY,Loo TL

更新日期：1983-03-01 00:00:00

abstract：:3,3',5-Triiodo-L-thyronine (200 microgram/100 g) is shown to be a potent liver parenchymal cell mitogen in the rat, and thyroidectomy is seen to severely inhibit hepatocyte proliferation in regenerating rat liver. Taken together, these observations point to a crucial role for the iodothyronine in liver cell hyperplasi...

journal_title：Cancer research

authors： Short J,Klein K,Kibert L,Ove P

更新日期：1980-07-01 00:00:00

abstract：:Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate the skeletal preference (orthotropism) of specific types of cancers remains poorly understood. There is a significant clinical correlation between the expression of bone sialoprotein (BSP) and skeletal ...

journal_title：Cancer research

authors： Barnes GL,Javed A,Waller SM,Kamal MH,Hebert KE,Hassan MQ,Bellahcene A,Van Wijnen AJ,Young MF,Lian JB,Stein GS,Gerstenfeld LC

更新日期：2003-05-15 00:00:00

abstract：:The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confi...

journal_title：Cancer research

authors： Draffin JE,McFarlane S,Hill A,Johnston PG,Waugh DJ

更新日期：2004-08-15 00:00:00

abstract：:Studies involving transcriptomics have revealed multiple molecular subtypes of hepatocellular carcinoma (HCC). Positron emission tomography/computed tomography (PET/CT) has also identified distinct molecular imaging subtypes, including those with increased and decreased choline metabolism as measured by the tissue upt...

journal_title：Cancer research

authors： Kwee SA,Tiirikainen M,Sato MM,Acoba JD,Wei R,Jia W,Le Marchand L,Wong LL

更新日期：2019-04-01 00:00:00

abstract：:Sporadic prostate carcinoma is the most common male cancer in the Western world, yet many of the major genetic events involved in the progression of this often fatal cancer remain to be elucidated. Numerous cytogenetic and allelotype studies have reported frequent loss of heterozygosity on chromosomal arm 10q in spora...

journal_title：Cancer research

authors： Cairns P,Okami K,Halachmi S,Halachmi N,Esteller M,Herman JG,Jen J,Isaacs WB,Bova GS,Sidransky D

更新日期：1997-11-15 00:00:00

abstract：:Vaccines represent an attractive treatment modality for the management of cancer primarily because of their specificity and generation of immunologic memory important for controlling recurrences. However, the efficacy of therapeutic vaccines may require formulations that not only generate effective immune responses bu...

journal_title：Cancer research

authors： Sharma RK,Elpek KG,Yolcu ES,Schabowsky RH,Zhao H,Bandura-Morgan L,Shirwan H

更新日期：2009-05-15 00:00:00

abstract：:Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

journal_title：Cancer research

authors： Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

更新日期：2012-05-01 00:00:00

abstract：:HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we report that constitutively active ERBB2 sensitizes human breast epithelial...

journal_title：Cancer research

authors： Martín-Pérez R,Palacios C,Yerbes R,Cano-González A,Iglesias-Serret D,Gil J,Reginato MJ,López-Rivas A

更新日期：2014-03-15 00:00:00

abstract：:Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogeni...

journal_title：Cancer research

authors： Bertotti A,Comoglio PM,Trusolino L

更新日期：2005-12-01 00:00:00

abstract：:Targeting the tyrosine kinase activity of Bcr-Abl is an attractive therapeutic strategy in chronic myeloid leukemia (CML) and in Bcr-Abl-positive acute lymphoblastic leukemia. Whereas imatinib, a selective inhibitor of Bcr-Abl tyrosine kinase, is now used in frontline therapy for CML, second-generation inhibitors of B...

journal_title：Cancer research

authors： Mahon FX,Hayette S,Lagarde V,Belloc F,Turcq B,Nicolini F,Belanger C,Manley PW,Leroy C,Etienne G,Roche S,Pasquet JM

