Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor.

abstract：:Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key enzyme of de novo fatty acid synthesis responsible for generating cytosolic acetyl-CoA and oxaloacetate. To evaluate its role in lung cancer progression, we here analyzed ACLY expression in ...

journal_title：Cancer research

authors： Migita T,Narita T,Nomura K,Miyagi E,Inazuka F,Matsuura M,Ushijima M,Mashima T,Seimiya H,Satoh Y,Okumura S,Nakagawa K,Ishikawa Y

更新日期：2008-10-15 00:00:00

abstract：:Mutated KRAS protein is a pivotal tumor driver in pancreatic cancer. However, despite comprehensive efforts, effective therapeutics that can target oncogenic KRAS are still under investigation or awaiting clinical approval. Using a specific KRAS-dependent gene signature, we implemented a computer-assisted inspection o...

journal_title：Cancer research

authors： Mottini C,Tomihara H,Carrella D,Lamolinara A,Iezzi M,Huang JK,Amoreo CA,Buglioni S,Manni I,Robinson FS,Minelli R,Kang Y,Fleming JB,Kim MP,Bristow CA,Trisciuoglio D,Iuliano A,Del Bufalo D,Di Bernardo D,Melisi D,Dra

更新日期：2019-11-01 00:00:00

abstract：:In vitro experiments selected optimal conditions to radiolabel with 131I the whole immunoglobulin and F(ab')2 fragments of the monoclonal antibody (MoAb) 225.28S to a high-molecular-weight melanoma-associated antigen (HMW-MAA). Injection of the radiolabeled whole immunoglobulin and F(ab')2 fragments of the MoAb 225.28...

journal_title：Cancer research

authors： Buraggi GL,Callegaro L,Mariani G,Turrin A,Cascinelli N,Attili A,Bombardieri E,Terno G,Plassio G,Dovis M

更新日期：1985-07-01 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and combretastatin A4 phosphate (CA-4-P) markedly inhibit tumor blood flow in mice and are both currently in clinical trial. One of the challenges in clinical evaluation of antivascular agents is the monitoring of tumor blood flow inhibition in individual patients. This stu...

journal_title：Cancer research

authors： Siim BG,Laux WT,Rutland MD,Palmer BN,Wilson WR

更新日期：2000-08-15 00:00:00

abstract：:Allelic loss of chromosome 18q has been noted in intestinal type gastric adenocarcinomas. Smad4 is a gene located at 18q that was recently cloned in humans and found to be significantly altered in pancreatic cancers. We sought to determine whether Smad4 genetic alterations played a significant role in gastric tumorige...

journal_title：Cancer research

authors： Powell SM,Harper JC,Hamilton SR,Robinson CR,Cummings OW

更新日期：1997-10-01 00:00:00

abstract：:Upon incubation of cultured mammalian cells with the new anthracycline analogues cyanomorpholinyldoxorubicin and morpholinyldoxorubicin, nucleoli irreversibly segregate into their substructures which form individual portions of the nucleolar mass and characteristic electron-dense components adjacent to the nucleolonem...

journal_title：Cancer research

authors： Wassermann K,Newman RA,Davis FM,Mullins TD,Rose KM

更新日期：1988-07-15 00:00:00

abstract：:Although trastuzumab (Herceptin) has substantially improved the overall survival of patients with mammary carcinomas, even initially well-responding tumors often become resistant. Because natural killer (NK) cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is thought to contribute to the therapeutic ...

journal_title：Cancer research

authors： Reim F,Dombrowski Y,Ritter C,Buttmann M,Häusler S,Ossadnik M,Krockenberger M,Beier D,Beier CP,Dietl J,Becker JC,Hönig A,Wischhusen J

更新日期：2009-10-15 00:00:00

abstract：:Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue culture models are extremely useful in understanding the biology of prostate cancer, they cannot recapitulate the complex cellular interactions within the tumor m...

journal_title：Cancer research

authors： Ittmann M,Huang J,Radaelli E,Martin P,Signoretti S,Sullivan R,Simons BW,Ward JM,Robinson BD,Chu GC,Loda M,Thomas G,Borowsky A,Cardiff RD

更新日期：2013-05-01 00:00:00

abstract：:Mithramycin (MIT) and tolfenamic acid (TA) inhibit the activity of the transcription factor Sp1. In the present study, we investigated whether pancreatic cancer treatment with a combination of these compounds has a synergistic effect on Sp1 activity, tumor growth, and their underlying response mechanisms. Treatment of...

journal_title：Cancer research

authors： Jia Z,Gao Y,Wang L,Li Q,Zhang J,Le X,Wei D,Yao JC,Chang DZ,Huang S,Xie K

