The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.

Abstract:

:Invasion and metastasis are the hallmarks of malignant tumor progression and the main cause of death in cancer. The embryonic program "epithelial-mesenchymal transition" (EMT) is thought to trigger invasion by allowing tumor cell dissemination. Here, we describe that the EMT-inducing transcriptional repressor ZEB1 promotes colorectal cancer cell metastasis and loss of cell polarity. Thereby, ZEB1 suppresses the expression of cell polarity factors, in particular of Lgl2, which we found reduced in colorectal and breast cancers. We further show that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis. Thus, by linking EMT, loss of polarity, and metastasis, ZEB1 is a crucial promoter of malignant tumor progression.

journal_name

Cancer Res

journal_title

Cancer research

authors

Spaderna S,Schmalhofer O,Wahlbuhl M,Dimmler A,Bauer K,Sultan A,Hlubek F,Jung A,Strand D,Eger A,Kirchner T,Behrens J,Brabletz T

doi

10.1158/0008-5472.CAN-07-5682

subject

Has Abstract

pub_date

2008-01-15 00:00:00

pages

537-44

issue

2

eissn

0008-5472

issn

1538-7445

pii

68/2/537

journal_volume

68

pub_type

杂志文章
  • Long-term adjuvant therapy with tamoxifen: effects on sex hormone binding globulin and antithrombin III.

    abstract::Plasma levels of luteinizing hormone, sex hormone binding globulin, and antithrombin III were measured in pre- and postmenopausal breast cancer patients receiving adjuvant combination chemotherapy or combination chemotherapy and long-term tamoxifen therapy. The aim was to determine the estrogen-like effects of tamoxif...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Jordan VC,Fritz NF,Tormey DC

    更新日期:1987-08-15 00:00:00

  • Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents.

    abstract::Chemical and biological studies are presented for a new series of platinum(II) antitumor agents that violate the classical structure-activity relationships established for platinum complexes. These new agents, which have demonstrated activity against murine and human tumor systems, are cis-[Pt(NH3)2(Am)Cl]+ cations, i...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hollis LS,Sundquist WI,Burstyn JN,Heiger-Bernays WJ,Bellon SF,Ahmed KJ,Amundsen AR,Stern EW,Lippard SJ

    更新日期:1991-04-01 00:00:00

  • Chromosomal breakpoints in primary colon cancer cluster at sites of structural variants in the genome.

    abstract::Genomic aberrations on chromosome 8 are common in colon cancer, and are associated with lymph node and distant metastases as well as with disease susceptibility. This prompted us to generate a high-resolution map of genomic imbalances of chromosome 8 in 51 primary colon carcinomas using a custom-designed genomic array...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-07-2864

    authors: Camps J,Grade M,Nguyen QT,Hörmann P,Becker S,Hummon AB,Rodriguez V,Chandrasekharappa S,Chen Y,Difilippantonio MJ,Becker H,Ghadimi BM,Ried T

    更新日期:2008-03-01 00:00:00

  • An experimental approach to relate a tumor-associated enzyme marker to tumor cell numbers.

    abstract::Alkaline phosphatase was monitored in 17 mice with s.c.-implanted tumors to relate the total circulating alkaline phosphatase to the total number of tumor cells in each mouse. There was a semilogarithmic relationship between the alkaline phosphatase units and the number of tumor cells. A time-independent standard plot...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hiramoto RN,Ghanta VK,Soong SJ,Hurst DC

    更新日期:1977-02-01 00:00:00

  • The suppression of drug-induced apoptosis by activation of v-ABL protein tyrosine kinase.

    abstract::Cells with a temperature-sensitive mutant of the v-abl oncoprotein (IC.DP) were treated with the anticancer drugs melphalan or hydroxyurea. At the restrictive temperature for v-ABL protein tyrosine kinase activity, drug-treated IC.DP cells died by apoptosis. In contrast, apoptotic cell death induced by either drug was...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Chapman RS,Whetton AD,Dive C

    更新日期:1994-10-01 00:00:00

  • Plasmin-catalyzed proteolysis in colorectal neoplasia.

