Abstract:
:We investigated whether a polymorphism in the cytochrome P450c17alpha gene (CYP17), which is associated with higher endogenous hormone levels, influences the use of hormone replacement therapy (HRT). The study included 749 postmenopausal women ages 44-75 years at baseline randomly selected from a larger multiethnic cohort. African-American, Japanese, Latina, and white women were included in the study. Women who carry the CYP17 A2/A2 genotype were about half as likely as women with the A1/A1 genotype to be current HRT users (odds ratio = 0.52; 95% confidence interval, 0.31-0.86). This association was present in all four racial/ethnic groups and for women above and below the median weight of 150 pounds. These findings suggest that the actual risk of breast cancer associated with HRT use may be higher than previously reported.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Feigelson HS,McKean-Cowdin R,Pike MC,Coetzee GA,Kolonel LN,Nomura AM,Le Marchand L,Henderson BEsubject
Has Abstractpub_date
1999-08-15 00:00:00pages
3908-10issue
16eissn
0008-5472issn
1538-7445journal_volume
59pub_type
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