Abstract：
:One of the body's natural defense mechanisms against tumor cells is lysis of the invading cell by cytotoxic T-cells and natural killer (NK) cells. Five human hepatocellular carcinoma cell lines were found to have different sensitivities to killing by peripheral blood monocytes in a 51Cr release assay. This killing was demonstrated to be due to NK cell lysis. Electrical recording measurements of the membrane potentials of these five cell lines showed different values for each line, all below values reported for normal hepatocytes. Correlation between mean cell membrane potential, and sensitivity to NK lysis, revealed an inverse relationship. In this study we demonstrate that the lower the mean membrane potential of a human hepatocellular carcinoma cell line, the more sensitive it is to NK cell cytolysis. Cell surface positive potential did not correlate with NK cytolysis and only a weak correlation was found between cell membrane negative potential and cell surface positive potential between cell lines.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Stevenson D,Binggeli R,Weinstein RC,Keck JG,Lai MC,Tong MJsubject
Has Abstractpub_date
1989-09-01 00:00:00pages
4842-5issue
17eissn
0008-5472issn
1538-7445journal_volume
49pub_type
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