    abstract::The expression of different components of the plasminogen activator (PA)/plasmin system was explored in a series of colorectal neoplasia. We have found that urokinase (uPA) and urokinase receptor (uPA-R) gene expression is upregulated in adenomas and carcinomas, and that uPA/uPA-R production is confined to stromal cel...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Delbaldo C,Cunningham M,Vassalli JD,Sappino AP

    更新日期:1995-10-15 00:00:00

  • Retinoid binding protein activities in murine embryonal carcinoma cells and their differentiated derivatives.

    abstract::It has been proposed that cellular retinoic acid binding protein is essential for retinoid-induced differentiation of embryonal carcinoma line PCC4.aza1R. To assess the generality of this proposal, we have tested for the presence of cellular retinoic acid binding protein activities in several other embryonal carcinoma...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Matthaei KI,McCue PA,Sherman MI

    更新日期:1983-06-01 00:00:00

  • Fatty acid composition transport and metabolism in doxorubicin-sensitive and-resistant rat glioblastoma cells.

    abstract::We have studied the lipid composition and the acyl group composition, transport, and metabolism of doxorubicin-sensitive and -resistant rat glioblastoma cells in monolayer cultures (C6 clone). No difference in lipid composition was evidenced; the acyl group composition was, in contrast, highly modified in resistant ce...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Vrignaud P,Montaudon D,Londos-Gagliardi D,Robert J

    更新日期:1986-07-01 00:00:00

  • Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts.

    abstract::Combined cytogenetic and biochemical approaches were used to investigate the contributions of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) in the maintenance of genomic stability in nonirradiated and irradiated primary mouse embryo fibroblasts (MEF). We show that telomere dysfunction contributes on...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-05-0932

    authors: Martín M,Genescà A,Latre L,Jaco I,Taccioli GE,Egozcue J,Blasco MA,Iliakis G,Tusell L

    更新日期:2005-11-15 00:00:00

  • Unraveling the "known unknowns": lessons and reflections from the new directions in leukemia research 2012 conference.

    abstract::Patients diagnosed with leukemia approach their treatment with the hope of cure despite the effect on their quality of life. Some patients will be cured, others will die from treatment, and some will die of their disease. A common theme at the New Directions in Leukemia Research (NDLR 2012) meeting was that cure will ...

    journal_title:Cancer research

    pub_type:

    doi:10.1158/0008-5472.CAN-12-1832

    authors: White DL,Brown AL,D'Andrea RJ,Rice AM

    更新日期:2012-09-01 00:00:00

  • Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus.

    abstract::UDP-N-acetylglucosamine: beta-D-mannoside beta-1,4-N-acetylglucosaminyl-transferase III (GnT-III) is a key enzyme in the branching of asparagine-linked oligosaccharides, which are present in surface membrane proteins of various tissues and in secretory glycoproteins. The activity of GnT-III was assayed in 2 human hepa...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Miyoshi E,Nishikawa A,Ihara Y,Hayashi N,Fusamoto H,Kamada T,Taniguchi N

    更新日期:1994-04-01 00:00:00

  • Intratumor heterogeneity: evolution through space and time.

    abstract::Recent technologic advances have permitted higher resolution and more rapid analysis of individual cancer genomes at the single-nucleotide level. Such advances have shown bewildering intertumor heterogeneity with limited somatic alterations shared between tumors of the same histopathologic subtype. Exacerbating such c...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-12-2217

    authors: Swanton C

    更新日期:2012-10-01 00:00:00

  • Follicle-stimulating hormone peptide can facilitate paclitaxel nanoparticles to target ovarian carcinoma in vivo.

    abstract::Chemotherapy is an important treatment for ovarian cancer. However, conventional chemotherapy has inevitable drawbacks due to side effects from nonspecific biodistribution of the chemotherapeutic drugs. To solve such problem, targeted delivery approaches were developed. The targeted delivery approaches combine drug ca...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-08-4721

    authors: Zhang XY,Chen J,Zheng YF,Gao XL,Kang Y,Liu JC,Cheng MJ,Sun H,Xu CJ

    更新日期:2009-08-15 00:00:00

  • Pathology, Chemoprevention, and Preclinical Models for Target Validation in Barrett Esophagus.

