Abstract：
:To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-drug conjugates, respectively, represent a second revolution in antibody-mediated cancer therapy. Thus, highly toxic compounds are delivered to the interior of cancer cells based on antibody specificity for cell-surface target antigens.
journal_name
Cancer Resjournal_title
Cancer researchauthors
FitzGerald DJ,Wayne AS,Kreitman RJ,Pastan Idoi
10.1158/0008-5472.CAN-11-1374subject
Has Abstractpub_date
2011-10-15 00:00:00pages
6300-9issue
20eissn
0008-5472issn
1538-7445pii
71/20/6300journal_volume
71pub_type
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