Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates.

Abstract:

:To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens.

journal_name

Cancer Res

journal_title

Cancer research

authors

FitzGerald DJ,Wayne AS,Kreitman RJ,Pastan I

doi

10.1158/0008-5472.CAN-11-1374

subject

Has Abstract

pub_date

2011-10-15 00:00:00

pages

6300-9

issue

20

eissn

0008-5472

issn

1538-7445

pii

71/20/6300

journal_volume

71

pub_type

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