Chicken fetal and adult antigen expression on erythroleukemia cells before and after induced differentiation.

abstract：:Breast cancers expressing estrogen receptor-alpha (ERalpha) are associated with a favorable biology and are more likely to respond to hormonal therapy. In addition to ERalpha, other pathways of estrogen response have been identified including ERbeta and GPR30, a membrane receptor for estrogen, and the key mechanisms r...

journal_title：Cancer research

authors： Woodfield GW,Horan AD,Chen Y,Weigel RJ

更新日期：2007-09-15 00:00:00

abstract：:We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated with clinical parameters relevant to tumor metastasis, and we report here on the identification of N-myc downstream regulated gene 2...

journal_title：Cancer research

authors： Lee DC,Kang YK,Kim WH,Jang YJ,Kim DJ,Park IY,Sohn BH,Sohn HA,Lee HG,Lim JS,Kim JW,Song EY,Kim DM,Lee MN,Oh GT,Kim SJ,Park KC,Yoo HS,Choi JY,Yeom YI

更新日期：2008-06-01 00:00:00

abstract：:Previous studies have demonstrated the suitability of image analysis of tetrazolium-stained colonies to assess growth and drug sensitivity of human tumor cells cultivated in soft agar culture. In the present study, the potential utility of colorimetric analysis to expedite experimental drug evaluations using human tum...

journal_title：Cancer research

authors： Alley MC,Pacula-Cox CM,Hursey ML,Rubinstein LR,Boyd MR

更新日期：1991-02-15 00:00:00

abstract：:Using computerized pharmacy records from 1969 to 1973 for a cohort of 143,574 members of the Kaiser Permanente Medical Care Program, we have been testing associations of 215 drugs or drug groups with subsequent incidence of cancer at 56 sites. This paper presents findings with follow-up through 1984. There were 227 st...

journal_title：Cancer research

authors： Selby JV,Friedman GD,Fireman BH

更新日期：1989-10-15 00:00:00

abstract：:Inhibition of the survival kinase Akt can trigger apoptosis, and also has been found to activate autophagy, which may confound tumor attack. In this study, we investigated regulatory mechanisms through which apoptosis and autophagy were modulated in tumor cells subjected to Akt inhibition by MK-2206, the first alloste...

journal_title：Cancer research

authors： Cheng Y,Ren X,Zhang Y,Patel R,Sharma A,Wu H,Robertson GP,Yan L,Rubin E,Yang JM

更新日期：2011-04-01 00:00:00

abstract：:Insulin-like growth factor II is a growth factor important in fetal development. Several cancer tissues and cell lines have been reported to express IGF-II and rat IGF-II is mitogenic for breast cancer cell lines. Using Northern analysis and ribonuclease protection assays, IGF-II mRNA was detected in normal fibroblast...

journal_title：Cancer research

authors： Yee D,Cullen KJ,Paik S,Perdue JF,Hampton B,Schwartz A,Lippman ME,Rosen N

更新日期：1988-12-01 00:00:00

abstract：:XPC protein is a critical DNA damage recognition factor in nucleotide excision repair for which genetic deficiency confers a predisposition to cancer. In this study, we show that XPC has a function that is independent of its canonical function in DNA repair, potentially altering the interpretation of how XPC deficienc...

journal_title：Cancer research

authors： Wang QE,Han C,Zhang B,Sabapathy K,Wani AA

更新日期：2012-02-01 00:00:00

abstract：:Formalin-fixed, paraffin-embedded tissues from 108 cases of invasive carcinoma of the uterine cervix, consisting of 40 cases of adenocarcinoma, 44 cases of adenosquamous carcinoma, and, as a control, 24 cases of squamous cell carcinoma were examined for the presence of human papillomavirus (HPV) DNA by in situ hybridi...

journal_title：Cancer research

authors： Tase T,Okagaki T,Clark BA,Manias DA,Ostrow RS,Twiggs LB,Faras AJ

更新日期：1988-02-15 00:00:00

abstract：:Expression of non-self antigens by tumors can induce activation of T cells in vivo, although this activation can lead to either immunity or tolerance. CD8+ T-cell activation can be direct (if the tumor expresses MHC class I molecules) or indirect (after the capture and cross-presentation of tumor antigens by dendritic...

journal_title：Cancer research

authors： Zeelenberg IS,Ostrowski M,Krumeich S,Bobrie A,Jancic C,Boissonnas A,Delcayre A,Le Pecq JB,Combadière B,Amigorena S,Théry C

更新日期：2008-02-15 00:00:00

abstract：:The level of steroid receptors in target cells affects the responsiveness of the cell to the hormone. In mouse AtT-20 cells, it has been shown that chronic glucocorticoid treatment causes a down-regulation of glucocorticoid receptor (GR) levels (F. Svec and M. Rudis, J. Biol. Chem., 256:5984-5987, 1981). The current s...

