A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis.

abstract：:Eighteen-day-old fetal urogenital sinus mesenchyme (UGM), 0-day-old neonatal seminal vesicle mesenchyme (SVM), 0-day-old neonatal bulbourethral gland mesenchyme (BUG-M), and 3-day-old neonatal urinary bladder mesenchyme (BLM) were isolated from rats and combined in vitro with 0.5-mm cubes of the R3327 androgen-depende...

journal_title：Cancer research

authors： Hayashi N,Cunha GR,Wong YC

更新日期：1990-08-01 00:00:00

abstract：:The photosensitization and survival recovery of cultured EJ human urinary bladder carcinoma cells containing nonexchangeable hematoporphyrin derivative (HPD) were studied. Cultures were incubated at 37 degrees C in growth medium supplemented with HPD (50 micrograms/ml) and 5% fetal bovine serum for 12 h followed by in...

journal_title：Cancer research

authors： Bellnier DA,Lin CW

更新日期：1985-06-01 00:00:00

abstract：:Pim serine/threonine kinases contribute to prostate tumorigenesis and therapeutic resistance, yet Pim kinase inhibitors seem to have only limited effects on prostate cancer cell survival. Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated th...

journal_title：Cancer research

authors： Song JH,Kraft AS

更新日期：2012-01-01 00:00:00

abstract：:Ascites tumor cells can be cultivated at a reduced serum concentration if cholesterol (2.50 mg per 100 ml of medium) is added to the culture medium. At serum concentrations of 3%, optimal growth properties are obtained; below 3%, cell cultures usually perish after a few days. Cells grown in the presence of added chole...

journal_title：Cancer research

authors： Haeffner EW,Hoffmann CJ,Stoehr M,Scherf H

更新日期：1984-06-01 00:00:00

abstract：:Tumor cell fractions isolated from tumor lines SH-3 (breast carcinoma) and RPMI-7932 (malignant melanoma) by differential centrifugations were capable of transforming lymphocytes into cytotoxic effector cells. Lymphocytes cultured alone in human AB plasma did not become cytotoxic to tumor cells. However, when cultured...

journal_title：Cancer research

authors： Sharma B

更新日期：1977-12-01 00:00:00

abstract：:Angiogenesis is essential for the growth of solid tumors. We have observed previously that the vascular endothelial cells of astrocytic brain tumors express human telomerase reverse transcriptase (hTERT) mRNA, suggesting a role for telomerase in the angiogenesis of these neoplasms. Here, we used an in vitro model to d...

journal_title：Cancer research

authors： Falchetti ML,Pierconti F,Casalbore P,Maggiano N,Levi A,Larocca LM,Pallini R

更新日期：2003-07-01 00:00:00

abstract：:We investigated the potential role of mitochondrial manganese superoxide dismutase (Mn-SOD) in protective activity against irradiation by analyzing cell viability by a colony formation assay and by detecting apoptosis in stably human Mn-SOD gene-transfected HLE, a hepatocellular carcinoma cell line. We found that over...

journal_title：Cancer research

authors： Motoori S,Majima HJ,Ebara M,Kato H,Hirai F,Kakinuma S,Yamaguchi C,Ozawa T,Nagano T,Tsujii H,Saisho H

更新日期：2001-07-15 00:00:00

abstract：:FET cells, derived from an early-stage colon carcinoma, are nontumorigenic in athymic mice. Stable transfection of a dominant-negative transforming growth factor beta (TGFbeta) type II receptor (DNRII) into FET cells that express autocrine TGFbeta shows loss of TGFbeta signaling and increased tumorigenicity in vivo in...

journal_title：Cancer research

authors： Wang J,Yang L,Yang J,Kuropatwinski K,Wang W,Liu XQ,Hauser J,Brattain MG

更新日期：2008-05-01 00:00:00

abstract：:Two aminoanthraquinone analogs 1,4-bis(2-[(2-hydroxyethyl)amino]ethylamino)-9,10-anthracenedione (HAQ) and 1,4-dihydroxy-5,8-bis(2-[(2-hydroxyethyl)amino]ethylamino]-9,10-anthracenedione (DHAQ) have been shown to possess similar therapeutic activities against experimental tumors but different toxicities to the animal...

journal_title：Cancer research

authors： Au WW,Butler MA,Matney TS,Loo TL

更新日期：1981-02-01 00:00:00

abstract：:In order to determine the potential role of sex steroid and 1,25-dihydroxyvitamin D3 in the spreading of colorectal cancer, previously hypothesized from epidemiological and experimental data, specific androgen (AR, n = 94), estrogen (ER, n = 60), progesterone (PGR, n = 50), and 1,25-dihydroxyvitamin D3 receptors (VDR,...

