Abstract:
:We clarified the role of mold exposure in pituitary tumor induction using 53 germ-free Wistar rats exposed before birth and continually exposed thereafter, to Aspergillus versicolor alone. Rats were autopsied at 540 to 730 days. Untreated germ-free controls were autopsied on day 730. Thirty-three of the 53 monoassociated rats had pituitary tumors (62.3%), while only three of the 41 control germ-free rats had tumors (7.3%). It seems likely that this high incidence of pituitary tumor in the experimental rats is due to metabolites derived from the mold.
journal_name
Cancer Resjournal_title
Cancer researchauthors
Sumi Y,Nagura H,Miyakawa Msubject
Has Abstractpub_date
1990-01-15 00:00:00pages
400-2issue
2eissn
0008-5472issn
1538-7445journal_volume
50pub_type
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