Cross-reactivity between Bacillus Calmette-Guérin and Rous Virus-induced sarcoma detected in rats by tube leukocyte adherence inhibition assay.

abstract：:Recent studies have demonstrated that cytochrome c plays an important role in cell death. In the present study, we report that teniposide and various other chemotherapeutic agents induced a dose-dependent increase in the expression of the mitochondrial respiratory chain proteins cytochrome c, subunits I and IV of cyto...

journal_title：Cancer research

authors： Sánchez-Alcázar JA,Khodjakov A,Schneider E

更新日期：2001-02-01 00:00:00

abstract：:In the epidermis, p53 plays an important role in UV-B protection that led us to examine the role, if any, that p63, a p53 homologue highly expressed in the basal layer of the epidermis, might play in the epidermal UV-B response. One p63 isoform, deltaNp63alpha, decreased dramatically in normal keratinocytes or newborn...

journal_title：Cancer research

authors： Liefer KM,Koster MI,Wang XJ,Yang A,McKeon F,Roop DR

更新日期：2000-08-01 00:00:00

abstract：:Elongation factor-2 kinase (eEF-2 kinase), also known as Ca(2+)/calmodulin-dependent kinase III, regulates protein synthesis by controlling the rate of peptide chain elongation. The activity of eEF-2 kinase is increased in glioblastoma and other malignancies, yet its role in neoplasia is uncertain. Recent evidence sug...

journal_title：Cancer research

authors： Wu H,Yang JM,Jin S,Zhang H,Hait WN

更新日期：2006-03-15 00:00:00

abstract：:Metastases from prostatic adenocarcinoma (prostate cancer) are characterized by their predilection for bone and typical osteoblastic features. An in vitro model of bone metastases from prostate cancer was developed using a bicompartment coculture system of mouse osteoblasts and human prostate cancer cells. In this mod...

journal_title：Cancer research

authors： Yang J,Fizazi K,Peleg S,Sikes CR,Raymond AK,Jamal N,Hu M,Olive M,Martinez LA,Wood CG,Logothetis CJ,Karsenty G,Navone NM

更新日期：2001-07-15 00:00:00

abstract：:Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which includes C-reactive protein (CRP). PTX3 has been implicated in angiogenesis, proliferation, and immune escape in cancer. In the present study, we evaluated PTX3 tissue expression and serum concentration as a biomarker to discrimi...

journal_title：Cancer research

authors： Stallone G,Cormio L,Netti GS,Infante B,Selvaggio O,Fino GD,Ranieri E,Bruno F,Prattichizzo C,Sanguedolce F,Tortorella S,Bufo P,Grandaliano G,Carrieri G

更新日期：2014-08-15 00:00:00

abstract：:We previously found that a Salmonella typhimurium vector engineered to secrete soluble tumor antigen induces CD4(+) T cells resistant to CD4(+)CD25(+) regulatory T cells (Treg) and that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) signal is involved in the development of this resist...

journal_title：Cancer research

authors： Nishikawa H,Kato T,Hirayama M,Orito Y,Sato E,Harada N,Gnjatic S,Old LJ,Shiku H

更新日期：2008-07-15 00:00:00

abstract：:Avian erythroblastosis virus strain R (AEV)-transformed, cloned erythroleukemia cells from three different ages of SC strain chickens were analyzed before and after differentiation induced by 1.0 mM butyric acid for expression of chicken fetal antigens (CFAs) and chicken adult antigens (CAAs) and for hemoglobin expres...

journal_title：Cancer research

authors： Nelson CH,Allison JP,Kline K,Sanders BG

更新日期：1982-11-01 00:00:00

abstract：:We examined the effect of rate of temperature rise on the thermosensitivity of a murine lymphoblastic leukemia. L1210 cells suspended in RPMI 1630 medium:5% fetal bovine serum at pH 7.4 were heated from 37 degrees C-42 degrees C, or 44 degrees C over variable times (immediately, 30, 60, 120, 180 min) in a circulating ...

journal_title：Cancer research

authors： Burns CP,Lambert BJ,Haugstad BN,Guffy MM

更新日期：1986-04-01 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-agent preclinical activity in cancers with high levels of replication st...

