Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.

abstract：:Cancer procoagulant (CP) is a Mr 68,000 cysteine proteinase that initiates blood coagulation and is expressed by a variety of malignant cells but not by normally differentiated cells. Polyclonal immunoglobulin G and monoclonal immunoglobulin M antibodies were developed to purified CP and used to develop an enzyme-link...

journal_title：Cancer research

authors： Gordon SG,Cross BA

更新日期：1990-10-01 00:00:00

abstract：:An animal model to investigate the invasive and metastatic properties of human bladder transitional cell carcinoma (HTCC) was established. Two long-term HTCC cell lines (RT4 and EJ) and one HTCC cell line derived in our laboratory (LD-71) were tumorigenic when injected s.c. into nude mice but had little potential to i...

journal_title：Cancer research

authors： Ahlering TE,Dubeau L,Jones PA

更新日期：1987-12-15 00:00:00

abstract：:The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically reduces susceptibility to the classical two-stage protocol of inflammatory skin...

journal_title：Cancer research

authors： Mazzieri R,Pietrogrande G,Gerasi L,Gandelli A,Colombo P,Moi D,Brombin C,Ambrosi A,Danese S,Mignatti P,Blasi F,D'Alessio S

更新日期：2015-11-15 00:00:00

abstract：:We have recently identified a new gene, interleukin-17 receptor-like (IL-17RL), which is expressed in normal prostate and prostate cancer. This investigation is focused on the role of IL-17RL in prostate cancer. We found that IL-17RL was expressed at significantly higher levels in several androgen-independent prostate...

journal_title：Cancer research

authors： You Z,Shi XB,DuRaine G,Haudenschild D,Tepper CG,Lo SH,Gandour-Edwards R,de Vere White RW,Reddi AH

更新日期：2006-01-01 00:00:00

abstract：:Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10%-30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of part...

journal_title：Cancer research

authors： Prior IA,Hood FE,Hartley JL

更新日期：2020-07-15 00:00:00

abstract：:Many N-nitroso compounds (NOC) are carcinogens. In this controlled study of 21 healthy male volunteers, levels of NOC on a high (420 grams) red meat diet were significantly greater (P = 0.001) than on a low (60 grams) meat diet but not significantly greater when an equivalent amount of vegetable protein was fed. An 8-...

journal_title：Cancer research

authors： Cross AJ,Pollock JR,Bingham SA

更新日期：2003-05-15 00:00:00

abstract：:The effect of Adriamycin on the invasive capacity of rat ascites hepatoma cells, W1, was studied. The invasive capacity of W1 cells was estimated in vitro by counting the number of penetrated single tumor cells and tumor cell colonies formed from the penetrated cells underneath a cultured mesothelial cell monolayer (H...

journal_title：Cancer research

authors： Imamura F,Horai T,Mukai M,Shinkai K,Akedo H

更新日期：1990-04-01 00:00:00

abstract：:A method was elaborated for high-yield 125I-trap labeling of rat colon carcinoma cells using conjugates of dichlorotriazine aminofluorescein and bovine serum albumin substituted with either N-acetylgalactosamine or N-acetylglucosamine as vehicles. Fluorescence microscopy revealed that the ligands accumulated in perinu...

journal_title：Cancer research

authors： Rushfeldt C,Smedsrød B

更新日期：1993-02-01 00:00:00

abstract：:In cancer chemoprevention studies, the identification of better antitumor-promoting agents is highly desired because they may have a wider applicability against the development of clinical cancers. Both epidemiological and animal studies have suggested that microchemicals present in the diet and several herbs and plan...

journal_title：Cancer research

authors： Lahiri-Chatterjee M,Katiyar SK,Mohan RR,Agarwal R

更新日期：1999-02-01 00:00:00

abstract：:Ewing Sarcoma (ES) shows several deregulated autocrine loops mediating cell survival and proliferation. Therefore, their blockade is a promising therapeutic approach. We previously reported the in vitro effect of insulin-like growth factor 1 receptor (IGF1R)/KIT pathway blockade on ES cell lines, and we now extend our...

journal_title：Cancer research

authors： Martins AS,Ordoñez JL,García-Sánchez A,Herrero D,Sevillano V,Osuna D,Mackintosh C,Caballero G,Otero AP,Poremba C,Madoz-Gúrpide J,de Alava E

