Purification of the Mr 22,000 calcium-binding protein (sorcin) associated with multidrug resistance and its detection with monoclonal antibodies.

abstract：:The ability of cancer cells to evade apoptosis is dictated by a shift in the balance between proapoptotic and antiapoptotic gene expression programs. Monocyte chemotactic protein-induced protein 1 (MCPIP1) is a zinc-finger RNA binding protein with important roles in mediating inflammatory responses. Overexpression of ...

journal_title：Cancer research

authors： Lu W,Ning H,Gu L,Peng H,Wang Q,Hou R,Fu M,Hoft DF,Liu J

更新日期：2016-03-15 00:00:00

abstract：:A monoclonal antibody (5E8) has been used to identify and structurally characterize a previously unreported macromolecule present on the surface of human lung tumors. This antibody was derived from a hybrid clone that was produced using spleen cells of mice immunized with a surgically excised squamous cell carcinoma. ...

journal_title：Cancer research

authors： Zylstra S,Chen FA,Ghosh SK,Repasky EA,Rao U,Takita H,Bankert RB

更新日期：1986-12-01 00:00:00

abstract：:The cell line AR230 was established from the peripheral blood mononuclear cells of a patient with chronic myeloid leukemia and t(9;22) translocation bearing a variant type of BCR/ABL rearrangement. AR230 expresses a BCR/ABL fusion protein with a molecular mass of 230 kilodaltons (kDa) due to the insertion of 180 amino...

journal_title：Cancer research

authors： Wada H,Mizutani S,Nishimura J,Usuki Y,Kohsaki M,Komai M,Kaneko H,Sakamoto S,Delia D,Kanamaru A

更新日期：1995-07-15 00:00:00

abstract：:B7-H3, a surface immunomodulatory glycoprotein, inhibits natural killer cells and T cells. The monoclonal antibody (mAb) 8H9 is specific for 4Ig-B7-H3, the long and principal form of B7-H3. Early results from radioimmunotherapy using 8H9 have shown promise in patients with metastatic solid tumors to the central nervou...

journal_title：Cancer research

authors： Xu H,Cheung IY,Guo HF,Cheung NK

更新日期：2009-08-01 00:00:00

abstract：:Although many clinicians and researchers work to understand cancer, there has been limited success to effectively combine forces and collaborate over time, distance, data, and budget constraints. Here we present a workflow template for multidisciplinary cancer therapy that was developed during the 2nd Annual Workshop ...

journal_title：Cancer research

authors： McGuire MF,Enderling H,Wallace DI,Batra J,Jordan M,Kumar S,Panetta JC,Pasquier E

更新日期：2013-10-15 00:00:00

abstract：:The monoclonal antibodies (MAbs) 323/A3 and 17-1A both recognize a 40-kDa carcinoma-associated epithelial glycoprotein (EGP40). MAb 17-1A has been used in many therapeutic trials as an immunotherapeutic agent to combat advanced colorectal cancer, and about 5-10% overall responses have been observed. It has been shown ...

journal_title：Cancer research

authors： Velders MP,Litvinov SV,Warnaar SO,Gorter A,Fleuren GJ,Zurawski VR Jr,Coney LR

更新日期：1994-04-01 00:00:00

abstract：:Electron spin resonance (ESR) studies at -130 degrees have been made on frozen samples of normal human cervix and uterus and on frozen samples of various pathological conditions of the cervix and uterus including fibroleiomyoma and carcinoma. Fifty-five samples of normal cervix and endometrium, 40 samples of nonmalign...

journal_title：Cancer research

authors： Benedetto C,Bocci A,Dianzani MU,Ghiringhello B,Slater TF,Tomasi A,Vannini V

更新日期：1981-07-01 00:00:00

abstract：:Invasion and metastasis are the hallmarks of malignant tumor progression and the main cause of death in cancer. The embryonic program "epithelial-mesenchymal transition" (EMT) is thought to trigger invasion by allowing tumor cell dissemination. Here, we describe that the EMT-inducing transcriptional repressor ZEB1 pro...

journal_title：Cancer research

authors： Spaderna S,Schmalhofer O,Wahlbuhl M,Dimmler A,Bauer K,Sultan A,Hlubek F,Jung A,Strand D,Eger A,Kirchner T,Behrens J,Brabletz T

更新日期：2008-01-15 00:00:00

abstract：:The treatment of HeLa and HL-60 cells with various concentrations of pentakis(arizidino)thiatriazadiphosphorine oxide results in inhibition of growth and modification of cell cycle distribution. These phenomena were observed at 10(-4) M and 5 X 10(-5) M for HeLa cells and 10(-5) M and 5 X 10(-6) M for HL-60 cells. The...