journal_title：Cancer research

authors： Rogers RF,Walton MI,Cherry DL,Collins I,Clarke PA,Garrett MD,Workman P

更新日期：2020-04-15 00:00:00

abstract：:Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

journal_title：Cancer research

authors： Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

更新日期：1977-02-01 00:00:00

abstract：:Glioblastoma is an aggressive brain tumor characterized by an abnormal blood vasculature that is hyperpermeable. Here, we report a novel role for CD93 in regulating angiogenesis in this setting by modulating cell-cell and cell-matrix adhesion of endothelial cells. Tissue microarray analysis demonstrated that vascular ...

journal_title：Cancer research

authors： Langenkamp E,Zhang L,Lugano R,Huang H,Elhassan TE,Georganaki M,Bazzar W,Lööf J,Trendelenburg G,Essand M,Pontén F,Smits A,Dimberg A

更新日期：2015-11-01 00:00:00

abstract：:Vascular permeability factor (VPF) is one of the most potent known inducers of microvascular hyperpermeability; in addition, it is a selective endothelial cell growth factor, hence its alternate name, vascular endothelial growth factor. VPF exerts its actions on the microvasculature by interacting with specific endoth...

journal_title：Cancer research

authors： Brown LF,Berse B,Jackman RW,Tognazzi K,Manseau EJ,Senger DR,Dvorak HF

更新日期：1993-10-01 00:00:00

abstract：:Modest clinical outcomes of dendritic cell (DC) vaccine trials call for novel strategies. In this study, we have created a chimeric CD40 molecule that incorporates a single chain Fv (scFv) molecule specific for human ErbB2 antigen and fusing to the membrane spanning and cytosolic domains of murine CD40. After adenovir...

journal_title：Cancer research

authors： Wei H,Wang H,Lu B,Li B,Hou S,Qian W,Fan K,Dai J,Zhao J,Guo Y

更新日期：2008-05-15 00:00:00

abstract：:The transcription factor activating transcription factor 2 (ATF2) has been shown to be associated with melanocytic oncogenesis and melanoma tumor proliferation in preclinical models. The clinical significance of ATF2 expression is unknown. To determine the prognostic value of ATF2 in melanoma, we evaluated the pattern...

journal_title：Cancer research

authors： Berger AJ,Kluger HM,Li N,Kielhorn E,Halaban R,Ronai Z,Rimm DL

更新日期：2003-12-01 00:00:00

abstract：:Head and neck squamous cell carcinomas (HNSCC) often metastasize to locoregional lymph nodes, and lymph node involvement represents one of the most important prognostic factors of poor clinical outcome. HNSCCs are remarkably lymphangiogenic and represent a clear example of a cancer that utilizes the lymphatic vasculat...

journal_title：Cancer research

authors： Doçi CL,Mikelis CM,Lionakis MS,Molinolo AA,Gutkind JS

更新日期：2015-07-15 00:00:00

abstract：:Mechanism, in addition to protein kinase C activation may mediate 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated differentiation of leukemic cells. We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the pro...

journal_title：Cancer research

authors： Ways DK,Dodd RC,Earp HS

更新日期：1987-07-01 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:Noninvasive, nonmetastatic BW5147 T-lymphoma cells were transfected with the activated human c-Ha-ras oncogene and were examined subsequently for the acquisition of invasive properties in vitro and of metastatic potential in vivo. It was found that several transfectants harboring the ras gene had become invasive in vi...

journal_title：Cancer research

authors： Collard JG,Schijven JF,Roos E

更新日期：1987-02-01 00:00:00

abstract：:Aberrant crypt foci (ACF) are distinct microscopic lesions of the colon thought to be the earliest identifiable precursors of colon cancer. As precursors of colon cancer, ACF may contain mutations in genes that are altered early in colorectal tumorigenesis. Candidates for these genes include APC, K-Ras, and those of t...

journal_title：Cancer research

authors： Heinen CD,Shivapurkar N,Tang Z,Groden J,Alabaster O

更新日期：1996-12-01 00:00:00

abstract：:Radiolabeled antibodies have produced encouraging remissions in patients with chemotherapy-resistant hematological malignancies; however, the selection of therapeutic radionuclides for clinical trials remains controversial. In this study, we compared the internalization, lysosomal targeting, metabolism, and cellular r...

journal_title：Cancer research

authors： Press OW,Shan D,Howell-Clark J,Eary J,Appelbaum FR,Matthews D,King DJ,Haines AM,Hamann P,Hinman L,Shochat D,Bernstein ID