更新日期：2008-08-01 00:00:00

abstract：:The effect of i.v. administration of the nitric oxide synthase (NOS) inhibitor N(omega)-nitro-L-arginine (L-NNA) on tumor blood flow compared with normal tissue blood flow was studied in anesthetized BD9 rats bearing subcutaneous P22 carcinosarcomas. Blood flow was measured by the tissue uptake of radiolabeled iodoant...

journal_title：Cancer research

authors： Tozer GM,Prise VE,Chaplin DJ

更新日期：1997-03-01 00:00:00

abstract：:The growth of solid tumors and the formation of metastases are dependent on neoangiogenesis. One of the most important factors in inducing the formation of new blood vessels is the vascular endothelial growth factor (VEGF), which acts specifically on endothelial cells. VEGF is expressed and secreted by almost all soli...

journal_title：Cancer research

authors： Barleon B,Siemeister G,Martiny-Baron G,Weindel K,Herzog C,Marmé D

更新日期：1997-12-01 00:00:00

abstract：:Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility m...

journal_title：Cancer research

authors： Wokolorczyk D,Gliniewicz B,Sikorski A,Zlowocka E,Masojc B,Debniak T,Matyjasik J,Mierzejewski M,Medrek K,Oszutowska D,Suchy J,Gronwald J,Teodorczyk U,Huzarski T,Byrski T,Jakubowska A,Górski B,van de Wetering T,Walczak

更新日期：2008-12-01 00:00:00

abstract：:The response to Photofrin II-induced photosensitization on the activities of mitochondrial monoamine oxidase (MAO) and adenylate kinase (AK) were studied in order to gain further insight into site specific effects. Utilizing intact mitochondria in vitro, both MAO, located on the cytoplasmic side of the outer mitochond...

journal_title：Cancer research

authors： Murant RS,Gibson SL,Hilf R

更新日期：1987-08-15 00:00:00

abstract：:Neuroblastoma is a common solid tumor of childhood that is derived from the neural crest. Expression of epidermal growth factor (EGF) receptors (EGFRs) has been associated with enhanced cell growth and aggressive behavior in other tumors. Here, we examined the expression profile of EGFRs in neuroblastoma cell lines an...

journal_title：Cancer research

authors： Ho R,Minturn JE,Hishiki T,Zhao H,Wang Q,Cnaan A,Maris J,Evans AE,Brodeur GM

更新日期：2005-11-01 00:00:00

abstract：:Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. These modifications take place throughout development with subsequent events occurring later in adulthood. Recent studies, however, suggest that some epigenetic alterations that influ...

journal_title：Cancer research

authors： Fleming JL,Huang TH,Toland AE

更新日期：2008-11-15 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein who...

journal_title：Cancer research

authors： Zhang FL,Cao JL,Xie HY,Sun R,Yang LF,Shao ZM,Li DQ

更新日期：2018-10-15 00:00:00

abstract：:Activation of c-Met signaling and beta-catenin mutations are frequent genetic events observed in liver cancer development. Recently, we demonstrated that activated beta-catenin can cooperate with c-Met to induce liver cancer formation in a mouse model. Cyclin D1 (CCND1) is an important cell cycle regulator that is con...

journal_title：Cancer research

authors： Patil MA,Lee SA,Macias E,Lam ET,Xu C,Jones KD,Ho C,Rodriguez-Puebla M,Chen X

更新日期：2009-01-01 00:00:00

abstract：:A common pathobiological feature of malignant gliomas is the insidious infiltration of single tumor cells into the brain parenchyma, rendering these deadly tumors virtually incurable with available therapies. In this study, we report that ADP-ribosylation factor 6 (ARF6), a Ras superfamily small GTPase, is abundantly ...

journal_title：Cancer research

authors： Hu B,Shi B,Jarzynka MJ,Yiin JJ,D'Souza-Schorey C,Cheng SY

更新日期：2009-02-01 00:00:00

abstract：:A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells an...

journal_title：Cancer research

authors： Mujoo K,Cheresh DA,Yang HM,Reisfeld RA

更新日期：1987-02-15 00:00:00

abstract：:The development of toxicity to 4'-demethylepipodophyllotoxin-9-(4,6,-O-thenylidene-beta-glucopyranoside) an epipodophyllotoxin with oncolytic activity, was characterized in mice treated three times at 3-day intervals with 10 mg of drug i.p. per kg of body weight. Changes in organ function and general metabolism were d...