    abstract::Despite esophageal adenocarcinoma (EAC) being the most widespread among gastrointestinal cancers, with an 11-fold increase in the risk of cancer for patients with Barrett esophagus (BE), its prognosis is still poor. There is a critical need to better perceive the biology of cancer progression and identification of spe...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:10.1158/0008-5472.CAN-18-0206

    authors: Urbanska AM,Ponnazhagan S,Mozafari M

    更新日期:2018-07-15 00:00:00

  • Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

    abstract::Breast cancer is the second leading cause of cancer death for women in the United States. Of the different subtypes, estrogen receptor-negative (ER(-)) tumors, which are ErbB2+ or triple-negative, carry a relatively poor prognosis. In this study, we used system-wide analysis of breast cancer proteomes to identify prot...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-11-3711

    authors: Geiger T,Madden SF,Gallagher WM,Cox J,Mann M

    更新日期:2012-05-01 00:00:00

  • High tumorigenicity of the 3,4-dihydrodiol of 7-methylbenz[c]acridine on mouse skin and in newborn mice.

    abstract::The tumorigenicities of 7-methylbenz[c]acridine (7MB[c]ACR) and its five metabolically possible trans-dihydrodiols were determined in two mouse tumor models. In initiation-promotion studies on mouse skin, a single topical application of 0.15 to 0.75 mumol of compound was followed 9 days later by twice weekly applicati...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Chang RL,Levin W,Wood AW,Shirai N,Ryan AJ,Duke CC,Jerina DM,Holder GM,Conney AH

    更新日期:1986-09-01 00:00:00

  • Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction.

    abstract::Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain: (a) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies; (b) H19, an untranslated RNA that is a putative growth suppress...

    journal_title:Cancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Feinberg AP

    更新日期:1999-04-01 00:00:00

  • Deoxycytidine Release from Pancreatic Stellate Cells Promotes Gemcitabine Resistance.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths in the United States. The deoxynucleoside analogue gemcitabine is among the most effective therapies to treat PDAC, however, nearly all patients treated with gemcitabine either fail to respond or rapidly develop resistance. One hallmark of PDA...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-19-0960

    authors: Dalin S,Sullivan MR,Lau AN,Grauman-Boss B,Mueller HS,Kreidl E,Fenoglio S,Luengo A,Lees JA,Vander Heiden MG,Lauffenburger DA,Hemann MT

    更新日期:2019-11-15 00:00:00

  • Coupling tumor necrosis factor-alpha with alphaV integrin ligands improves its antineoplastic activity.

    abstract::Despite the impressive results obtained in animal models, the clinical use of tumor necrosis factor-alpha (TNF) as an anticancer drug is limited by severe toxicity. We have shown previously that targeted delivery of TNF to aminopeptidase N (CD13), a marker of angiogenic vessels, improved the therapeutic index of this ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.can-03-1753

    authors: Curnis F,Gasparri A,Sacchi A,Longhi R,Corti A

    更新日期:2004-01-15 00:00:00

  • Comparison of the structural and cytotoxic activity of novel 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone analogues.

    abstract::Eight analogues of 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone have been synthesized and tested for cytotoxicity against four different leukemic and lymphomic cell lines. For K562 and BSM cells, the toxicity could be correlated with the ease of reduction of the compounds as determined by the one-electr...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Dzielendziak A,Butler J,Hoey BM,Lea JS,Ward TH

    更新日期:1990-04-01 00:00:00

  • Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats.

    abstract::The biochemical and clinical effects of selenium (Na2SeO3) on 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in male Sprague-Dawley rats are presented. A 4-ppm selenium supplement to the drinking water was provided before, during, and after 20 weekly injections of 20 mg DMH per kg body weight. Immediately af...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Jacobs MM,Forst CF,Beams FA

    更新日期:1981-11-01 00:00:00

  • Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.

    abstract::The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression w...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:10.1158/0008-5472.CAN-15-1025

    authors: Oh AY,Jung YS,Kim J,Lee JH,Cho JH,Chun HY,Park S,Park H,Lim S,Ha NC,Park JS,Park CS,Song GY,Park BJ

    更新日期:2016-08-15 00:00:00

  • Enhancement of metastatic potential by gamma-interferon.