journal_title：Cancer research

authors： Hecquet C,Nafziger J,Ronot X,Marie JP,Adolphe M

更新日期：1985-02-01 00:00:00

abstract：:Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic with potassium selective ionophoric activity. This drug has been reported to display antitumor effects but its utilization has been limited by its extreme toxicity. Here we report that the incorporation of valinomycin into multilamellar liposomes composed of...

journal_title：Cancer research

authors： Daoud SS,Juliano RL

更新日期：1986-11-01 00:00:00

abstract：:The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murine and human intestinal cancers. Usp28 was previously shown to interact with its...

journal_title：Cancer research

authors： Diefenbacher ME,Chakraborty A,Blake SM,Mitter R,Popov N,Eilers M,Behrens A

更新日期：2015-04-01 00:00:00

abstract：:Phosphate ore mining and processing operations are associated with dusty conditions and potential exposure to gamma radiation and radon daughter products. Although most current measurements are within Occupational Safety and Health Administration (OSHA) guidelines, no measurements exist for the era preceding modern st...

journal_title：Cancer research

authors： Block G,Matanoski GM,Seltser R,Mitchell T

更新日期：1988-12-15 00:00:00

abstract：:The increased proteolytic activity of membrane-bound and secreted proteases on the surface of cancer cells and in the transformed stroma is a common characteristic of aggressive metastatic prostate cancer. We describe here the development of an active site-specific probe for detecting a secreted peritumoral protease e...

journal_title：Cancer research

authors： LeBeau AM,Sevillano N,Markham K,Winter MB,Murphy ST,Hostetter DR,West J,Lowman H,Craik CS,VanBrocklin HF

更新日期：2015-04-01 00:00:00

abstract：:microRNAs (miRNA) are small noncoding RNAs that participate in diverse biological processes by suppressing target gene expression. Altered expression of miR-21 has been reported in cancer. To gain insights into its potential role in tumorigenesis, we generated miR-21 knockout colon cancer cells through gene targeting....

journal_title：Cancer research

authors： Wang P,Zou F,Zhang X,Li H,Dulak A,Tomko RJ Jr,Lazo JS,Wang Z,Zhang L,Yu J

更新日期：2009-10-15 00:00:00

abstract：:KAI1 (CD82) belongs to the transmembrane 4 superfamily in which members have inhibitory effects on tumor cell motility and metastasis. During reverse transcription-PCR analysis, we found a splice variant of KAI1 (spliced-KAI1) in which exon 7 was deleted. This exon encodes the 28 amino acids that span from the distal ...

journal_title：Cancer research

authors： Lee JH,Seo YW,Park SR,Kim YJ,Kim KK

更新日期：2003-11-01 00:00:00

abstract：:A truncated retinoblastoma (RB) protein of approximately 94 kDa (RB94), lacking the NH2 -terminal 112 amino acid residues of the full-length RB, has been found to have great efficacy in tumor suppression. This study investigated the role of adenovirus-mediated RB94 (Ad-RB94) gene therapy for human head and neck squamo...

journal_title：Cancer research

authors： Li D,Day KV,Yu S,Shi G,Liu S,Guo M,Xu Y,Sreedharan S,O'Malley BW Jr

更新日期：2002-08-15 00:00:00

abstract：:Allelic loss of chromosome 9p21 is common in small cell lung cancer (SCLC), but inactivation of the tumor suppressor gene CDKN2a is rare, implying the existence of another target gene at 9p21. A recent deletion mapping study of chromosome 9p has also identified a site of deletion in non-small cell lung cancer (NSCLC) ...

journal_title：Cancer research

authors： Cairns P,Okami K,King P,Bonacum J,Ahrendt S,Wu L,Mao L,Jen J,Sidransky D

更新日期：1997-12-01 00:00:00

abstract：:Recent work has begun to explore the instrumental role that small noncoding RNA species, particularly microRNAs (miRNA), have both in classifying human tumors and in directing embryonic development. These studies suggest that developmental programs in essentially all organisms studied are set, in part, by varied expre...

journal_title：Cancer research

authors： Marsit CJ,Eddy K,Kelsey KT

更新日期：2006-11-15 00:00:00

abstract：:A direct ligand-banding radioassay for methotrexate (MTX) has been developed using dihydrofolate reductase, contained in the lysate of L1210 leukemia cells, as the binding determinant. The procedure is a two-phase reaction system where standard MTX concentrations or the sample being assayed in incubated with the reage...

journal_title：Cancer research

authors： Arons E,Rothenberg SP,Costa MD,Fischer C,Iqbal MP

更新日期：1975-08-01 00:00:00

abstract：:Checkpoint kinase 1 (CHK1) is a key mediator of the DNA damage response that regulates cell-cycle progression, DNA damage repair, and DNA replication. Small-molecule CHK1 inhibitors sensitize cancer cells to genotoxic agents and have shown single-agent preclinical activity in cancers with high levels of replication st...