journal_title：Cancer research

authors： Hacker M,Roberts DW

更新日期：1975-07-01 00:00:00

abstract：:Although the aromatase inhibitor anastrozole has been shown to be very effective in the treatment of hormone-dependent postmenopausal breast cancer, some patients with advanced disease will develop resistance to treatment. To investigate therapeutic strategies to overcome resistance to anastrozole treatment, we have u...

journal_title：Cancer research

authors： Macedo LF,Sabnis GJ,Goloubeva OG,Brodie A

更新日期：2008-05-01 00:00:00

abstract：:Although numerous studies have implicated vitamin D in preventing prostate cancer, the underlying mechanism(s) remains unclear. Using normal human prostatic epithelial cells, we examined the role of mitogen-activated protein kinase phosphatase 5 (MKP5) in mediating cancer preventive activities of vitamin D. Up-regulat...

journal_title：Cancer research

authors： Nonn L,Peng L,Feldman D,Peehl DM

更新日期：2006-04-15 00:00:00

abstract：:Previous molecular analyses of human astrocytomas have identified many genetic changes associated with astrocytoma formation and progression. In an effort to identify novel gene expression changes associated with astrocytoma formation, which might reveal new potential targets for glioma therapeutic drug design, we use...

journal_title：Cancer research

authors： Huang ZY,Wu Y,Burke SP,Gutmann DH

更新日期：2003-06-01 00:00:00

abstract：:The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation, growth, and survival of malignant cells, and has emerged as a general and promising target for cancer treatment. However, no fully selective IGF-1R inhibitors have thus far been found. This is explained by the fact that IGF-1R i...

journal_title：Cancer research

authors： Girnita A,Girnita L,del Prete F,Bartolazzi A,Larsson O,Axelson M

更新日期：2004-01-01 00:00:00

abstract：:Pluripotent cells within embryonal carcinoma (EC) can differentiate in vivo or in vitro on treatment with specific agents. Differentiating EC cells express lower levels of stem cell-related genes, such as Cripto-1. We show that migration of human EC cells (NTERA/2 and NCCIT) can be reduced following treatment with the...

journal_title：Cancer research

authors： Mancino M,Esposito C,Watanabe K,Nagaoka T,Gonzales M,Bianco C,Normanno N,Salomon DS,Strizzi L

更新日期：2009-03-01 00:00:00

abstract：:Expression of resistance to cis-diamminedichloroplatinum(II) (CDDP), one of the most effective chemotherapeutic drugs used to treat a variety of malignancies, remains a serious obstacle for improving cancer treatment. To study possible genetic mechanisms underlying the development of CDDP resistance, we have adopted t...

journal_title：Cancer research

authors： Lu SJ,Man S,Bani MR,Adachi D,Hawley RG,Kerbel RS,Ben-David Y

更新日期：1995-03-01 00:00:00

abstract：:Cyclooxygenase-2 and prostaglandin E(2) (PGE(2)) levels are increased in colorectal cancers and a subset of adenomas. PGE(2) signaling through the EP4 receptor has previously been associated with colorectal tumorigenesis. However, changes in EP4 expression during adenoma to carcinoma progression have not been investig...

journal_title：Cancer research

authors： Chell SD,Witherden IR,Dobson RR,Moorghen M,Herman AA,Qualtrough D,Williams AC,Paraskeva C

更新日期：2006-03-15 00:00:00

abstract：:Prostate cancer subtypes are poorly defined and functional validation of drivers of ETS rearrangement-negative prostate cancer has not been conducted. Here, we identified an ETS(-) subtype of aggressive prostate cancer (ERG(-)MAP3K7(del)CHD1(del)) and used a novel developmental model and a cell line xenograft model to...

journal_title：Cancer research

authors： Rodrigues LU,Rider L,Nieto C,Romero L,Karimpour-Fard A,Loda M,Lucia MS,Wu M,Shi L,Cimic A,Sirintrapun SJ,Nolley R,Pac C,Chen H,Peehl DM,Xu J,Liu W,Costello JC,Cramer SD

更新日期：2015-03-15 00:00:00

abstract：:The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we demonstrate that several different CD44 variants bind to OPN in an arginine-glycineaspartic acid-independent manner, bu...

journal_title：Cancer research

authors： Katagiri YU,Sleeman J,Fujii H,Herrlich P,Hotta H,Tanaka K,Chikuma S,Yagita H,Okumura K,Murakami M,Saiki I,Chambers AF,Uede T

更新日期：1999-01-01 00:00:00