更新日期：2008-12-01 00:00:00

abstract：:Pim serine/threonine kinases contribute to prostate tumorigenesis and therapeutic resistance, yet Pim kinase inhibitors seem to have only limited effects on prostate cancer cell survival. Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated th...

journal_title：Cancer research

authors： Song JH,Kraft AS

更新日期：2012-01-01 00:00:00

abstract：:Beta-adrenoceptors are highly expressed on SW 480 colon carcinoma cells as was assessed by flow cytometry. We investigated the influence of norepinephrine on the migration of these cells using time-lapse videomicroscopy. Norepinephrine-treatment increased the locomotor activity within the population from 25% spontaneo...

journal_title：Cancer research

authors： Masur K,Niggemann B,Zanker KS,Entschladen F

更新日期：2001-04-01 00:00:00

abstract：:A novel method for high-efficiency and region- controlled in vivo gene transfer was developed by combining in vivo electroporation and intraarterial plasmid DNA injection. A mammalian expression plasmid for the Escherichia coli lacZ gene (driven with a SV40 early promoter) was injected into the internal carotid artery...

journal_title：Cancer research

authors： Nishi T,Yoshizato K,Yamashiro S,Takeshima H,Sato K,Hamada K,Kitamura I,Yoshimura T,Saya H,Kuratsu J,Ushio Y

更新日期：1996-03-01 00:00:00

abstract：:The ability of the phorbol ester tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA) to lead to the activation of cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase was investigated in three cell lines. In the Reuber H35 hepatoma cells, TPA (1.6 microM) led to an increase in the protein kinase...

journal_title：Cancer research

authors： Byus CV,Trevillyan JM,Cavit LJ,Fletcher WH

更新日期：1983-07-01 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and combretastatin A4 phosphate (CA-4-P) markedly inhibit tumor blood flow in mice and are both currently in clinical trial. One of the challenges in clinical evaluation of antivascular agents is the monitoring of tumor blood flow inhibition in individual patients. This stu...

journal_title：Cancer research

authors： Siim BG,Laux WT,Rutland MD,Palmer BN,Wilson WR

更新日期：2000-08-15 00:00:00

abstract：:During the course of a mechanism-based screening program designed to identify new microtubule-disrupting agents from natural products, we identified a crude extract from Tacca chantrieri that initiated Taxol-like microtubule bundling. Bioassay-directed purification of the extract yielded the highly oxygenated steroids...

journal_title：Cancer research

authors： Tinley TL,Randall-Hlubek DA,Leal RM,Jackson EM,Cessac JW,Quada JC Jr,Hemscheidt TK,Mooberry SL

更新日期：2003-06-15 00:00:00

abstract：:Advocates bring unique and important viewpoints to the cancer research process, ensuring that scientific and medical advances are patient-centered and relevant. In this article, we discuss the benefits of engaging advocates in cancer research and underscore ways in which both the scientific and patient communities can...

journal_title：Cancer research

authors： Salamone JM,Lucas W,Brundage SB,Holloway JN,Stahl SM,Carbine NE,London M,Greenwood N,Goyes R,Chisholm DC,Price E,Carlin R,Winarsky S,Baker KB,Maues J,Shajahan-Haq AN

更新日期：2018-10-15 00:00:00

abstract：:A major obstacle to successful treatment of colorectal cancer is chemotherapy resistance. Enhanced expression of variant CD44 isoforms has been associated with aggressive tumor behavior, prompting the question of whether signaling from this receptor might modulate drug sensitivity. Activation of variant CD44 in colon ...

journal_title：Cancer research

authors： Bates RC,Edwards NS,Burns GF,Fisher DE

更新日期：2001-07-01 00:00:00

abstract：:Increased sialyltransferase (ST) activity promotes cancer cell metastasis, and overexpression of cell surface sialic acid correlates with poor prognosis in cancer patients. To seek therapies targeting metastasis for cancer treatment, we developed a novel ST inhibitor, Lith-O-Asp, and investigated its antimetastatic an...