journal_title：Cancer research

authors： Vedeckis WV,Ali M,Allen HR

更新日期：1989-04-15 00:00:00

abstract：:The effects of 5-fluoro-2'-deoxyuridine (FdUrd) and 5,8-dideazaisofolic acid on the coordination of thymidylate synthase activity and DNA synthesis were examined in human CCRF-CEM leukemic cells following a continuous exposure to these agents. In logarithmically growing control tumor cells, the rate of in situ thymidy...

journal_title：Cancer research

authors： Fernandes DJ,Cranford SK

更新日期：1986-04-01 00:00:00

abstract：:UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4-N-acetylglucosaminyl-transferase III (GnT-III) is a key enzyme in the branching of asparagine-linked oligosaccharides, which are present in surface membrane proteins of various tissues and in secretory glycoproteins. The activity of GnT-III was assayed in 2 human hepa...

journal_title：Cancer research

authors： Miyoshi E,Nishikawa A,Ihara Y,Hayashi N,Fusamoto H,Kamada T,Taniguchi N

更新日期：1994-04-01 00:00:00

abstract：:A transplantable mammary tumor derived from an outgrowth of nodule-like alveolar lesions induced by 7,12-dimethylbenz[a]anthracene in cultures of whole mammary gland was shown to produce a family of somatomedin-like polypeptides when cultured in vitro. Minced mammary tumor tissue as well as monolayer cultures of tumor...

journal_title：Cancer research

authors： Knauer DJ,Iyer AP,Banerjee MR,Smith GL

更新日期：1980-12-01 00:00:00

abstract：:The endoplasmic reticulum aminopeptidase ERAP1 regulates innate and adaptive immune responses by trimming peptides for presentation by MHC class I (MHC-I) molecules. Herein, we demonstrate that genetic or pharmacological inhibition of ERAP1 on human tumor cell lines perturbs their ability to engage several classes of ...

journal_title：Cancer research

authors： Cifaldi L,Romania P,Falco M,Lorenzi S,Meazza R,Petrini S,Andreani M,Pende D,Locatelli F,Fruci D

更新日期：2015-03-01 00:00:00

abstract：:Glucocorticoids are used for the treatment of lymphoid neoplasms, taking advantage of the well-known ability of these compounds to cause apoptosis in lymphoid tissues. Previously, we have shown that dexamethasone, a synthetic glucocorticoid, causes a down-regulation of several antioxidant defense enzymes and proteins,...

journal_title：Cancer research

authors： Tome ME,Baker AF,Powis G,Payne CM,Briehl MM

更新日期：2001-03-15 00:00:00

abstract：:Photoimmunotherapy (using a monoclonal antibody-targeted photosensitizer and red light) may be a strategy to overcome the limitations inherent in photodynamic therapy of liver tumors. The aims of this study were (a) to test the efficacy of selective treatment of hepatic metastases of colorectal cancer in an orthotopic...

journal_title：Cancer research

authors： Del Governatore M,Hamblin MR,Shea CR,Rizvi I,Molpus KG,Tanabe KK,Hasan T

更新日期：2000-08-01 00:00:00

abstract：:Although regulatory T cells (Tregs) have been detected in clinically apparent and experimentally induced tumors, the significance of their presence is obscured because past studies examined late-stage tumors that had formed in immunocompetent hosts and thus had evolved mechanisms to escape immunologic recognition and/...

journal_title：Cancer research

authors： Bui JD,Uppaluri R,Hsieh CS,Schreiber RD

更新日期：2006-07-15 00:00:00

abstract：:A low molecular weight cytoplasmic protein (Mr 19,000-22,000) has been reported to be overexpressed in some multidrug-resistant cells. We have found that a cytoplasmic protein with a molecular weight of 22,000 is highly expressed in the human myelogenous leukemia K562 cells resistant to Adriamycin (K562/ADM). The Mr 2...

journal_title：Cancer research

authors： Hamada H,Okochi E,Oh-hara T,Tsuruo T

更新日期：1988-06-01 00:00:00

abstract：:The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains poor despite decades of effort. The abundant extracellular matrix (ECM) in PDAC comprises a major fraction of the tumor mass and plays various roles in promoting resistance to therapies. However, nonselective depletion of ECM has led to poor patient out...

journal_title：Cancer research

authors： Tian C,Öhlund D,Rickelt S,Lidström T,Huang Y,Hao L,Zhao RT,Franklin O,Bhatia SN,Tuveson DA,Hynes RO

更新日期：2020-04-01 00:00:00

abstract：:10-Ethyl-10-deazaaminopterin (10-EdAM) is an antifolate compound with greater therapeutic activity than methotrexate against transplanted tumors in mice. When given weekly for 3 weeks, the 10% lethal dose in rats was 125 mg/kg (i.p.) and in dogs it was 2.5 mg/kg (i.v.). The major histopathological findings in intoxica...