更新日期：2010-02-01 00:00:00

abstract：:The purpose of this study was to characterize the transport properties of trimetrexate in WI-L2 human lymphoblastoid cells and determine the mode of resistance that had developed in a subline, WI-L2/TMQ, that was grown in increasing concentrations of trimetrexate. WI-L2/TMQ cells were 62-fold resistant to trimetrexate...

journal_title：Cancer research

authors： Fry DW,Besserer JA

更新日期：1988-12-15 00:00:00

abstract：:The activity of an endonuclease(s) acting on double-stranded, ultraviolet-irradiated, and 2-acetylaminofluorene-bound DNA but not on double-stranded undamaged DNA triples within two hr after partial hepatectomy. Although the activity drops between four and six hr after operation, it remains above levels measured in li...

journal_title：Cancer research

authors： Van Lancker JL,Tomura T

更新日期：1981-06-01 00:00:00

abstract：:Surgical resection followed by radiation therapy is the mainstay of treatment for glioblastoma multiforme (GBM), the most aggressive of the malignant gliomas. The poor clinical response of GBM and the intrinsic radiation resistance of this tumor type have prompted clinical investigations seeking to define the role of ...

journal_title：Cancer research

authors： Yount GL,Haas-Kogan DA,Levine KS,Aldape KD,Israel MA

更新日期：1998-09-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascer...

journal_title：Cancer research

authors： Santiago C,Pagán B,Isidro AA,Appleyard CB

更新日期：2007-11-15 00:00:00

abstract：:The conditions for growing preneoplastic mammary epithelial cells in primary cell cultures with serum-free factor-defined medium were established in a series of experiments. The cells, grown in Dulbecco's modified Eagle's medium with 0.6 mM Ca2+, epidermal growth factor, transferrin, insulin, and Na2SeO3, were fibrobl...

journal_title：Cancer research

authors： Medina D,Oborn CJ

更新日期：1980-11-01 00:00:00

abstract：:R115777 [(B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] is a potent and selective inhibitor of farnesyl protein transferase with significant antitumor effects in vivo subsequent to oral administration in mice. In vitro, using isolated human farnesyl prote...

journal_title：Cancer research

authors： End DW,Smets G,Todd AV,Applegate TL,Fuery CJ,Angibaud P,Venet M,Sanz G,Poignet H,Skrzat S,Devine A,Wouters W,Bowden C

更新日期：2001-01-01 00:00:00

abstract：:Preliminary results from a pilot trial on trastuzumab's mechanism of action against operable breast tumors overexpressing Her2 suggested a role for antibody-dependent cell cytotoxicity (ADCC). To examine factors affecting ADCC intensity and variability, we extended this study to the phenotypic and functional analysis ...

journal_title：Cancer research

authors： Varchetta S,Gibelli N,Oliviero B,Nardini E,Gennari R,Gatti G,Silva LS,Villani L,Tagliabue E,Ménard S,Costa A,Fagnoni FF

更新日期：2007-12-15 00:00:00

abstract：:We have previously identified amplification at 4q12 in testicular germ cell tumors of adolescents and adults centered around the KIT gene encoding a tyrosine kinase transmembrane receptor. Analysis of primary testicular germ cell tumors totaling 190 cases revealed 21% of the seminoma subtype with an increased copy num...

journal_title：Cancer research

authors： McIntyre A,Summersgill B,Grygalewicz B,Gillis AJ,Stoop J,van Gurp RJ,Dennis N,Fisher C,Huddart R,Cooper C,Clark J,Oosterhuis JW,Looijenga LH,Shipley J

更新日期：2005-09-15 00:00:00

abstract：:The effects of temperature in the fever range (37-42 degrees) on the membrane potentials of normal and simian virus 40-transformed hamster lymphocytes were analyzed. The transmembrane distributions of radiolabeled triphenylmethylphosphonium and thiocyanate were measured, and they provide upper and lower limits for the...

journal_title：Cancer research

authors： Mikkelsen RB,Koch B

更新日期：1981-01-01 00:00:00

abstract：:Successful systemic gene therapy has been hindered by vector-related limitations, including toxicity and inefficient gene delivery to tumor cells after i.v. administration. To circumvent these problems, we developed a novel formulation between the polycation polyethyleneimine and DNA that mediates high-level tumor cel...

journal_title：Cancer research

authors： Sweeney P,Karashima T,Ishikura H,Wiehle S,Yamashita M,Benedict WF,Cristiano RJ,Dinney CP

更新日期：2003-07-15 00:00:00

abstract：:Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor that secretes various angiogenic factors. The main inhibitor of plasminogen activators, PAI-1 (SERPINE1), has been implicated in tumor progression and angiogenesis, and high PAI-1 expression has been associated with poor prognosis in MPM patients. I...

journal_title：Cancer research

authors： Takayama Y,Hattori N,Hamada H,Masuda T,Omori K,Akita S,Iwamoto H,Fujitaka K,Kohno N