journal_title：Cancer research

authors： Chen JY,Tang YA,Huang SM,Juan HF,Wu LW,Sun YC,Wang SC,Wu KW,Balraj G,Chang TT,Li WS,Cheng HC,Wang YC

更新日期：2011-01-15 00:00:00

abstract：:Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or par...

journal_title：Cancer research

authors： Nam HY,Han MW,Chang HW,Lee YS,Lee M,Lee HJ,Lee BW,Lee HJ,Lee KE,Jung MK,Jeon H,Choi SH,Park NH,Kim SY,Kim SW

更新日期：2013-07-15 00:00:00

abstract：:Previous studies have shown dose-dependent growth inhibition of the human mammary carcinoma cell line MDA-MB-231 xenotransplanted in athymic mice using retinol. In this study, the growth inhibitory effect of retinoic acid (RA) and 13-cis-retinoic acid (13-cis-RA) was examined in vitro and in vivo. With both agents the...

journal_title：Cancer research

authors： Halter SA,Fraker LD,Adcock D,Vick S

更新日期：1988-07-01 00:00:00

abstract：:Sodium saccharin and sodium ascorbate are known to promote urinary bladder carcinogenesis in rats following initiation with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) or N-butyl-N-(4-hydroxybutyl) nitrosamine. Sodium salts of other organic acids have also been shown to be bladder tumor promoters. In addition...

journal_title：Cancer research

authors： Cohen SM,Ellwein LB,Okamura T,Masui T,Johansson SL,Smith RA,Wehner JM,Khachab M,Chappel CI,Schoenig GP

更新日期：1991-04-01 00:00:00

abstract：:The process of monoclonal antibody (MAb) binding to tumor cells is greatly influenced by the biology of the respective antigen. This was concluded from an analysis of binding and release of MAbs and MAb fragments to melanoma cells at different concentration levels and different temperatures. With an antigen known to b...

journal_title：Cancer research

authors： Matzku S,Bröcker EB,Brüggen J,Dippold WG,Tilgen W

更新日期：1986-08-01 00:00:00

abstract：:Previous studies have documented the roles of transport via the reduced folate carrier, retention via polyglutamylation, and increased levels of the target enzyme, dihydrofolate reductase in sensitivity to methotrexate. Recent studies have shown that the mitochondrial enzymes in the cellular metabolism of serine, fola...

journal_title：Cancer research

authors： Vazquez A,Tedeschi PM,Bertino JR

更新日期：2013-01-15 00:00:00

abstract：:Specific immunity to Rous virus-induced sarcoma (RSL) was investigated by the tube leukocyte adherence inhibition (LAI) assay in rats immunized with Bacillus Calmette-Guérin (BCG). Peritoneal cells from Lewis rats immunized s.c. with BCG gave positive reactions in the tube LAI assay with the antigen prepared from RSL ...

journal_title：Cancer research

authors： Holán V,Chutná J,Hasek M

更新日期：1979-02-01 00:00:00

abstract：:Pyrazine diazohydroxide (PZDH) is a novel antineoplastic agent that appears to form DNA adducts via the reactive pyrazine diazonium ion and produces substantial antitumor activity in preclinical models. We conducted a phase I trial to determine the maximally tolerated dose of PZDH that could be administered as a 5-min...

journal_title：Cancer research

authors： Vogelzang NJ,Mick R,Janisch L,Berezin F,Schilsky RL,Ratain MJ

更新日期：1994-01-01 00:00:00

abstract：:Microcephalin (MCPH1) is a BRCA1 COOH terminal (BRCT) domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double-strand breaks by phosphorylated histone H2AX (gammaH2AX), but the mechanism by ...

journal_title：Cancer research

authors： Wu X,Mondal G,Wang X,Wu J,Yang L,Pankratz VS,Rowley M,Couch FJ

更新日期：2009-07-01 00:00:00