journal_title：Cancer research

authors： Rogers RF,Walton MI,Cherry DL,Collins I,Clarke PA,Garrett MD,Workman P

更新日期：2020-04-15 00:00:00

abstract：:The expression of cytochrome P450 genes directly within target cells is an important determinant of human susceptibility to cancers, birth defects, and other chemically initiated diseases. One pivotal gene, CYP1A1, codes for an inducible cytochrome P450 isozyme (P450IA1) responsible for the bioactivation of numerous c...

journal_title：Cancer research

authors： Omiecinski CJ,Redlich CA,Costa P

更新日期：1990-07-15 00:00:00

abstract：:Malignant neuroblastomas contain stem-like cells. These tumors also overexpress the Forkhead box transcription factor FoxM1. In this study, we investigated the roles of FoxM1 in the tumorigenicity of neuroblastoma. We showed that depletion of FoxM1 inhibits anchorage-independent growth and tumorigenicity in mouse xeno...

journal_title：Cancer research

authors： Wang Z,Park HJ,Carr JR,Chen YJ,Zheng Y,Li J,Tyner AL,Costa RH,Bagchi S,Raychaudhuri P

更新日期：2011-06-15 00:00:00

abstract：:Genetic alterations that occur in human breast cancers are believed to be of importance for initiation as well as progression of the disease. In order to find a genetic alteration that may be used as a prognostic marker, 82 familial breast carcinomas were analyzed for loss of constitutional heterozygosity at polymorph...

journal_title：Cancer research

authors： Lindblom A,Rotstein S,Skoog L,Nordenskjöld M,Larsson C

更新日期：1993-08-15 00:00:00

abstract：:Cell lines designated SNG-P and SNG-M were established from operation specimens of primary and metastatic regions of human endometrial adenocarcinoma. The cell lines grew well without interruption for over 13 months and were subcultivated more than 65 times. They continue to exhibit stable growth. The cultured cells a...

journal_title：Cancer research

authors： Ishiwata I,Nozawa S,Inoue T,Okumura H

更新日期：1977-06-01 00:00:00

abstract：:Alteration in epidermal growth factor receptor (EGFR) expression is frequently associated with malignant transformation of epithelial tissues, including oral mucosa. This study examines the mutations in the coding region of the human EGFR gene in normal and malignant human oral keratinocytes. To examine the intragenic...

journal_title：Cancer research

authors： Shintani S,Matsuo K,Crohin CC,McBride J,Tsuji T,Donoff RB,Posner M,Todd R,Wong DT

更新日期：1999-08-15 00:00:00

abstract：:3-phosphoinositide-dependent protein kinase-1 (PDK1) plays a pivotal role in coupling growth factor receptor signaling to tumor cell proliferation, survival, and invasion. Protein kinase C (PKC) alpha, but not Akt1, was found previously to be downstream of PDK1-mediated transformation of mammary epithelial cells. To d...

journal_title：Cancer research

authors： Xie Z,Zeng X,Waldman T,Glazer RI

更新日期：2003-09-01 00:00:00

abstract：:The association between nonleukemic death and various features recorded at presentation in patients with refractory anemia (RA), RA with ring sideroblasts, and RA with excess of blasts was analyzed in 251 patients using the proportional hazards model. Features associated with higher nonleukemic death rates were: 1% or...

journal_title：Cancer research

authors： Oguma S,Yoshida Y,Uchino H,Maekawa T

更新日期：1987-07-01 00:00:00

abstract：:Many but not all of the cell surface antigens studied were released into tissue culture medium of human colorectal carcinoma and melanoma cells maintained in vitro. Two groups of monoclonal antibody-defined antigens are described. One group is composed of molecules that are released easily and in large quantitites int...

journal_title：Cancer research

authors： Steplewski Z,Chang TH,Herlyn M,Koprowski H

更新日期：1981-07-01 00:00:00

abstract：:Malignant gliomas are the most common central nervous system tumors and the molecular mechanism driving their development and recurrence is still largely unknown, limiting the treatment of this disease. Here, we show that restoring the expression of miR-218, a microRNA commonly downregulated in glioma, dramatically re...

journal_title：Cancer research

authors： Tu Y,Gao X,Li G,Fu H,Cui D,Liu H,Jin W,Zhang Y

更新日期：2013-10-01 00:00:00

abstract：:Human polynucleotide phosphorylase (hPNPase(old-35)) is a type I IFN-inducible 3',5' exoribonuclease that mediates mRNA degradation. In melanoma cells, slow and sustained overexpression of hPNPase(old-35) induces G(1) cell cycle arrest ultimately culminating in apoptosis, whereas rapid overexpression of hPNPase(old-35...

journal_title：Cancer research

authors： Sarkar D,Park ES,Barber GN,Fisher PB

更新日期：2007-09-01 00:00:00