更新日期：2016-06-01 00:00:00

abstract：:Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resistance in HNSCC is driven by alternative receptor tyrosine kinases (RTK), includ...

journal_title：Cancer research

authors： Leonard B,Brand TM,O'Keefe RA,Lee ED,Zeng Y,Kemmer JD,Li H,Grandis JR,Bhola NE

更新日期：2018-08-01 00:00:00

abstract：:The epidermal growth factor (EGF) receptor in two colon carcinoma lines and in one vulval carcinoma line tested contains carbohydrate determinants that are recognized by monoclonal antibodies to tumor-associated antigens. These antibodies are directed to sialylated Lea and to difucosylated structures of the Y type. Ce...

journal_title：Cancer research

authors： Basu A,Murthy U,Rodeck U,Herlyn M,Mattes L,Das M

更新日期：1987-05-15 00:00:00

abstract：:This study examines the effects of a combined modality regimen of long duration-low temperature whole body hyperthermia (6 h at 40.0 degrees C; LL-WBH), recombinant human tumor necrosis factor-alpha (TNF) and carboplatin (CBDCA) on a transplantable fibrosarcoma as well as normal tissue. We compare LL-WBH with short du...

journal_title：Cancer research

authors： Sakaguchi Y,Makino M,Kaneko T,Stephens LC,Strebel FR,Danhauser LL,Jenkins GN,Bull JM

更新日期：1994-04-15 00:00:00

abstract：:SPARC is an extracellular matrix protein that exerts pleiotropic effects on extracellular matrix organization, growth factor availability, cell adhesion, differentiation, and immunity in cancer. Chronic myelogenous leukemia (CML) cells resistant to the BCR-ABL inhibitor imatinib (IM-R cells) were found to overexpress ...

journal_title：Cancer research

authors： Fenouille N,Puissant A,Dufies M,Robert G,Jacquel A,Ohanna M,Deckert M,Pasquet JM,Mahon FX,Cassuto JP,Raynaud S,Tartare-Deckert S,Auberger P

更新日期：2010-12-01 00:00:00

abstract：:A single i.p. injection of cyclophosphamide (CY), 15 mg/kg, was shown previously to be curative if administered to BALB/c mice 10 to 16 days post-MOPC-315 tumor inoculation when the tumors reached 20 to 25 mm (large tumors) but not if administered to mice four days post-tumor inoculation when their tumors were nonpalp...

journal_title：Cancer research

authors： Hengst JC,Mokyr MB,Dray S

更新日期：1981-06-01 00:00:00

abstract：:Most patients' prostate cancers respond to androgen deprivation but relapse after periods of several months to years. Only two prostate cancer xenografts, LNCaP and PC-346, have been reported to be responsive to androgen deprivation and to relapse subsequently. Both of these tumors shrink slightly, if at all, and rela...

journal_title：Cancer research

authors： Nagabhushan M,Miller CM,Pretlow TP,Giaconia JM,Edgehouse NL,Schwartz S,Kung HJ,de Vere White RW,Gumerlock PH,Resnick MI,Amini SB,Pretlow TG

更新日期：1996-07-01 00:00:00

abstract：:The majority of advanced prostate cancer therapies aim to inhibit androgen receptor (AR) signaling. However, AR reactivation inevitably drives disease progression to castration-resistant prostate cancer (CRPC). Here we demonstrate that protein arginine methyltransferase 5 (PRMT5) functions as an epigenetic activator o...

journal_title：Cancer research

authors： Beketova E,Fang S,Owens JL,Liu S,Chen X,Zhang Q,Asberry AM,Deng X,Malola J,Huang J,Li C,Pili R,Elzey BD,Ratliff TL,Wan J,Hu CD

更新日期：2020-11-15 00:00:00

abstract：:Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine gl...

journal_title：Cancer research

authors： Chen G,Giambrone NE Jr,Dluzen DF,Muscat JE,Berg A,Gallagher CJ,Lazarus P

更新日期：2010-10-01 00:00:00

abstract：:The incidence, distribution, size, and histopathology of grossly visible colonic tumors induced by parenteral administration of 1,2-dimethylhydrazine were examined in rats fed either a chemically defined fiber-free diet or a nutritionally and calorically equivalent diet containing a purified fiber component, microcrys...

journal_title：Cancer research

authors： Freeman HJ,Spiller GA,Kim YS

更新日期：1978-09-01 00:00:00

abstract：:K-ras gene mutations have been reported as early events in colorectal tumorigenesis, but their role in tumor initiation and development is still unclear. To analyze and compare K-ras mutational patterns between colorectal tissues at different stages of tumor progression in individual patients, 65 colorectal tissue sam...

journal_title：Cancer research

authors： Zhu D,Keohavong P,Finkelstein SD,Swalsky P,Bakker A,Weissfeld J,Srivastava S,Whiteside TL

更新日期：1997-06-15 00:00:00