journal_title：Cancer research

authors： Meggouh F,Lointier P,Saez S

更新日期：1991-02-15 00:00:00

abstract：:Aluminum sulfonated phthalocyanine has potential as a suitable photosensitizer for use in the photodynamic therapy of cancer. In the present study, cellular uptake and retention of the individual mono-, di-, tri-, and tetrasulfonated derivatives (AlS1-4Pc) were examined in tissue culture and in normal and neoplastic t...

journal_title：Cancer research

authors： Chan WS,Marshall JF,Svensen R,Bedwell J,Hart IR

更新日期：1990-08-01 00:00:00

abstract：:Malignant gliomas are the most common central nervous system tumors and the molecular mechanism driving their development and recurrence is still largely unknown, limiting the treatment of this disease. Here, we show that restoring the expression of miR-218, a microRNA commonly downregulated in glioma, dramatically re...

journal_title：Cancer research

authors： Tu Y,Gao X,Li G,Fu H,Cui D,Liu H,Jin W,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Plasmin is shown to play a crucial role in many pathophysiologic processes primarily through its ability to degrade extracellular matrix (ECM) and/or mobilizing growth factors that are sequestered in the ECM. Cysteine-rich 61 (CCN1) is a matricellular protein of which expression is up-regulated in cancer and various v...

journal_title：Cancer research

authors： Pendurthi UR,Tran TT,Post M,Rao LV

更新日期：2005-11-01 00:00:00

abstract：:Members of cutaneous melanoma (CM) families with dysplastic nevi (DN) are at high risk of developing CM. Using a shuttle vector plasmid, pSP189, cell lines from three patients with CM plus DN were previously found to have elevated post-UV plasmid mutability. To investigate familial occurrence of this cellular phenotyp...

journal_title：Cancer research

authors： Moriwaki SI,Tarone RE,Tucker MA,Goldstein AM,Kraemer KH

更新日期：1997-10-15 00:00:00

abstract：:Loss of DNA mismatch repair (MMR) increases the risk of spontaneous mutations. We sought to determine whether there was an interaction between hypoxia and MMR deficiency that might contribute to the phenomenon of tumor progression. Human colon carcinoma HCT116+ch2 (MMR-deficient) and HCT116+ch3 (MMR-proficient) sublin...

journal_title：Cancer research

authors： Kondo A,Safaei R,Mishima M,Niedner H,Lin X,Howell SB

更新日期：2001-10-15 00:00:00

abstract：:The Inflammation and Cancer Think Tank Meeting was organized by the National Cancer Institute with the purpose of identifying research advances, gaps, and opportunities for the study and clinical application of the role of inflammation on tumorigenesis. The format of this meeting consisted of brief presentations that ...

journal_title：Cancer research

authors： Peek RM Jr,Mohla S,DuBois RN

更新日期：2005-10-01 00:00:00

abstract：:The PDLIM2 protein regulates stability of transcription factors including NF-κB and STATs in epithelial and hemopoietic cells. PDLIM2 is strongly expressed in certain cancer cell lines that exhibit an epithelial-to-mesenchymal phenotype, and its suppression is sufficient to reverse this phenotype. PDLIM2 supports the ...

journal_title：Cancer research

authors： Cox OT,Edmunds SJ,Simon-Keller K,Li B,Moran B,Buckley NE,Bustamante-Garrido M,Healy N,O'Flanagan CH,Gallagher WM,Kennedy RD,Bernards R,Caldas C,Chin SF,Marx A,O'Connor R

更新日期：2019-05-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiotherapy, chemotherapy, or a combination of these modalities, and surgery remains the only curative intervention for localized disease. Although cancer-associated fibroblasts (CAF) are abundant in PDAC tumors, the effects of radiotherapy on CAFs and th...

journal_title：Cancer research

authors： Pereira PMR,Edwards KJ,Mandleywala K,Carter LM,Escorcia FE,Campesato LF,Cornejo M,Abma L,Mohsen AA,Iacobuzio-Donahue CA,Merghoub T,Lewis JS

更新日期：2020-04-15 00:00:00

abstract：:Problems in the radioimmunodetection of cancer typically involve small lesions having low object contrast. As such, the imaging device utilized must have a high spatial resolution as well as high detection efficiency. In addition, the imaging device must be interfaced to a computer system to allow data manipulation to...

journal_title：Cancer research

authors： Rollo FD,Patton JA

更新日期：1980-08-01 00:00:00

abstract：:The possible alteration of transformation-related antigens in cells that revert to a normal phenotype but that continue to retain the viral genome, has been investigated in [3H]glucosamine-labeled extracts of rat cells exhibiting a reversible temperature-dependent restriction in the expression of transformation and in...