journal_title：Cancer research

authors： Fanucchi MP,Kinahan JJ,Samuels LL,Hancock C,Chou TC,Niedzwiecki D,Farag F,Vidal PM,DeGraw JI,Sternberg SS

更新日期：1987-05-01 00:00:00

abstract：:Protein kinase Ciota (PKCiota) is an oncogene required for maintenance of the transformed phenotype of non-small cell lung cancer cells. However, the role of PKCiota in lung tumor development has not been investigated. To address this question, we established a mouse model in which oncogenic Kras(G12D) is activated by...

journal_title：Cancer research

authors： Regala RP,Davis RK,Kunz A,Khoor A,Leitges M,Fields AP

更新日期：2009-10-01 00:00:00

abstract：:The mouse breast cancer cell lines 4T1, 4T07, and 67NR are highly tumorigenic but vary in metastatic potential: 4T1 widely disseminates, resulting in secondary tumors in the lung, liver, bone, and brain; 4T07 spreads to the lung and liver but is unable to establish metastatic nodules; 67NR is unable to metastasize. Th...

journal_title：Cancer research

authors： Manka D,Spicer Z,Millhorn DE

更新日期：2005-12-15 00:00:00

abstract：:Hepatocellular carcinoma is among the most common and lethal cancers in humans. Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneratio...

journal_title：Cancer research

authors： Farazi PA,Glickman J,Horner J,Depinho RA

更新日期：2006-05-01 00:00:00

abstract：:ADAMs (a disintegrin and metalloproteinase) have important roles in development and diseases such as cancer. Previously, an ADAM15 splice variant (ADAM15B), which contains an inserted cytoplasmic Src-binding site, was linked to clinical aggressiveness in breast cancer, yet little was known about how this splice varian...

journal_title：Cancer research

authors： Maretzky T,Le Gall SM,Worpenberg-Pietruk S,Eder J,Overall CM,Huang XY,Poghosyan Z,Edwards DR,Blobel CP

更新日期：2009-06-01 00:00:00

abstract：:Aneuploidy is invariably associated with poor proliferation of primary cells, but the specific contributions of abnormal karyotypes to cancer, a disease characterized by aneuploidy and dysregulated proliferation, remain unclear. In this study, I demonstrate that the transcriptional alterations caused by aneuploidy in ...

journal_title：Cancer research

authors： Sheltzer JM

更新日期：2013-11-01 00:00:00

abstract：:Cancer patients showing local failure after radiation treatment have increased probability for developing metastatic disease. The mechanisms behind this observation have not been identified. In the present work, metastatic spread after inadequate radiation therapy was studied by using R-18 human melanoma xenografts as...

journal_title：Cancer research

authors： Rofstad EK,Mathiesen B,Galappathi K

更新日期：2004-01-01 00:00:00

abstract：:DAB389 GRP is composed of the catalytic and transmembrane domains of diphtheria toxin fused to gastrin-releasing peptide (GRP). DAB389 GRP is selectively targeted to, and inhibits protein synthesis in, cell lines expressing GRP receptors. Protein synthesis in 5'ET4 cells (BALB/3T3 fibroblasts transfected with the gene...

journal_title：Cancer research

authors： vanderSpek JC,Sutherland JA,Zeng H,Battey JF,Jensen RT,Murphy JR

更新日期：1997-01-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs, thought to be involved in physiologic and developmental processes by negatively regulating expression of target genes. We have previously reported frequent down-regulation of the let-7 miRNA family in lung cancers and, in the present study, assessed alteration in a panel of...

journal_title：Cancer research

authors： Hayashita Y,Osada H,Tatematsu Y,Yamada H,Yanagisawa K,Tomida S,Yatabe Y,Kawahara K,Sekido Y,Takahashi T

更新日期：2005-11-01 00:00:00

abstract：:The EL4 lymphoma in C57BL/6 mice was used as a model to examine the effect of progressive tumor growth on a variety of cell mediated cytolytic effector functions which have been shown in other systems to have antitumor potential. The functions examined were those of cytolytic T-lymphocyte, lymphokine activated killer ...

journal_title：Cancer research

authors： Maccubbin DL,Mace KF,Ehrke MJ,Mihich E

更新日期：1989-08-01 00:00:00

abstract：:Recent preclinical studies have shown that frequent administration in vivo of low doses of chemotherapeutic drugs ("metronomic" dosing) can affect tumor endothelium and inhibit tumor angiogenesis, reducing significant side effects (e.g., myelosuppression) involving other tissues, even after chronic treatment. This sug...

journal_title：Cancer research

authors： Bocci G,Nicolaou KC,Kerbel RS

更新日期：2002-12-01 00:00:00