更新日期：1996-05-01 00:00:00

abstract：:Human breast cancer (HBC) cell growth suppression by okadaic acid (OA) was previously found to involve elevated expression of oncogenes c-myc and c-fos and apoptosis. Since, c-Myc influences diverse pathways of cell growth, we hypothesized that elevated levels of c-Myc are involved in HBC growth suppression. Here, we ...

journal_title：Cancer research

authors： Zhang L,Wali A,Ramana CV,Rishi AK

更新日期：2007-11-01 00:00:00

abstract：:Topotecan (SK&F 104864, hycamptamine, NSC 609699) is believed to exert its cytotoxic effects through inhibition of topoisomerase I, the activity of which recovers rapidly on removal of the drug in vitro. In vivo studies show that the activity of topotecan is schedule dependent, favoring repeated doses. Early human stu...

journal_title：Cancer research

authors： Haas NB,LaCreta FP,Walczak J,Hudes GR,Brennan JM,Ozols RF,O'Dwyer PJ

更新日期：1994-03-01 00:00:00

abstract：:In the chemotherapy of infectious diseases, selective toxicity has been achieved by designing curative regimens based on pharmacokinetic data. Selective toxicity of antitumor drugs has been demonstrated for rapidly growing large growth fraction tumors occurring in patients under age 30. In these tumors curative schedu...

journal_title：Cancer research

authors： Zubrod CG

更新日期：1978-12-01 00:00:00

abstract：:Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease. In this study, we examined the effects of antisense cyclin G1, in...

journal_title：Cancer research

authors： Skotzko M,Wu L,Anderson WF,Gordon EM,Hall FL

更新日期：1995-12-01 00:00:00

abstract：:We showed recently that Helicobacter infection induces expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the mouse stomach, and that transgenic mice expressing both cyclooxygenase-2 and microsomal prostaglandin E synthase-1 (K19-C2mE mice) develop hyperplastic gastric tumors with inflammatory...

journal_title：Cancer research

authors： Oshima M,Oshima H,Matsunaga A,Taketo MM

更新日期：2005-10-15 00:00:00

abstract：:Neocarzinostatin (NCS) is mutagenic in bacteria, yeast, fungi, and mammalian cells. In cell-free systems, DNA strand breakage induced by NCS requires a reducing agent like 2-mercaptoethanol, unless very high (greater than 100 micrograms/ml) concentrations of NCS are used. In this study, we have investigated the role o...

journal_title：Cancer research

authors： DeGraff WG,Mitchell JB

更新日期：1985-10-01 00:00:00

abstract：:One of the body's natural defense mechanisms against tumor cells is lysis of the invading cell by cytotoxic T-cells and natural killer (NK) cells. Five human hepatocellular carcinoma cell lines were found to have different sensitivities to killing by peripheral blood monocytes in a 51Cr release assay. This killing was...

journal_title：Cancer research

authors： Stevenson D,Binggeli R,Weinstein RC,Keck JG,Lai MC,Tong MJ

更新日期：1989-09-01 00:00:00

abstract：:A hormone-dependent subline of the transplantable rat mammary tumor MTW9 contains binding sites for both prolactin and estrogen. Prolactin binding is saturable (K-d similar to 2 times 10-9 M), hormone specific, and destroyed by proteases. By contrast, an autonomous subline derived from the same parent tumor has lost m...

journal_title：Cancer research

authors： Costlow ME,Buschow RA,Richert NJ,McGuire WL

更新日期：1975-04-01 00:00:00

abstract：:Tumor cell fractions isolated from tumor lines SH-3 (breast carcinoma) and RPMI-7932 (malignant melanoma) by differential centrifugations were capable of transforming lymphocytes into cytotoxic effector cells. Lymphocytes cultured alone in human AB plasma did not become cytotoxic to tumor cells. However, when cultured...

journal_title：Cancer research

authors： Sharma B

更新日期：1977-12-01 00:00:00

abstract：:Human kallikrein 10 (hK10) is a secreted serine protease that is highly expressed in ovarian tissue. We hypothesized that hK10 might represent a novel serological marker for ovarian cancer. We quantified by immunoassay, hK10 in sera from 97 normal women (controls), 141 patients with benign gynecologic diseases, and 14...

journal_title：Cancer research

authors： Luo LY,Katsaros D,Scorilas A,Fracchioli S,Bellino R,van Gramberen M,de Bruijn H,Henrik A,Stenman UH,Massobrio M,van der Zee AG,Vergote I,Diamandis EP

更新日期：2003-02-15 00:00:00