journal_title：Cancer research

authors： Rieber M,Bacalao J,Rieber M

更新日期：1977-04-01 00:00:00

abstract：:(E)-2'-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirm...

journal_title：Cancer research

authors： Coucke PA,Decosterd LA,Li YX,Cottin E,Chen X,Sun LQ,Stern S,Paschoud N,Denekamp J

更新日期：1999-10-15 00:00:00

abstract：:Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and antiproliferative action. In this study, the addition of metformin to 2-deoxyglucose (2DG) inhibited mitochondrial respiration and glycolysis in prostate cancer cells leadin...

journal_title：Cancer research

authors： Ben Sahra I,Laurent K,Giuliano S,Larbret F,Ponzio G,Gounon P,Le Marchand-Brustel Y,Giorgetti-Peraldi S,Cormont M,Bertolotto C,Deckert M,Auberger P,Tanti JF,Bost F

更新日期：2010-03-15 00:00:00

abstract：:Nonmyeloablative hematopoietic cell transplantation can cure patients with hematologic malignancies but has reported limited success against solid tumors. This is possibly because of profound peripheral tolerance mechanisms and/or suboptimal tumor recognition by effector T lymphocytes. We report that in mice developin...

journal_title：Cancer research

authors： Hess Michelini R,Freschi M,Manzo T,Jachetti E,Degl'Innocenti E,Grioni M,Basso V,Bonini C,Simpson E,Mondino A,Bellone M

更新日期：2010-05-01 00:00:00

abstract：:There is a paucity of data on whether or not women can be reinfected with human papillomavirus (HPV) types to which they were exposed to earlier in life and on the role of natural immunity. The observation of HPV infection at older ages may be explained by the reactivation of a latent infection or new exposure from se...

journal_title：Cancer research

authors： Trottier H,Ferreira S,Thomann P,Costa MC,Sobrinho JS,Prado JC,Rohan TE,Villa LL,Franco EL

更新日期：2010-11-01 00:00:00

abstract：:Exposure of mice to total body irradiation induces nuclear factor kappaB (NFkappaB) activation in a tissue-specific manner. In addition to the spleen, lymph nodes, and bone marrow, the tissues that exhibit NFkappaB activation now include the newly identified site of the intestinal epithelial cells. NFkappaB activated ...

journal_title：Cancer research

authors： Wang Y,Meng A,Lang H,Brown SA,Konopa JL,Kindy MS,Schmiedt RA,Thompson JS,Zhou D

更新日期：2004-09-01 00:00:00

abstract：:TuAg.1 is a tumor-associated membrane glycoprotein first identified in rat hepatocellular carcinoma by monoclonal antibodies (mAbs) 324.5 and 324.9. This oncofetal antigen is also expressed by hepatocytes in cell culture but not normal adult hepatocytes in vivo. Affinity chromatography and preparative continuous eluti...

journal_title：Cancer research

authors： Lim YP,Fowler LC,Hixson DC,Wehbe T,Thompson NL

更新日期：1996-09-01 00:00:00

abstract：:In the era of omics-driven research, it remains a common dilemma to stratify individual patients based on the molecular characteristics of their tumors. To improve molecular stratification of patients with breast cancer, we developed the Gaussian mixture model (GMM)-based classifier. This probabilistic classifier was ...

journal_title：Cancer research

authors： Prabakaran I,Wu Z,Lee C,Tong B,Steeman S,Koo G,Zhang PJ,Guvakova MA

更新日期：2019-07-01 00:00:00

abstract：:We have examined the distribution of radiolabeled liposomes in tumor-bearing mice after i.v. injection. Two mouse tumors (B16 melanoma, J6456 lymphoma) and a human tumor (LS174T colon carcinoma) inoculated i.m., s.c., or in the hind footpad were used in these studies. When various liposome compositions with a mean ves...

journal_title：Cancer research

authors： Gabizon A,Price DC,Huberty J,Bresalier RS,Papahadjopoulos D

更新日期：1990-10-01 00:00:00

abstract：:The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of ...

journal_title：Cancer research

authors： Fasching CL,Neumann AA,Muntoni A,Yeager TR,Reddel RR

更新日期：2007-08-01 00:00:00

abstract：:We present a light scattering study using angle-resolved low coherence interferometry (a/LCI) to assess nuclear morphology and subcellular structure within MCF-7 cells at several time points after treatment with chemotherapeutic agents. Although the nuclear diameter and eccentricity are not observed to change, the lig...

journal_title：Cancer research

authors： Chalut KJ,Ostrander JH,Giacomelli MG,Wax A

更新日期：2009-02-01 00:00:00