    abstract::Preincubation of murine colon 26 colon adenocarcinoma cells with gamma-interferon (IFN-gamma), but not alpha-interferon, produced a significant increase in experimental pulmonary metastases in syngeneic BALB/c and T-cell-deficient BALB/c nude mice. The enhancement was seen after as little as 1 h of exposure to 1 unit/...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Kelly SA,Gschmeissner S,East N,Balkwill FR

    更新日期:1991-08-01 00:00:00

  • The effect of exposure to dibutyryl cyclic adenylic acid on the membrane antigenicity of SV40 tumor cells.

    abstract::When SV40 tumor cells (F5-1) in culture were treated with dibutyryl cyclic adenylic acid (DbcAMP),marked alterations occurred in their growth and morphology. Additionally, the incorporation or uptake of labeled thymidine, uridine, phenylalanine, and choline were reduced by this treatment. These modifications with DbcA...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Hannon WH,Anderson NG,Coggin JH Jr

    更新日期:1976-09-01 00:00:00

  • Carcinogenic activity of di- and trifunctional alpha-chloro ethers and of 1,4-dichlorobutene-2 in ICR/HA swiss mice.

    abstract::Four bifunctional and one trifunctional alpha-chloro ethers were tested for carcinogenicity. These compounds were bis-1,2-(chloromethoxy)ethane (Compound I), bis-1,4-(chloromethoxy)butane (Compound II), bis-1,6-(chloromethoxy) hexane (Compound III), bis-1,4-(chloromethoxy)-p-xylene (Compound IV), and tris-1,2,3-(chlor...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Van Duuren BL,Goldschmidt BM,Seidman I

    更新日期:1975-09-01 00:00:00

  • Immunological block to synthetic alpha-melanocyte-stimulating hormone: melanocyte interaction by antibodies isolated from cell-column immunoadsorbents.

    abstract::Antibodies to formalin-fixed, syngeneic melanoma cells were prepared in mice, purified by immunoaffinity chromatography, and tested for binding activity to viable melanoma cells. The radiolabeled antibodies detected congruent to 9 X 10(6) melanoma antigenic sites/cell. The calculated average association constant (Ka) ...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Winkelhake JL,Elcombe BM,Hodach A

    更新日期:1979-08-01 00:00:00

  • Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks.

    abstract::The study of two major risk factors in the development of hepatocellular carcinoma, namely persistent hepatitis virus infection and exposure to dietary aflatoxins, has been hampered by lack of an experimental system. To this end we have used a Pekin duck model to examine the effect of congenital duck hepatitis B virus...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Cova L,Wild CP,Mehrotra R,Turusov V,Shirai T,Lambert V,Jacquet C,Tomatis L,Trépo C,Montesano R

    更新日期:1990-04-01 00:00:00

  • Meeting Report: Inaugural Chemotherapy-Induced Peripheral Neuropathy Symposium - Santa Barbara, CA, February 2015.

    abstract::Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer treatment. This conference was the first of its kind to bring together a wide range of clinicians, researchers, and industry professionals to address the potential causes, preventions, and treatments for this drug toxicity. Int...

    journal_title:Cancer research

    pub_type: 杂志文章,收录出版

    doi:10.1158/0008-5472.CAN-15-1145

    authors: Smith JA,Benbow SJ

    更新日期:2015-09-15 00:00:00

  • Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts.

    abstract::We have explored the therapeutic effects of anti-epidermal growth factor receptor monoclonal antibodies (MAbs) 225 and 528 on well established A431 epidermoid carcinoma xenografts, approximately 400 mm3 (1 cm in diameter) at the start of treatment. In previous reports we demonstrated that MAbs 225 and 528 prevented th...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Fan Z,Baselga J,Masui H,Mendelsohn J

    更新日期:1993-10-01 00:00:00

  • Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.

    abstract::Sustained proliferation of cancer cells requires telomerase to maintain telomeres that regulate chromosomal stability and cellular mitosis. Expression of human telomerase reverse transcriptase (hTERT) catalytic subunit, which modulates telomerase activity, is regulated at both the transcriptional level and via phospho...

    journal_title:Cancer research

    pub_type: 杂志文章

    doi:

    authors: Akiyama M,Hideshima T,Hayashi T,Tai YT,Mitsiades CS,Mitsiades N,Chauhan D,Richardson P,Munshi NC,Anderson KC

    更新日期:2003-01-01 00:00:00